Diagnostic use of cerebral and extracerebral oxysterols

Clinical Chemistry and Laboratory Medicine

Volumn 42, Issue 2, 2004, Pages 186-191

  Leoni, Valerio ^a,b   Masterman, Thomas ^c   Mousavi, Fariba S ^b   Wretlind, Bengt ^b   Wahlund, Lars Olof ^d   Diczfalusy, Ulf ^b   Hillert, Jan ^c   Björkhem, Ingemar ^b,d  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b Department of Laboratory Medicine ^*  (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

24S hydroxycholesterol; 27 hydroxycholesterol; Isotope dilution mass spectrometry; Neurological disease

Indexed keywords

26 HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; OXYSTEROL; STEROID;

ADULT; ALZHEIMER DISEASE; ARTICLE; BIOCHEMISTRY; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID ANALYSIS; CLINICAL CHEMISTRY; CONTROLLED STUDY; DEMYELINATING DISEASE; DEMYELINATION; DIAGNOSTIC VALUE; FEMALE; GERIATRIC DISORDER; HUMAN; ISOTOPE DILUTION ASSAY; LIPID BRAIN LEVEL; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MENINGITIS; MULTIPLE SCLEROSIS; NERVE CELL LESION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; STEROID BLOOD LEVEL;

ADULT; AGED; BRAIN DISEASES; FEMALE; HUMANS; HYDROXYCHOLESTEROLS; MALE; MIDDLE AGED;

EID: 1642525647     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2004.034     Document Type: Article

References (18)

1. Lütjohann D, Breuer O, Ahlborg G, Nennesmo I, Siden Å, Diczfalusy U, et al. Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci USA 1996;93:9799-804.
2. Björkhem I, Lütjohann D, Diczfalusy U, Ståhle L, Ahlborg G, Wahren J. Cholesterol homeostasis in the human brain: Turnover of the 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res 1998;39:1594-600.
3. Lund EG, Guileyardo JM, Russell DW. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci USA 1999;96:7238-43.
4. Bogdanovic N, Bretillion L, Lund EG, Diczfalusy U, Lannfelt L, Winblad B, et al. On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP 46 in glial cells. Neurosci Lett 2001;314:45-8.
5. Bretillon L, Siden Å, Wahlund LO, Lütjohann D, Minthon L, Crisby M, et al. Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. Neurosci Lett 2000;293:87-90.
6. Leoni V, Masterman T, Patel P, Meaney S, Diczfalusy U, Björkhem I. Side-chain oxidised oxysterols in cerebrospinal fluid and integrity of the blood-brain barrier. J Lipid Res 2003;44:793:9.
7. Lund E, Andersson O, Zhang J, Babiker A, Ahlborg G, Diczfalusy U, et al. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans. Arterioscler Thromb Vasc Biol 1996;16:208-12.
8. Björkhem I, Diczfalusy U, Lütjohann D. Removal of cholesterol from extrahepatic sources by oxidative mechanism. Curr Opin Lipidol 1999;10:161-5.
9. Babiker A, Andersson O, Lindblom D, van der Linden J, Wiklund B, Lütjohann D, et al. Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: Evidence that most of this steroid in the circulation is of pulmonary origin. J Lipid Res 1999;40:1417-25.
10. Reiber H, Peter JB. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci 2001;184:101-22.
11. Reiber H. Dynamics of brain-specific protein in cerebrospinal fluid. Clin Chim Acta 2001;310:173-86.
12. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebres GC, et al. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann Neurol 1983;13:227-31.
13. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer disease: Report of the NINCDS-ASDRA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
14. Dzeletovic S, Breuer O, Lund E, Diczfalusy U. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal Biochem 1995;225:73-80.
15. Bretillon L, Lütjohann D, Ståhle L, Widhe T, Bindl L, Eggersten G, et al. Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J Lipid Res 2000;41:840-5.
16. Leoni V, Masterman T, Diczfausy U, De Luca GC, Hillert J, Björkhem I. Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis. Neurosci Lett 2002;331:163-6.
17. Blennow K, Wallin A, Fredman P, Karlsson I, Gottfries CG, Svennerholm L. Blood brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors. Acta Neurol Scand 1990:81:323-6.
18. Schonknecht P, Lütjohann D, Pantel J, Bardenheuer H, Hartmann T, von Bergmann K, et al. Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls. Neurosci Lett 2002;324:83-8.