-
1
-
-
0037283601
-
The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes
-
Kahn SE 2003 The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3-19
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
2
-
-
12344323484
-
Type 2 diabetes - A matter of β-cell life and death?
-
Rhodes CJ 2005 Type 2 diabetes - a matter of β-cell life and death? Science 307:380-384
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
3
-
-
0035130272
-
β-Cell adaptation and decompensation during the progression of diabetes
-
Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A 2001 β-Cell adaptation and decompensation during the progression of diabetes. Diabetes 50 (Suppl 1):S154-S159
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Weir, G.C.1
Laybutt, D.R.2
Kaneto, H.3
Bonner-Weir, S.4
Sharma, A.5
-
4
-
-
9444242665
-
Five stages of evolving β-cell dys-function during progression to diabetes
-
Weir GC, Bonner-Weir S 2004 Five stages of evolving β-cell dys-function during progression to diabetes. Diabetes 53(Suppl 3):S16-S21
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
5
-
-
33847176604
-
A genome-wide association study identifies novel risk loci for type 2 diabetes
-
Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885
-
(2007)
Nature
, vol.445
, pp. 881-885
-
-
Sladek, R.1
Rocheleau, G.2
Rung, J.3
Dina, C.4
Shen, L.5
Serre, D.6
Boutin, P.7
Vincent, D.8
Belisle, A.9
Hadjadj, S.10
Balkau, B.11
Heude, B.12
Charpentier, G.13
Hudson, T.J.14
Montpetit, A.15
Pshezhetsky, A.V.16
Prentki, M.17
Posner, B.I.18
Balding, D.J.19
Meyre, D.20
Polychronakos, C.21
Froguel, P.22
more..
-
6
-
-
0026650928
-
Type II diabetes and syndrome X. Pathogenesis and glycemic management
-
Karam JH 1992 Type II diabetes and syndrome X. Pathogenesis and glycemic management. Endocrinol Metab Clin North Am 21:329-350
-
(1992)
Endocrinol Metab Clin North Am
, vol.21
, pp. 329-350
-
-
Karam, J.H.1
-
7
-
-
0028880997
-
Role of insulin resistance in the pathogenesis of NIDDM
-
Yki-Järvinen H 1995 Role of insulin resistance in the pathogenesis of NIDDM. Diabetologia 38:1378-1388
-
(1995)
Diabetologia
, vol.38
, pp. 1378-1388
-
-
Yki-Järvinen, H.1
-
8
-
-
0000803439
-
The islands of Langerhans in 19 cases of obesity
-
Ogilvie RF 1933 The islands of Langerhans in 19 cases of obesity. J Pathol Bacteriol 37:473-481
-
(1933)
J Pathol Bacteriol
, vol.37
, pp. 473-481
-
-
Ogilvie, R.F.1
-
9
-
-
0021777067
-
Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited
-
Klöppel G, Löhr M, Habich K, Oberholzer M, Heitz PU 1985 Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 4:110-125
-
(1985)
Surv Synth Pathol Res
, vol.4
, pp. 110-125
-
-
Klöppel, G.1
Löhr, M.2
Habich, K.3
Oberholzer, M.4
Heitz, P.U.5
-
10
-
-
0037219411
-
β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC 2003 β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
11
-
-
53549093011
-
Pancreatic β-cell mass in European subjects with type 2 diabetes
-
Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC 2008 Pancreatic β-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 10(Suppl 4):32-42
-
(2008)
Diabetes Obes Metab
, vol.10
, Issue.SUPPL. 4
, pp. 32-42
-
-
Rahier, J.1
Guiot, Y.2
Goebbels, R.M.3
Sempoux, C.4
Henquin, J.C.5
-
12
-
-
20444363538
-
β-Cells in type 2 diabetes: A loss of function and mass
-
Maedler K, Donath MY 2004 β-Cells in type 2 diabetes: a loss of function and mass. Horm Res 62(Suppl 3):67-73
-
(2004)
Horm Res
, vol.62
, Issue.SUPPL. 3
, pp. 67-73
-
-
Maedler, K.1
Donath, M.Y.2
-
13
-
-
0029933670
-
Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: Effects of weight reduction
-
Gumbiner B, Van Cauter E, Beltz WF, Ditzler TM, Griver K, Polonsky KS, Henry RR 1996 Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: effects of weight reduction. J Clin Endocrinol Metab 81:2061-2068
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 2061-2068
-
-
Gumbiner, B.1
Van Cauter, E.2
Beltz, W.F.3
Ditzler, T.M.4
Griver, K.5
Polonsky, K.S.6
Henry, R.R.7
-
14
-
-
0032449219
-
The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
-
Gerich JE 1998 The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 19:491-503
-
(1998)
Endocr Rev
, vol.19
, pp. 491-503
-
-
Gerich, J.E.1
-
15
-
-
0036314216
-
Phasic insulin release and metabolic regulation in type 2 diabetes
-
Del Prato S, Marchetti P, Bonadonna RC 2002 Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes 51(Suppl 1):S109-S116
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 1
-
-
Del Prato, S.1
Marchetti, P.2
Bonadonna, R.C.3
-
16
-
-
33744979065
-
Relationship between β-cell mass and fasting blood glucose concentration in humans
-
Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler PC 2006 Relationship between β-cell mass and fasting blood glucose concentration in humans. Diabetes Care 29:717-718
-
(2006)
Diabetes Care
, vol.29
, pp. 717-718
-
-
Ritzel, R.A.1
Butler, A.E.2
Rizza, R.A.3
Veldhuis, J.D.4
Butler, P.C.5
-
17
-
-
8744272467
-
Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
-
Marchetti P, Del Guerra S, Marselli L, Lupi R, Masini M, Pollera M, Bugliani M, Boggi U, Vistoli F, Mosca F, Del Prato S 2004 Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab 89:5535-5541
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5535-5541
-
-
Marchetti, P.1
Del Guerra, S.2
Marselli, L.3
Lupi, R.4
Masini, M.5
Pollera, M.6
Bugliani, M.7
Boggi, U.8
Vistoli, F.9
Mosca, F.10
Del Prato, S.11
-
18
-
-
10744222060
-
Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects
-
Deng S, Vatamaniuk M, Huang X, Doliba N, Lian MM, Frank A, Velidedeoglu E, Desai NM, Koeberlein B, Wolf B, Barker CF, Naji A, Matschinsky FM, Markmann JF 2004 Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 53:624-632
-
(2004)
Diabetes
, vol.53
, pp. 624-632
-
-
Deng, S.1
Vatamaniuk, M.2
Huang, X.3
Doliba, N.4
Lian, M.M.5
Frank, A.6
Velidedeoglu, E.7
Desai, N.M.8
Koeberlein, B.9
Wolf, B.10
Barker, C.F.11
Naji, A.12
Matschinsky, F.M.13
Markmann, J.F.14
-
19
-
-
20244376316
-
Functional and morphological alterations of mitochondria in pancreatic β cells from type 2 diabetic patients
-
Anello M, Lupi R, Spampinato D, Piro S, Masini M, Boggi U, Del Prato S, Rabuazzo AM, Purrello F, Marchetti P 2005 Functional and morphological alterations of mitochondria in pancreatic β cells from type 2 diabetic patients. Diabetologia 48:282-289
-
(2005)
Diabetologia
, vol.48
, pp. 282-289
-
-
Anello, M.1
Lupi, R.2
Spampinato, D.3
Piro, S.4
Masini, M.5
Boggi, U.6
Del Prato, S.7
Rabuazzo, A.M.8
Purrello, F.9
Marchetti, P.10
-
20
-
-
33644772589
-
Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients
-
Ostenson CG, Gaisano H, Sheu L, Tibell A, Bartfai T 2006 Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients. Diabetes 55:435-440
-
(2006)
Diabetes
, vol.55
, pp. 435-440
-
-
Ostenson, C.G.1
Gaisano, H.2
Sheu, L.3
Tibell, A.4
Bartfai, T.5
-
21
-
-
0029820477
-
Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture
-
Yuan S, Rosenberg L, Paraskevas S, Agapitos D, Duguid WP 1996 Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture. Differentiation 61:67-75
-
