메뉴 건너뛰기




Volumn 18, Issue 10, 2011, Pages 1515-1525

Oxysterol derivatives of cholesterol in neurodegenerative disorders

Author keywords

Cholesterol metabolism; Neurodegenerative syndromes; Oxysterols

Indexed keywords

CELL NUCLEUS RECEPTOR; CHOLESTEROL DERIVATIVE; LIGAND; MYELIN; OXYSTEROL;

EID: 79954986242     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986711795328445     Document Type: Article
Times cited : (49)

References (146)
  • 1
    • 67650751079 scopus 로고    scopus 로고
    • Cholesterol 24-hydroxylase: An enzyme of cholesterol turnover in the brain
    • Russell, D.W.; Haiford, R.W.; Ramirez, D.M.; Shah, R.; Kotti, T. Cholesterol 24-hydroxylase: An enzyme of cholesterol turnover in the brain. Annu. Rev Biochem., 2009, 78, 1017-1040.
    • (2009) Annu. Rev Biochem. , vol.78 , pp. 1017-1040
    • Russell, D.W.1    Haiford, R.W.2    Ramirez, D.M.3    Shah, R.4    Kotti, T.5
  • 2
    • 77955108799 scopus 로고    scopus 로고
    • Genetic connections between neurological disorders and cholesterol metabolism
    • Bjorkhem, I.; Leoni, V.; Meaney, S. Genetic connections between neurological disorders and cholesterol metabolism. J. Lipid Res., 2010, 51, 2489-2503.
    • (2010) J. Lipid Res. , vol.51 , pp. 2489-2503
    • Bjorkhem, I.1    Leoni, V.2    Meaney, S.3
  • 5
    • 0141459395 scopus 로고    scopus 로고
    • Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration
    • DOI 10.1194/jlr.M300164-JLR200
    • Xie, C.; Lund, E.G.; Turley, S.D.; Russell, D.W.; Dietschy, J.M. Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration. J. Lipid Res., 2003, 44, 1780-1789. (Pubitemid 37185890)
    • (2003) Journal of Lipid Research , vol.44 , Issue.9 , pp. 1780-1789
    • Xie, C.1    Lund, E.G.2    Turley, S.D.3    Russell, D.W.4    Dietschy, J.M.5
  • 6
    • 34648843244 scopus 로고    scopus 로고
    • A neuroscientist's guide to lipidomics
    • DOI 10.1038/nrn2233, PII NRN2233
    • Piomelli, D.; Astarita, G.; Rapaka, R. A neuroscientist's guide to lipidomics. Nat. Rev Neurosci., 2007, 8, 743-754. (Pubitemid 47462119)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.10 , pp. 743-754
    • Piomelli, D.1    Astarita, G.2    Rapaka, R.3
  • 7
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • DOI 10.1097/00041433-200104000-00003
    • Dietschy, J.M.; Turley, S.D. Cholesterol metabolism in the brain. Curr. Opin. Lipidol, 2001, 12, 105-112. (Pubitemid 32242918)
    • (2001) Current Opinion in Lipidology , vol.12 , Issue.2 , pp. 105-112
    • Dietschy, J.M.1    Turley, S.D.2
  • 8
    • 0030729021 scopus 로고    scopus 로고
    • 2 techniques in vivo and in vitro
    • DOI 10.1074/jbc.272.48.30178
    • Bjorkhem, I.; Lutjohann, D.; Breuer, O.; Sakinis, A.; Wennmalm, A. Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(s)-hydroxycholesterol in rat brain as measured with 18o2 techniques in vivo and in vitro. J. Biol. Chem., 1997, 272, 30178-30184. (Pubitemid 27512218)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.48 , pp. 30178-30184
    • Bjorkhem, I.1    Lutjohann, D.2    Breuer, O.3    Sakinis, A.4    Wennmalm, A.5
  • 9
    • 0013836382 scopus 로고
    • Brain sterol metabolism
    • Davison, A.N. Brain sterol metabolism. Adv. Lipid. Res., 1965, 3, 171-196.
    • (1965) Adv. Lipid. Res. , vol.3 , pp. 171-196
    • Davison, A.N.1
  • 10
    • 0034672672 scopus 로고    scopus 로고
    • Oxysterol biosynthetic enzymes
    • Russell, D.W. Oxysterol biosynthetic enzymes. Biochim. Biophys. Acta., 2000, 1529, 126-135.
    • (2000) Biochim. Biophys. Acta. , vol.1529 , pp. 126-135
    • Russell, D.W.1
  • 11
    • 0036736781 scopus 로고    scopus 로고
    • Do oxysterols control cholesterol homeostasis?
    • Bjorkhem, I. do oxysterols control cholesterol homeostasis? J. Clin. Invest., 2002, 110, 725-730.
    • (2002) J. Clin. Invest. , vol.110 , pp. 725-730
    • Bjorkhem, I.1
  • 12
    • 34648837875 scopus 로고    scopus 로고
    • Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers
    • DOI 10.1016/j.atherosclerosis.2006.09.026, PII S0021915006006009
    • Burkard, I.; von Eckardstein, A.; Waeber, G.; Vollenweider, P.; Rentsch, K.M. Lipoprotein distribution and biological variation of 24s-and 27-hydroxycholesterol in healthy volunteers. Atherosclerosis, 2007, 194, 71-78. (Pubitemid 47464309)
    • (2007) Atherosclerosis , vol.194 , Issue.1 , pp. 71-78
    • Burkard, I.1    Von Eckardstein, A.2    Waeber, G.3    Vollenweider, P.4    Rentsch, K.M.5
  • 14
    • 53149118574 scopus 로고    scopus 로고
    • Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised
    • Gill, S.; Chow, R.; Brown, A.J. Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised. Prog. Lipid Res., 2008, 47, 391-404.
    • (2008) Prog. Lipid Res. , vol.47 , pp. 391-404
    • Gill, S.1    Chow, R.2    Brown, A.J.3
  • 15
    • 0027517723 scopus 로고
    • 27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells
    • DOI 10.1016/0014-5793(93)80495-G
    • Bellosta, S.; Corsini, A.; Bernini, F.; Granata, A.; Didoni, G.; Mazzotti, M.; Fumagalli, R. 27-hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells. FEBS Lett., 1993, 332, 115-118. (Pubitemid 23295910)
    • (1993) FEBS Letters , vol.332 , Issue.1-2 , pp. 115-118
    • Bellosta, S.1    Corsini, A.2    Bernini, F.3    Granata, A.4    Didoni, G.5    Mazzotti, M.6    Fumagalli, R.7
  • 16
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXRα
    • DOI 10.1038/383728a0
    • Janowski, B.A.; Willy, P.J.; Devi, T.R.; Falck, J.R.; Mangelsdorf, D.J. An oxysterol signalling pathway mediated by the nuclear receptor lxr alpha. Nature, 1996, 383, 728-731. (Pubitemid 26360651)
    • (1996) Nature , vol.383 , Issue.6602 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 18
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • DOI 10.1172/JCI27883
    • Zelcer, N.; Tontonoz, P. Liver x receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest., 2006, 116, 607-614. (Pubitemid 43326865)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 19
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the abc1 promoter by the liver x receptor/retinoid x receptor
    • Costet, P.; Luo, Y.; Wang, N.; Tall, A.R. Sterol-dependent transactivation of the abc1 promoter by the liver x receptor/retinoid x receptor. J. Biol. Chem., 2000, 275, 28240-28245.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 20
    • 4944247161 scopus 로고    scopus 로고
    • Nuclear receptor signaling in the control of cholesterol homeostasis: Have the orphans found a home?
