-
1
-
-
34248223285
-
Biology of incretins: GLP-1 and GIP
-
Baggio, L.L. & D.J. Drucker 2007. Biology of incretins: GLP-1 and GIP. Gastroenterology. 132: 2131-2157.
-
(2007)
Gastroenterology
, vol.132
, pp. 2131-2157
-
-
Baggio, L.L.1
Drucker, D.J.2
-
2
-
-
33644841711
-
Cholecystokinin and gastrin receptors
-
Dufresne, M., C. Seva & D. Fourmy 2006. Cholecystokinin and gastrin receptors. Physiol. Rev. 86: 805-847.
-
(2006)
Physiol. Rev
, vol.86
, pp. 805-847
-
-
Dufresne, M.1
Seva, C.2
Fourmy, D.3
-
3
-
-
0026582549
-
CCK-8-stimulated insulin secretion in vivo is mediated by CCKA receptors
-
Karlsson, S. & B. Ahren 1992. CCK-8-stimulated insulin secretion in vivo is mediated by CCKA receptors. Eur. J. Pharmacol. 213: 145-146.
-
(1992)
Eur. J. Pharmacol
, vol.213
, pp. 145-146
-
-
Karlsson, S.1
Ahren, B.2
-
4
-
-
0025899034
-
Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man
-
Ahren, B., M. Pettersson, K. Uvnas-Moberg, et al 1991. Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man. Diabetes Res. Clin. Pract. 13: 153-161.
-
(1991)
Diabetes Res. Clin. Pract
, vol.13
, pp. 153-161
-
-
Ahren, B.1
Pettersson, M.2
Uvnas-Moberg, K.3
-
5
-
-
0025800942
-
Effect of a cholecystokinin antagonist on meal-stimulated insulin and pancreatic polypeptide release in humans
-
Hildebrand, P., J.W. Ensinck, S. Ketterer, et al 1991. Effect of a cholecystokinin antagonist on meal-stimulated insulin and pancreatic polypeptide release in humans. J. Clin. Endocrinol. Metab. 72: 1123-1129.
-
(1991)
J. Clin. Endocrinol. Metab
, vol.72
, pp. 1123-1129
-
-
Hildebrand, P.1
Ensinck, J.W.2
Ketterer, S.3
-
6
-
-
0034454424
-
Antidiabetogenic action of cholecystokinin-8 in type 2 diabetes
-
Ahren, B., J.J. Holst & S. Efendic 2000. Antidiabetogenic action of cholecystokinin-8 in type 2 diabetes. J. Clin. Endocrinol. Metab. 85: 1043-1048.
-
(2000)
J. Clin. Endocrinol. Metab
, vol.85
, pp. 1043-1048
-
-
Ahren, B.1
Holst, J.J.2
Efendic, S.3
-
7
-
-
53549094111
-
Relationship between beta-cell mass and diabetes onset
-
Matveyenko, A.V. & P.C. Butler 2008. Relationship between beta-cell mass and diabetes onset. Diabetes Obes. Metab. 10(Suppl 4): 23-31.
-
(2008)
Diabetes Obes. Metab
, vol.10
, Issue.SUPPL. 4
, pp. 23-31
-
-
Matveyenko, A.V.1
Butler, P.C.2
-
8
-
-
53549086121
-
Pancreatic beta-cell mass or beta-cell function? That is the question!
-
Henquin, J.C., E. Cerasi, S. Efendic, et al 2008. Pancreatic beta-cell mass or beta-cell function? That is the question!. Diabetes Obes. Metab. 10(Suppl 4): 1-4.
-
(2008)
Diabetes Obes. Metab
, vol.10
, Issue.SUPPL. 4
, pp. 1-4
-
-
Henquin, J.C.1
Cerasi, E.2
Efendic, S.3
-
9
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler, A.E., J. Janson, S. Bonner-Weir, et al 2003. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 52: 102-110.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
-
10
-
-
77950290798
-
{beta}-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes
-
Hanley, S.C., E. Austin, B. Assouline-Thomas, et al 2010. {beta}-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes. Endocrinology. 151: 1462-1472.
-
(2010)
Endocrinology
, vol.151
, pp. 1462-1472
-
-
Hanley, S.C.1
Austin, E.2
Assouline-Thomas, B.3
-
11
-
-
53549093011
-
Pancreatic beta-cell mass in European subjects with type 2 diabetes
-
Rahier, J., Y. Guiot, R.M. Goebbels, et al 2008. Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes. Metab. 10(Suppl 4): 32-42.
-
(2008)
Diabetes Obes. Metab
, vol.10
, Issue.SUPPL. 4
, pp. 32-42
-
-
Rahier, J.1
Guiot, Y.2
Goebbels, R.M.3
-
12
-
-
33744979065
-
Relationship between beta-cell mass and fasting blood glucose concentration in humans
-
Ritzel, R.A., A.E. Butler, R.A. Rizza, et al 2006. Relationship between beta-cell mass and fasting blood glucose concentration in humans. Diabetes Care. 29: 717-718.
-
(2006)
Diabetes Care
, vol.29
, pp. 717-718
-
-
Ritzel, R.A.1
Butler, A.E.2
Rizza, R.A.3
-
13
-
-
0021777067
-
Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited
-
Kloppel, G., M. Lohr, K. Habich, et al 1985. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv. Synth. Pathol. Res. 4: 110-125.
-
(1985)
Surv. Synth. Pathol. Res
, vol.4
, pp. 110-125
-
-
Kloppel, G.1
Lohr, M.2
Habich, K.3
-
14
-
-
0034522773
-
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
-
Perfetti, R., J. Zhou, M.E. Doyle & J.M. Egan 2000. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology. 141: 4600-4605.