(1996)
Differentiation
, vol.61
, pp. 67-75
-
-
Yuan, S.1
Rosenberg, L.2
Paraskevas, S.3
Agapitos, D.4
Duguid, W.P.5
-
22
-
-
21744435617
-
Morphogenetic plasticity of adult human pancreatic islets of Langerhans
-
Jamal AM, Lipsett M, Sladek R, Laganière S, Hanley S, Rosenberg L 2005 Morphogenetic plasticity of adult human pancreatic islets of Langerhans. Cell Death Differ 12:702-712
-
(2005)
Cell Death Differ
, vol.12
, pp. 702-712
-
-
Jamal, A.M.1
Lipsett, M.2
Sladek, R.3
Laganière, S.4
Hanley, S.5
Rosenberg, L.6
-
23
-
-
0043268785
-
Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture
-
Gao R, Ustinov J, Pulkkinen MA, Lundin K, Korsgren O, Otonkoski T 2003 Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 52:2007-2015
-
(2003)
Diabetes
, vol.52
, pp. 2007-2015
-
-
Gao, R.1
Ustinov, J.2
Pulkkinen, M.A.3
Lundin, K.4
Korsgren, O.5
Otonkoski, T.6
-
24
-
-
11144315998
-
Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells
-
Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM 2004 Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306:2261-2264
-
(2004)
Science
, vol.306
, pp. 2261-2264
-
-
Gershengorn, M.C.1
Hardikar, A.A.2
Wei, C.3
Geras-Raaka, E.4
Marcus-Samuels, B.5
Raaka, B.M.6
-
25
-
-
27744593347
-
In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells
-
Gao R, Ustinov J, Korsgren O, Otonkoski T 2005 In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia 48:2296-2304
-
(2005)
Diabetologia
, vol.48
, pp. 2296-2304
-
-
Gao, R.1
Ustinov, J.2
Korsgren, O.3
Otonkoski, T.4
-
26
-
-
11144283080
-
Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue
-
Lechner A, Nolan AL, Blacken RA, Habener JF 2005 Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun 327:581-588
-
(2005)
Biochem Biophys Res Commun
, vol.327
, pp. 581-588
-
-
Lechner, A.1
Nolan, A.L.2
Blacken, R.A.3
Habener, J.F.4
-
27
-
-
31444455909
-
Expansion and redifferentiation of adult human pancreatic islet cells
-
Ouziel-Yahalom L, Zalzman M, Anker-Kitai L, Knoller S, Bar Y, Glandt M, Herold K, Efrat S 2006 Expansion and redifferentiation of adult human pancreatic islet cells. Biochem Biophys Res Commun 341:291-298
-
(2006)
Biochem Biophys Res Commun
, vol.341
, pp. 291-298
-
-
Ouziel-Yahalom, L.1
Zalzman, M.2
Anker-Kitai, L.3
Knoller, S.4
Bar, Y.5
Glandt, M.6
Herold, K.7
Efrat, S.8
-
28
-
-
46049120816
-
Cell origins of adult human islet in vitro dedifferentiation
-
Hanley SC, Pilotte A, Massie B, Rosenberg L 2008 Cell origins of adult human islet in vitro dedifferentiation. Lab Invest 88:761-772
-
(2008)
Lab Invest
, vol.88
, pp. 761-772
-
-
Hanley, S.C.1
Pilotte, A.2
Massie, B.3
Rosenberg, L.4
-
29
-
-
44749087001
-
In vitro proliferation of cells derived from adult human β-cells revealed by cell-lineage tracing
-
Russ HA, Bar Y, Ravassard P, Efrat S 2008 In vitro proliferation of cells derived from adult human β-cells revealed by cell-lineage tracing. Diabetes 57:1575-1583
-
(2008)
Diabetes
, vol.57
, pp. 1575-1583
-
-
Russ, H.A.1
Bar, Y.2
Ravassard, P.3
Efrat, S.4
-
30
-
-
52749088737
-
Hes1 is involved in adaptation of adult human β cells to proliferation in vitro
-
Bar Y, Russ HA, Knoller S, Ouziel-Yahalom L, Efrat S 2008 Hes1 is involved in adaptation of adult human β cells to proliferation in vitro. Diabetes 57:2413-2420
-
(2008)
Diabetes
, vol.57
, pp. 2413-2420
-
-
Bar, Y.1
Russ, H.A.2
Knoller, S.3
Ouziel-Yahalom, L.4
Efrat, S.5
-
31
-
-
0033606972
-
Notch signalling controls pancreatic cell differentiation
-
Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H 1999 Notch signalling controls pancreatic cell differentiation. Nature 400:877-881