    • DOI 10.1161/01.RES.0000143422.83209.be
    • Ory, D.S. Nuclear receptor signaling in the control of cholesterol homeostasis: Have the orphans found a home? Circ. Res., 2004, 95, 660-670. (Pubitemid 39331925)
    • (2004) Circulation Research , vol.95 , Issue.7 , pp. 660-670
    • Ory, D.S.1
  • 21
    • 77956176288 scopus 로고    scopus 로고
    • Sterol metabolism and srebp activation
    • Sato, R. Sterol metabolism and srebp activation. Arch. Biochem. Biophys., 2010, 501, 177-181.
    • (2010) Arch. Biochem. Biophys. , vol.501 , pp. 177-181
    • Sato, R.1
  • 22
    • 0242660992 scopus 로고    scopus 로고
    • Quantitation of Receptor Ligands by Mass Spectrometry
    • DOI 10.1016/S0076-6879(03)64002-4
    • Lund, E.G.; Diczfalusy, U. Quantitation of receptor ligands by mass spectrometry. Methods Enzymol., 2003, 364, 24-37. (Pubitemid 37419916)
    • (2003) Methods in Enzymology , vol.364 , pp. 24-37
    • Lund, E.G.1    Diczfalusy, U.2
  • 23
    • 0028801536 scopus 로고
    • Cholesterol for synthesis of myelin is made locally, not imported into brain
    • Jurevics, H.; Morell, P. Cholesterol for synthesis of myelin is made locally, not imported into brain. J. Neurochem., 1995, 64, 895-901.
    • (1995) J. Neurochem. , vol.64 , pp. 895-901
    • Jurevics, H.1    Morell, P.2
  • 24
    • 68949132399 scopus 로고    scopus 로고
    • Lipid mediators in the neural cell nucleus: Their metabolism, signaling, and association with neurological disorders
    • Farooqui, A.A. Lipid mediators in the neural cell nucleus: Their metabolism, signaling, and association with neurological disorders. Neuroscientist, 2009, 15, 392-407.
    • (2009) Neuroscientist , vol.15 , pp. 392-407
    • Farooqui, A.A.1
  • 26
    • 33947706821 scopus 로고    scopus 로고
    • Rediscovery of cerebrosterol
    • DOI 10.1007/s11745-006-1003-2
    • Bjorkhem, I. Rediscovery of cerebrosterol. Lipids, 2007, 42, 5-14. (Pubitemid 46490739)
    • (2007) Lipids , vol.42 , Issue.1 , pp. 5-14
    • Bjorkhem, I.1
  • 28
    • 0031848338 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Turnover of 24S- hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
    • Bjorkhem, I.; Lutjohann, D.; Diczfalusy, U.; Stahle, L.; Ahlborg, G.; Wahren, J. Cholesterol homeostasis in human brain: Turnover of 24s-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J. Lipid Res., 1998, 39, 1594-1600. (Pubitemid 28377923)
    • (1998) Journal of Lipid Research , vol.39 , Issue.8 , pp. 1594-1600
    • Bjorkhem, I.1    Lutjohann, D.2    Diczfalusy, U.3    Stahle, L.4    Ahlborg, G.5    Wahren, J.6
  • 29
    • 3543104951 scopus 로고    scopus 로고
    • Cholesterol metabolism in the central nervous system during early development and in the mature animal
    • DOI 10.1194/jlr.R400004-JLR200
    • Dietschy, J.M.; Turley, S.D. Thematic review series: Brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res., 2004, 45, 1375-1397. (Pubitemid 39022664)
    • (2004) Journal of Lipid Research , vol.45 , Issue.8 , pp. 1375-1397
    • Dietschy, J.M.1    Turley, S.D.2
  • 30
    • 0034902235 scopus 로고    scopus 로고
    • Interactions of cholesterol with lipid bilayers: The preferred configuration and fluctuations
    • Kessel, A.; Ben-Tal, N.; May, S. Interactions of cholesterol with lipid bilayers: The preferred configuration and fluctuations. Biophys. J., 2001, 81, 643-658. (Pubitemid 32721440)
    • (2001) Biophysical Journal , vol.81 , Issue.2 , pp. 643-658
    • Kessel, A.1    Ben-Tal, N.2    May, S.3
  • 31
    • 0023080585 scopus 로고
    • Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
    • DOI 10.1016/0005-2760(87)90295-5
    • Pitas, R.E.; Boyles, J.K.; Lee, S.H.; Foss, D.; Mahley, R.W. Astrocytes synthesize apolipoprotein e and metabolize apolipoprotein e-containing lipoproteins. Biochim. Biophys. Acta., 1987, 917, 148-161. (Pubitemid 17231059)
    • (1987) Biochimica et Biophysica Acta - Lipids and Lipid Metabolism , vol.917 , Issue.1 , pp. 148-161
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3
  • 32
    • 0024394549 scopus 로고
    • Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
    • Andersson, S.; Davis, D.L.; Dahlback, H.; Jornvall, H.; Russell, D.W. Cloning, structure, and expression of the mitochondrial cytochrome p-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem., 1989, 264, 8222-8229. (Pubitemid 19137311)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.14 , pp. 8222-8229
    • Anderson, S.1    Davis, D.L.2    Dahlback, H.3    Jornvall, H.4    Russell, D.W.5
  • 40
    • 0041922374 scopus 로고    scopus 로고
    • Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR
    • Nishimura, M.; Yaguti, H.; Yoshitsugu, H.; Naito, S.; Satoh, T. Tissue distribution of mrna expression of human cytochrome p450 isoforms assessed by high-sensitivity real-time reverse transcription pcr. Yakugaku Zasshi, 2003, 123, 369-375. (Pubitemid 41327466)
    • (2003) Yakugaku Zasshi , vol.123 , Issue.5 , pp. 369-375
    • Nishimura, M.1    Yaguti, H.2    Yoshitsugu, H.3    Naito, S.4    Satoh, T.5
  • 41
    • 3042683304 scopus 로고    scopus 로고
    • Expression of human cytochrome P450 46A1 in Escherichia coli: Effects of N- and C-terminal modifications
    • DOI 10.1016/j.abb.2004.05.012, PII S0003986104003078
    • Mast, N.; Andersson, U.; Nakayama, K.; Bjorkhem, I.; Pikuleva, I.A. Expression of human cytochrome p450 46a1 in Escherichia coli: Effects of n-and c-terminal modifications. Arch. Biochem. Biophys., 2004, 428, 99-108. (Pubitemid 38844913)
    • (2004) Archives of Biochemistry and Biophysics , vol.428 , Issue.1 , pp. 99-108
    • Mast, N.1    Andersson, U.2    Nakayama, K.3    Bjorkhem, I.4    Pikuleva, I.A.5
  • 42
    • 0021271971 scopus 로고
    • Clinical diagnosis of alzheimer's disease: Report of the nincds-adrda work group under the auspices of
    • department of health and human services task force on Alzheimer's disease
    • McKhann, G.; Drachman, D.; Folstein, M.; Katzman, R.; Price, D.; Stadlan, E.M. Clinical diagnosis of alzheimer's disease: Report of the nincds-adrda work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology, 1984, 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 43
    • 0025773225 scopus 로고
    • Neuritic pathology and dementia in alzheimer's disease
    • McKee, A.C.; Kosik, K.S.; Kowall, N.W. Neuritic pathology and dementia in alzheimer's disease. Ann. Neurol., 1991, 30, 156-165.
