Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury

Journal of Neuropathology and Experimental Neurology

Volumn 65, Issue 7, 2006, Pages 652-663

  He, Xin ^a   Jenner, Andrew M ^a   Ong, Wei Yi ^a   Farooqui, Akhlaq A ^b   Patel, Shutish C ^c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b OHIO STATE UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

24 hydroxycholesterol; Cholesterol; Cholesterol 24 hydroxylase; Excitotoxic injury; Oxidative stress; Oxysterol; Statins

Indexed keywords

24 HYDROXYCHOLESTEROL; 7 OXOCHOLESTEROL; CHOLESTEROL; CHOLESTEROL 24 HYDROXYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KAINIC ACID; MEVINOLIN; OXYGENASE; OXYSTEROL; UNCLASSIFIED DRUG; 24-HYDROXYCHOLESTEROL; 7-KETOCHOLESTEROL; AMINO ACID RECEPTOR STIMULATING AGENT; CHOLESTEROL 24-HYDROXYLASE; CHOLESTEROL DERIVATIVE; ENZYME INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; NEUROPROTECTIVE AGENT; STEROID MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BRAIN LEVEL; BRAIN SLICE; CELL LOSS; CONTROLLED STUDY; HIPPOCAMPUS; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; IN VITRO STUDY; METABOLISM; NERVE CELL; PATHOLOGY; WISTAR RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CELL SURVIVAL; CHOLESTEROL; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; HYDROXYCHOLESTEROLS; KAINIC ACID; KETOCHOLESTEROLS; LOVASTATIN; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; STEROID HYDROXYLASES;

EID: 33747821467     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000225906.82428.69     Document Type: Article

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