-
(2000)
Endocrinology
, vol.141
, pp. 4600-4605
-
-
Perfetti, R.1
Zhou, J.2
Doyle, M.E.3
Egan, J.M.4
-
15
-
-
33745315716
-
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass
-
Buteau, J., M.L. Spatz & D. Accili 2006. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes. 55: 1190-1196.
-
(2006)
Diabetes
, vol.55
, pp. 1190-1196
-
-
Buteau, J.1
Spatz, M.L.2
Accili, D.3
-
16
-
-
12744259876
-
beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1
-
Li, Y., X. Cao, L.X. Li, et al 2005. beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes 54: 482-491.
-
(2005)
Diabetes
, vol.54
, pp. 482-491
-
-
Li, Y.1
Cao, X.2
Li, L.X.3
-
17
-
-
33644850386
-
Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function
-
Park, S., X. Dong, T.L. Fisher, et al 2006. Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J. Biol. Chem. 281: 1159-1168.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 1159-1168
-
-
Park, S.1
Dong, X.2
Fisher, T.L.3
-
18
-
-
52749096469
-
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation
-
Song, W.J., W.E. Schreiber, E. Zhong, et al 2008. Exendin-4 stimulation of cyclin A2 in beta-cell proliferation. Diabetes 57: 2371-2381.
-
(2008)
Diabetes
, vol.57
, pp. 2371-2381
-
-
Song, W.J.1
Schreiber, W.E.2
Zhong, E.3
-
19
-
-
66649084335
-
Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice
-
Tschen, S.I., S. Dhawan, T. Gurlo & A. Bhushan 2009. Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes 58: 1312-1320.
-
(2009)
Diabetes
, vol.58
, pp. 1312-1320
-
-
Tschen, S.I.1
Dhawan, S.2
Gurlo, T.3
Bhushan, A.4
-
20
-
-
74849108033
-
Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats
-
Kwon, D.Y., Y.S. Kim, I.S. Ahn, et al 2009. Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats. J. Pharmacol. Sci. 111: 361-371.
-
(2009)
J. Pharmacol. Sci
, vol.111
, pp. 361-371
-
-
Kwon, D.Y.1
Kim, Y.S.2
Ahn, I.S.3
-
21
-
-
0033513455
-
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
-
Xu, G., D.A. Stoffers, J.F. Habener & S. Bonner-Weir 1999. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48: 2270-2276.
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
Stoffers, D.A.2
Habener, J.F.3
Bonner-Weir, S.4
-
22
-
-
50949114536
-
PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation
-
Wang, Z.V., J. Mu, T.D. Schraw, et al 2008. PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation. Diabetes 57: 2137-2148.
-
(2008)
Diabetes
, vol.57
, pp. 2137-2148
-
-
Wang, Z.V.1
Mu, J.2
Schraw, T.D.3
-
23
-
-
34547672616
-
Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes
-
Zhang, J., Y. Tokui, K. Yamagata, et al 2007. Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes. Diabetologia 50: 1900-1909.
-
(2007)
Diabetologia
, vol.50
, pp. 1900-1909
-
-
Zhang, J.1
Tokui, Y.2
Yamagata, K.3
-
24
-
-
77954521533
-
Decrease in {beta}-cell proliferation precedes apoptosis during diabetes development in bio-breeding/worcester rat: beneficial role of Exendin-4
-
Perez-Arana, G., Blandino-Rosano, M., Prada-Oliveira, A., et al 2010. Decrease in {beta}-cell proliferation precedes apoptosis during diabetes development in bio-breeding/worcester rat: beneficial role of Exendin-4. Endocrinology 151: 2538-2546.
-
(2010)
Endocrinology
, vol.151
, pp. 2538-2546
-
-
Perez-Arana, G.1
Blandino-Rosano, M.2
Prada-Oliveira, A.3
-
25
-
-
33745937115
-
Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice
-
Green, B.D., K.S. Lavery, N. Irwin, et al 2006. Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice. J. Pharmacol. Exp. Ther. 318: 914-921.
-
(2006)
J. Pharmacol. Exp. Ther
, vol.318
, pp. 914-921
-
-
Green, B.D.1
Lavery, K.S.2
Irwin, N.3
-
26
-
-
57349099271
-
Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-L- valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes
-
Cheng, Q., P.K. Law, M. De Gasparo & P.S. Leung 2008. Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1, 1'-biphenyl]-4-yl]methyl]-L- valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes. J. Pharmacol. Exp. Ther. 327: 683-691.
-
(2008)
J. Pharmacol. Exp. Ther
, vol.327
, pp. 683-691
-
-
Cheng, Q.1
Law, P.K.2
De Gasparo, M.3
Leung, P.S.4
-
27
-
-
0037339649
-
Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo
-
Kim, J.G., L.L. Baggio, D.P. Bridon, et al 2003. Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo. Diabetes 52: 751-759.
-
(2003)
Diabetes
, vol.52
, pp. 751-759
-
-
Kim, J.G.1
Baggio, L.L.2
Bridon, D.P.3
-
28
-
-
70349779631
-
Poly-GLP-1, a novel long-lasting glucagon-like peptide-1 polymer, ameliorates hyperglycaemia by improving insulin sensitivity and increasing pancreatic beta-cell proliferation
-
Ma, X., H. Hui, Z. Liu, et al 2009. Poly-GLP-1, a novel long-lasting glucagon-like peptide-1 polymer, ameliorates hyperglycaemia by improving insulin sensitivity and increasing pancreatic beta-cell proliferation. Diabetes Obes. Metab. 11: 953-965.
-
(2009)
Diabetes Obes. Metab
, vol.11
, pp. 953-965
-
-
Ma, X.1
Hui, H.2
Liu, Z.3
-
29
-
-
0036381989
-
Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
-
Wang, Q. & P.L. Brubaker 2002. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia 45: 1263-1273.
-
(2002)
Diabetologia
, vol.45
, pp. 1263-1273
-
-
Wang, Q.1
Brubaker, P.L.2
-
30
-
-
0036828227
-
Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
-
Farilla, L., H. Hui, C. Bertolotto, et al 2002. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 143: 4397-4408.