    • (1991) Ann. Neurol. , vol.30 , pp. 156-165
    • McKee, A.C.1    Kosik, K.S.2    Kowall, N.W.3
  • 45
    • 64049098761 scopus 로고    scopus 로고
    • Neuropathology and cognitive impairment in alzheimer disease: A complex but coherent relationship
    • Nelson, P.T.; Braak, H.; Markesbery, W.R. Neuropathology and cognitive impairment in alzheimer disease: A complex but coherent relationship. J. Neuropathol. Exp. Neurol, 2009, 68, 1-14.
    • (2009) J. Neuropathol. Exp. Neurol , vol.68 , pp. 1-14
    • Nelson, P.T.1    Braak, H.2    Markesbery, W.R.3
  • 46
    • 0034049944 scopus 로고    scopus 로고
    • Proteolytic processing and cell biological functions of the amyloid precursor protein
    • De Strooper, B.; Annaert, W. Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell Sci., 2000, 113 (Pt 11), 1857-1870. (Pubitemid 30386490)
    • (2000) Journal of Cell Science , vol.113 , Issue.11 , pp. 1857-1870
    • De Strooper, B.1    Annaert, W.2
  • 48
    • 58849154028 scopus 로고    scopus 로고
    • Impact of 27-hydroxycholesterol on amyloid-beta peptide production and atp-binding cassette transporter expression in primary human neurons
    • Kim, W.S.; Chan, S.L.; Hill, A.F.; Guillemin, G.J.; Garner, B. Impact of 27-hydroxycholesterol on amyloid-beta peptide production and atp-binding cassette transporter expression in primary human neurons. J. Alzheimer's Dis., 2009, 16, 121-131.
    • (2009) J. Alzheimer's Dis. , vol.16 , pp. 121-131
    • Kim, W.S.1    Chan, S.L.2    Hill, A.F.3    Guillemin, G.J.4    Garner, B.5
  • 49
    • 62549132123 scopus 로고    scopus 로고
    • Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in alzheimer's disease, but does extend lifespan
    • Halford, R.W.; Russell, D.W. Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in alzheimer's disease, but does extend lifespan. Proc. Natl. Acad. Sci. U.S.A., 2009, 106, 3502-3506.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 3502-3506
    • Halford, R.W.1    Russell, D.W.2
  • 50
    • 62149140601 scopus 로고    scopus 로고
    • Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma sh-sy5y cells
    • Prasanthi, J.R.; Huls, A.; Thomasson, S.; Thompson, A.; Schommer, E.; Ghribi, O. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma sh-sy5y cells. Mol. Neurodegener., 2009, 4, 1.
    • (2009) Mol. Neurodegener. , vol.4 , pp. 1
    • Prasanthi, J.R.1    Huls, A.2    Thomasson, S.3    Thompson, A.4    Schommer, E.5    Ghribi, O.6
  • 52
    • 34247506244 scopus 로고    scopus 로고
    • Transport pathways for clearance of human Alzheimer's amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system
    • DOI 10.1038/sj.jcbfm.9600419, PII 9600419
    • Bell, R.D.; Sagare, A.P.; Friedman, A.E.; Bedi, G.S.; Holtzman, D.M.; Deane, R.; Zlokovic, B.V. Transport pathways for clearance of human alzheimer's amyloid beta-peptide and apolipoproteins e and j in the mouse central nervous system. J. Cereb. Blood Flow Metab., 2007, 27, 909-918. (Pubitemid 46659038)
    • (2007) Journal of Cerebral Blood Flow and Metabolism , vol.27 , Issue.5 , pp. 909-918
    • Bell, R.D.1    Sagare, A.P.2    Friedman, A.E.3    Bedi, G.S.4    Holtzman, D.M.5    Deane, R.6    Zlokovic, B.V.7
  • 55
    • 70350778518 scopus 로고    scopus 로고
    • Cholesterol 24-hydroxylase (cyp46a1) polymorphisms are associated with faster cognitive deterioration in chinese older persons: A two-year follow up study
    • Fu, B.Y.; Ma, S.L.; Tang, N.L.; Tam, C.W.; Lui, V.W.; Chiu, H.F.; Lam, L.C. Cholesterol 24-hydroxylase (cyp46a1) polymorphisms are associated with faster cognitive deterioration in chinese older persons: A two-year follow up study. Int. J. Geriatr. Psychiatry, 2009, 24, 921-926.
    • (2009) Int. J. Geriatr. Psychiatry , vol.24 , pp. 921-926
    • Fu, B.Y.1    Ma, S.L.2    Tang, N.L.3    Tam, C.W.4    Lui, V.W.5    Chiu, H.F.6    Lam, L.C.7
  • 56
    • 30844460819 scopus 로고    scopus 로고
    • Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOE 3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease
    • DOI 10.1159/000090215
    • Fernandez Del Pozo, V.; Alvarez Alvarez, M.; Fernandez Martinez, M.; Galdos Alcelay, L.; Gomez Busto, F.; Pena, J.A.; Alfonso-Sanchez, M.A.; Zarranz Imirizaldu, J.J.; de Pancorbo, M.M. Polymorphism in the cholesterol 24s-hydroxylase gene (cyp46a1) associated with the apoepsilon3 allele increases the risk of alzheimer's disease and of mild cognitive impairment progressing to alzheimer's disease. Dement. Geriatr Cogn. Disord., 2006, 21, 81-87. (Pubitemid 43107133)
    • (2006) Dementia and Geriatric Cognitive Disorders , vol.21 , Issue.2 , pp. 81-87
    • Del Pozo, V.F.1    Alvarez, M.A.2    Martinez, M.F.3    Alcelay, L.G.4    Busto, F.G.5    Pena, J.A.6    Alfonso-Sanchez, M.A.7    Zarranz Imirizaldu, J.J.8    De Pancorbo, M.M.9
  • 57
    • 33645655021 scopus 로고    scopus 로고
    • Polymorphisms of the cholesterol 24-hydroxylase (cyp46a1) gene and the risk of alzheimer's disease in a chinese population
    • Ma, S.L.; Tang, N.L.; Lam, L.C.; Chiu, H.F. Polymorphisms of the cholesterol 24-hydroxylase (cyp46a1) gene and the risk of alzheimer's disease in a chinese population. Int. Psychogeriatr, 2006, 18, 37-45.
