Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells

Journal of Clinical Investigation

Volumn 114, Issue 7, 2004, Pages 928-936

  Bernal Mizrachi, Ernesto ^a   Fatrai, Szabolcs ^a   Johnson, James D ^a   Ohsugi, Mitsuru ^a   Otani, Kenichi ^a   Han, Zhiqiang ^a   Polonsky, Kenneth S ^a   Permutt, M Alan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN KINASE B; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; EXOCYTOSIS; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE TOLERANCE; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BODY WEIGHT; CALCIUM; CULTURE TECHNIQUES; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FATS; DISEASE SUSCEPTIBILITY; GENE EXPRESSION REGULATION; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 9644270397     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200420016     Document Type: Article

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