Reg genes are CCK2 receptor targets in ElasCCK2 mice pancreas

Regulatory Peptides

Volumn 146, Issue 1-3, 2008, Pages 88-98

  Gigoux, V ^a   Clerc, P ^a   Sanchez, D ^a   Coll, M G ^a   Corominola, H ^b   Leung Theung Long, S ^a   Penicaud L ^c   Gomis, R ^b   Seva, C ^a   Fourmy, D ^a   Dufresne, M ^a  

^a INSERM   (France)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c CNRS   (France)

Author keywords

CCK2 receptor; Gastrin; Neogenesis; Pancreatic cancer; Reg

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; GASTRIN RECEPTOR; PROTEIN; PROTEIN REG I; PROTEIN REG II; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DIVISION; CONTROLLED STUDY; GENE EXPRESSION; GENE IDENTIFICATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; IMMUNOHISTOCHEMISTRY; INSULIN; MICE; MICE, TRANSGENIC; ORGAN SIZE; PANCREAS; PROTEIN ARRAY ANALYSIS; PROTEINS; RECEPTOR, CHOLECYSTOKININ B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

MUS;

EID: 38349022253     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2007.08.020     Document Type: Article

References (71)

1. Terazono K., Yamamoto H., Takasawa S., Shiga K., Yonemura Y., Tochino Y., and Okamoto H. A novel gene activated in regenerating islets. J Biol Chem 263 5 (1988) 2111-2114
2. Watanabe T., Yonekura H., Terazono K., Yamamoto H., and Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem 265 13 (1990) 7432-7439
3. Simon M.T., Pauloin A., Normand G., Lieu H.T., Mouly H., Pivert G., Carnot F., Tralhao J.G., Brechot C., and Christa L. HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway. Faseb J 17 11 (2003) 1441-1450
4. Kinoshita Y., Ishihara S., Kadowaki Y., Fukui H., and Chiba T. Reg protein is a unique growth factor of gastric mucosal cells. J Gastroenterol 39 6 (2004) 507-513
5. Bimmler D., Schiesser M., Perren A., Scheele G., Angst E., Meili S., Ammann R., and Graf R. Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis. J Surg Res 118 2 (2004) 122-135
6. Honda H., Nakamura H., and Otsuki M. The elongated PAP II/Reg III mRNA is upregulated in rat pancreas during acute experimental pancreatitis. Pancreas 25 2 (2002) 192-197
7. Lawrance I.C., Fiocchi C., and Chakravarti S. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet 10 5 (2001) 445-456
8. Ogawa H., Fukushima K., Naito H., Funayama Y., Unno M., Takahashi K., Kitayama T., Matsuno S., Ohtani H., Takasawa S., Okamoto H., and Sasaki I. Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model. Inflamm Bowel Dis 9 3 (2003) 162-170
9. Oue N., Mitani Y., Aung P.P., Sakakura C., Takeshima Y., Kaneko M., Noguchi T., Nakayama H., and Yasui W. Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J Pathol 207 2 (2005) 185-198
10. Dhar D.K., Udagawa J., Ishihara S., Otani H., Kinoshita Y., Takasawa S., Okamoto H., Kubota H., Fujii T., Tachibana M., and Nagasue N. Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival. Cancer 100 6 (2004) 1130-1136
11. Violette S., Festor E., Pandrea-Vasile I., Mitchell V., Adida C., Dussaulx E., Lacorte J.M., Chambaz J., Lacasa M., and Lesuffleur T. Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. Int J Cancer 103 2 (2003) 185-193
12. Sekikawa A., Fukui H., Fujii S., Nanakin A., Kanda N., Uenoyama Y., Sawabu T., Hisatsune H., Kusaka T., Ueno S., Nakase H., Seno H., Fujimori T., and Chiba T. Possible role of REG Ialpha protein in ulcerative colitis and colitic cancer. Gut 54 10 (2005) 1437-1444
13. Rechreche H., Montalto G., Mallo G.V., Vasseur S., Marasa L., Soubeyran P., Dagorn J.C., and Iovanna J.L. pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis. Int J Cancer 81 5 (1999) 688-694
