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Volumn 16, Issue 1, 2009, Pages 121-131

Impact of 27-hydroxycholesterol on amyloid-β peptide production and ATP-binding cassette transporter expression in primary human neurons

Author keywords

27 hydroxycholesterol; Alzheimer's disease; Amyloid ; Apolipoprotein E; ATP binding cassette transporters; Primary human neurons

Indexed keywords

26 HYDROXYCHOLESTEROL; ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER G1; ALPHA SECRETASE; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BETA SECRETASE; GAMMA SECRETASE; LIVER X RECEPTOR; BREAST CANCER RESISTANCE PROTEIN;

EID: 58849154028     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2009-0944     Document Type: Article
Times cited : (56)

References (86)
  • 1
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • Dietschy JM, Turley SD (2001) Cholesterol metabolism in the brain. Curr Opin Lipidol 12, 105-112.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 105-112
    • Dietschy, J.M.1    Turley, S.D.2
  • 2
    • 0037710127 scopus 로고    scopus 로고
    • Cholesterol homeostasis and function in neurons of the central nervous system
    • Pfrieger FW (2003) Cholesterol homeostasis and function in neurons of the central nervous system. Cell Mol Life Sci 60, 1158-1171.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1158-1171
    • Pfrieger, F.W.1
  • 4
    • 2442557294 scopus 로고    scopus 로고
    • Brain cholesterol: Long secret life behind a barrier
    • Bjorkhem I, Meaney S (2004) Brain cholesterol: long secret life behind a barrier. Arterioscler Thromb Vasc Biol 24, 806-815.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 806-815
    • Bjorkhem, I.1    Meaney, S.2
  • 5
    • 33751221596 scopus 로고    scopus 로고
    • Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex
    • Gylys KH, Fein JA, Yang F, Miller CA, Cole GM (2007) Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Neurobiol Aging 28, 8-17.
    • (2007) Neurobiol Aging , vol.28 , pp. 8-17
    • Gylys, K.H.1    Fein, J.A.2    Yang, F.3    Miller, C.A.4    Cole, G.M.5
  • 6
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: The cholesterol connection
    • Puglielli L, Tanzi RE, Kovacs DM(2003) Alzheimer's disease: the cholesterol connection. Nat Neurosci 6, 345-351.
    • (2003) Nat Neurosci , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 7
    • 4143141815 scopus 로고    scopus 로고
    • Cholesterol efflux as a critical component of Alzheimer's disease pathogenesis
    • Rebeck GW (2004) Cholesterol efflux as a critical component of Alzheimer's disease pathogenesis. J Mol Neurosci 23, 219-224.
    • (2004) J Mol Neurosci , vol.23 , pp. 219-224
    • Rebeck, G.W.1
  • 10
    • 0347318065 scopus 로고    scopus 로고
    • Cholesterol and the biology of Alzheimer's disease
    • Wolozin B (2004) Cholesterol and the biology of Alzheimer's disease. Neuron 41, 7-10.
    • (2004) Neuron , vol.41 , pp. 7-10
    • Wolozin, B.1
  • 12
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81, 741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 14
    • 0034611980 scopus 로고    scopus 로고
    • Neuroinflammation and Alzheimer's disease: Critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E
    • discussion 451-423
    • Bales KR, Du Y, Holtzman D, Cordell B, Paul SM (2000) Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E. Neurobiol Aging 21, 427-432; discussion 451-423.
    • (2000) Neurobiol Aging , vol.21 , pp. 427-432
    • Bales1    KR, D.Y.2    Holtzman, D.3    Cordell, B.4    Paul, S.M.5
  • 17
    • 0141482022 scopus 로고    scopus 로고
    • Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein
    • Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ (2003) Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 100, 11735-11740.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11735-11740
    • Cordy, J.M.1    Hussain, I.2    Dingwall, C.3    Hooper, N.M.4    Turner, A.J.5
  • 18
    • 0037421206 scopus 로고    scopus 로고
    • Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
    • Ehehalt R, Keller P, Haass C, Thiele C, Simons K(2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160, 113-123.
    • (2003) J Cell Biol , vol.160 , pp. 113-123
    • Ehehalt, R.1    Keller, P.2    Haass, C.3    Thiele, C.4    Simons, K.5
  • 19
    • 27744501797 scopus 로고    scopus 로고