-
(2002)
Endocrinology
, vol.143
, pp. 4397-4408
-
-
Farilla, L.1
Hui, H.2
Bertolotto, C.3
-
31
-
-
0030845706
-
Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats
-
Takiguchi, S., Y. Takata, A. Funakoshi, et al 1997. Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats. Gene 197: 169-175.
-
(1997)
Gene
, vol.197
, pp. 169-175
-
-
Takiguchi, S.1
Takata, Y.2
Funakoshi, A.3
-
32
-
-
44249084503
-
[Effects of GLP-1 treatment on protection of B cells in Otsuka Long-Evans Tokushima fatty rats
-
Wang, Y. & X.H. Guo 2006. [Effects of GLP-1 treatment on protection of B cells in Otsuka Long-Evans Tokushima fatty rats. Beijing Da Xue Xue Bao. 38: 375-380.
-
(2006)
Beijing Da Xue Xue Bao
, vol.38
, pp. 375-380
-
-
Wang, Y.1
Guo, X.H.2
-
33
-
-
48249109559
-
GLP-1 C-terminal structures affect its blood glucose lowering-function
-
Li, Y., C. Shi, Q. Lv, et al 2008. GLP-1 C-terminal structures affect its blood glucose lowering-function. J. Pept. Sci. 14: 777-785.
-
(2008)
J. Pept. Sci
, vol.14
, pp. 777-785
-
-
Li, Y.1
Shi, C.2
Lv, Q.3
-
34
-
-
70350203952
-
Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes
-
Mu, J., A. Petrov, G.J. Eiermann, et al 2009. Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes. Eur. J. Pharmacol. 623: 148-154.
-
(2009)
Eur. J. Pharmacol
, vol.623
, pp. 148-154
-
-
Mu, J.1
Petrov, A.2
Eiermann, G.J.3
-
35
-
-
0035069103
-
Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice
-
Ling, Z., D. Wu, Y. Zambre, et al 2001. Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice. Virchows Arch. 438: 382-387.
-
(2001)
Virchows Arch
, vol.438
, pp. 382-387
-
-
Ling, Z.1
Wu, D.2
Zambre, Y.3
-
36
-
-
0037312829
-
Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy
-
De Leon, D.D., S. Deng, R. Madani, et al 2003. Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy. Diabetes 52: 365-371.
-
(2003)
Diabetes
, vol.52
, pp. 365-371
-
-
De Leon, D.D.1
Deng, S.2
Madani, R.3
-
37
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor, Y., J. Brown, O.I. Martinez & D.A. Melton 2004. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46.
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
38
-
-
0033857422
-
Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action
-
Scrocchi, L.A., M.E. Hill, J. Saleh, et al 2000. Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action. Diabetes 49: 1552-1560.
-
(2000)
Diabetes
, vol.49
, pp. 1552-1560
-
-
Scrocchi, L.A.1
Hill, M.E.2
Saleh, J.3
-
39
-
-
0037315423
-
Role of leptin in the regulation of glucagon-like peptide-1 secretion
-
Anini, Y. & P.L. Brubaker 2003. Role of leptin in the regulation of glucagon-like peptide-1 secretion. Diabetes 52: 252-259.
-
(2003)
Diabetes
, vol.52
, pp. 252-259
-
-
Anini, Y.1
Brubaker, P.L.2
-
40
-
-
33645239679
-
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
-
Friedrichsen, B.N., N. Neubauer, Y.C. Lee, et al 2006. Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways. J. Endocrinol. 188: 481-492.
-
(2006)
J. Endocrinol
, vol.188
, pp. 481-492
-
-
Friedrichsen, B.N.1
Neubauer, N.2
Lee, Y.C.3
-
41
-
-
33645226637
-
Exendin-4 induction of cyclin D1 expression in INS-1 beta-cells: involvement of cAMP-responsive element
-
Kim, M.J., J.H. Kang, Y.G. Park, et al 2006. Exendin-4 induction of cyclin D1 expression in INS-1 beta-cells: involvement of cAMP-responsive element. J. Endocrinol. 188: 623-633.
-
(2006)
J. Endocrinol
, vol.188
, pp. 623-633
-
-
Kim, M.J.1
Kang, J.H.2
Park, Y.G.3
-
42
-
-
70350445980
-
Cyclin D2 protein stability is regulated in pancreatic beta-cells
-
He, L.M., D.J. Sartori, M. Teta, et al 2009. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol. Endocrinol. 23: 1865-1875.
-
(2009)
Mol. Endocrinol
, vol.23
, pp. 1865-1875
-
-
He, L.M.1
Sartori, D.J.2
Teta, M.3
-
43
-
-
0032768616
-
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
-
Buteau, J., R. Roduit, S. Susini & M. Prentki 1999. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 42: 856-864.
-
(1999)
Diabetologia
, vol.42
, pp. 856-864
-
-
Buteau, J.1
Roduit, R.2
Susini, S.3
Prentki, M.4
-
44
-
-
0034845958
-
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses
-
Lawlor, M.A. & D.R. Alessi 2001. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses. J. Cell Sci. 114: 2903-2910.
-
(2001)
J. Cell Sci
, vol.114
, pp. 2903-2910
-
-
Lawlor, M.A.1
Alessi, D.R.2
-
45
-
-
1842855402
-
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
-
Wang, Q., L. Li, E. Xu, et al 2004. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia 47: 478-487.
-
(2004)
Diabetologia
, vol.47
, pp. 478-487
-
-
Wang, Q.1
Li, L.2
Xu, E.3
-
46
-
-
0037341252
-
Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
-
Stoffers, D.A., B.M. Desai, D.D. DeLeon & R.A. Simmons 2003. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes 52: 734-740.