    • (2006) Int. Psychogeriatr , vol.18 , pp. 37-45
    • Ma, S.L.1    Tang, N.L.2    Lam, L.C.3    Chiu, H.F.4
  • 59
    • 2542422805 scopus 로고    scopus 로고
    • Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population
    • DOI 10.1016/j.neulet.2004.03.066, PII S030439400400388X
    • Kabbara, A.; Payet, N.; Cottel, D.; Frigard, B.; Amouyel, P.; Lambert, J.C. Exclusion of cyp46 and apom as candidate genes for alzheimer's disease in a french population. Neurosci. Lett., 2004, 363, 139-143. (Pubitemid 38692606)
    • (2004) Neuroscience Letters , vol.363 , Issue.2 , pp. 139-143
    • Kabbara, A.1    Payet, N.2    Cottel, D.3    Frigard, B.4    Amouyel, P.5    Lambert, J.-C.6
  • 60
    • 19444383616 scopus 로고    scopus 로고
    • Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2004.11.001, PII S0197458004003380
    • Ozturk, A.; Desai, P.P.; Minster, R.L.; Dekosky, S.T.; Kamboh, M.I. Three snps in the gsto1, gsto2 and prss11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. Neurobiol. Aging., 2005, 26, 1161-1165. (Pubitemid 40726008)
    • (2005) Neurobiology of Aging , vol.26 , Issue.8 , pp. 1161-1165
    • Ozturk, A.1    Desai, P.P.2    Minster, R.L.3    DeKosky, S.T.4    Kamboh, M.I.5
  • 61
    • 33645975169 scopus 로고    scopus 로고
    • Lack of association between the cyp46 gene polymorphism and italian late-onset sporadic alzheimer's disease
    • Tedde, A.; Rotondi, M.; Cellini, E.; Bagnoli, S.; Muratore, L.; Nacmias, B.; Sorbi, S. Lack of association between the cyp46 gene polymorphism and italian late-onset sporadic alzheimer's disease. Neurobiol. Aging, 2006, 27, 773 e771-773 e773.
    • (2006) Neurobiol. Aging , vol.27
    • Tedde, A.1    Rotondi, M.2    Cellini, E.3    Bagnoli, S.4    Muratore, L.5    Nacmias, B.6    Sorbi, S.7
  • 62
    • 4344576749 scopus 로고    scopus 로고
    • Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease
    • DOI 10.1016/j.neulet.2004.06.011, PII S0304394004007451
    • Ingelsson, M.; Jesneck, J.; Irizarry, M.C.; Hyman, B.T.; Rebeck, G.W. Lack of association of the cholesterol 24-hydroxylase (cyp46) intron 2 polymorphism with alzheimer's disease. Neurosci. Lett., 2004, 367, 228-231. (Pubitemid 39141233)
    • (2004) Neuroscience Letters , vol.367 , Issue.2 , pp. 228-231
    • Ingelsson, M.1    Jesneck, J.2    Irizarry, M.C.3    Hyman, B.T.4    Rebeck, G.W.5
  • 64
    • 61649126681 scopus 로고    scopus 로고
    • Oxysterols as markers of neurological disease-a review
    • Leoni, V. Oxysterols as markers of neurological disease-a review. Scand. J. Clin. Lab. Invest., 2009, 69, 22-25.
    • (2009) Scand. J. Clin. Lab. Invest. , vol.69 , pp. 22-25
    • Leoni, V.1
  • 66
    • 4544282709 scopus 로고    scopus 로고
    • Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients
    • DOI 10.1016/j.neulet.2004.07.031, PII S0304394004008961
    • Kolsch, H.; Heun, R.; Kerksiek, A.; Bergmann, K. V.; Maier, W.; Lutjohann, D. Altered levels of plasma 24s-and 27-hydroxycholesterol in demented patients. Neurosci. Lett., 2004, 368, 303-308. (Pubitemid 39214973)
    • (2004) Neuroscience Letters , vol.368 , Issue.3 , pp. 303-308
    • Kolsch, H.1    Heun, R.2    Kerksiek, A.3    Bergmann, K.V.4    Maier, W.5    Lutjohann, D.6
  • 71
    • 0037052771 scopus 로고    scopus 로고
    • Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls
    • DOI 10.1016/S0304-3940(02)00164-7, PII S0304394002001647
    • Schonknecht, P.; Lutjohann, D.; Pantel, J.; Bardenheuer, H.; Hartmann, T.; von Bergmann, K.; Beyreuther, K.; Schroder, J. Cerebrospinal fluid 24s-hydroxycholesterol is increased in patients with alzheimer's disease compared to healthy controls. Neurosci. Lett., 2002, 324, 83-85. (Pubitemid 34442684)
    • (2002) Neuroscience Letters , vol.324 , Issue.1 , pp. 83-85
    • Schonknecht, P.1    Lutjohann, D.2    Pantel, J.3    Bardenheuer, H.4    Hartmann, T.5    Von Bergmann, K.6    Beyreuther, K.7    Schroder, J.8
  • 73
    • 11144297111 scopus 로고    scopus 로고
    • Biological markers in CSF and blood for axonal degeneration in multiple sclerosis
    • DOI 10.1016/S1474-4422(04)00964-0, PII S1474442204009640
    • Teunissen, C.E.; Dijkstra, C.; Polman, C. Biological markers in csf and blood for axonal degeneration in multiple sclerosis. Lancet Neurol., 2005, 4, 32-41. (Pubitemid 40023234)
    • (2005) Lancet Neurology , vol.4 , Issue.1 , pp. 32-41
    • Teunissen, C.E.1    Dijkstra, P.C.2    Polman, C.3
  • 74
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and Remitting Multiple Sclerosis: Pathology of the Newly Forming Lesion
    • DOI 10.1002/ana.20016
    • Barnett, M.H.; Prineas, J. W. Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Ann. Neurol., 2004, 55, 458-468. (Pubitemid 38391962)
    • (2004) Annals of Neurology , vol.55 , Issue.4 , pp. 458-468
    • Barnett, M.H.1    Prineas, J.W.2
  • 75
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: A complicated picture of autoimmunity
    • DOI 10.1038/ni1507, PII NI1507
    • McFarland, H.F.; Martin, R. Multiple sclerosis: A complicated picture of autoimmunity. Nat Immunol, 2007, 8, 913-919. (Pubitemid 47300005)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 76
    • 0037441487 scopus 로고    scopus 로고
    • Axonal loss in the pathology of MS: Consequences for understanding the progressive phase of the disease
    • DOI 10.1016/S0022-510X(02)00069-2, PII S0022510X02000692
    • Bjartmar, C.; Wujek, J.R.; Trapp, B.D. Axonal loss in the pathology of ms: Consequences for understanding the progressive phase of the disease. J Neurol Sci, 2003, 206, 165-171. (Pubitemid 36143722)
    • (2003) Journal of the Neurological Sciences , vol.206 , Issue.2 , pp. 165-171
    • Bjartmar, C.1    Wujek, J.R.2    Trapp, B.D.3
  • 77
    • 69149108015 scopus 로고    scopus 로고
    • Molecular and immunogenic features of myelin lipids: Incitants or modulators of multiple sclerosis?
