메뉴 건너뛰기




Volumn 90, Issue 6, 2005, Pages 3401-3409

Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet β-cells from pancreatic duct cells and an increase in functional β-cell mass

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CYTOKERATIN; FIBRINOGEN; GAMMA UROGASTRONE; GASTRIN 17; INSULIN; EPIDERMAL GROWTH FACTOR; GASTRIN; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; TRANSACTIVATOR PROTEIN;

EID: 21244441973     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0761     Document Type: Article
Times cited : (169)

References (47)
  • 3
    • 0035814696 scopus 로고    scopus 로고
    • Science, medicine and the future: Islet and stem cell transplantation for treating diabetes
    • Serup P, Madsen OD, Mandrup-Poulsen T 2001 Science, medicine and the future: islet and stem cell transplantation for treating diabetes. Br Med J 322:29-32
    • (2001) Br Med J , vol.322 , pp. 29-32
    • Serup, P.1    Madsen, O.D.2    Mandrup-Poulsen, T.3
  • 4
    • 0037303120 scopus 로고    scopus 로고
    • Stem/progenitor cells derived from adult tissues: Potential for the treatment of diabetes mellitus
    • Lechner A, Habener JF 2003 Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am J Physiol 284:E259-E266
    • (2003) Am J Physiol , vol.284
    • Lechner, A.1    Habener, J.F.2
  • 5
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas: A possible recapitulation of embryonic development
    • Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE 1993 A second pathway for regeneration of adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development. Diabetes 42:1715-1720
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 6
    • 0027276885 scopus 로고
    • Epithelial cell proliferation and islet neogenesis in IFN-γ transgenic mice
    • Gu D, Sarvetnick N 1993 Epithelial cell proliferation and islet neogenesis in IFN-γ transgenic mice. Development 118:33-46
    • (1993) Development , vol.118 , pp. 33-46
    • Gu, D.1    Sarvetnick, N.2
  • 7
    • 0030017385 scopus 로고    scopus 로고
    • Determinants of pancreatic islet cell mass: A balance between neogenesis and senescence/apoptosis
    • Vinik A, Pittenger G, Rafaeloff R, Rosenberg L, Duguid WP 1996 Determinants of pancreatic islet cell mass: a balance between neogenesis and senescence/apoptosis. Diabet Rev 4:235-263
    • (1996) Diabet Rev , vol.4 , pp. 235-263
    • Vinik, A.1    Pittenger, G.2    Rafaeloff, R.3    Rosenberg, L.4    Duguid, W.P.5
  • 8
    • 0038522555 scopus 로고    scopus 로고
    • Specific and combined effects of insulin and glucose on functional pancreatic β-cell mass in vivo in adult rats
    • Paris M, Bernard-Kargar C, Berthault MF, Bouwens L, Ktorza A 2003 Specific and combined effects of insulin and glucose on functional pancreatic β-cell mass in vivo in adult rats. Endocrinology 144:2717-2727
    • (2003) Endocrinology , vol.144 , pp. 2717-2727
    • Paris, M.1    Bernard-Kargar, C.2    Berthault, M.F.3    Bouwens, L.4    Ktorza, A.5
  • 9
    • 0034100823 scopus 로고    scopus 로고
    • Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
    • Ramiya VK, Maraist M, Arfors KE, Schatz DA, Peck AB, Cornelius JG 2000 Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 6:278-282
    • (2000) Nat Med , vol.6 , pp. 278-282
    • Ramiya, V.K.1    Maraist, M.2    Arfors, K.E.3    Schatz, D.A.4    Peck, A.B.5    Cornelius, J.G.6
  • 10
    • 0033911990 scopus 로고    scopus 로고
    • Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro
    • Rooman I, Heremans Y, Heimberg H, Bouwens L 2000 Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 43:907-914
    • (2000) Diabetologia , vol.43 , pp. 907-914
    • Rooman, I.1    Heremans, Y.2    Heimberg, H.3    Bouwens, L.4
  • 11
    • 0035002954 scopus 로고    scopus 로고
    • Association between islets of Langerhans and pancreatic ductal system in adult rat. Where endocrine and exocrine meet together?
    • Bertelli E, Regoli M, Orazioli D, Bendayan M 2001 Association between islets of Langerhans and pancreatic ductal system in adult rat. Where endocrine and exocrine meet together? Diabetologia 44:575-584
    • (2001) Diabetologia , vol.44 , pp. 575-584
    • Bertelli, E.1    Regoli, M.2    Orazioli, D.3    Bendayan, M.4
  • 14
    • 0043268785 scopus 로고    scopus 로고
    • Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture
    • Gao R, Ustinov J, Pulkkinen M-A, Lundin K, Korsgren I, Otonkoski T 2003 Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 52:2007-2015
    • (2003) Diabetes , vol.52 , pp. 2007-2015
    • Gao, R.1    Ustinov, J.2    Pulkkinen, M.-A.3    Lundin, K.4    Korsgren, I.5    Otonkoski, T.6
  • 17
    • 0035143062 scopus 로고    scopus 로고
    • Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: Effects of the ob gene and compensatory growth of the implantation organ
    • Tyrberg B, Ustinov J, Otonkoski T, Andersson A 2001 Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ. Diabetes 50:301-307
    • (2001) Diabetes , vol.50 , pp. 301-307
    • Tyrberg, B.1    Ustinov, J.2    Otonkoski, T.3    Andersson, A.4
  • 19
    • 0029944459 scopus 로고    scopus 로고
    • Islet neogenesis in the pancreas
    • Bouwens L, Kloppel G 1996 Islet neogenesis in the pancreas. Virchows Arch 427:553-560
    • (1996) Virchows Arch , vol.427 , pp. 553-560
    • Bouwens, L.1    Kloppel, G.2
  • 22
    • 0035406148 scopus 로고    scopus 로고
    • Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: A balance between proliferation and differentiation
    • Cras-Meneur C, Elghazi L, Czernichow P, Scharfmann R 2001 Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation. Diabetes 50:1571-1579
    • (2001) Diabetes , vol.50 , pp. 1571-1579
    • Cras-Meneur, C.1    Elghazi, L.2    Czernichow, P.3    Scharfmann, R.4
  • 23
    • 0032813242 scopus 로고    scopus 로고
    • Transgenic expression of epidermal growth factor and keratinocyte growth factor in β-cells results in substantial morphological changes
    • Krakowski ML, Kritzik MR, Jones EM, Krachl T, Lee J, Arnush M, Gu D, Mroczkowski B, Sarvetnick N 1999 Transgenic expression of epidermal growth factor and keratinocyte growth factor in β-cells results in substantial morphological changes. J Endocrinol 162:167-175
    • (1999) J Endocrinol , vol.162 , pp. 167-175
    • Krakowski, M.L.1    Kritzik, M.R.2    Jones, E.M.3    Krachl, T.4    Lee, J.5    Arnush, M.6    Gu, D.7    Mroczkowski, B.8    Sarvetnick, N.9
  • 24
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S 1999 Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 25
    • 0035405821 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and exendin-4 stimulate β-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
    • Tourrel C, Bailbè D, Meile MJ, Kergoat M, Portha B 2001 Glucagon-like peptide-1 and exendin-4 stimulate β-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 50:1562-1570
    • (2001) Diabetes , vol.50 , pp. 1562-1570
    • Tourrel, C.1    Bailbè, D.2    Meile, M.J.3    Kergoat, M.4    Portha, B.5
  • 26
    • 0036310118 scopus 로고    scopus 로고
    • Gastrin stimulates β-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreatic tissue
    • Rooman I, Lardon J, Bouwens L 2002 Gastrin stimulates β-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreatic tissue. Diabetes 51:686-690
    • (2002) Diabetes , vol.51 , pp. 686-690
    • Rooman, I.1    Lardon, J.2    Bouwens, L.3
  • 27
    • 22544443534 scopus 로고    scopus 로고
    • Islet neogenesis in the regeneration model of rat pancreatic duct ligation requires endogenous gastrin action via CCK2 receptors
    • Rooman I, Bouwens L 2002 Islet neogenesis in the regeneration model of rat pancreatic duct ligation requires endogenous gastrin action via CCK2 receptors. Diabetologia 45(Suppl 2):A26
    • (2002) Diabetologia , vol.45 , Issue.2 SUPPL.
    • Rooman, I.1    Bouwens, L.2
  • 28
    • 0036968693 scopus 로고    scopus 로고
    • Pharmacological treatment of chronic diabetes by stimulating pancreatic β-cell regeneration with systemic co-administration of EGF and gastrin
    • Brand SJ, Tagerud S, Lambert P, Magil SG, Tartarkiewicz K, Doiron K, Yan Y 2002 Pharmacological treatment of chronic diabetes by stimulating pancreatic β-cell regeneration with systemic co-administration of EGF and gastrin. Pharmacol Toxicol 91:414-420
    • (2002) Pharmacol Toxicol , vol.91 , pp. 414-420
    • Brand, S.J.1    Tagerud, S.2    Lambert, P.3    Magil, S.G.4    Tartarkiewicz, K.5    Doiron, K.6    Yan, Y.7
  • 29
    • 1542284736 scopus 로고    scopus 로고
    • Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycemia in C57BL6/J mice treated with alloxan
