Noncanonical activation of Akt/protein kinase B in β-cells by the incretin hormone glucose-dependent insulinotropic polypeptide

Journal of Biological Chemistry

Volumn 284, Issue 16, 2009, Pages 10764-10773

  Widenmaier, Scott B ^a   Sampaio, Arthur V ^a   Underhill, T Michael ^a   McIntosh, Christopher H S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY ASSAYS; AKT ACTIVATION; APOPTOTIC SIGNALING; CELL LINES; CELL MASS; CELL SURVIVAL; HUMAN HEALTH; INSULIN-LIKE GROWTH FACTOR-I; ISOLATED MOUSE; PANCREATIC ISLET; PHOSPHOINOSITIDE 3-KINASE; THERAPEUTIC TARGETS; TYPE 2 DIABETES MELLITUS;

ACTIVATION ANALYSIS; AMINES; CELL CULTURE; FETAL MONITORING; GLUCOSE; HORMONES; INDUSTRIAL LABORATORIES; PHOSPHORYLATION;

CHEMICAL ACTIVATION;

CYCLIC AMP; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; THREONINE; ADENYLATE CYCLASE; FORSKOLIN; GLUCOSE; INCRETIN; INSULIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; HORMONE ACTION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CYTOLOGY; GENETICS; HUMAN; METABOLISM; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENYLATE CYCLASE; ANIMALS; CELL LINE; ENZYME ACTIVATION; FORSKOLIN; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; HUMANS; INCRETINS; INSULIN; INSULIN-SECRETING CELLS; MICE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS;

EID: 67449102908     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809116200     Document Type: Article

References (57)