    • Podbielska, M.; Hogan, E.L. Molecular and immunogenic features of myelin lipids: Incitants or modulators of multiple sclerosis? Mult. Scler., 2009, 15, 1011-1029.
    • (2009) Mult. Scler. , vol.15 , pp. 1011-1029
    • Podbielska, M.1    Hogan, E.L.2
  • 78
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek, B.; Storch, M.K.; Weissert, R.; Wallstroem, E.; Stefferl, A.; Olsson, T.; Linington, C.; Schmidbauer, M.; Lassmann, H. Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am. J. Pathol., 2000, 157, 267-276. (Pubitemid 30641742)
    • (2000) American Journal of Pathology , vol.157 , Issue.1 , pp. 267-276
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, E.4    Stefferl, A.5    Olsson, T.6    Linington, C.7    Schmidbauer, M.8    Lassmann, H.9
  • 79
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • Bitsch, A.; Schuchardt, J.; Bunkowski, S.; Kuhlmann, T.; Bruck, W. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain, 2000, 123 (Pt 6), 1174-1183. (Pubitemid 30312109)
    • (2000) Brain , vol.123 , Issue.6 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Bruck, W.5
  • 80
    • 43249098296 scopus 로고    scopus 로고
    • Axon-glial signaling and the glial support of axon function
    • Nave, K.A.; Trapp, B.D. Axon-glial signaling and the glial support of axon function. Annu. Rev. Neurosci., 2008, 31, 535-561.
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 535-561
    • Nave, K.A.1    Trapp, B.D.2
  • 81
    • 0037491616 scopus 로고    scopus 로고
    • Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination
    • DOI 10.1016/S0168-0102(03)00127-5
    • Hisahara, S.; Okano, H.; Miura, M. Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination. Neurosci. Res., 2003, 46, 387-397. (Pubitemid 36842790)
    • (2003) Neuroscience Research , vol.46 , Issue.4 , pp. 387-397
    • Hisahara, S.1    Okano, H.2    Miura, M.3
  • 82
    • 68049129538 scopus 로고    scopus 로고
    • Neuroprotective effects of the complement terminal pathway during demyelination: Implications for oligodendrocyte survival
    • Tegla, C.A.; Cudrici, C.; Rus, V.; Ito, T.; Vlaicu, S.; Singh, A.; Rus, H. Neuroprotective effects of the complement terminal pathway during demyelination: Implications for oligodendrocyte survival. J. Neuroimmunol., 2009, 213, 3-11.
    • (2009) J. Neuroimmunol. , vol.213 , pp. 3-11
    • Tegla, C.A.1    Cudrici, C.2    Rus, V.3    Ito, T.4    Vlaicu, S.5    Singh, A.6    Rus, H.7
  • 83
    • 33745311758 scopus 로고    scopus 로고
    • Oligodendrocyte cell death in pathogenesis of multiple sclerosis: Protection of oligodendrocytes from apoptosis by complement
    • DOI 10.1682/JRRD.2004.08.0111
    • Cudrici, C.; Niculescu, T.; Niculescu, F.; Shin, M.L.; Rus, H. Oligodendrocyte cell death in pathogenesis of multiple sclerosis: Protection of oligodendrocytes from apoptosis by complement. J. Rehabil. Res. Dev., 2006, 43, 123-132. (Pubitemid 43938753)
    • (2006) Journal of Rehabilitation Research and Development , vol.43 , Issue.1 , pp. 123-132
    • Cudrici, C.1    Niculescu, T.2    Niculescu, F.3    Shin, M.L.4    Rus, H.5
  • 84
    • 73549089256 scopus 로고    scopus 로고
    • Multiple sclerosis: Distribution of inflammatory cells in newly forming lesions
    • Henderson, A.P.; Barnett, M.H.; Parratt, J.D.; Prineas, J.W. Multiple sclerosis: Distribution of inflammatory cells in newly forming lesions. Ann. Neurol., 2009, 66, 739-753.
    • (2009) Ann. Neurol. , vol.66 , pp. 739-753
    • Henderson, A.P.1    Barnett, M.H.2    Parratt, J.D.3    Prineas, J.W.4
  • 85
    • 0031852514 scopus 로고    scopus 로고
    • Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study
    • DOI 10.1093/brain/121.8.1469
    • De Stefano, N.; Matthews, P.M.; Fu, L.; Narayanan, S.; Stanley, J.; Francis, G.S.; Antel, J. P.; Arnold, D.L. Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain, 1998, 121 (Pt 8), 1469-1477. (Pubitemid 28349900)
    • (1998) Brain , vol.121 , Issue.8 , pp. 1469-1477
    • De Stefano, N.1    Matthews, P.M.2    Fu, L.3    Narayanan, S.4    Stanley, J.5    Francis, G.S.6    Antel, J.P.7    Arnold, D.L.8
  • 86
    • 41949128622 scopus 로고    scopus 로고
    • Biological markers for axonal degeneration in csf and blood of patients with the first event indicative for multiple sclerosis
    • Hein Nee Maier, K.; Kohler, A.; Diem, R.; Sattler, M.B.; Demmer, I.; Lange, P.; Bahr, M.; Otto, M. Biological markers for axonal degeneration in csf and blood of patients with the first event indicative for multiple sclerosis. Neurosci. Lett., 2008, 436, 72-76.
    • (2008) Neurosci. Lett. , vol.436 , pp. 72-76
    • Hein Nee Maier, K.1    Kohler, A.2    Diem, R.3    Sattler, M.B.4    Demmer, I.5    Lange, P.6    Bahr, M.7    Otto, M.8
  • 87
    • 0342316532 scopus 로고    scopus 로고
    • Oxysterols: Modulators of cholesterol metabolism and other processes
    • Schroepfer, G.J., Jr. Oxysterols: Modulators of cholesterol metabolism and other processes. Physiol. Rev., 2000, 80, 361-554. (Pubitemid 30060568)
    • (2000) Physiological Reviews , vol.80 , Issue.1 , pp. 361-554
    • Schroepfer Jr., G.J.1    Wilson, W.K.2
  • 89
    • 66349136255 scopus 로고    scopus 로고
    • Are side-chain oxidized oxysterols regulators also in vivo?