    • Lipids as modulators of proteolytic activity of BACE: Involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro
    • Kalvodova L, Kahya N, Schwille P, Ehehalt R, Verkade P, Drechsel D, Simons K (2005) Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J Biol Chem 280, 36815-36823.
    • (2005) J Biol Chem , vol.280 , pp. 36815-36823
    • Kalvodova, L.1    Kahya, N.2    Schwille, P.3    Ehehalt, R.4    Verkade, P.5    Drechsel, D.6    Simons, K.7
  • 20
    • 0035928732 scopus 로고    scopus 로고
    • Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
    • Riddell DR, Christie G, Hussain I, Dingwall C (2001) Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr Biol 11, 1288-1293.
    • (2001) Curr Biol , vol.11 , pp. 1288-1293
    • Riddell, D.R.1    Christie, G.2    Hussain, I.3    Dingwall, C.4
  • 24
    • 0029671454 scopus 로고    scopus 로고
    • Cholesterol modulates alphasecretase cleavage of amyloid precursor protein
    • Bodovitz S, Klein WL (1996) Cholesterol modulates alphasecretase cleavage of amyloid precursor protein. J Biol Chem 271, 4436-4440.
    • (1996) J Biol Chem , vol.271 , pp. 4436-4440
    • Bodovitz, S.1    Klein, W.L.2
  • 25
    • 33746299216 scopus 로고    scopus 로고
    • High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus
    • Ghribi O, Larsen B, Schrag M, Herman MM (2006) High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol 200, 460-467.
    • (2006) Exp Neurol , vol.200 , pp. 460-467
    • Ghribi, O.1    Larsen, B.2    Schrag, M.3    Herman, M.M.4
  • 26
    • 0036523031 scopus 로고    scopus 로고
    • Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells
    • Runz H, Rietdorf J, Tomic I, de Bernard M, Beyreuther K, Pepperkok R, Hartmann T (2002) Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J Neurosci 22, 1679-1689.
    • (2002) J Neurosci , vol.22 , pp. 1679-1689
    • Runz, H.1    Rietdorf, J.2    Tomic, I.3    de Bernard, M.4    Beyreuther, K.5    Pepperkok, R.6    Hartmann, T.7
  • 28
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • Lutjohann D, Breuer O, Ahlborg G, Nennesmo I, Siden A, Diczfalusy U, Bjorkhem I (1996) Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci U S A 93, 9799-9804.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9799-9804
    • Lutjohann, D.1    Breuer, O.2    Ahlborg, G.3    Nennesmo, I.4    Siden, A.5    Diczfalusy, U.6    Bjorkhem, I.7
  • 30
    • 0035997373 scopus 로고    scopus 로고
    • Lipoprotein receptors in the nervous system
    • Herz J, Bock HH (2002) Lipoprotein receptors in the nervous system. Annu Rev Biochem 71, 405-434.
    • (2002) Annu Rev Biochem , vol.71 , pp. 405-434
    • Herz, J.1    Bock, H.H.2
  • 32
    • 0023280054 scopus 로고
    • Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain
    • Pitas RE, Boyles JK, Lee SH, Hui D, Weisgraber KH (1987) Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. J Biol Chem 262, 14352-14360.
    • (1987) J Biol Chem , vol.262 , pp. 14352-14360
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3    Hui, D.4    Weisgraber, K.H.5
  • 33
    • 34047250984 scopus 로고    scopus 로고
    • Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein-E discs and suppression of amyloidbeta peptide generation
    • Kim WS, Suryo Rahmanto A, Kamili A, Rye KA, Guillemin GJ, Gelissen IC, Jessup W, Hill AF, Garner B (2007) Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein-E discs and suppression of amyloidbeta peptide generation. J Biol Chem 282, 2851-2861.
    • (2007) J Biol Chem , vol.282 , pp. 2851-2861
    • Kim, W.S.1    Suryo Rahmanto, A.2    Kamili, A.3    Rye, K.A.4    Guillemin, G.J.5    Gelissen, I.C.6    Jessup, W.7    Hill, A.F.8    Garner, B.9
  • 35
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383, 728-731.
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 36
    • 0031045545 scopus 로고    scopus 로고
    • Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons
    • Zhang J, Akwa Y, el-Etr M, Baulieu EE, Sjovall J (1997) Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. Biochem J 322, 175-184.
    • (1997) Biochem J , vol.322 , pp. 175-184
    • Zhang, J.1    Akwa, Y.2    el-Etr, M.3    Baulieu, E.E.4    Sjovall, J.5
  • 38
    • 0033951112 scopus 로고    scopus 로고
    • Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta
    • Alberti S, Steffensen KR, Gustafsson JA (2000) Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Gene 243, 93-103.