-
(2003)
Diabetes
, vol.52
, pp. 734-740
-
-
Stoffers, D.A.1
Desai, B.M.2
DeLeon, D.D.3
Simmons, R.A.4
-
47
-
-
0038339191
-
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2
-
Jhala, U.S., G. Canettieri, R.A. Screaton, et al 2003. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 17: 1575-1580.
-
(2003)
Genes Dev
, vol.17
, pp. 1575-1580
-
-
Jhala, U.S.1
Canettieri, G.2
Screaton, R.A.3
-
48
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers, D.J., J.S. Gutierrez, H. Towery, et al 1998. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391: 900-904.
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
-
49
-
-
0037221488
-
Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor
-
Buteau, J., S. Foisy, E. Joly & M. Prentki 2003. Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 52: 124-132.
-
(2003)
Diabetes
, vol.52
, pp. 124-132
-
-
Buteau, J.1
Foisy, S.2
Joly, E.3
Prentki, M.4
-
50
-
-
0035489990
-
Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation
-
Buteau, J., S. Foisy, C.J. Rhodes, et al 2001. Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation. Diabetes 50: 2237-2243.
-
(2001)
Diabetes
, vol.50
, pp. 2237-2243
-
-
Buteau, J.1
Foisy, S.2
Rhodes, C.J.3
-
51
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
Le Good, J.A., W.H. Ziegler, D.B. Parekh, et al 1998. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281: 2042-2045.
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
-
52
-
-
0032926648
-
Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway
-
Furukawa, N., T. Shirotani, E. Araki, et al 1999. Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway. Endocr. J. 46: 43-58.
-
(1999)
Endocr. J
, vol.46
, pp. 43-58
-
-
Furukawa, N.1
Shirotani, T.2
Araki, E.3
-
53
-
-
48949088649
-
Anti-proliferative effect of pro-inflammatory cytokines in cultured beta cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide -1
-
Blandino-Rosano, M., G. Perez-Arana, J.M. Mellado-Gil, et al 2008. Anti-proliferative effect of pro-inflammatory cytokines in cultured beta cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide -1. J. Mol. Endocrinol. 41: 35-44.
-
(2008)
J. Mol. Endocrinol
, vol.41
, pp. 35-44
-
-
Blandino-Rosano, M.1
Perez-Arana, G.2
Mellado-Gil, J.M.3
-
54
-
-
23844487799
-
The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells
-
Trumper, J., D. Ross, H. Jahr, et al 2005. The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells. Diabetologia 48: 1534-1540.
-
(2005)
Diabetologia
, vol.48
, pp. 1534-1540
-
-
Trumper, J.1
Ross, D.2
Jahr, H.3
-
55
-
-
0037382719
-
Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells
-
Briaud, I., M.K. Lingohr, L.M. Dickson, et al 2003. Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells. Diabetes 52: 974-983.
-
(2003)
Diabetes
, vol.52
, pp. 974-983
-
-
Briaud, I.1
Lingohr, M.K.2
Dickson, L.M.3
-
56
-
-
55649098154
-
Wnt signaling: relevance to beta-cell biology and diabetes
-
Welters, H.J. & R.N. Kulkarni 2008. Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol. Metab. 19: 349-355.
-
(2008)
Trends Endocrinol. Metab
, vol.19
, pp. 349-355
-
-
Welters, H.J.1
Kulkarni, R.N.2
-
57
-
-
43749120731
-
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
-
Liu, Z. & J.F. Habener 2008. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J. Biol. Chem. 283: 8723-8735.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 8723-8735
-
-
Liu, Z.1
Habener, J.F.2
-
59
-
-
0036068322
-
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
-
Miyawaki, K., Y. Yamada, N. Ban, et al 2002. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat. Med. 8: 738-742.
-
(2002)
Nat. Med
, vol.8
, pp. 738-742
-
-
Miyawaki, K.1
Yamada, Y.2
Ban, N.3
-
60
-
-
23644434110
-
Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes
-
Gault, V.A., N. Irwin, B.D. Green, et al 2005. Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. Diabetes 54: 2436-2446.
-
(2005)
Diabetes
, vol.54
, pp. 2436-2446
-
-
Gault, V.A.1
Irwin, N.2
Green, B.D.3
-
61
-
-
33747188115
-
Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide
-
Irwin, N., G.C. Clarke, B.D. Green, et al 2006. Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide. Biochem. Pharmacol. 72: 719-728.
-
(2006)
Biochem. Pharmacol
, vol.72
, pp. 719-728
-
-
Irwin, N.1
Clarke, G.C.2
Green, B.D.3
-
62
-
-
0018474455
-
Mild chronic watery diarrhea-hypokalemia syndrome associated with pancreatic islet cell hyperplasia. Elevated plasma and tissue levels of gastric inhibitory polypeptide and successful management with nicotinic acid
-
Kidd, G.S., Donowitz, M., O'Dorisio, T., et al 1979. Mild chronic watery diarrhea-hypokalemia syndrome associated with pancreatic islet cell hyperplasia. Elevated plasma and tissue levels of gastric inhibitory polypeptide and successful management with nicotinic acid. Am. J. Med. 66: 883-888.
-
(1979)
Am. J. Med.
, vol.66
, pp. 883-888
-
-
Kidd, G.S.1
Donowitz, M.2
O'Dorisio, T.3
-
63
-
-
0141785429
-
Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase
-
Ehses, J.A., V.R. Casilla, T. Doty, et al 2003. Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase. Endocrinology 144: 4433-4445.
-
(2003)
Endocrinology
, vol.144
, pp. 4433-4445
-
-
Ehses, J.A.1
Casilla, V.R.2
Doty, T.3
-
64
-
-
0036687655
-
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells
-
Trumper, A., K. Trumper & D. Horsch 2002. Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells. J. Endocrinol. 174: 233-246.