    • Bjorkhem, I. Are side-chain oxidized oxysterols regulators also in vivo? J. Lipid Res., 2009, 50 Suppl, S213-218.
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Bjorkhem, I.1
  • 93
    • 34248186478 scopus 로고    scopus 로고
    • 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis
    • DOI 10.1002/jnr.21266
    • Teunissen, C.E.; Floris, S.; Sonke, M.; Dijkstra, C.D.; De Vries, H.E.; Lutjohann, D. 24s-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. J. Neurosci. Res., 2007, 85, 1499-1505. (Pubitemid 46724393)
    • (2007) Journal of Neuroscience Research , vol.85 , Issue.7 , pp. 1499-1505
    • Teunissen, C.E.1    Floris, S.2    Sonke, M.3    Dijkstra, C.D.4    De Vries, H.E.5    Lutjohann, D.6
  • 95
    • 0041589132 scopus 로고    scopus 로고
    • Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients
    • DOI 10.1016/S0304-3940(03)00667-0
    • Teunissen, C.E.; Dijkstra, C.D.; Polman, C.H.; Hoogervorst, E.L.; von Bergmann, K.; Lutjohann, D. Decreased levels of the brain specific 24s-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients. Neurosci. Lett., 2003, 347, 159-162. (Pubitemid 37271941)
    • (2003) Neuroscience Letters , vol.347 , Issue.3 , pp. 159-162
    • Teunissen, C.E.1    Dijkstra, C.D.2    Polman, C.H.3    Hoogervorst, E.L.J.4    Von Bergmann, K.5    Lutjohann, D.6
  • 97
    • 33751096969 scopus 로고    scopus 로고
    • Crossing the barrier: Oxysterols as cholesterol transporters and metabolic modulators in the brain
    • DOI 10.1111/j.1365-2796.2006.01725.x
    • Bjorkhem, I. Crossing the barrier: Oxysterols as cholesterol transporters and metabolic modulators in the brain. J. Intern. Med., 2006, 260, 493-508. (Pubitemid 44772369)
    • (2006) Journal of Internal Medicine , vol.260 , Issue.6 , pp. 493-508
    • Bjorkhem, I.1
  • 99
    • 33747821467 scopus 로고    scopus 로고
    • Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury
    • DOI 10.1097/01.jnen.0000225906.82428.69, PII 0000507220060700000003
    • He, X.; Jenner, A.M.; Ong, W.Y.; Farooqui, A.A.; Patel, S.C. Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. J. Neuropathol. Exp. Neurol, 2006, 65, 652-663. (Pubitemid 44297256)
    • (2006) Journal of Neuropathology and Experimental Neurology , vol.65 , Issue.7 , pp. 652-663
    • He, X.1    Jenner, A.M.2    Ong, W.-Y.3    Farooqui, A.A.4    Patel, S.C.5
  • 100
    • 0344737604 scopus 로고    scopus 로고
    • Activation of Microglial Poly(ADP-Ribose)-Polymerase-1 by Cholesterol Breakdown Products during Neuroinflammation: A Link between Demyelination and Neuronal Damage
    • DOI 10.1084/jem.20030975
    • Diestel, A.; Aktas, O.; Hackel, D.; Hake, I.; Meier, S.; Raine, C.S.; Nitsch, R.; Zipp, F.; Ullrich, O. Activation of microglial poly(adp-ribose)- polymerase-1 by cholesterol breakdown products during neuroinflammation: A link between demyelination and neuronal damage. J. Exp. Med., 2003, 198, 1729-1740. (Pubitemid 37494165)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.11 , pp. 1729-1740
    • Diestel, A.1    Aktas, O.2    Hackel, D.3    Hake, I.4    Meier, S.5    Raine, C.S.6    Nitsch, R.7    Zipp, F.8    Ullrich, O.9
  • 101
    • 13944273308 scopus 로고    scopus 로고
    • Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis
    • DOI 10.1194/jlr.C400005-JLR200
    • Leoni, V.; Lutjohann, D.; Masterman, T. Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis. J. Lipid Res., 2005, 46, 191-195. (Pubitemid 40271081)
    • (2005) Journal of Lipid Research , vol.46 , Issue.2 , pp. 191-195
    • Leoni, V.1    Lutjohann, D.2    Masterman, T.3
  • 103
    • 52949150827 scopus 로고    scopus 로고
    • Side effects of oxysterols: Cytotoxicity, oxidation, inflammation, and phospholipidosis
    • Vejux, A.; Malvitte, L.; Lizard, G. Side effects of oxysterols: Cytotoxicity, oxidation, inflammation, and phospholipidosis. Braz. J. Med. Biol. Res., 2008, 41, 545-556.
    • (2008) Braz. J. Med. Biol. Res. , vol.41 , pp. 545-556
    • Vejux, A.1    Malvitte, L.2    Lizard, G.3
  • 104
    • 67349159434 scopus 로고    scopus 로고
    • Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
    • Vejux, A.; Lizard, G. Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis. Mol. Aspects. Med., 2009, 30, 153-170.
    • (2009) Mol. Aspects. Med. , vol.30 , pp. 153-170
    • Vejux, A.1    Lizard, G.2
  • 107
    • 0041522770 scopus 로고    scopus 로고
    • The hereditary spastic paraplegias: Nine genes and counting
    • DOI 10.1001/archneur.60.8.1045
    • Fink, J.K. The hereditary spastic paraplegias: Nine genes and counting. Arch. Neurol, 2003, 60, 1045-1049. (Pubitemid 36975789)
    • (2003) Archives of Neurology , vol.60 , Issue.8 , pp. 1045-1049
    • Fink, J.K.1
  • 108
    • 36048936624 scopus 로고    scopus 로고
    • Hereditary spastic paraplegias: An update
    • DOI 10.1097/WCO.0b013e3282f190ba, PII 0001905220071200000013
    • Depienne, C.; Stevanin, G.; Brice, A.; Durr, A. Hereditary spastic paraplegias: An update Curr. Opin. Neurol., 2007, 20, 674-680. (Pubitemid 350085009)
    • (2007) Current Opinion in Neurology , vol.20 , Issue.6 , pp. 674-680
    • Depienne, C.1    Stevanin, G.2    Brice, A.3    Durr, A.4
  • 109
    • 0015945194 scopus 로고
    • Strumpell's familial spastic paraplegia: Genetics and neuropathology
    • Behan, W.M.; Maia, M. Strumpell's familial spastic paraplegia: Genetics and neuropathology. J. Neurol. Neurosurg. Psychiatry, 1974, 37, 8-20.
    • (1974) J. Neurol. Neurosurg. Psychiatry , vol.37 , pp. 8-20
    • Behan, W.M.1    Maia, M.2
  • 110
    • 0001519052 scopus 로고
    • Hereditary (familial) spastic paraplegia; further clinical and pathologic observations
    • Schwarz, G.A.; Liu, C.N. Hereditary (familial) spastic paraplegia; further clinical and pathologic observations. AMA Arch. Neurol. Psychiatry, 1956, 75, 144-162.
