7α-hyroxylation of 127-hydroxycholesterol: Biologic role in the regulation of cholesterol synthesis

Journal of Lipid Research

Volumn 38, Issue 5, 1997, Pages 1053-1058

  Martin, Kumiko O ^a   Reiss, Allison B ^a   Lathe, Richard ^b   Javitt, Norman B ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

27 hydroxycholesterol 7 hydroxylase; 293 T cells; CDNA mcyp7b; CHO cells; Cholest 5 ene 3 ,7 ,27 triol; Cholesterol 7 hydroxylase; Transfection

Indexed keywords

CHOLESTEROL DERIVATIVE; 26 HYDROXYCHOLESTEROL; 27-HYDROXYCHOLESTEROL; CHOLESTEROL; CYP7B1 PROTEIN, MOUSE; CYTOCHROME P450; STEROID MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CHO CELL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; HUMAN; HUMAN CELL; HYDROXYLATION; LIPID ANALYSIS; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CHEMISTRY; ENZYME SPECIFICITY; HAMSTER; METABOLISM; MOUSE;

ANIMALS; CHO CELLS; CHOLESTEROL; CRICETINAE; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYCHOLESTEROLS; HYDROXYLATION; MICE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

EID: 0030610365     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Martin, K. O., K. Budai, and N. B. Javitt. 1993. Cholesterol and 27-hydroxycholesterol 7α-hydroxylation: evidence for two different enzymes. J. Lipid Res. 34: 581-588.
2. Lee, C., K. O. Martin, and N. B. Javitt. 1996. Bile acid synthesis: 7α-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. J. Lipid Res. 37: 1356-1362.
3. 3H. J. Clin. Invest. 51: 112-117.
4. Ayaki, A., E. Kok, and N. B. Javitt. 1989. Cholic acid synthesis from 26-hydroxycholesterol and 3β-hydroxy-5-cholenoic acid in the rabbit. J. Biol. Chem. 264: 3818-3821.
5. Esterman, A. L., H. Baum, N. B. Javitt, and G. J. Darlington. 1983. 26-Hydroxycholesterol: regulation of hydroxymethylglutaryl-CoA reductase activity in Chinese hamster ovary cell culture. J. Lipid Res. 24: 1304-1309.
6. Taylor, F. R., S. E. Saucier, E. P. Shown, E. J. Parish, and A. A. Kandutsch. 1984. Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme reductase. J. Biol. Chem. 259: 12382-12387.
7. Stapleton, G., M. Steel, M. Richardson, J. Rose, R. Morris, and R. Lathe. 1995. A novel cytochrome P450 expressed primarily in brain. J. Biol. Chem. 270: 29739-29745.
8. 2O for determination of synthesis rate in cell culture. J. Lipid Res. 26: 950-954.
9. Javitt, N. B., R. Pfeffer, E. Kok, S. Burstein, B. I. Cohen, and K. Budai. 1989. Bile acid synthesis in cell culture. J. Biol. Chem. 264: 10384-10387.
10. Starka, L. 1961. Reaktion der steroide mit tert-butyl peroxybenzoat. I. Uber die 7-acyloxylierung delt-5-ungrsattiger steroide. Collect. Czech. Chem. Commun. 26: 2452-2455.
11. Reiss, A. B., K. O. Martin, N. B. Javitt, D. W. Martin, E. A. Grossi, and A. C. Galloway. 1994. Sterol 27-hydroxylase activity: high level of activity in vascular endothelium. J. Lipid Res. 35: 1026-1030.
12. 2O for metabolic studies. Biomed. Environ. Mass Spectrom. 18: 640-644.
13. Miao, E., S. R. Wilson, and N. B. Javitt. 1988. Cholesterol metabolism: effect of 26-thiacholesterol and 26-amino-cholesterol, analogues of 26-hydroxycholesterol, on cholesterol synthesis and low-density lipoprotein receptor binding. Biochem. J. 255: 1049-1052.
14. Sheng, Z., H. Otani, M. S. Brown, and J. L. Goldstein. 1995. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA. 92: 935-938.
15. Andersson, S., D. L. Davis, H. Dahlbäck, H. Jörnvall, and D. W. Russell. 1989. Coning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem. 264: 8222-8229.
16. Björkhem, I., O. Andersson, U. Diczfalusy, B. Sevastik, R. Xiu, C. Duan, and E. Lund. 1994. Atherosclerosis and sterol-27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from the human macrophage. Proc. Natl. Acad. Sci. USA. 91: 8592-8596.
17. Rennert, H., R. T. Fisher, J. G. Alvarez, J. M. Trzaskos, and J. F. Strauss 3d. 1990. Generation of regulatory oxysterols: 26-hydroxylation of cholesterol in ovarian mitochondria. Endocrinology. 127: 738-746.
18. Payne, D. W., C. Shackleton, H. Toms, I. Ben-Shlomo, S. Kos, M. deMoura, J. F. Strauss 3d, and E. Y. Adashi. 1995. A novel nonhepatic hydroxycholesterol 7 alpha-hydroxylase that is markedly stimulated by interleukin-1-beta. Characterization in the immature ovary. J. Biol. Chem. 270: 18888-18896.
19. Dugan, R. E., L. L. Slakey, A. V. Breidis, and J. W. Porter. 1972. Factors affecting the diurnal variation in the level of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol-synthesizing activity in rat liver. Arch. Biochem. Biophys. 152: 21-27.
20. Dietschy, J. M., and M. D. Siperstein. 1967. Effect of cholesterol feeding and fasting on sterol synthesis in 17 tissues of the rat. J. Lipid Res. 8: 97-104.
21. 2O) and mass isotopomer analysis. Am. J. Physiol. 266: E372-E383.
22. 29-steroids. Biomed. Mass Spectrom. 8:183-203.