APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

Cell Metabolism

Volumn 9, Issue 5, 2009, Pages 417-427

  Cheng, Kenneth K Y ^a   Iglesias, Miguel A ^b   Lam, Karen S L ^a   Wang, Yu ^a   Sweeney, Gary ^c   Zhu, Weidong ^a   Vanhoutte, Paul M ^a   Kraegen, Edward W ^b   Xu, Aimin ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c YORK UNIVERSITY   (Canada)

Author keywords

HUMDISEASE; SIGNALING

Indexed keywords

ADAPTOR PROTEIN; GLUCOSE; INSULIN; PROTEIN APPL1; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL STIMULATION; DIABETES MELLITUS; ENDOSOME; ENZYME ACTIVATION; ENZYME INHIBITION; GLUCONEOGENESIS; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER CELL; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; GENE KNOCKDOWN TECHNIQUES; GLUCONEOGENESIS; GLUCOSE; HEPATOCYTES; INSULIN; MICE; MICE, INBRED C57BL; MICE, OBESE; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

MUS;

EID: 65449161015     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.03.013     Document Type: Article

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