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Volumn 45, Issue 1, 2004, Pages 186-193

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Author keywords

Cerebral cholesterol; Cholesterol 24S hydroxylase; Oxysterols; Sterol 27 hydroxylase

Indexed keywords

24 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; CHOLESTEROL; LATHOSTEROL; OXYSTEROL; PHYTOSTEROL; STEROL; UNCLASSIFIED DRUG;

EID: 0842303768     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M300320-JLR200     Document Type: Article
Times cited : (277)

References (38)
  • 1
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: The cholesterol connection
    • Puglielli, L., R. E. Tanzi, and D. M. Kovacs. 2003. Alzheimer's disease: the cholesterol connection. Nat. Neurosci. 6: 345-351.
    • (2003) Nat. Neurosci. , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 6
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with HMG CoA reductase inhibitors
    • Wolozin, B., W. Kellman, and P. Ruosseau. 2000. Decreased prevalence of Alzheimer disease associated with HMG CoA reductase inhibitors. Arch. Neurol. 57: 1439-1443.
    • (2000) Arch. Neurol. , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3
  • 8
    • 0036550239 scopus 로고    scopus 로고
    • Pharmacological concentrations of the HMG CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients
    • Buxbaum, J. D., E. I. Cullen, and L. T. Friedhoff. 2002. Pharmacological concentrations of the HMG CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients. Front. Biosci. 7: 50-59.
    • (2002) Front. Biosci. , vol.7 , pp. 50-59
    • Buxbaum, J.D.1    Cullen, E.I.2    Friedhoff, L.T.3
  • 9
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • Dietschy, J. M., and S. D. Turley. 2001. Cholesterol metabolism in the brain. Curr. Opin. Lipidol. 12: 105-112.
    • (2001) Curr. Opin. Lipidol. , vol.12 , pp. 105-112
    • Dietschy, J.M.1    Turley, S.D.2
  • 10
    • 0030628019 scopus 로고    scopus 로고
    • Cholesterol and myelin
    • R. Bittman, editor. Plenum Press, New York
    • Snipes, G. J., and U. Suter. 1997. Cholesterol and myelin. In Subcellular Biochemistry. Vol. 28. R. Bittman, editor. Plenum Press, New York. 173-204.
    • (1997) Subcellular Biochemistry , vol.28 , pp. 173-204
    • Snipes, G.J.1    Suter, U.2
  • 11
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • Lütjohann, D., O. Breuer, G. Ahlborg, I. Nennesmo, Å. Sidén, U. Diczfalusy, and I. Björkhem. 1996. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA. 93: 9799-9804.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9799-9804
    • Lütjohann, D.1    Breuer, O.2    Ahlborg, G.3    Nennesmo, I.4    Sidén, Å.5    Diczfalusy, U.6    Björkhem, I.7
  • 12
    • 0030729021 scopus 로고    scopus 로고
    • Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro
    • Björkhem, I., D. Lütjohann, O. Breuer, A. Sakinis, and A. Wennmalm. 1997. Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. J. Biol. Chem. 272: 30178-30184.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30178-30184
    • Björkhem, I.1    Lütjohann, D.2    Breuer, O.3    Sakinis, A.4    Wennmalm, A.5
  • 13
    • 0031848338 scopus 로고    scopus 로고
    • Cholesterol homeostasis in the human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
    • Björkhem, I., D. Lütjohann, U. Diczfalusy, L. Ståhle, G. Ahlborg, and J. Wahren. 1998. Cholesterol homeostasis in the human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J. Lipid Res. 39: 1594-1600.
    • (1998) J. Lipid Res. , vol.39 , pp. 1594-1600
    • Björkhem, I.1    Lütjohann, D.2    Diczfalusy, U.3    Ståhle, L.4    Ahlborg, G.5    Wahren, J.6
  • 14
    • 0033594903 scopus 로고    scopus 로고
    • cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
    • Lund, E. G., J. M. Guileyardo, and D. W. Russell. 1999. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc. Natl. Acad. Sci. USA. 16: 7238-7243.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.16 , pp. 7238-7243
    • Lund, E.G.1    Guileyardo, J.M.2    Russell, D.W.3
  • 17
    • 0035856407 scopus 로고    scopus 로고
    • On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
    • Bogdanovic, N., L. Bretillon, E. Lund, U. Diczfalusy, L. Lannfelt, B. Winblad, D. Russell, and I. Björkhem. 2001. On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neurosci. Lett. 314: 45-48.
    • (2001) Neurosci. Lett. , vol.314 , pp. 45-48
    • Bogdanovic, N.1    Bretillon, L.2    Lund, E.3    Diczfalusy, U.4    Lannfelt, L.5    Winblad, B.6    Russell, D.7    Björkhem, I.8
  • 19
    • 0025339140 scopus 로고
    • Blood brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors
    • Blennow, K., A. Wallin, P. Fredman, I. Karlsson, C. G. Gottfries, and L. Svennerholm. 1990. Blood brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors. Acta Neurol Scand. 81: 323-326.
    • (1990) Acta Neurol Scand. , vol.81 , pp. 323-326
    • Blennow, K.1    Wallin, A.2    Fredman, P.3    Karlsson, I.4    Gottfries, C.G.5    Svennerholm, L.6
  • 22
    • 0141700567 scopus 로고    scopus 로고
    • Side-chain oxidized oxysterols in cerebrospinal fluid and integrity of the blood-brain barrier
    • Leoni, M., T. Masterman, P. Patel, S. Meaney, U. Diczfalusy, and I. Björkhem. 2003. Side-chain oxidized oxysterols in cerebrospinal fluid and integrity of the blood-brain barrier. J. Lipid Res. 44: 793-799.
    • (2003) J. Lipid Res. , vol.44 , pp. 793-799
    • Leoni, M.1    Masterman, T.2    Patel, P.3    Meaney, S.4    Diczfalusy, U.5    Björkhem, I.6
  • 23
    • 0032892176 scopus 로고    scopus 로고
    • Removal of cholesterol from extrahepatic sources by oxidative mechanisms
    • Björkhem, I., U. Diczfalusy, and D. Lütjohann. 1999. Removal of cholesterol from extrahepatic sources by oxidative mechanisms. Curr. Opin. Lipidol. 10: 161-165.
    • (1999) Curr. Opin. Lipidol. , vol.10 , pp. 161-165
    • Björkhem, I.1    Diczfalusy, U.2    Lütjohann, D.3
  • 24
    • 0025908356 scopus 로고
    • The consortium to establish a register for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra, S. S., A. Heyman, D. McKeel, S. M. Sumi, B. J. Crain, L. M. Brownlee, F. S. Vogel, J. P. Hughes, G. van Belle, and L. Berg. 1991. The consortium to establish a register for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41: 479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 25
    • 0003051013 scopus 로고
    • Diagnostic criteria for Alzheimer's disease in multicentre brain banking
    • F. F. Cruz-Sanchez, R. Ravid, and M. L. Cuzner, editors. Biomedical and Health Research Series. IOS Press, Amsterdam, The Netherlands
    • Bogdanovic, N., and J. H. Morris. 1995. Diagnostic criteria for Alzheimer's disease in multicentre brain banking. In Neuropathological Diagnostic Criteria for Brain Banking. F. F. Cruz-Sanchez, R. Ravid, and M. L. Cuzner, editors. Biomedical and Health Research Series. IOS Press, Amsterdam, The Netherlands. 20-29.
    • (1995) Neuropathological Diagnostic Criteria for Brain Banking , pp. 20-29
    • Bogdanovic, N.1    Morris, J.H.2
  • 26
    • 0016227772 scopus 로고
    • Determinations of cholesterol by mass fragmentography
    • Björkhem, I., R. Blomstrand, and L. Svensson. 1974. Determinations of cholesterol by mass fragmentography. Clin. Chim. Acta. 54: 185-193.
    • (1974) Clin. Chim. Acta , vol.54 , pp. 185-193
    • Björkhem, I.1    Blomstrand, R.2    Svensson, L.3
