-
1
-
-
0033604585
-
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
-
Kandel E.S., Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 1999, 253:210-229.
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 210-229
-
-
Kandel, E.S.1
Hay, N.2
-
2
-
-
72449195397
-
Molecular mechanisms of metabolic regulation by insulin in Drosophila
-
Teleman A.A. Molecular mechanisms of metabolic regulation by insulin in Drosophila. Biochem. J. 2009, 425:13-26.
-
(2009)
Biochem. J.
, vol.425
, pp. 13-26
-
-
Teleman, A.A.1
-
3
-
-
68149169938
-
Signals of youth: endocrine regulation of aging in Caenorhabditis elegans
-
Panowski S.H., Dillin A. Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol. Metab. 2009, 20:259-264.
-
(2009)
Trends Endocrinol. Metab.
, vol.20
, pp. 259-264
-
-
Panowski, S.H.1
Dillin, A.2
-
4
-
-
0038624395
-
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
-
Peng X.D., et al. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 2003, 17:1352-1365.
-
(2003)
Genes Dev.
, vol.17
, pp. 1352-1365
-
-
Peng, X.D.1
-
5
-
-
0036066970
-
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
-
Mauvais-Jarvis F., et al. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin. Endocrinol. (Oxf.) 2002, 57:1-9.
-
(2002)
Clin. Endocrinol. (Oxf.)
, vol.57
, pp. 1-9
-
-
Mauvais-Jarvis, F.1
-
6
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers D.J., et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998, 391:900-904.
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
-
7
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
Cho H., et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001, 292:1728-1731.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
-
8
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
-
Garofalo R.S., et al. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J. Clin. Invest. 2003, 112:197-208.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 197-208
-
-
Garofalo, R.S.1
-
9
-
-
2542528670
-
A family with severe insulin resistance and diabetes due to a mutation in AKT2
-
George S., et al. A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 2004, 304:1325-1328.
-
(2004)
Science
, vol.304
, pp. 1325-1328
-
-
George, S.1
-
10
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
11
-
-
34047095297
-
The two TORCs and Akt
-
Bhaskar P.T., Hay N. The two TORCs and Akt. Dev. Cell 2007, 12:487-502.
-
(2007)
Dev. Cell
, vol.12
, pp. 487-502
-
-
Bhaskar, P.T.1
Hay, N.2
-
13
-
-
34548289502
-
Dynamic FoxO transcription factors
-
Huang H., Tindall D.J. Dynamic FoxO transcription factors. J. Cell Sci. 2007, 120:2479-2487.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 2479-2487
-
-
Huang, H.1
Tindall, D.J.2
-
14
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
Chen W.S., et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001, 15:2203-2208.
-
(2001)
Genes Dev.
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
-
15
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho H., et al. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 2001, 276:38349-38352.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
-
16
-
-
23144449547
-
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
-
Tschopp O., et al. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 2005, 132:2943-2954.
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
-
17
-
-
20044382806
-
Role for Akt3/protein kinase Bgamma in attainment of normal brain size
-
Easton R.M., et al. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol. Cell Biol. 2005, 25:1869-1878.
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 1869-1878
-
-
Easton, R.M.1
-
18
-
-
66349106496
-
Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice
-
Chen W.S., et al. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol. Cell Biol. 2009, 29:3151-3162.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 3151-3162
-
-
Chen, W.S.1
-
19
-
-
75149152059
-
Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass
-
Buzzi F., et al. Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. Mol. Cell Biol. 2010, 30:601-612.
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 601-612
-
-
Buzzi, F.1
-
20
-
-
34247849262
-
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice
-
Cantley J., et al. Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia 2007, 50:1248-1256.
-
(2007)
Diabetologia
, vol.50
, pp. 1248-1256
-
-
Cantley, J.1
-
21
-
-
27944493875
-
Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice
-
Yang Z.Z., et al. Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol. Cell Biol. 2005, 25:10407-10418.
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 10407-10418
-
-
Yang, Z.Z.1
-
22
-
-
33750380920
-
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
-
Dummler B., et al. Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol. Cell Biol. 2006, 26:8042-8051.
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 8042-8051
-
-
Dummler, B.1
-
23
-
-
14144250240
-
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
-
Brachmann S.M., et al. Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol. Cell Biol. 2005, 25:1596-1607.
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 1596-1607
-
-
Brachmann, S.M.1
-
25
-
-
28244446188
-
Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis
-
Kushner J.A., et al. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J. Biol. Chem. 2005, 280:39388-39393.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39388-39393
-
-
Kushner, J.A.1
-
26
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi D.R., et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 1997, 7:261-269.