    • (1956) AMA Arch. Neurol. Psychiatry , vol.75 , pp. 144-162
    • Schwarz, G.A.1    Liu, C.N.2
  • 111
    • 0027759812 scopus 로고
    • Hereditary spastic paraplegias
    • Harding, A.E. Hereditary spastic paraplegias. Semin. Neurol., 1993, 13, 333-336. (Pubitemid 24017067)
    • (1993) Seminars in Neurology , vol.13 , Issue.4 , pp. 333-336
    • Harding, A.E.1
  • 116
    • 77950044357 scopus 로고    scopus 로고
    • Foraging in an oxidative environment: Relationship between delta13c values and oxidative status in adelie penguins
    • Beaulieu, M.; Ropert-Coudert, Y.; Le Maho, Y.; Ancel, A.; Criscuolo, F. Foraging in an oxidative environment: Relationship between delta13c values and oxidative status in adelie penguins. Proc. Biol. Sci., 2010, 277, 1087-1092.
    • (2010) Proc. Biol. Sci. , vol.277 , pp. 1087-1092
    • Beaulieu, M.1    Ropert-Coudert, Y.2    Le Maho, Y.3    Ancel, A.4    Criscuolo, F.5
  • 117
    • 0033386688 scopus 로고    scopus 로고
    • Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1
    • Wu, Z.; Martin, K.O.; Javitt, N.B.; Chiang, J.Y. Structure and functions of human oxysterol 7alpha-hydroxylase cdnas and gene cyp7b1. J. Lipid Res., 1999, 40, 2195-2203. (Pubitemid 30017521)
    • (1999) Journal of Lipid Research , vol.40 , Issue.12 , pp. 2195-2203
    • Wu, Z.1    Martin, K.O.2    Javitt, N.B.3    Chiang, J.Y.L.4
  • 118
    • 70350417597 scopus 로고    scopus 로고
    • Cyp7b1: One cytochrome p450, two human genetic diseases, and multiple physiological functions
    • Stiles, A.R.; McDonald, J.G.; Bauman, D.R.; Russell, D.W. Cyp7b1: One cytochrome p450, two human genetic diseases, and multiple physiological functions. J. Biol. Chem., 2009, 284, 28485-28489.
    • (2009) J. Biol. Chem. , vol.284 , pp. 28485-28489
    • Stiles, A.R.1    McDonald, J.G.2    Bauman, D.R.3    Russell, D.W.4
  • 119
    • 0030610365 scopus 로고    scopus 로고
    • 7α-hyroxylation of 127-hydroxycholesterol: Biologic role in the regulation of cholesterol synthesis
    • Martin, K.O.; Reiss, A.B.; Lathe, R.; Javitt, N.B. 7 alpha-hydroxylation of 27-hydroxycholesterol: Biologic role in the regulation of cholesterol synthesis. J. Lipid Res., 1997, 38, 1053-1058. (Pubitemid 27255213)
    • (1997) Journal of Lipid Research , vol.38 , Issue.5 , pp. 1053-1058
    • Martin, K.O.1    Reiss, A.B.2    Lathe, R.3    Javitt, N.B.4
  • 120
    • 0014112259 scopus 로고
    • Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180
    • Danielsson, H.; Einarsson, K.; Johansson, G. Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180. Eur. J. Biochem., 1967, 2, 44-49.
    • (1967) Eur. J. Biochem. , vol.2 , pp. 44-49
    • Danielsson, H.1    Einarsson, K.2    Johansson, G.3
  • 121
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • DOI 10.1146/annurev.biochem.72.121801.161712
    • Russell, D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem., 2003, 72, 137-174. (Pubitemid 36930444)
    • (2003) Annual Review of Biochemistry , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 125
    • 41449114765 scopus 로고    scopus 로고
    • Neonatal cholestatic liver disease in an Asian patient with a homozygous mutation in the oxysterol 7α-hydroxylase gene
    • DOI 10.1097/MPG.0b013e31815a9911, PII 0000517620080400000020
    • Ueki, I.; Kimura, A.; Nishiyori, A.; Chen, H.L.; Takei, H.; Nittono, H.; Kurosawa, T. Neonatal cholestatic liver disease in an asian patient with a homozygous mutation in the oxysterol 7alpha-hydroxylase gene. J. Pediatr. Gastroenterol. Nutr., 2008, 46, 465-469. (Pubitemid 351457885)
    • (2008) Journal of Pediatric Gastroenterology and Nutrition , vol.46 , Issue.4 , pp. 465-469
    • Ueki, I.1    Kimura, A.2    Nishiyori, A.3    Chen, H.-L.4    Takei, H.5    Nittono, H.6    Kurosawa, T.7
  • 126
    • 67649395907 scopus 로고    scopus 로고
    • Prevalence of hereditary ataxia and spastic paraplegia in southeast norway: A population-based study
    • Erichsen, A.K.; Koht, J.; Stray-Pedersen, A.; Abdelnoor, M.; Tallaksen, C.M. Prevalence of hereditary ataxia and spastic paraplegia in southeast norway: A population-based study. Brain, 2009, 132, 1577-1588.
    • (2009) Brain , vol.132 , pp. 1577-1588
    • Erichsen, A.K.1    Koht, J.2    Stray-Pedersen, A.3    Abdelnoor, M.4    Tallaksen, C.M.5
  • 128
    • 70349730033 scopus 로고    scopus 로고
    • 25-hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin a production
    • Bauman, D.R.; Bitmansour, A.D.; McDonald, J.G.; Thompson, B.M.; Liang, G.; Russell, D.W. 25-hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin a production. Proc. Natl Acad. Sci. U.S.A., 2009, 106, 16764-16769.