14. Lasserre C., Christa L., Simon M.T., Vernier P., and Brechot C. A novel gene (HIP) activated in human primary liver cancer. Cancer Res 52 18 (1992) 5089-5095
15. Harada K., Zen Y., Kanemori Y., Chen T.C., Chen M.F., Yeh T.S., Jan Y.Y., Masuda S., Nimura Y., Takasawa S., Okamoto H., and Nakanuma Y. Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions. Hepatology 33 5 (2001) 1036-1042
16. Kimura N., Yonekura H., Okamoto H., and Nagura H. Expression of human regenerating gene mRNA and its product in normal and neoplastic human pancreas. Cancer 70 7 (1992) 1857-1863
17. Rosty C., Christa L., Kuzdzal S., Baldwin W.M., Zahurak M.L., Carnot F., Chan D.W., Canto M., Lillemoe K.D., Cameron J.L., Yeo C.J., Hruban R.H., and Goggins M. Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res 62 6 (2002) 1868-1875
18. Reubi J.C., and Waser B. Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting. Eur J Nucl Med Mol Imaging 30 5 (2003) 781-793
19. Harris J.C., Clarke P.A., Awan A., Jankowski J., and Watson S.A. An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus. Cancer Res 64 6 (2004) 1915-1919
20. Zhou J.J., Chen M.L., Zhang Q.Z., Hu J.K., and Wang W.L. Coexpression of cholecystokinin-B/gastrin receptor and gastrin gene in human gastric tissues and gastric cancer cell line. World J Gastroenterol 10 6 (2004) 791-794
21. Caplin M., Savage K., Khan K., Brett B., Rode J., Varro A., and Dhillon A. Expression and processing of gastrin in pancreatic adenocarcinoma. Br J Surg 87 8 (2000) 1035-1040
22. Goetze J.P., Nielsen F.C., Burcharth F., and Rehfeld J.F. Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma. Cancer 88 11 (2000) 2487-2494
23. Saillan-Barreau C., Clerc P., Adato M., Escrieut C., Vaysse N., Fourmy D., and Dufresne M. Transgenic CCK-B/gastrin receptor mediates murine exocrine pancreatic secretion. Gastroenterology 115 4 (1998) 988-996
24. Clerc P., Leung-Theung-Long S., Wang T.C., Dockray G.J., Bouisson M., Delisle M.B., Vaysse N., Pradayrol L., Fourmy D., and Dufresne M. Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells, and neoplasia. Gastroenterology 122 2 (2002) 428-437
25. Clerc P., Saillan-Barreau C., Desbois C., Pradayrol L., Fourmy D., and Dufresne M. Transgenic mice expressing cholecystokinin 2 receptors in the pancreas. Pharmacol Toxicol 91 6 (2002) 321-326
26. Bierkamp C., Bonhoure S., Mathieu A., Clerc P., Fourmy D., Pradayrol L., Seva C., and Dufresne M. Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo. Am J Pathol 165 6 (2004) 2135-2145
27. Mathieu A., Clerc P., Portolan G., Bierkamp C., Lulka H., Pradayrol L., Seva C., Fourmy D., and Dufresne M. Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation. Int J Cancer 115 1 (2005) 46-54
28. Higham A.D., Bishop L.A., Dimaline R., Blackmore C.G., Dobbins A.C., Varro A., Thompson D.G., and Dockray G.J. Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia. Gastroenterology 116 6 (1999) 1310-1318
29. Ashcroft F.J., Varro A., Dimaline R., and Dockray G.J. Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochem J 381 Pt 2 (2004) 397-403
30. Scopsi L., Wang B.L., and Larsson L.I. Nonspecific immunocytochemical reactions with certain neurohormonal peptides and basic peptide sequences. J Histochem Cytochem 34 11 (1986) 1469-1475
31. Gigoux V., L'Hoste S., Raynaud F., Camonis J., and Garbay C. Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins. J Biol Chem 277 26 (2002) 23742-23746
32. Chirgwin J.M., Przybyla A.E., MacDonald R.J., and Rutter W.J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18 24 (1979) 5294-5299