-
(1999)
Nature
, vol.400
, pp. 877-881
-
-
Apelqvist, A.1
Li, H.2
Sommer, L.3
Beatus, P.4
Anderson, D.J.5
Honjo, T.6
Hrabe De Angelis, M.7
Lendahl, U.8
Edlund, H.9
-
32
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD 2000 Control of endodermal endocrine development by Hes-1. Nat Genet 24:36-44
-
(2000)
Nat Genet
, vol.24
, pp. 36-44
-
-
Jensen, J.1
Pedersen, E.E.2
Galante, P.3
Hald, J.4
Heller, R.S.5
Ishibashi, M.6
Kageyama, R.7
Guillemot, F.8
Serup, P.9
Madsen, O.D.10
-
33
-
-
33645080922
-
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
-
Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K 2006 Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab 3:59-65
-
(2006)
Cell Metab
, vol.3
, pp. 59-65
-
-
Fujikura, J.1
Hosoda, K.2
Iwakura, H.3
Tomita, T.4
Noguchi, M.5
Masuzaki, H.6
Tanigaki, K.7
Yabe, D.8
Honjo, T.9
Nakao, K.10
-
34
-
-
33846338921
-
Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate
-
Greenwood AL, Li S, Jones K, Melton DA 2007 Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev 124:97-107
-
(2007)
Mech Dev
, vol.124
, pp. 97-107
-
-
Greenwood, A.L.1
Li, S.2
Jones, K.3
Melton, D.A.4
-
35
-
-
0042665560
-
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
-
Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J 2003 Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol 260:426-437
-
(2003)
Dev Biol
, vol.260
, pp. 426-437
-
-
Hald, J.1
Hjorth, J.P.2
German, M.S.3
Madsen, O.D.4
Serup, P.5
Jensen, J.6
-
36
-
-
0030268113
-
Neurogenins, a novel family of atonal-related bH LH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
-
Sommer L, Ma Q, Anderson DJ 1996 Neurogenins, a novel family of atonal-related bH LH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci 8:221-241
-
(1996)
Mol Cell Neurosci
, vol.8
, pp. 221-241
-
-
Sommer, L.1
Ma, Q.2
Anderson, D.J.3
-
37
-
-
0030273134
-
Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development
-
Lardelli M, Williams R, Mitsiadis T, Lendahl U 1996 Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development. Mech Dev 59:177-190
-
(1996)
Mech Dev
, vol.59
, pp. 177-190
-
-
Lardelli, M.1
Williams, R.2
Mitsiadis, T.3
Lendahl, U.4
-
38
-
-
0023912253
-
Automated method for isolation of human pancreatic islets
-
Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW 1988 Automated method for isolation of human pancreatic islets. Diabetes 37:413-420
-
(1988)
Diabetes
, vol.37
, pp. 413-420
-
-
Ricordi, C.1
Lacy, P.E.2
Finke, E.H.3
Olack, B.J.4
Scharp, D.W.5
-
40
-
-
0035149758
-
Factors mediating the transdifferentiation of islets of Langerhans to duct epithelial-like structures
-
Wang R, Li J, Rosenberg L 2001 Factors mediating the transdifferentiation of islets of Langerhans to duct epithelial-like structures. J Endocrinol 171:309-318
-
(2001)
J Endocrinol
, vol.171
, pp. 309-318
-
-
Wang, R.1
Li, J.2
Rosenberg, L.3
-
41
-
-
33750908049
-
Evidence for the homeostatic regulation of induced β cell mass expansion
-
Lipsett MA, Austin EB, Castellarin ML, Lemay J, Rosenberg L 2006 Evidence for the homeostatic regulation of induced β cell mass expansion. Diabetologia 49:2910-2919
-
(2006)
Diabetologia
, vol.49
, pp. 2910-2919
-
-
Lipsett, M.A.1
Austin, E.B.2
Castellarin, M.L.3
Lemay, J.4
Rosenberg, L.5
-
42
-
-
42149118941
-
Donor and isolation variables predicting human islet isolation success
-
Hanley SC, Paraskevas S, Rosenberg L 2008 Donor and isolation variables predicting human islet isolation success. Transplantation 85:950-955