1. Salehi, M., Aulinger, B. A., and D'Alessio, D. A. (2008) Endocr. Rev. 29, 367-379
2. McIntosh, C. H. (2008) Front Biosci. 13, 1753-1773
3. Baggio, L. L., and Drucker, D. J. (2007) Gastroenterology 132, 2131-2157
4. Lingohr, M. K., Buettner, R., and Rhodes, C. J. (2002) Trends Mol. Med. 8, 375-384
5. Wang, Q., Li, L., Xu, E., Wong, V., Rhodes, C., and Brubaker, P. L. (2004) Diabetologia 47, 478-487
6. Liu, Z., and Habener, J. F. (2008) J. Biol. Chem. 283, 8723-8735
7. Kim, S. J., Winter, K., Nian, C., Tsuneoka, M., Koda, Y., and McIntosh, C. H. (2005) J. Biol. Chem. 280, 22297-22307
8. Trumper, A., Trumper, K., and Horsch, D. (2002) J. Endocrinol. 174, 233-246
9. Elghazi, L., Balcazar, N., and Bernal-Mizrachi, E. (2006) Int. J. Biochem. Cell Biol. 38, 157-163
10. Dickson, L. M., and Rhodes, C. J. (2004) Am. J. Physiol. 287, E192-E198
11. Rhodes, C. J. (2005) Science 307, 380-384
12. Hanada, M., Feng, J., and Hemmings, B. A. (2004) Biochim. Biophys. Acta 1697, 3-16
13. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
14. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R., Reese, C. B., McCormick, F., Tempst, P., Coadwell, J., and Hawkins, P. T. (1998) Science 279, 710-714
15. Manning, B. D., and Cantley, L. C. (2007) Cell 129, 1261-1274
16. Yang, J., Cron, P., Good, V. M., Thompson, V., Hemmings, B. A., and Barford, D. (2002) Nat. Struct. Biol. 9, 940-944
17. Yang, J., Cron, P., Thompson, V., Good, V. M., Hess, D., Hemmings, B. A., and Barford, D. (2002) Mol. Cell 9, 1227-1240
18. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
19. Park, S., Dong, X., Fisher, T. L., Dunn, S., Omer, A. K., Weir, G., and White, M. F. (2006) J. Biol. Chem. 281, 1159-1168
20. Buteau, J., Roduit, R., Susini, S., and Prentki, M. (1999) Diabetologia 42, 856-864
21. Buteau, J., Foisy, S., Joly, E., and Prentki, M. (2003) Diabetes 52, 124-132
22. Trumper, A., Trumper, K., Trusheim, H., Arnold, R., Goke, B., and Horsch, D. (2001) Mol. Endocrinol. 15, 1559-1570
23. Salvalaggio, P. R., Deng, S., Ariyan, C. E., Millet, I., Zawalich, W. S., Basadonna, G. P., and Rothstein, D. M. (2002) Transplantation 74, 877-879
24. Hsieh, A. C., Bo, R., Manola, J., Vazquez, F., Bare, O., Khvorova, A., Scaringe, S., and Sellers, W. R. (2004) Nucleic Acids Res. 32, 893-901
25. Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A., and Cohen, P. (1996) FEBS Lett. 399, 333-338
26. Obata, T., Yaffe, M. B., Leparc, G. G., Piro, E. T., Maegawa, H., Kashiwagi, A., Kikkawa, R., and Cantley, L. C. (2000) J. Biol. Chem. 275, 36108-36115
27. Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R., and Sutherland, C. (2007) Diabetes 56, 2218-2227
28. Barnett, S. F., Defeo-Jones, D., Fu, S., Hancock, P. J., Haskell, K. M., Jones, R. E., Kahana, J. A., Kral, A. M., Leander, K., Lee, L. L., Malinowski, J., McAvoy, E. M., Nahas, D. D., Robinson, R. G., and Huber, H. E. (2005) Biochem. J. 385, 399-408
29. Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K., and Hundal, H. S. (2008) J. Biol. Chem. 283, 27653-27667
30. Drucker, D. J. (2006) Cell Metab. 3, 153-165
31. Kashima, Y., Miki, T., Shibasaki, T., Ozaki, N., Miyazaki, M., Yano, H., and Seino, S. (2001) J. Biol. Chem. 276, 46046-46053
32. Seleznev, K., Zhao, C., Zhang, X. H., Song, K., and Ma, Z. A. (2006) J. Biol. Chem. 281, 22275-22288
33. Friedrichsen, B. N., Neubauer, N., Lee, Y. C., Gram, V. K., Blume, N., Petersen, J. S., Nielsen, J. H., and Moldrup, A. (2006) J. Endocrinol. 188, 481-492
34. Kahn, S. E. (2003) Diabetologia 46, 3-19
35. Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., and Butler, P. C. (2003) Diabetes 52, 102-110
36. Wajchenberg, B. L. (2007) Endocr. Rev. 28, 187-218
37. Balas, B., Baig, M. R., Watson, C., Dunning, B. E., Ligueros-Saylan, M., Wang, Y., He, Y. L., Darland, C., Holst, J. J., Deacon, C. F., Cusi, K., Mari, A., Foley, J. E., and DeFronzo, R. A. (2007) J. Clin. Endocrinol. Metab. 92, 1249-1255
38. DeFronzo, R. A., Ratner, R. E., Han, J., Kim, D. D., Fineman, M. S., and Baron, A. D. (2005) Diabetes Care 28, 1092-1100
39. Davies, S. P., Reddy, H., Caivano, M., and Cohen, P. (2000) Biochem. J. 351, 95-105
40. Wicksteed, B., Alarcon, C., Briaud, I., Lingohr, M. K., and Rhodes, C. J. (2003) J. Biol. Chem. 278, 42080-42090
41. Dickson, L. M., Lingohr, M. K., McCuaig, J., Hugl, S. R., Snow, L., Kahn, B. B., Myers, M. G., Jr., and Rhodes, C. J. (2001) J. Biol. Chem. 276, 21110-21120
42. Ehses, J. A., Casilla, V. R., Doty, T., Pospisilik, J. A., Winter, K. D., Demuth, H. U., Pederson, R. A., and McIntosh, C. H. (2003) Endocrinology 144, 4433-4445
43. Siegel, E. G., and Creutzfeldt, W. (1985) Diabetologia 28, 857-861
44. Leech, C. A., Holz, G. G., and Habener, J. F. (1996) Ann. N. Y. Acad. Sci. 805, 81-92; Discussion 92-83
45. Holz, G. G. (2004) Diabetes 53, 5-13
46. Kim, W., and Egan, J. M. (2008) Pharmacol. Rev. 60, 470-512
47. Yusta, B., Baggio, L. L., Estall, J. L., Koehler, J. A., Holland, D. P., Li, H., Pipeleers, D., Ling, Z., and Drucker, D. J. (2006) Cell Metab. 4, 391-406
48. Tews, D., Werner, U., and Eckel, J. (2008) Horm. Metab. Res. 40, 172-180
49. Whiteman, E. L., Cho, H., and Birnbaum, M. J. (2002) Trends Endocrinol. Metab. 13, 444-451
50. Tuttle, R. L., Gill, N. S., Pugh, W., Lee, J. P., Koeberlein, B., Furth, E. E., Polonsky, K. S., Naji, A., and Birnbaum, M. J. (2001) Nat. Med. 7, 1133-1137
51. Bernal-Mizrachi, E., Wen, W., Stahlhut, S., Welling, C. M., and Permutt, M. A. (2001) J. Clin. Investig. 108, 1631-1638
52. Rao, P., Roccisana, J., Takane, K. K., Bottino, R., Zhao, A., Trucco, M., and Garcia-Ocana, A. (2005) Diabetes 54, 1664-1675
53. Bernal-Mizrachi, E., Fatrai, S., Johnson, J. D., Ohsugi, M., Otani, K., Han, Z., Polonsky, K. S., and Permutt, M. A. (2004) J. Clin. Investig. 114, 928-936
54. Sable, C. L., Filippa, N., Hemmings, B., and Van Obberghen, E. (1997) FEBS Lett. 409, 253-257
55. Filippa, N., Sable, C. L., Filloux, C., Hemmings, B., and Van Obberghen, E. (1999) Mol. Cell. Biol. 19, 4989-5000
56. Yano, S., Tokumitsu, H., and Soderling, T. R. (1998) Nature 396, 584-587
57. Moule, S. K., Welsh, G. I., Edgell, N. J., Foulstone, E. J., Proud, C. G., and Denton, R. M. (1997) J. Biol. Chem. 272, 7713-7719