-
(2002)
J. Endocrinol
, vol.174
, pp. 233-246
-
-
Trumper, A.1
Trumper, K.2
Horsch, D.3
-
65
-
-
0034838323
-
Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling
-
Trumper, A., K. Trumper, H. Trusheim, et al 2001. Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling. Mol. Endocrinol. 15: 1559-1570.
-
(2001)
Mol. Endocrinol
, vol.15
, pp. 1559-1570
-
-
Trumper, A.1
Trumper, K.2
Trusheim, H.3
-
66
-
-
0037020242
-
Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway
-
Ehses, J.A., S.L. Pelech, R.A. Pederson & C.H. McIntosh 2002. Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. J. Biol. Chem. 277: 37088-37097.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 37088-37097
-
-
Ehses, J.A.1
Pelech, S.L.2
Pederson, R.A.3
McIntosh, C.H.4
-
67
-
-
27644596079
-
Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats
-
Kuntz, E., M. Pinget & P. Damge 2004. Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats. JOP 5: 464-475.
-
(2004)
JOP
, vol.5
, pp. 464-475
-
-
Kuntz, E.1
Pinget, M.2
Damge, P.3
-
68
-
-
36148950565
-
Measurement of pancreatic islet cell proliferation by heavy water labeling
-
Chen, S., S. Turner, E. Tsang, et al 2007. Measurement of pancreatic islet cell proliferation by heavy water labeling. Am. J. Physiol. Endocrinol. Metab. 293: E1459-E1464.
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.293
-
-
Chen, S.1
Turner, S.2
Tsang, E.3
-
69
-
-
0032714403
-
Pathoetiology and prevention of NIDDM lessons from the OLETF rat
-
Shima, K., M. Zhu & A. Mizuno 1999. Pathoetiology and prevention of NIDDM lessons from the OLETF rat. J. Med. Invest. 46: 121-129.
-
(1999)
J. Med. Invest
, vol.46
, pp. 121-129
-
-
Shima, K.1
Zhu, M.2
Mizuno, A.3
-
70
-
-
0025974318
-
Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: implications for pregnancy
-
Brelje, T.C. & R.L. Sorenson 1991. Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: implications for pregnancy. Endocrinology 128: 45-57.
-
(1991)
Endocrinology
, vol.128
, pp. 45-57
-
-
Brelje, T.C.1
Sorenson, R.L.2
-
71
-
-
75149158507
-
Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note
-
Lavine, J.A., P.W. Raess, D.B. Davis, et al 2010. Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note. Mol. Endocrinol. 24: 464-467.
-
(2010)
Mol. Endocrinol
, vol.24
, pp. 464-467
-
-
Lavine, J.A.1
Raess, P.W.2
Davis, D.B.3
-
72
-
-
0023550314
-
Proglumide, a cholecystokinin receptor antagonist, exacerbates alloxan-induced diabetes mellitus in Swiss mice
-
Parmar, N.S., M. Tariq & A.M. Ageel 1987. Proglumide, a cholecystokinin receptor antagonist, exacerbates alloxan-induced diabetes mellitus in Swiss mice. J. Pharm. Pharmacol. 39: 1028-1030.
-
(1987)
J. Pharm. Pharmacol
, vol.39
, pp. 1028-1030
-
-
Parmar, N.S.1
Tariq, M.2
Ageel, A.M.3
-
73
-
-
33749428116
-
Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans
-
Meier, J.J., A.E. Butler, R. Galasso, et al 2006. Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans. Diabetologia. 49: 2689-2696.
-
(2006)
Diabetologia
, vol.49
, pp. 2689-2696
-
-
Meier, J.J.1
Butler, A.E.2
Galasso, R.3
-
74
-
-
34848887156
-
Recovery from diabetes in mice by beta cell regeneration
-
Nir, T., D.A. Melton & Y. Dor 2007. Recovery from diabetes in mice by beta cell regeneration. J. Clin. Invest. 117: 2553-2561.
-
(2007)
J. Clin. Invest
, vol.117
, pp. 2553-2561
-
-
Nir, T.1
Melton, D.A.2
Dor, Y.3
-
75
-
-
58149378342
-
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
-
Inada, A., C. Nienaber, H. Katsuta, et al 2008. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc. Natl. Acad. Sci. USA 105: 19915-19919.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19915-19919
-
-
Inada, A.1
Nienaber, C.2
Katsuta, H.3
-
76
-
-
71649092364
-
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth
-
Solar, M., C. Cardalda, I. Houbracken, et al 2009. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev. Cell. 17: 849-860.
-
(2009)
Dev. Cell
, vol.17
, pp. 849-860
-
-
Solar, M.1
Cardalda, C.2
Houbracken, I.3
-
77
-
-
77951611220
-
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
-
Thorel, F., V. Nepote, I. Avril, et al 2010. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464: 1149-1154.
-
(2010)
Nature
, vol.464
, pp. 1149-1154
-
-
Thorel, F.1
Nepote, V.2
Avril, I.3
-
78
-
-
0035405821
-
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
-
Tourrel, C., D. Bailbe, M.J. Meile, et al 2001. Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 50: 1562-1570.
-
(2001)
Diabetes
, vol.50
, pp. 1562-1570
-
-
Tourrel, C.1
Bailbe, D.2
Meile, M.J.3
-
79
-
-
58149357117
-
Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice
-
Suarez-Pinzon, W.L., R.F. Power, Y. Yan, et al 2008. Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice. Diabetes 57: 3281-3288.
-
(2008)
Diabetes
, vol.57
, pp. 3281-3288
-
-
Suarez-Pinzon, W.L.1
Power, R.F.2
Yan, Y.3
-
80
-
-
70349213581
-
Reversal of diabetes in rats using GLP-1-expressing adult pancreatic duct-like precursor cells transformed from acinar to ductal cells
-
Lee, J., J. Wen, J.Y. Park, et al 2009. Reversal of diabetes in rats using GLP-1-expressing adult pancreatic duct-like precursor cells transformed from acinar to ductal cells. Stem Cells Dev. 18: 991-1002.