-
(2008)
Transplantation
, vol.85
, pp. 950-955
-
-
Hanley, S.C.1
Paraskevas, S.2
Rosenberg, L.3
-
43
-
-
2942653252
-
Analysis of donor factors affecting human islet isolation with current isolation protocol
-
Matsumoto S, Zhang G, Qualley S, Clever J, Tombrello Y, Strong DM, Reems JA 2004 Analysis of donor factors affecting human islet isolation with current isolation protocol. Transplant Proc 36:1034-1036
-
(2004)
Transplant Proc
, vol.36
, pp. 1034-1036
-
-
Matsumoto, S.1
Zhang, G.2
Qualley, S.3
Clever, J.4
Tombrello, Y.5
Strong, D.M.6
Reems, J.A.7
-
44
-
-
0028987251
-
Dynamics of β-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
-
Finegood DT, Scaglia L, Bonner-Weir S 1995 Dynamics of β-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44:249-256
-
(1995)
Diabetes
, vol.44
, pp. 249-256
-
-
Finegood, D.T.1
Scaglia, L.2
Bonner-Weir, S.3
-
45
-
-
0031841517
-
Extra-insular β cells associated with ductules are frequent in adult human pancreas
-
Bouwens L, Pipeleers DG 1998 Extra-insular β cells associated with ductules are frequent in adult human pancreas. Diabetologia 41:629-633
-
(1998)
Diabetologia
, vol.41
, pp. 629-633
-
-
Bouwens, L.1
Pipeleers, D.G.2
-
46
-
-
0024213009
-
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: Quantitative changes in the pancreas in type 2 diabetes
-
Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Cooper GJ, Holman RR, Turner RC 1988 Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 9:151-159
-
(1988)
Diabetes Res
, vol.9
, pp. 151-159
-
-
Clark, A.1
Wells, C.A.2
Buley, I.D.3
Cruickshank, J.K.4
Vanhegan, R.I.5
Matthews, D.R.6
Cooper, G.J.7
Holman, R.R.8
Turner, R.C.9
-
47
-
-
0038707331
-
Selective β-cell loss and β-cell expansion in patients with type 2 diabetes mellitus in Korea
-
Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim HS, Lee IK, Bonner-Weir S 2003 Selective β-cell loss and β-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 88:2300-2308
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2300-2308
-
-
Yoon, K.H.1
Ko, S.H.2
Cho, J.H.3
Lee, J.M.4
Ahn, Y.B.5
Song, K.H.6
Yoo, S.J.7
Kang, M.I.8
Cha, B.Y.9
Lee, K.W.10
Son, H.Y.11
Kang, S.K.12
Kim, H.S.13
Lee, I.K.14
Bonner-Weir, S.15
-
48
-
-
23744439083
-
Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
-
Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR 2005 Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122:337-349
-
(2005)
Cell
, vol.122
, pp. 337-349
-
-
Gunton, J.E.1
Kulkarni, R.N.2
Yim, S.3
Okada, T.4
Hawthorne, W.J.5
Tseng, Y.H.6
Roberson, R.S.7
Ricordi, C.8
O'Connell, P.J.9
Gonzalez, F.J.10
Kahn, C.R.11
-
49
-
-
0033009460
-
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration
-
Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir S 1999 The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48:507-513
-
(1999)
Diabetes
, vol.48
, pp. 507-513
-
-
Sharma, A.1
Zangen, D.H.2
Reitz, P.3
Taneja, M.4
Lissauer, M.E.5
Miller, C.P.6
Weir, G.C.7
Habener, J.F.8
Bonner-Weir, S.9
-
50
-
-
0031785161
-
Δ-1 activation of notch-1 signaling results in HES-1 transactivation
-
Jarriault S, Le Bail O, Hirsinger E, Pourquié O, Logeat F, Strong CF, Brou C, Seidah NG, Israel A 1998 Δ-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol 18:7423-7431
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7423-7431
-
-
Jarriault, S.1
Le Bail, O.2
Hirsinger, E.3
Pourquié, O.4
Logeat, F.5
Strong, C.F.6
Brou, C.7
Seidah, N.G.8
Israel, A.9
-
51
-
-
29044433213
-
Notch signaling: A mediator of β-cell de-differentiation in diabetes?
