Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro

Journal of Biological Chemistry

Volumn 272, Issue 48, 1997, Pages 30178-30184

  Björkhem, Ingemar ^a   Lütjohann, Dieter ^a   Breuer, Olof ^a   Sakinis, Augustinas ^b   Wennmalm, Åke ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL DERIVATIVE; OXYGEN 18; TRITIUM;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN MICROSOME; CELL FRACTIONATION; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; GAS CHROMATOGRAPHY; ISOTOPE LABELING; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CHOLESTEROL; HOMEOSTASIS; HYDROXYCHOLESTEROLS; MALE; MICROSOMES; NADP; OXIDATION-REDUCTION; OXYGEN RADIOISOTOPES; RATS; RATS, SPRAGUE-DAWLEY; STEROID HYDROXYLASES;

ANIMALIA; TRITIUM;

EID: 0030729021     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.48.30178     Document Type: Article

References (30)

1. Tint, G. S., Irons, M., Elias, E. R., Batta, A. K., Frieden, R., and Chen, T. S. (1994) New Engl. J. Med. 330, 107-113
2. Dietschy, J. M., Turley, S. D., and Spady, D. K. (1993) J. Lipid Res. 34, 1637-1659
3. Snipes, G. J., and Suter, U. (1997) in Subcellular Biochemistry (Bittman, R., ed) Vol. 28, pp. 173-204, Plenum Press, New York
4. Serougne-Gautheron, C., and Chevallier, F. (1913) Biochim. Biophys. Acta 316, 244-250
5. Andersson, M., Elmberger, P. G., Edlund, C., Kristensson, K., and Dallner, G. (1990) FEBS Lett. 269, 15-18
6. Gordion, E. L., Danielsson, P. E., Ngvyen, T. S., and Winn, H. R. (1991) In Vitro Cell Dev. Biol. 27A, 312-326
7. De Vries, H. (1995) Characteristics of Blood-Brain Barrier Endothelial Cells in Response to Inflammatory Stimuli. Thesis, Costar Europe Ltd., Badhoevededorp, The Netherlands
8. Lütjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Sidén, Å., Diczfalusy, U., and Björkhem, I. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9799-9804
9. Breuer, O., and Björkhem, I. (1995) J. Biol. Chem. 270, 20278-20284
10. Lin, Y., and Smith, L. L. (1974) Biochim. Biophys. Acta 348, 189-196
11. Dhar, A. K., Teng, J. I., and Smith, L. L. (1973) J. Neurochem. 21, 51-60
12. Aringer, L., and Eneroth, P. (1971) Steroids 18, 381-388
13. Shefer, S., Cheng, F. W., Hauser, S., Batta, A. K., and Salen, G. (1981) J. Lipid Res. 22, 532-536
14. Dzeletovic, S., Breuer, O., Lund, E., and Diczfalusy, U. (1995) Anal. Biochem. 225, 73-80
15. Björkhem, I., Blomstrand, R., and Svensson, L. (1974) Clin. Chim. Acta 54, 185-193
16. Björkhem, I., and Lewenhaupt, A. (1979) J. Biol. Chem. 254, 5252-5256
17. Benthin, G., Björkhem, I., Breuer, O., Sakinis, A., and Wennmalm, Å. (1997) Biochem. J. 323, 853-858
18. Zhang, J. (1996) Studies on 7α-Hydroxylation of 25- and 27-Hydroxycholesterol in Extrahepatic Tissues and Cells. Thesis, Karolinska Institutet. Repro Print AB, Stockholm
19. Lange, Y., and Strebel, F. (1995) J. Lipid Res. 36, 1092-1097
20. Björkhem, I., Reihner, E., Angelin, B., Ewerth, S., Åkerlund, J.-E., and Einarsson, K. (1987) J. Lipid Res. 28, 889-894
21. Lund, E., Andersson, O., Zhang, J., Babiker, A., Ahlborg, G., Diczfalusy, U., Einarsson, K., Sjövall, J., and Björkhem, I. (1996) Arterioscl. Thromb. Vasc. Biol. 16, 208-212
22. Pedersen, J. I., Oftebro, H., and Björkhem, I. (1989) Biochem. Int. 18, 615-622
23. Zhang, J., Akwa, Y., Baulieu, E. E., and Sjövall, J. (1995) Compt. Rend. 318, 345-349
24. Mellon, S. H., and Deschepper, C. F. (1993) Brain Res. 629, 283-292
25. Jung-Testas, I., Hu, Z. Y., Baulieu, E. E., and Robel, P. (1989) Endocrinology 125, 2083-2091
26. Stapleton, G., Steel, M., Richardson, M., Mason, J. O., Rose, K. A., Morris, R. G. M., and Lathe, R. (1996) J. Biol. Chem. 270, 29739-29745
27. Rose, K. A., Stapleton, G., Dott, K., Kieny, M. P., Best, R., Schwarz, M., Russel, D. W., Björkhem, I., Seckl, J., and Lathe, R. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4925-4930
28. Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., and Mahley, R. W. (1987) Biochim. Biophys. Acta 917, 148-161
29. Björkhem, I., Andersson, O., Diczfalusy, U., Sevastik, B., Xiu, R.-J., Duan, C., and Lund, E. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8592-8596
30. Saucier, S. E., Kandutsch, A. A., Gayen, A. K., Swahn, D. K., and Spencer, T. A. (1989) J. Biol. Chem. 264, 6863-6869