-
(2009)
Stem Cells Dev
, vol.18
, pp. 991-1002
-
-
Lee, J.1
Wen, J.2
Park, J.Y.3
-
81
-
-
53749089728
-
Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice
-
Suarez-Pinzon, W.L., J.R. Lakey & A. Rabinovitch 2008. Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice. Cell Transplant. 17: 631-640.
-
(2008)
Cell Transplant
, vol.17
, pp. 631-640
-
-
Suarez-Pinzon, W.L.1
Lakey, J.R.2
Rabinovitch, A.3
-
82
-
-
0036918960
-
Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1
-
Bulotta, A., H. Hui, E. Anastasi, et al 2002. Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. J. Mol. Endocrinol. 29: 347-360.
-
(2002)
J. Mol. Endocrinol
, vol.29
, pp. 347-360
-
-
Bulotta, A.1
Hui, H.2
Anastasi, E.3
-
83
-
-
0035084164
-
Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells
-
Hui, H., C. Wright & R. Perfetti 2001. Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 50: 785-796.
-
(2001)
Diabetes
, vol.50
, pp. 785-796
-
-
Hui, H.1
Wright, C.2
Perfetti, R.3
-
84
-
-
58849146524
-
The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells
-
Mao, G.H., G.A. Chen, H.Y. Bai, et al 2009. The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials 30: 1706-1714.
-
(2009)
Biomaterials
, vol.30
, pp. 1706-1714
-
-
Mao, G.H.1
Chen, G.A.2
Bai, H.Y.3
-
85
-
-
33750964909
-
Glucagon-like peptide-1 differentiation of primate embryonic stem cells into insulin-producing cells
-
Yue, F., L. Cui, K. Johkura, et al 2006. Glucagon-like peptide-1 differentiation of primate embryonic stem cells into insulin-producing cells. Tissue Eng. 12: 2105-2116.
-
(2006)
Tissue Eng
, vol.12
, pp. 2105-2116
-
-
Yue, F.1
Cui, L.2
Johkura, K.3
-
86
-
-
9944251348
-
Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development
-
Herbach, N., B. Goeke, M. Schneider, et al 2005. Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development. Regul. Pept. 125: 103-117.
-
(2005)
Regul. Pept
, vol.125
, pp. 103-117
-
-
Herbach, N.1
Goeke, B.2
Schneider, M.3
-
87
-
-
40749088079
-
Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP
-
McClean, P.L., V.A. Gault, N. Irwin, et al 2008. Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP. Diabetes Obes. Metab. 10: 336-342.
-
(2008)
Diabetes Obes. Metab
, vol.10
, pp. 336-342
-
-
McClean, P.L.1
Gault, V.A.2
Irwin, N.3
-
88
-
-
33746192085
-
A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones
-
Marenah, L., J.T. McCluskey, Y.H. Abdel-Wahab, et al 2006. A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones. Biol. Chem. 387: 941-947.
-
(2006)
Biol. Chem
, vol.387
, pp. 941-947
-
-
Marenah, L.1
McCluskey, J.T.2
Abdel-Wahab, Y.H.3
-
89
-
-
0027194337
-
Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells
-
Wang, T.C., S. Bonner-Weir, P.S. Oates, et al 1993. Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J. Clin. Invest. 92: 1349-1356.
-
(1993)
J. Clin. Invest
, vol.92
, pp. 1349-1356
-
-
Wang, T.C.1
Bonner-Weir, S.2
Oates, P.S.3
-
90
-
-
38349022253
-
Reg genes are CCK2 receptor targets in ElasCCK2 mice pancreas
-
Gigoux, V., P. Clerc, D. Sanchez, et al 2008. Reg genes are CCK2 receptor targets in ElasCCK2 mice pancreas. Regul. Pept. 146: 88-98.
-
(2008)
Regul. Pept
, vol.146
, pp. 88-98
-
-
Gigoux, V.1
Clerc, P.2
Sanchez, D.3
-
91
-
-
0036310118
-
Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue
-
Rooman, I., J. Lardon & L. Bouwens 2002. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 51: 686-690.
-
(2002)
Diabetes
, vol.51
, pp. 686-690
-
-
Rooman, I.1
Lardon, J.2
Bouwens, L.3
-
92
-
-
1542284736
-
Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan
-
Rooman, I. & L. Bouwens 2004. Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan. Diabetologia 47: 259-265.
-
(2004)
Diabetologia
, vol.47
, pp. 259-265
-
-
Rooman, I.1
Bouwens, L.2
-
93
-
-
0036968693
-
Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin
-
Brand, S.J., S. Tagerud, P. Lambert, et al 2002. Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin. Pharmacol. Toxicol. 91: 414-420.
-
(2002)
Pharmacol. Toxicol
, vol.91
, pp. 414-420
-
-
Brand, S.J.1
Tagerud, S.2
Lambert, P.3
-
94
-
-
21244441973
-
Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass
-
Suarez-Pinzon, W.L., J.R. Lakey, S.J. Brand & A. Rabinovitch 2005. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass. J. Clin. Endocrinol. Metab. 90: 3401-3409.
-
(2005)
J. Clin. Endocrinol. Metab
, vol.90
, pp. 3401-3409
-
-
Suarez-Pinzon, W.L.1
Lakey, J.R.2
Brand, S.J.3
Rabinovitch, A.4
-
95
-
-
0036721411
-
Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin
-
Hardikar, A.A., X.Y. Wang, L.J. Williams, et al 2002. Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin. Endocrinology 143: 3505-3514.