    • Rooman I, Bouwens L 2004 Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycemia in C57BL6/J mice treated with alloxan. Diabetologia 47:259-265
    • (2004) Diabetologia , vol.47 , pp. 259-265
    • Rooman, I.1    Bouwens, L.2
  • 36
    • 0019449179 scopus 로고
    • Acid potency and elimination of the 15-leucine gastrin-17 analogue in man
    • Petersen B, Christinsen J, Rehfeld JF 1981 Acid potency and elimination of the 15-leucine gastrin-17 analogue in man. Scand J Gastroenterol 16:437-440
    • (1981) Scand J Gastroenterol , vol.16 , pp. 437-440
    • Petersen, B.1    Christinsen, J.2    Rehfeld, J.F.3
  • 37
    • 0026502893 scopus 로고
    • Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy
    • Wang T, Singh B, Warnock G, Rajotte RV 1992 Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy. Diabetes 41:114-117
    • (1992) Diabetes , vol.41 , pp. 114-117
    • Wang, T.1    Singh, B.2    Warnock, G.3    Rajotte, R.V.4
  • 38
    • 7944228597 scopus 로고    scopus 로고
    • Cellular sources of new pancreatic β-cells and therapeutic implications for regenerative medicine
    • Halban PA 2004 Cellular sources of new pancreatic β-cells and therapeutic implications for regenerative medicine. Nat Cell Biol 6:1021-1025
    • (2004) Nat Cell Biol , vol.6 , pp. 1021-1025
    • Halban, P.A.1
  • 39
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic β-cells are formed by self-replication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton D 2004 Adult pancreatic β-cells are formed by self-replication rather than stem-cell differentiation. Nature 429:41-46
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.4
  • 41
    • 0030969443 scopus 로고    scopus 로고
    • Functional β-cell mass after transplantation of human fetal pancreatic cells: Differentiation or proliferation?
    • Beattie GM, Otonkoski T, Lopez AD, Hayek A 1997 Functional β-cell mass after transplantation of human fetal pancreatic cells: differentiation or proliferation? Diabetes 46:244-248
    • (1997) Diabetes , vol.46 , pp. 244-248
    • Beattie, G.M.1    Otonkoski, T.2    Lopez, A.D.3    Hayek, A.4
  • 42
    • 0035107896 scopus 로고    scopus 로고
    • Development of human fetal pancreas after transplantation into SCID mice
    • Si Z, Tuch BE, Walsh DA 2001 Development of human fetal pancreas after transplantation into SCID mice. Cells Tissues Organs 168:147-157
    • (2001) Cells Tissues Organs , vol.168 , pp. 147-157
    • Si, Z.1    Tuch, B.E.2    Walsh, D.A.3
  • 43
    • 0031841517 scopus 로고    scopus 로고
    • Extra-insular β cells associated with ductules are frequent in adult human pancreas
    • Bouwens L, Pipeleers DG 1998 Extra-insular β cells associated with ductules are frequent in adult human pancreas. Diabetologia 41:629-633
    • (1998) Diabetologia , vol.41 , pp. 629-633
    • Bouwens, L.1    Pipeleers, D.G.2
  • 44
    • 0018183984 scopus 로고
    • Islet cell survival determined by morphology: An immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus
    • Gepts W, DeMey J 1978 Islet cell survival determined by morphology: an immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus. Diabetes 27(Suppl 1):251-261
    • (1978) Diabetes , vol.27 , Issue.1 SUPPL. , pp. 251-261
    • Gepts, W.1    DeMey, J.2
  • 45
    • 0030747583 scopus 로고    scopus 로고
    • Expression of gastrin and transforming growth factor-α during duct to islet cell differentiation in the pancreas of duct-ligated adult rats
    • Wang RN, Rehfeld JF, Nielsen FC, Kloppel G 1997 Expression of gastrin and transforming growth factor-α during duct to islet cell differentiation in the pancreas of duct-ligated adult rats. Diabetologia 40:887-893
    • (1997) Diabetologia , vol.40 , pp. 887-893
    • Wang, R.N.1    Rehfeld, J.F.2    Nielsen, F.C.3    Kloppel, G.4
  • 47
    • 0023887393 scopus 로고
    • Differential gastrin gene expression in rat gastrointestinal tract and pancreas during neonatal development
    • Brand SJ, Fuller PJ 1988 Differential gastrin gene expression in rat gastrointestinal tract and pancreas during neonatal development. J Biol Chem 263:5341-5347
    • (1988) J Biol Chem , vol.263 , pp. 5341-5347
    • Brand, S.J.1    Fuller, P.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.