    • (2009) Proc. Natl Acad. Sci. U.S.A. , vol.106 , pp. 16764-16769
    • Bauman, D.R.1    Bitmansour, A.D.2    McDonald, J.G.3    Thompson, B.M.4    Liang, G.5    Russell, D.W.6
  • 129
    • 12244306965 scopus 로고    scopus 로고
    • Mutations in the sterol 27-hydroxylase gene (CYP27A) cause hepatitis of infancy as well as cerebrotendinous xanthomatosis
    • DOI 10.1023/A:1021211520034
    • Clayton, P.T.; Verrips, A.; Sistermans, E.; Mann, A.; Mieli-Vergani, G.; Wevers, R. Mutations in the sterol 27-hydroxylase gene (cyp27a) cause hepatitis of infancy as well as cerebrotendinous xanthomatosis. J. Inherit. Metab. Dis., 2002, 25, 501-513. (Pubitemid 36104385)
    • (2002) Journal of Inherited Metabolic Disease , vol.25 , Issue.6 , pp. 501-513
    • Clayton, P.T.1    Verrips, A.2    Sistermans, E.3    Mann, A.4    Mieli-Vergani, G.5    Wevers, R.6
  • 132
    • 0032054279 scopus 로고    scopus 로고
    • Neurotoxicity of cholesterol oxides on cultured cerebellar granule cells
    • DOI 10.1016/S0197-0186(97)00103-4, PII S0197018697001034
    • Chang, J.Y; .Liu, L.Z. Neurotoxicity of cholesterol oxides on cultured cerebellar granule cells. Neurochem. Int., 1998, 32, 317-323. (Pubitemid 28174983)
    • (1998) Neurochemistry International , vol.32 , Issue.4 , pp. 317-323
    • Chang, J.Y.1    Liu, L.-Z.2
  • 133
    • 0031975868 scopus 로고    scopus 로고
    • Toxicity of cholesterol oxides on cultured neuroretinal cells
    • DOI 10.1076/ceyr.17.1.95.5252
    • Chang, J.Y.; Liu, L.Z. Toxicity of cholesterol oxides on cultured neuroretinal cells. Curr. Eye Res., 1998, 17, 95-103. (Pubitemid 28039674)
    • (1998) Current Eye Research , vol.17 , Issue.1 , pp. 95-103
    • Chang, J.Y.1    Liu, L.-Z.2
  • 134
    • 0032053144 scopus 로고    scopus 로고
    • Neurotoxicity of 25-OH-cholesterol on sympathetic neurons
    • DOI 10.1016/S0361-9230(97)00461-9, PII S0361923097004619
    • Chang, J.Y.; Phelan, K.D.; Chavis, J.A. Neurotoxicity of 25-oh-cholesterol on sympathetic neurons. Brain Res. Bull., 1998, 45, 615-622. (Pubitemid 28259033)
    • (1998) Brain Research Bulletin , vol.45 , Issue.6 , pp. 615-622
    • Chang, J.Y.1    Phelan, K.D.2    Chavis, J.A.3
  • 135
    • 0031894742 scopus 로고    scopus 로고
    • Neurotoxicity of 25-OH-cholesterol on NGF-differentiated PC12 cells
    • DOI 10.1023/A:1022437000893
    • Chang, J.Y.; Phelan, K.D.; Liu, L.Z. Neurotoxicity of 25-oh-cholesterol on ngf-differentiated pc12 cells. Neurochem. Res., 1998, 23, 7-16. (Pubitemid 28145685)
    • (1998) Neurochemical Research , vol.23 , Issue.1 , pp. 7-16
    • Chang, J.Y.1    Phelan, K.D.2    Liu, L.-Z.3
  • 136
    • 79955023890 scopus 로고    scopus 로고
    • Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells
    • In press
    • Riendeau, V.; Garenc, C. Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells. J. Alzheimers Dis., In press.
    • J. Alzheimers Dis.
    • Riendeau, V.1    Garenc, C.2
  • 137
    • 0141700567 scopus 로고    scopus 로고
    • Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
    • DOI 10.1194/jlr.M200434-JLR200
    • Leoni, V.; Masterman, T.; Patel, P.; Meaney, S.; Diczfalusy, U.; Bjorkhem, I. Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. J. Lipid Res., 2003, 44, 793-799. (Pubitemid 37279681)
    • (2003) Journal of Lipid Research , vol.44 , Issue.4 , pp. 793-799
    • Leoni, V.1    Masterman, T.2    Patel, P.3    Meaney, S.4    Diczfalusy, U.5    Bjorkhem, I.6
  • 138
    • 0037073676 scopus 로고    scopus 로고
    • Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes
    • DOI 10.1074/jbc.M205244200
    • Pandak, W.M.; Ren, S.; Marques, D.; Hall, E.; Redford, K.; Mallonee, D.; Bohdan, P.; Heuman, D.; Gil, G.; Hylemon, P. Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes. J. Biol. Chem., 2002, 277, 48158-48164. (Pubitemid 35470765)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.50 , pp. 48158-48164
    • Pandak, W.M.1    Ren, S.2    Marques, D.3    Hall, E.4    Redford, K.5    Mallonee, D.6    Bohdan, P.7    Heuman, D.8    Gill, G.9    Hylemon, P.10
  • 141
    • 33746334783 scopus 로고    scopus 로고
    • Endogenous neuroprotective factors: Neurosteroids
    • Wojtal, K.; Trojnar, M.K.; Czuczwar, S.J. Endogenous neuroprotective factors: Neurosteroids. Pharmacol. Rep., 2006, 58, 335-340. (Pubitemid 44111068)
    • (2006) Pharmacological Reports , vol.58 , Issue.3 , pp. 335-340
    • Wojtal, K.1    Trojnar, M.K.2    Czuczwar, S.J.3
  • 142
    • 23844452781 scopus 로고    scopus 로고
    • New nuclear functions of the glycolytic protein, glyceraldehyde-3- phosphate dehydrogenase, in mammalian cells
    • DOI 10.1002/jcb.20399
    • Sirover, M.A. New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells. J. Cell Biochem., 2005, 95, 45-52. (Pubitemid 41420214)
    • (2005) Journal of Cellular Biochemistry , vol.95 , Issue.1 , pp. 45-52
    • Sirover, M.A.1
  • 143
    • 0030845921 scopus 로고    scopus 로고
    • Identification and characterization of a mouse oxysterol 7α-hydroxylase cDNA
    • DOI 10.1074/jbc.272.38.23995
    • Schwarz, M.; Lund, E.G.; Lathe, R.; Bjorkhem, I.; Russell, D.W. Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cdna. J. Biol. Chem., 1997, 272, 23995-24001. (Pubitemid 27410983)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.38 , pp. 23995-24001
    • Schwarz, M.1    Lund, E.G.2    Lathe, R.3    Bjorkhem, I.4    Russell, D.W.5
  • 144
    • 0034595445 scopus 로고    scopus 로고
    • Disruption of the oxysterol 7α-hydroxylase gene in mice
    • DOI 10.1074/jbc.M001811200
    • Li-Hawkins, J.; Lund, E.G.; Turley, S.D.; Russell, D.W. Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J. Biol. Chem., 2000, 275, 16536-16542. (Pubitemid 30398877)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 16536-16542
    • Li-Hawkins, J.1    Lund, E.G.2    Turley, S.D.3    Russell, D.W.4
  • 145
    • 0037072799 scopus 로고    scopus 로고
    • Human sterol 27-hydroxylase (cyp27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis
    • Meir, K.; Kitsberg, D.; Alkalay, I.; Szafer, F.; Rosen, H.; Shpitzen, S.; Avi, L.B.; Staels, B.; Fievet, C.; Meiner, V.; Bjorkhem, I.; Leitersdorf, E. Human sterol 27-hydroxylase (cyp27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. J. Biol. Chem., 2002, 277, 34036-34041.
    • (2002) J. Biol. Chem. , vol.277 , pp. 34036-34041
    • Meir, K.1    Kitsberg, D.2    Alkalay, I.3    Szafer, F.4    Rosen, H.5    Shpitzen, S.6    Avi, L.B.7    Staels, B.8    Fievet, C.9    Meiner, V.10    Bjorkhem, I.11    Leitersdorf, E.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.