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
-
27
-
-
43249093752
-
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
-
Bayascas J.R., et al. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol. Cell Biol. 2008, 28:3258-3272.
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 3258-3272
-
-
Bayascas, J.R.1
-
28
-
-
0032061042
-
Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways
-
Leibiger I.B., et al. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Mol. Cell 1998, 1:933-938.
-
(1998)
Mol. Cell
, vol.1
, pp. 933-938
-
-
Leibiger, I.B.1
-
29
-
-
0037021433
-
Insulin feedback action on pancreatic beta-cell function
-
Leibiger I.B., et al. Insulin feedback action on pancreatic beta-cell function. FEBS Lett. 2002, 532:1-6.
-
(2002)
FEBS Lett.
, vol.532
, pp. 1-6
-
-
Leibiger, I.B.1
-
30
-
-
42349086872
-
Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice
-
Shigeyama Y., et al. Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol. Cell Biol. 2008, 28:2971-2979.
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 2971-2979
-
-
Shigeyama, Y.1
-
31
-
-
48249146208
-
Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
-
Rachdi L., et al. Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:9250-9255.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 9250-9255
-
-
Rachdi, L.1
-
32
-
-
9644270397
-
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
-
Bernal-Mizrachi E., et al. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J. Clin. Invest. 2004, 114:928-936.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 928-936
-
-
Bernal-Mizrachi, E.1
-
33
-
-
0035210374
-
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
-
Bernal-Mizrachi E., et al. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J. Clin. Invest. 2001, 108:1631-1638.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1631-1638
-
-
Bernal-Mizrachi, E.1
-
34
-
-
0034781057
-
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
-
Tuttle R.L., et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat. Med. 2001, 7:1133-1137.
-
(2001)
Nat. Med.
, vol.7
, pp. 1133-1137
-
-
Tuttle, R.L.1
-
36
-
-
70350417158
-
Akt2 is required for hepatic lipid accumulation in models of insulin resistance
-
Leavens K.F., et al. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab. 2009, 10:405-418.
-
(2009)
Cell Metab.
, vol.10
, pp. 405-418
-
-
Leavens, K.F.1
-
37
-
-
0037115464
-
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice
-
Laustsen P.G., et al. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev. 2002, 16:3213-3222.
-
(2002)
Genes Dev.
, vol.16
, pp. 3213-3222
-
-
Laustsen, P.G.1
-
38
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
Pelleymounter M.A., et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995, 269:540-543.
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
-
39
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
40
-
-
85011486581
-
A leptin dose-response study in obese (ob/ob) and lean (+/?) mice
-
Harris R.B., et al. A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 1998, 139:8-19.
-
(1998)
Endocrinology
, vol.139
, pp. 8-19
-
-
Harris, R.B.1
-
41
-
-
0030784253
-
Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
-
Rossetti L., et al. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J. Biol. Chem. 1997, 272:27758-27763.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27758-27763
-
-
Rossetti, L.1
-
42
-
-
0032835376
-
Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition
-
O'Doherty R.M., et al. Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition. Am. J. Physiol. 1999, 277:E544-550.
-
(1999)
Am. J. Physiol.
, vol.277
-
-
O'Doherty, R.M.1
-
43
-
-
52949140814
-
Making insulin-deficient type 1 diabetic rodents thrive without insulin
-
Yu X., et al. Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:14070-14075.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 14070-14075
-
-
Yu, X.1
-
44
-
-
77950373635
-
Leptin therapy in insulin-deficient type I diabetes
-
Wang M.Y., et al. Leptin therapy in insulin-deficient type I diabetes. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:4813-4819.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 4813-4819
-
-
Wang, M.Y.1
-
45
-
-
73049107663
-
Antidiabetic effects of IGFBP2, a leptin-regulated gene
-
Hedbacker K., et al. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metab. 2010, 11:11-22.
-
(2010)
Cell Metab.
, vol.11
, pp. 11-22
-
-
Hedbacker, K.1
-
46
-
-
34548175209
-
High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice
-
Cohen S.E., et al. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J. Biol. Chem. 2007, 282:23672-23678.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 23672-23678
-
-
Cohen, S.E.1
-
47
-
-
31044446941
-
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
-
Dong X., et al. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J. Clin. Invest. 2006, 116:101-114.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 101-114
-
-
Dong, X.1
-
48
-
-
33646148946
-
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta
-
Taniguchi C.M., et al. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab. 2006, 3:343-353.
-
(2006)
Cell Metab.
, vol.3
, pp. 343-353
-
-
Taniguchi, C.M.1
-
49
-
-
41849093037
-
The role of FoxO in the regulation of metabolism
-
Gross D.N., et al. The role of FoxO in the regulation of metabolism. Oncogene 2008, 27:2320-2336.