    • (2000) Gene , vol.243 , pp. 93-103
    • Alberti, S.1    Steffensen, K.R.2    Gustafsson, J.A.3
  • 40
    • 36249006573 scopus 로고    scopus 로고
    • Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis
    • Wong J, Quinn CM, Guillemin G, Brown AJ (2007) Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis. J Neurochem 103, 1764-1773.
    • (2007) J Neurochem , vol.103 , pp. 1764-1773
    • Wong, J.1    Quinn, C.M.2    Guillemin, G.3    Brown, A.J.4
  • 43
    • 0042346382 scopus 로고    scopus 로고
    • Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion
    • Sun Y, Yao J, Kim TW, Tall AR (2003) Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem 278, 27688-27694.
    • (2003) J Biol Chem , vol.278 , pp. 27688-27694
    • Sun, Y.1    Yao, J.2    Kim, T.W.3    Tall, A.R.4
  • 47
    • 33645237578 scopus 로고    scopus 로고
    • Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia
    • Karten B, Campenot RB, Vance DE, Vance JE (2006) Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia. J Biol Chem 281, 4049-4057.
    • (2006) J Biol Chem , vol.281 , pp. 4049-4057
    • Karten, B.1    Campenot, R.B.2    Vance, D.E.3    Vance, J.E.4
  • 48
    • 34147131740 scopus 로고    scopus 로고
    • Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: Relevance to Alzheimer's disease therapeutics
    • Cao G, Bales KR, DeMattos RB, Paul SM (2007) Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics. Curr Alzheimer Res 4, 179-184.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 179-184
    • Cao, G.1    Bales, K.R.2    DeMattos, R.B.3    Paul, S.M.4
  • 49
    • 34147176022 scopus 로고    scopus 로고
    • Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach
    • Koldamova R, Lefterov I (2007) Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach. Curr Alzheimer Res 4, 171-178.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 171-178
    • Koldamova, R.1    Lefterov, I.2
  • 55
    • 33845587711 scopus 로고    scopus 로고
    • Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice
    • Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW (2007) Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab 5, 73-79.
    • (2007) Cell Metab , vol.5 , pp. 73-79
    • Chen, W.1    Chen, G.2    Head, D.L.3    Mangelsdorf, D.J.4    Russell, D.W.5
  • 56
    • 38349112601 scopus 로고    scopus 로고
    • Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase
    • Lange Y, Ory DS, Ye J, Lanier MH, Hsu FF, Steck TL (2008) Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem 283, 1445-1455.
    • (2008) J Biol Chem , vol.283 , pp. 1445-1455
    • Lange, Y.1    Ory, D.S.2    Ye, J.3    Lanier, M.H.4    Hsu, F.F.5    Steck, T.L.6
  • 57
    • 0032903412 scopus 로고    scopus 로고
    • Apolipoprotein Epromotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner
    • Yang DS, Small DH, Seydel U, Smith JD, Hallmayer J, Gandy SE, Martins RN (1999) Apolipoprotein Epromotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience 90, 1217-1226.
    • (1999) Neuroscience , vol.90 , pp. 1217-1226
    • Yang, D.S.1    Small, D.H.2    Seydel, U.3    Smith, J.D.4    Hallmayer, J.5    Gandy, S.E.6    Martins, R.N.7
  • 58
    • 0037969631 scopus 로고    scopus 로고
    • 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    • Koldamova RP, Lefterov IM, Ikonomovic MD, Skoko J, Lefterov PI, Isanski BA, DeKosky ST, Lazo JS (2003) 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J Biol Chem 278, 13244-13256.
    • (2003) J Biol Chem , vol.278 , pp. 13244-13256
    • Koldamova, R.P.1    Lefterov, I.M.2    Ikonomovic, M.D.3    Skoko, J.4    Lefterov, P.I.5    Isanski, B.A.6    DeKosky, S.T.7    Lazo, J.S.8
  • 64
    • 0032485464 scopus 로고    scopus 로고
    • Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex
    • Kerr SJ, Armati PJ, Guillemin GJ, Brew BJ (1998) Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex. AIDS 12, 355-363.
    • (1998) AIDS , vol.12 , pp. 355-363
    • Kerr, S.J.1    Armati, P.J.2    Guillemin, G.J.3    Brew, B.J.4
  • 66
    • 0024550204 scopus 로고
    • Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
    • Weidemann A, Konig G, Bunke D, Fischer P, Salbaum JM, Masters CL, Beyreuther K (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126.
    • (1989) Cell , vol.57 , pp. 115-126