33. Clerc P., Dufresne M., Saillan C., Chastre E., Andre T., Escrieut C., Kennedy K., Vaysse N., Gespach C., and Fourmy D. Differential expression of the CCK-A and CCK-B/gastrin receptor genes in human cancers of the esophagus, stomach and colon. Int J Cancer 72 6 (1997) 931-936
34. Bouwens L. Rooman I. Regulation of pancreatic beta-cell mass. Physiol Rev 85 4 (2005) 1255-1270
35. Saillan-Barreau C., Dufresne M., Clerc P., Sanchez D., Corominola H., Moriscot C., Guy-Crotte O., Escrieut C., Vaysse N., Gomis R., Tarasova N., and Fourmy D. Evidence for a functional role of the cholecystokinin-B/gastrin receptor in the human fetal and adult pancreas. Diabetes 48 10 (1999) 2015-2021
36. Leung-Theung-Long S., Roulet E., Clerc P., Escrieut C., Marchal-Victorion S., Ritz-Laser B., Philippe J., Pradayrol L., Seva C., Fourmy D., and Dufresne M. Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells. J Biol Chem 280 9 (2005) 7976-7984
37. Xie M.J., Motoo Y., Iovanna J.L., Su S.B., Ohtsubo K., Matsubara F., and Sawabu N. Overexpression of pancreatitis-associated protein (PAP) in human pancreatic ductal adenocarcinoma. Dig Dis Sci 48 3 (2003) 459-464
38. Fukushima N., Koopmann J., Sato N., Prasad N., Carvalho R., Leach S.D., Hruban R.H., and Goggins M. Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma. Mod Pathol 18 6 (2005) 779-787
39. Means A.L., Meszoely I.M., Suzuki K., Miyamoto Y., Rustgi A.K., Coffey Jr. R.J., Wright C.V., Stoffers D.A., and Leach S.D. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development 132 16 (2005) 3767-3776
40. Bockman D.E., Boydston W.R., and Parsa I. Architecture of human pancreas: implications for early changes in pancreatic disease. Gastroenterology 85 1 (1983) 55-61
41. Parsa I., Longnecker D.S., Scarpelli D.G., Pour P., Reddy J.K., and Lefkowitz M. Ductal metaplasia of human exocrine pancreas and its association with carcinoma. Cancer Res 45 3 (1985) 1285-1290
42. Zhu L., Shi G., Schmidt C.M., Hruban R.H., and Konieczny S.F. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 171 1 (2007) 263-273
43. Miyamoto Y., Maitra A., Ghosh B., Zechner U., Argani P., Iacobuzio-Donahue C.A., Sriuranpong V., Iso T., Meszoely I.M., Wolfe M.S., Hruban R.H., Ball D.W., Schmid R.M., and Leach S.D. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3 6 (2003) 565-576
44. Guerra C., Schuhmacher A.J., Canamero M., Grippo P.J., Verdaguer L., Perez-Gallego L., Dubus P., Sandgren E.P., and Barbacid M. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11 3 (2007) 291-302
45. Sanchez D., Gmyr V., Kerr-Conte J., Kloppel G., Zenilman M.E., Guy-Crotte O., Pattou F., and Figarella C. Implication of Reg I in human pancreatic duct-like cells in vivo in the pathological pancreas and in vitro during exocrine dedifferentiation. Pancreas 29 1 (2004) 14-21
46. Zhang Y.W., Ding L.S., and Lai M.D. Reg gene family and human diseases. World J Gastroenterol 9 12 (2003) 2635-2641
47. Del Zotto H., Massa L., Rafaeloff R., Pittenger G.L., Vinik A., Gold G., Reifel-Miller A., and Gagliardino J.J. Possible relationship between changes in islet neogenesis and islet neogenesis-associated protein-positive cell mass induced by sucrose administration to normal hamsters. J Endocrinol 165 3 (2000) 725-733
48. Hervieu V., Christa L., Gouysse G., Bouvier R., Chayvialle J.A., Brechot C., and Scoazec J.Y. HIP/PAP, a member of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors. Hum Pathol 37 8 (2006) 1066-1075
49. Gagliardino J.J., Del Zotto H., Massa L., Flores L.E., and Borelli M.I. Pancreatic duodenal homeobox-1 and islet neogenesis-associated protein: a possible combined marker of activateable pancreatic cell precursors. J Endocrinol 177 2 (2003) 249-259