-
(2008)
Oncogene
, vol.27
, pp. 2320-2336
-
-
Gross, D.N.1
-
50
-
-
34250740323
-
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator
-
Li X., et al. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 2007, 447:1012-1016.
-
(2007)
Nature
, vol.447
, pp. 1012-1016
-
-
Li, X.1
-
51
-
-
11144357516
-
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
-
Inoue H., et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat. Med. 2004, 10:168-174.
-
(2004)
Nat. Med.
, vol.10
, pp. 168-174
-
-
Inoue, H.1
-
52
-
-
33745362866
-
Critical role of STAT3 in leptin's metabolic actions
-
Buettner C., et al. Critical role of STAT3 in leptin's metabolic actions. Cell Metab. 2006, 4:49-60.
-
(2006)
Cell Metab.
, vol.4
, pp. 49-60
-
-
Buettner, C.1
-
53
-
-
11144357287
-
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
-
Asilmaz E., et al. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J. Clin. Invest. 2004, 113:414-424.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 414-424
-
-
Asilmaz, E.1
-
54
-
-
58849155132
-
Mechanism and management of AKT inhibitor-induced hyperglycemia
-
Crouthamel M.C., et al. Mechanism and management of AKT inhibitor-induced hyperglycemia. Clin. Cancer Res. 2009, 15:217-225.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 217-225
-
-
Crouthamel, M.C.1
-
55
-
-
1542781732
-
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
-
Bae S.S., et al. Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J. Biol. Chem. 2003, 278:49530-49536.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 49530-49536
-
-
Bae, S.S.1
-
56
-
-
0033588098
-
Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes
-
Summers S.A., et al. Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes. J. Biol. Chem. 1999, 274:23858-23867.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23858-23867
-
-
Summers, S.A.1
-
57
-
-
67650523945
-
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway
-
Zhang H.H., et al. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One 2009, 4:e6189.
-
(2009)
PLoS One
, vol.4
-
-
Zhang, H.H.1
-
58
-
-
33846806078
-
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
-
Le Bacquer O., et al. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J. Clin. Invest. 2007, 117:387-396.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 387-396
-
-
Le Bacquer, O.1
-
59
-
-
77952893054
-
S6K1 plays a critical role in early adipocyte differentiation
-
Carnevalli L.S., et al. S6K1 plays a critical role in early adipocyte differentiation. Dev. Cell 2010, 18:763-774.
-
(2010)
Dev. Cell
, vol.18
, pp. 763-774
-
-
Carnevalli, L.S.1
-
60
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili D., Arden K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004, 117:421-426.
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
61
-
-
0036787607
-
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
-
Nakae J., et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 2002, 32:245-253.
-
(2002)
Nat. Genet.
, vol.32
, pp. 245-253
-
-
Nakae, J.1
-
62
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
Kitamura T., et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 2002, 110:1839-1847.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
-
63
-
-
70350418625
-
MTOR signaling at a glance
-
Laplante M., Sabatini D.M. mTOR signaling at a glance. J. Cell Sci. 2009, 122:3589-3594.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
64
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N., Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004, 18:1926-1945.
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
65
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K., et al. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
-
66
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn D.M., et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 2008, 30:214-226.
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
-
67
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
Hahn-Windgassen A., et al. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J. Biol. Chem. 2005, 280:32081-32089.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
-
68
-
-
1242329177
-
Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1
-
El-Chaar D., et al. Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1. Int. J. Obes. Relat. Metab. Disord. 2004, 28:191-198.
-
(2004)
Int. J. Obes. Relat. Metab. Disord.
, vol.28
, pp. 191-198
-
-
El-Chaar, D.1
-
69
-
-
54849431380
-
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
-
Polak P., et al. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab. 2008, 8:399-410.
-
(2008)
Cell Metab.
, vol.8
, pp. 399-410
-
-
Polak, P.1
-
70
-
-
0038242819
-
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
-
Du K., et al. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 2003, 300:1574-1577.
-
(2003)
Science
, vol.300
, pp. 1574-1577
-
-
Du, K.1
-
71
-
-
65449161015
-
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice
-
Cheng K.K., et al. APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metab. 2009, 9:417-427.
-
(2009)
Cell Metab.
, vol.9
, pp. 417-427
-
-
Cheng, K.K.1
-
72
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., et al. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
-
74
-
-
47249105677
-
PHLiPPing the switch on Akt and protein kinase C signaling
-
Brognard J., Newton A.C. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol. Metab. 2008, 19:223-230.
-
(2008)
Trends Endocrinol. Metab.
, vol.19
, pp. 223-230
-
-
Brognard, J.1
Newton, A.C.2
|