-
(2002)
Endocrinology
, vol.143
, pp. 3505-3514
-
-
Hardikar, A.A.1
Wang, X.Y.2
Williams, L.J.3
-
96
-
-
0037414781
-
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
-
Li, Y., T. Hansotia, B. Yusta, et al 2003. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J. Biol. Chem. 278: 471-478.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 471-478
-
-
Li, Y.1
Hansotia, T.2
Yusta, B.3
-
97
-
-
70649094346
-
Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice
-
Maida, A., T. Hansotia, C. Longuet, et al 2009. Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice. Gastroenterology 137: 2146-2157.
-
(2009)
Gastroenterology
, vol.137
, pp. 2146-2157
-
-
Maida, A.1
Hansotia, T.2
Longuet, C.3
-
98
-
-
33750448469
-
GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
-
Yusta, B., L.L. Baggio, J.L. Estall, et al 2006. GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab. 4: 391-406.
-
(2006)
Cell Metab
, vol.4
, pp. 391-406
-
-
Yusta, B.1
Baggio, L.L.2
Estall, J.L.3
-
99
-
-
15844389890
-
Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue
-
Uckaya, G., P. Delagrange, A. Chavanieu, et al 2005. Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue. J. Endocrinol. 184: 505-513.
-
(2005)
J. Endocrinol
, vol.184
, pp. 505-513
-
-
Uckaya, G.1
Delagrange, P.2
Chavanieu, A.3
-
100
-
-
70349190405
-
Glucagon-like peptide-1 functionalized PEG hydrogels promote survival and function of encapsulated pancreatic beta-cells
-
Lin, C.C. & K.S. Anseth 2009. Glucagon-like peptide-1 functionalized PEG hydrogels promote survival and function of encapsulated pancreatic beta-cells. Biomacromolecules 10: 2460-2467.
-
(2009)
Biomacromolecules
, vol.10
, pp. 2460-2467
-
-
Lin, C.C.1
Anseth, K.S.2
-
101
-
-
50449094466
-
Liraglutide, a long-acting human glucagon-like peptide 1 analog, improves glucose homeostasis in marginal mass islet transplantation in mice
-
Merani, S., W. Truong, J.A. Emamaullee, et al 2008. Liraglutide, a long-acting human glucagon-like peptide 1 analog, improves glucose homeostasis in marginal mass islet transplantation in mice. Endocrinology 149: 4322-4328.
-
(2008)
Endocrinology
, vol.149
, pp. 4322-4328
-
-
Merani, S.1
Truong, W.2
Emamaullee, J.A.3
-
102
-
-
38649087041
-
GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis
-
Toyoda, K., T. Okitsu, S. Yamane, et al 2008. GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis. Biochem. Biophys. Res. Commun. 367: 793-798.
-
(2008)
Biochem. Biophys. Res. Commun
, vol.367
, pp. 793-798
-
-
Toyoda, K.1
Okitsu, T.2
Yamane, S.3
-
103
-
-
58849144338
-
Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept
-
Faradji, R.N., T. Tharavanij, S. Messinger, et al 2008. Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept. Transplantation 86: 1658-1665.
-
(2008)
Transplantation
, vol.86
, pp. 1658-1665
-
-
Faradji, R.N.1
Tharavanij, T.2
Messinger, S.3
-
104
-
-
49849105507
-
The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects
-
Froud, T., R.N. Faradji, A. Pileggi, et al 2008. The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. Transplantation 86: 36-45.
-
(2008)
Transplantation
, vol.86
, pp. 36-45
-
-
Froud, T.1
Faradji, R.N.2
Pileggi, A.3
-
105
-
-
44449092051
-
Islet transplantation for brittle type 1 diabetes: the UIC protocol
-
Gangemi, A., P. Salehi, B. Hatipoglu, et al 2008. Islet transplantation for brittle type 1 diabetes: the UIC protocol. Am. J. Transplant. 8: 1250-1261.
-
(2008)
Am. J. Transplant
, vol.8
, pp. 1250-1261
-
-
Gangemi, A.1
Salehi, P.2
Hatipoglu, B.3
-
106
-
-
68049136013
-
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop
-
Cornu, M., J.Y. Yang, E. Jaccard, et al 2009. Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop. Diabetes 58: 1816-1825.
-
(2009)
Diabetes
, vol.58
, pp. 1816-1825
-
-
Cornu, M.1
Yang, J.Y.2
Jaccard, E.3
-
107
-
-
33748603481
-
Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)
-
Wideman, R.D., I.L. Yu, T.D. Webber, et al 2006. Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proc. Natl Acad. Sci. USA 103: 13468-13473.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 13468-13473
-
-
Wideman, R.D.1
Yu, I.L.2
Webber, T.D.3
-
108
-
-
15744381238
-
The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro
-
Bregenholt, S., A. Moldrup, N. Blume, et al 2005. The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro. Biochem. Biophys. Res. Commun. 330: 577-584.
-
(2005)
Biochem. Biophys. Res. Commun
, vol.330
, pp. 577-584
-
-
Bregenholt, S.1
Moldrup, A.2
Blume, N.3
-
109
-
-
34447128330
-
Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets
-
Sarkar, S.A., J. Gunter, R. Bouchard, et al 2007. Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia 50: 1649-1659.
-
(2007)
Diabetologia
, vol.50
, pp. 1649-1659
-
-
Sarkar, S.A.1
Gunter, J.2
Bouchard, R.3
-
110
-
-
48449104756
-
Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway
-
Ferdaoussi, M., S. Abdelli, J.Y. Yang, et al 2008. Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes 57: 1205-1215.
-
(2008)
Diabetes
, vol.57
, pp. 1205-1215
-
-
Ferdaoussi, M.1
Abdelli, S.2
Yang, J.Y.3
-
111
-
-
0034596017
-
IB1 reduces cytokine-induced apoptosis of insulin-secreting cells
-
Bonny, C., A. Oberson, M. Steinmann, et al 2000. IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. J. Biol. Chem. 275: 16466-16472.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 16466-16472
-
-
Bonny, C.1
Oberson, A.2
Steinmann, M.3
-
112
-
-
0034104298
-
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
-
Waeber, G., J. Delplanque, C. Bonny, et al 2000. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat. Genet. 24: 291-295.