  • 27
    • 0024523769 scopus 로고
    • Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry
    • Lund, E., L. Sisfontes, E. Reihner, and I. Björkhem. 1989. Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry. Scand. J. Clin. Lab. Invest. 49: 165-171.
    • (1989) Scand. J. Clin. Lab. Invest. , vol.49 , pp. 165-171
    • Lund, E.1    Sisfontes, L.2    Reihner, E.3    Björkhem, I.4
  • 28
    • 0028816863 scopus 로고
    • Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry
    • Dzeletovic, S., O. Breuer, E. G. Lund, and U. Diczfalusy. 1995. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal. Biochem. 225: 73-80.
    • (1995) Anal. Biochem. , vol.225 , pp. 73-80
    • Dzeletovic, S.1    Breuer, O.2    Lund, E.G.3    Diczfalusy, U.4
  • 29
    • 0025914556 scopus 로고
    • Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis
    • Cali, J. J., C. L. Hsieh, U. Francke, and D. W. Russell. 1991. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J. Biol. Chem. 266: 7779-7783.
    • (1991) J. Biol. Chem. , vol.266 , pp. 7779-7783
    • Cali, J.J.1    Hsieh, C.L.2    Francke, U.3    Russell, D.W.4
  • 30
    • 0032925484 scopus 로고    scopus 로고
    • Recent advances in cholesterol dynamics: Transport, domains and Alzheimer disease
    • Wood, W. G., F. Schroeder, N. A. Adulov, S. V. Chochina, and U. Igbavboda. 1999. Recent advances in cholesterol dynamics: transport, domains and Alzheimer disease. Lipids. 34: 225-234.
    • (1999) Lipids , vol.34 , pp. 225-234
    • Wood, W.G.1    Schroeder, F.2    Adulov, N.A.3    Chochina, S.V.4    Igbavboda, U.5
  • 31
    • 0034870813 scopus 로고    scopus 로고
    • Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse of Alzheimer's disease
    • Poduslo, J. F., G. L. Curran, T M. Wengenack, B. Malester, and K. Duff. 2001. Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse of Alzheimer's disease. Neurobiol. Dis. 8: 555-567.
    • (2001) Neurobiol. Dis. , vol.8 , pp. 555-567
    • Poduslo, J.F.1    Curran, G.L.2    Wengenack, T.M.3    Malester, B.4    Duff, K.5
  • 32
    • 0032770376 scopus 로고    scopus 로고
    • Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: Evidence that most of this steroid in the circulation is of pulmonary origin
    • Babiker, A., O. Andersson, D. Lindblom, J. van der Linden, B. Wiklund, D. Lütjohann, U. Diczfalusy, and I. Björkhem. 1999. Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin. J. Lipid Res. 40: 1417-1425.
    • (1999) J. Lipid Res. , vol.40 , pp. 1417-1425
    • Babiker, A.1    Andersson, O.2    Lindblom, D.3    Van Der Linden, J.4    Wiklund, B.5    Lütjohann, D.6    Diczfalusy, U.7    Björkhem, I.8
  • 33
    • 0036916491 scopus 로고    scopus 로고
    • On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: Critical importance of the position of the oxygen function
    • Meaney, S., K. Bodin, U. Diczfalusy, and I. Björkhem. 2003. On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. J. Lipid Res. 44: 2130-2135.
    • (2003) J. Lipid Res. , vol.44 , pp. 2130-2135
    • Meaney, S.1    Bodin, K.2    Diczfalusy, U.3    Björkhem, I.4
  • 37
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • Lund, E. G., C. Xie, T. Kotti, S. D. Turley, J. M. Dietschy, and D. W. Russell. 2003. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 278: 22980-22988.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.M.5    Russell, D.W.6
  • 38
    • 0842295126 scopus 로고    scopus 로고
    • The emerging neurobiology of cholesterol
    • Simmonds, M. A. 2002. The emerging neurobiology of cholesterol. Neurobiol. Lipids. 1: 1-4.
    • (2002) Neurobiol. Lipids , vol.1 , pp. 1-4
    • Simmonds, M.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.