    • Weidemann, A.1    Konig, G.2    Bunke, D.3    Fischer, P.4    Salbaum, J.M.5    Masters, C.L.6    Beyreuther, K.7
  • 70
    • 0037199994 scopus 로고    scopus 로고
    • Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
    • Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA (2002) Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem 277, 31900-31908.
    • (2002) J Biol Chem , vol.277 , pp. 31900-31908
    • Mak, P.A.1    Laffitte, B.A.2    Desrumaux, C.3    Joseph, S.B.4    Curtiss, L.K.5    Mangelsdorf, D.J.6    Tontonoz, P.7    Edwards, P.A.8
  • 71
    • 12144287442 scopus 로고    scopus 로고
    • Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis
    • Quinn CM, Kagedal K, Terman A, Stroikin U, Brunk UT, Jessup W, Garner B (2004) Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis. Biochem J 378, 753-761.
    • (2004) Biochem J , vol.378 , pp. 753-761
    • Quinn, C.M.1    Kagedal, K.2    Terman, A.3    Stroikin, U.4    Brunk, U.T.5    Jessup, W.6    Garner, B.7
  • 74
    • 0037119427 scopus 로고    scopus 로고
    • Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice
    • Gong JS, Kobayashi M, Hayashi H, Zou K, Sawamura N, Fujita SC, Yanagisawa K, Michikawa M (2002) Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice. J Biol Chem 277, 29919-29926.
    • (2002) J Biol Chem , vol.277 , pp. 29919-29926
    • Gong, J.S.1    Kobayashi, M.2    Hayashi, H.3    Zou, K.4    Sawamura, N.5    Fujita, S.C.6    Yanagisawa, K.7    Michikawa, M.8
  • 75
    • 0028816863 scopus 로고
    • Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry
    • Dzeletovic S, Breuer O, Lund E, Diczfalusy U (1995) Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal Biochem 225, 73-80.
    • (1995) Anal Biochem , vol.225 , pp. 73-80
    • Dzeletovic, S.1    Breuer, O.2    Lund, E.3    Diczfalusy, U.4
  • 76
    • 0036916491 scopus 로고    scopus 로고
    • On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: Critical importance of the position of the oxygen function
    • Meaney S, Bodin K, Diczfalusy U, Bjorkhem I (2002) On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. J Lipid Res 43, 2130-2135.
    • (2002) J Lipid Res , vol.43 , pp. 2130-2135
    • Meaney, S.1    Bodin, K.2    Diczfalusy, U.3    Bjorkhem, I.4
  • 79
    • 0025914556 scopus 로고
    • Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis
    • Cali JJ, Hsieh CL, Francke U, Russell DW (1991) Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J Biol Chem 266, 7779-7783.
    • (1991) J Biol Chem , vol.266 , pp. 7779-7783
    • Cali, J.J.1    Hsieh, C.L.2    Francke, U.3    Russell, D.W.4
  • 80
    • 0034921902 scopus 로고    scopus 로고
    • Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol 27-hydroxylase gene (CYP27)
    • Sugama S, Kimura A, Chen W, Kubota S, Seyama Y, Taira N, Eto Y (2001) Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol 27-hydroxylase gene (CYP27). J Inherit Metab Dis 24, 379-392.
    • (2001) J Inherit Metab Dis , vol.24 , pp. 379-392
    • Sugama, S.1    Kimura, A.2    Chen, W.3    Kubota, S.4    Seyama, Y.5    Taira, N.6    Eto, Y.7
  • 84
    • 34249828178 scopus 로고    scopus 로고
    • Regulation of alpha- and beta-secretase activity by oxysterols: Cerebrosterol stimulates processing of APP via the alpha-secretase pathway
    • Famer D, Meaney S, Mousavi M, Nordberg A, Bjorkhem I, Crisby M (2007) Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway. Biochem Biophys Res Commun 359, 46-50.
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 46-50
    • Famer, D.1    Meaney, S.2    Mousavi, M.3    Nordberg, A.4    Bjorkhem, I.5    Crisby, M.6
  • 85
    • 0033528279 scopus 로고    scopus 로고
    • The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells
    • Kolsch H, Lutjohann D, Tulke A, Bjorkhem I, Rao ML (1999) The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. Brain Res 818, 171-175.
    • (1999) Brain Res , vol.818 , pp. 171-175
    • Kolsch, H.1    Lutjohann, D.2    Tulke, A.3    Bjorkhem, I.4    Rao, M.L.5
  • 86
    • 21344469049 scopus 로고    scopus 로고
    • 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells
    • Alexandrov P, Cui JG, Zhao Y, Lukiw WJ (2005) 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells. Neuroreport 16, 909-913.
    • (2005) Neuroreport , vol.16 , pp. 909-913
    • Alexandrov, P.1    Cui, J.G.2    Zhao, Y.3    Lukiw, W.J.4


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