50. Lu Y., Ponton A., Okamoto H., Takasawa S., Herrera P.L., and Liu J.L. Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas. Am J Physiol Endocrinol Metab 291 1 (2006) E50-E58
51. De Leon D.D., Farzad C., Crutchlow M.F., Brestelli J., Tobias J., Kaestner K.H., and Stoffers D.A. Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment. Physiol Genomics 24 2 (2006) 133-143
52. Holland A.M., Gonez L.J., Naselli G., Macdonald R.J., and Harrison L.C. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes 54 9 (2005) 2586-2595
53. Bonner-Weir S., and Sharma A. Pancreatic stem cells. J Pathol 197 4 (2002) 519-526
54. Dor Y., Brown J., Martinez O.I., and Melton D.A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429 6987 (2004) 41-46
55. Frazier M.L. Gene expression in pancreatic adenocarcinoma. Ann N Y Acad Sci 880 (1999) 1-4
56. Song S.Y., Gannon M., Washington M.K., Scoggins C.R., Meszoely I.M., Goldenring J.R., Marino C.R., Sandgren E.P., Coffey Jr. R.J., Wright C.V., and Leach S.D. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology 117 6 (1999) 1416-1426
57. Bardeesy N., and DePinho R.A. Pancreatic cancer biology and genetics. Nat Rev Cancer 2 12 (2002) 897-909
58. Pour P.M., and Schmied B. The link between exocrine pancreatic cancer and the endocrine pancreas. Int J Pancreatol 25 2 (1999) 77-87
59. Borelli M.I., Stoppiglia L.F., Rezende L.F., Flores L.E., Del Zotto H., Boschero A.C., and Gagliardino J.J. INGAP-related pentadecapeptide: its modulatory effect upon insulin secretion. Regul Pept 131 1-3 (2005) 97-102
60. Vasavada R.C., Garcia-Ocana A., Zawalich W.S., Sorenson R.L., Dann P., Syed M., Ogren L., Talamantes F., and Stewart A.F. Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. J Biol Chem 275 20 (2000) 15399-15406
61. Garcia-Ocana A., Vasavada R.C., Cebrian A., Reddy V., Takane K.K., Lopez-Talavera J.C., and Stewart A.F. Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes 50 12 (2001) 2752-2762
62. Melloul D., Marshak S., and Cerasi E. Regulation of insulin gene transcription. Diabetologia 45 3 (2002) 309-326
63. Leibiger I.B., Leibiger B., and Berggren P.O. Insulin feedback action on pancreatic beta-cell function. FEBS Lett 532 1-2 (2002) 1-6
64. Saito A., Williams J.A., and Kanno T. Potentiation of cholecystokinin-induced exocrine secretion by both exogenous and endogenous insulin in isolated and perfused rat pancreata. J Clin Invest 65 4 (1980) 777-782
65. Bruzzone R., Trimble E.R., Gjinovci A., and Renold A.E. Glucose-insulin interactions on exocrine secretion from the perfused rat pancreas. Gastroenterology 87 6 (1984) 1305-1312
66. Trimble E.R., Bruzzone R., Gjinovci A., and Renold A.E. Activity of the insulo-acinar axis in the isolated perfused rat pancreas. Endocrinology 117 3 (1985) 1246-1252
67. Trimble E.R., Bruzzone R., and Belin D. Insulin resistance is accompanied by impairment of amylase-gene expression in the exocrine pancreas of the obese Zucker rat. Biochem J 237 3 (1986) 807-812
68. Bavare C., Prabhu R., and Supe A. Early morphological and functional changes in pancreas following necrosectomy for acute severe necrotizing pancreatitis. Indian J Gastroenterol 23 6 (2004) 203-205
69. Bouwens L. Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas. Microsc Res Tech 43 4 (1998) 332-336
70. Basso D., Valerio A., Seraglia R., Mazza S., Piva M.G., Greco E., Fogar P., Gallo N., Pedrazzoli S., Tiengo A., and Plebani M. Putative pancreatic cancer-associated diabetogenic factor: 2030MW peptide. Pancreas 24 1 (2002) 8-14
71. Schneider M.B., Matsuzaki H., Haorah J., Ulrich A., Standop J., Ding X.Z., Adrian T.E., and Pour P.M. Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology 120 5 (2001) 1263-1270