Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers

Atherosclerosis

Volumn 194, Issue 1, 2007, Pages 71-78

  Burkard, Ines ^a   von Eckardstein, Arnold ^a   Waeber, Gérard ^b   Vollenweider, Peter ^b   Rentsch, Katharina M ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

24S Hydroxycholesterol; 27 Hydroxycholesterol; Cholesterol homeostasis; Lipoprotein subfractions; Lipoproteins; Oxysterol esters; Oxysterols

Indexed keywords

24 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; CHOLESTEROL; CHOLESTEROL DERIVATIVE; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; OXYSTEROL; OXYSTEROL ESTER; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CIRCADIAN RHYTHM; CLINICAL STUDY; CORRELATION ANALYSIS; ESTERIFICATION; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIPID ANALYSIS; LIPID COMPOSITION; LIPID DEGRADATION; LIPID TRANSPORT; LIPOPROTEIN SUBFRACTION; MALE; MASS SPECTROMETER; MENSTRUAL CYCLE; METABOLITE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REFERENCE VALUE; SEX RATIO; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; CHEMISTRY, CLINICAL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCADIAN RHYTHM; ESTERIFICATION; FEMALE; HUMANS; HYDROXYCHOLESTEROLS; MALE; MENSTRUAL CYCLE; MIDDLE AGED; REFERENCE VALUES; TRIGLYCERIDES;

EID: 34648837875     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.09.026     Document Type: Article

References (32)

1. Chawla A., Repa J.J., Evans R.M., et al. Nuclear receptors and lipid physiology: opening the X-files. Science 294 (2001) 1866-1870
2. Brown A.J., and Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 142 (1999) 1-28
3. Smith L.L., and Johnson B.H. Biological activities of oxysterols. Free Radic Biol Med 7 (1989) 285-332
4. Lemaire-Ewing S., Prunet C., Montange T., et al. Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol 21 (2005) 97-114
5. Haigh W.G., and Lee S.P. Identification of oxysterols in human bile and pigment gallstones. Gastroenterology 121 (2001) 118-123
6. Meaney S., Bodin K., Diczfalusy U., et al. On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. J Lipid Res 43 (2002) 2130-2135
7. Björkhem I. Do oxysterols control cholesterol homeostasis?. J Clin Invest 110 (2002) 725-730
8. Lund E.G., Guileyardo J.M., and Russel D.W. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci USA 96 (1999) 7238-7243
9. Björkhem I., Lütjohann D., Diczfalusy U., et al. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res 39 (1998) 1594-1600
10. 2 techniques in vivo and in vitro. J Biol Chem 272 (1997) 30178-30184
11. Björkhem I., Meaney S., and Diczfalusy U. Oxysterols in human circulation: which role do they have?. Curr Opin Lipidol 13 (2002) 247-253
12. Babiker A., Andersson O., Lund E., et al. Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport. J Biol Chem 272 (1997) 26253-26261
13. Reiss A.B., Martin K.O., Rojer D.E., et al. Sterol 27-hydroxylase: expression in human arterial endothelium. J Lipid Res 38 (1997) 1254-1260
14. Björkhem I., Andersson O., Diczfalusy U., et al. Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. Proc Natl Acad Sci USA 91 (1994) 8592-8596
15. Björkhem I., Diczfalusy U., and Lütjohann D. Removal of cholesterol from extrahepatic sources by oxidative mechanisms. Curr Opin Lipidol 10 (1999) 161-165
16. Diczfalusy U., Lund E., Lütjohann D., et al. Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols. Scand J Clin Lab Invest Suppl 226 (1996) 9-17
17. Cali J.J., Hsieh C.L., Francke U., et al. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J Biol Chem 266 (1991) 7779-7783
18. Federico A., and Dotti M.T. Cerebrotendinous xanthomatosis: clinical manifestations, diagnostic criteria, pathogenesis, and therapy. J Child Neurol 18 (2003) 633-638
19. Björkhem I., Boberg K.M., and Leitersorf E. Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol. In: Scriver C.R., Beaudet A.L., Sly W.S., and Valle D. (Eds). The metabolic and molecular bases of inherited disease (2001), McGraw-Hill, New York, NY 2961-2988
20. Burkard I., Rentsch K.M., and von Eckardstein A. Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. J Lipid Res 45 (2004) 776-781
21. Chapman M.J., Goldstein S., Lagrange D., et al. A density gradient ultracentrifugal procedure for the isolation of the major lipoprotein classes from human serum. J Lipid Res 22 (1981) 339-358
22. 2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem 28 (1982) 1379-1388
23. Babiker A., and Diczfalusy U. Transport of side-chain oxidized oxysterols in the human circulation. Biochim Biophys Acta 1392 (1998) 333-339
24. Havel R.J., and Kane J.P. Introduction: structure and metabolism of plasma lipoproteins. In: Scriver C.R., Beaudet A.L., Sly W.S., and Valle D. (Eds). The metabolic and molecular bases of inherited disease (2001), McGraw-Hill, New York, NY 2705-2752
25. Tall A.R., Breslow J.L., and Rubin E.M. Genetic disorders affecting plasma high-density lipoproteins. In: Scriver C.R., Beaudet A.L., Sly W.S., and Valle D. (Eds). The metabolic and molecular bases of inherited disease (2001), McGraw-Hill, New York, NY 2915-2936
26. Schwartz C.C., VandenBroek J.M., and Cooper P.S. Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans. J Lipid Res 45 (2004) 1594-1607
27. Dzeletovic S., Breuer O., Lund E., et al. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal Biochem 225 (1995) 73-80
28. Lütjohann D., Breuer O., Ahlborg G., et al. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci USA 93 (1996) 9799-9804
29. Lütjohann D., Papassotiropoulos A., Björkhem I., et al. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J Lipid Res 41 (2000) 195-198
30. Bretillon L., Lütjohann D., Stahle L., et al. Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J Lipid Res 41 (2000) 840-845
31. Schultz J.R., Tu H., Luk A., et al. Role of LXRs in control of lipogenesis. Genes Dev 14 (2000) 2831-2838
32. Hersberger M., and von Eckardstein A. Low high-density lipoprotein cholesterol: physiological background, clinical importance and drug treatment. Drugs 63 (2003) 1907-1945