-
(2000)
Nat. Genet
, vol.24
, pp. 291-295
-
-
Waeber, G.1
Delplanque, J.2
Bonny, C.3
-
113
-
-
0038068111
-
The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells
-
Haefliger, J.A., T. Tawadros, L. Meylan, et al 2003. The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells. J. Cell Sci. 116: 1463-1469.
-
(2003)
J. Cell Sci
, vol.116
, pp. 1463-1469
-
-
Haefliger, J.A.1
Tawadros, T.2
Meylan, L.3
-
114
-
-
37649025080
-
Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes
-
Xie, T., M. Chen, Q.H. Zhang, et al 2007. Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes. Proc. Natl Acad. Sci. USA 104: 19601-19606.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19601-19606
-
-
Xie, T.1
Chen, M.2
Zhang, Q.H.3
-
115
-
-
23944479411
-
Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B
-
Li, L., W. El-Kholy, C.J. Rhodes & P.L. Brubaker 2005. Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia 48: 1339-1349.
-
(2005)
Diabetologia
, vol.48
, pp. 1339-1349
-
-
Li, L.1
El-Kholy, W.2
Rhodes, C.J.3
Brubaker, P.L.4
-
116
-
-
77951246517
-
Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression
-
Cornu, M., H. Modi, D. Kawamori, et al 2010. Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression. J. Biol. Chem. 285: 10538-10545.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 10538-10545
-
-
Cornu, M.1
Modi, H.2
Kawamori, D.3
-
117
-
-
34247340606
-
Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies
-
Tsunekawa, S., N. Yamamoto, K. Tsukamoto, et al 2007. Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies. J. Endocrinol. 193: 65-74.
-
(2007)
J. Endocrinol
, vol.193
, pp. 65-74
-
-
Tsunekawa, S.1
Yamamoto, N.2
Tsukamoto, K.3
-
118
-
-
2942568445
-
Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
-
Buteau, J., W. El-Assaad, C.J. Rhodes, et al 2004. Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 47: 806-815.
-
(2004)
Diabetologia
, vol.47
, pp. 806-815
-
-
Buteau, J.1
El-Assaad, W.2
Rhodes, C.J.3
-
119
-
-
67449102908
-
Noncanonical activation of Akt/protein kinase B in {beta}-cells by the incretin hormone glucose-dependent insulinotropic polypeptide
-
Widenmaier, S.B., A.V. Sampaio, T.M. Underhill & C.H. McIntosh 2009. Noncanonical activation of Akt/protein kinase B in {beta}-cells by the incretin hormone glucose-dependent insulinotropic polypeptide. J. Biol. Chem. 284: 10764-10773.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 10764-10773
-
-
Widenmaier, S.B.1
Sampaio, A.V.2
Underhill, T.M.3
McIntosh, C.H.4
-
120
-
-
0037386156
-
Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway
-
Hui, H., A. Nourparvar, X. Zhao & R. Perfetti 2003. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 144: 1444-1455.
-
(2003)
Endocrinology
, vol.144
, pp. 1444-1455
-
-
Hui, H.1
Nourparvar, A.2
Zhao, X.3
Perfetti, R.4
-
121
-
-
77949693550
-
A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control
-
Widenmaier, S.B., Kim, S.J., Yang, G.K., et al 2010. A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control. PLoS One 5: e9590.
-
(2010)
PLoS One
, vol.5
-
-
Widenmaier, S.B.1
Kim, S.J.2
Yang, G.K.3
-
122
-
-
20444491588
-
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression
-
Kim, S.J., K. Winter, C. Nian, et al 2005. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. J. Biol. Chem. 280: 22297-22307.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 22297-22307
-
-
Kim, S.J.1
Winter, K.2
Nian, C.3
-
123
-
-
40749157994
-
Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2
-
Kim, S.J., C. Nian, S. Widenmaier & C.H. McIntosh 2008. Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2. Mol. Cell Biol. 28: 1644-1656.
-
(2008)
Mol. Cell Biol
, vol.28
, pp. 1644-1656
-
-
Kim, S.J.1
Nian, C.2
Widenmaier, S.3
McIntosh, C.H.4
-
124
-
-
71049146229
-
Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide
-
Widenmaier, S.B., Z. Ao, S.J. Kim, et al 2009. Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide. J. Biol. Chem. 284: 30372-30382.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 30372-30382
-
-
Widenmaier, S.B.1
Ao, Z.2
Kim, S.J.3
-
125
-
-
33845865582
-
Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase
-
Huang, Q., S. Bu, Y. Yu, et al 2007. Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase. Endocrinology 148: 81-91.
-
(2007)
Endocrinology
, vol.148
, pp. 81-91
-
-
Huang, Q.1
Bu, S.2
Yu, Y.3
-
126
-
-
42949144937
-
Increased beta-cell apoptosis and impaired insulin signaling pathway contributes to the onset of diabetes in OLETF rats
-
Zhao, J., N. Zhang, M. He, et al 2008. Increased beta-cell apoptosis and impaired insulin signaling pathway contributes to the onset of diabetes in OLETF rats. Cell Physiol. Biochem. 21: 445-454.
-
(2008)
Cell Physiol. Biochem
, vol.21
, pp. 445-454
-
-
Zhao, J.1
Zhang, N.2
He, M.3
-
127
-
-
77954896463
-
Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival
-
Lavine, J.A., P.W. Raess, D.S. Stapleton, et al 2010. Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival. Endocrinology 151: 3577-3588.
-
(2010)
Endocrinology
, vol.151
, pp. 3577-3588
-
-
Lavine, J.A.1
Raess, P.W.2
Stapleton, D.S.3
|