-
Darville MI, Eizirik DL 2006 Notch signaling: a mediator of β-cell de-differentiation in diabetes? Biochem Biophys Res Commun 339:1063-1068
-
(2006)
Biochem Biophys Res Commun
, vol.339
, pp. 1063-1068
-
-
Darville, M.I.1
Eizirik, D.L.2
-
52
-
-
0035029867
-
Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays
-
Cardozo AK, Kruhøffer M, Leeman R, Orntoft T, Eizirik DL 2001 Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays. Diabetes 50:909-920
-
(2001)
Diabetes
, vol.50
, pp. 909-920
-
-
Cardozo, A.K.1
Kruhøffer, M.2
Leeman, R.3
Orntoft, T.4
Eizirik, D.L.5
-
53
-
-
10744223624
-
Notch mediates TGF α-induced changes in epithelial differentiation during pancreatic tumorigenesis
-
Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD 2003 Notch mediates TGF α-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3:565-576
-
(2003)
Cancer Cell
, vol.3
, pp. 565-576
-
-
Miyamoto, Y.1
Maitra, A.2
Ghosh, B.3
Zechner, U.4
Argani, P.5
Iacobuzio-Donahue, C.A.6
Sriuranpong, V.7
Iso, T.8
Meszoely, I.M.9
Wolfe, M.S.10
Hruban, R.H.11
Ball, D.W.12
Schmid, R.M.13
Leach, S.D.14
-
54
-
-
0242363618
-
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells
-
Kutlu B, Cardozo AK, Darville MI, Kruhøffer M, Magnusson N, Ørntoft T, Eizirik DL 2003 Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes 52:2701-2719
-
(2003)
Diabetes
, vol.52
, pp. 2701-2719
-
-
Kutlu, B.1
Cardozo, A.K.2
Darville, M.I.3
Kruhøffer, M.4
Magnusson, N.5
Ørntoft, T.6
Eizirik, D.L.7
-
55
-
-
33644962142
-
Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation
-
Chen CD, Oh SY, Hinman JD, Abraham CR 2006 Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. J Neurochem 97:30-43
-
(2006)
J Neurochem
, vol.97
, pp. 30-43
-
-
Chen, C.D.1
Oh, S.Y.2
Hinman, J.D.3
Abraham, C.R.4
-
56
-
-
0141593480
-
Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
-
Hart A, Papadopoulou S, Edlund H 2003 Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev Dyn 228:185-193
-
(2003)
Dev Dyn
, vol.228
, pp. 185-193
-
-
Hart, A.1
Papadopoulou, S.2
Edlund, H.3
-
57
-
-
0030029605
-
Are the β-cell signaling molecules malonyl-Co A and cystolic long-chain acyl-Co A implicated in multiple tissue defects of obesity and NIDDM?
-
Prentki M, Corkey BE 1996 Are the β-cell signaling molecules malonyl-Co A and cystolic long-chain acyl-Co A implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283
-
(1996)
Diabetes
, vol.45
, pp. 273-283
-
-
Prentki, M.1
Corkey, B.E.2
-
58
-
-
0036896505
-
Malonyl-Co A signaling, lipid partitioning, and glucolipotoxicity: Role in β-cell adaptation and failure in the etiology of diabetes
-
Prentki M, Joly E, El-Assaad W, Roduit R 2002 Malonyl-Co A signaling, lipid partitioning, and glucolipotoxicity: role in β-cell adaptation and failure in the etiology of diabetes. Diabetes 51(Suppl 3):S405-S413
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 3
-
-
Prentki, M.1
Joly, E.2
El-Assaad, W.3
Roduit, R.4
-
59
-
-
53549094111
-
Relationship between β-cell mass and diabetes onset
-
Matveyenko AV, Butler PC 2008 Relationship between β-cell mass and diabetes onset. Diabetes Obes Metab 10(Suppl 4):23-31
-
(2008)
Diabetes Obes Metab
, vol.10
, Issue.SUPPL. 4
, pp. 23-31
-
-
Matveyenko, A.V.1
Butler, P.C.2
-
60
-
-
0037474332
-
Critical reduction in β-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes
-
Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC 2003 Critical reduction in β-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem 278:2997-3005
-
(2003)
J Biol Chem
, vol.278
, pp. 2997-3005
-
-
Laybutt, D.R.1
Glandt, M.2
Xu, G.3
Ahn, Y.B.4
Trivedi, N.5
Bonner-Weir, S.6
Weir, G.C.7
-
61
-
-
59049086079
-
Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: Epithelial-mesenchymal transition is an artifact of cell culture
-
Seeberger KL, Eshpeter A, Rajotte RV, Korbutt GS 2009 Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture. Lab Invest 89:110-121
-
(2009)
Lab Invest
, vol.89
, pp. 110-121
-
-
Seeberger, K.L.1
Eshpeter, A.2
Rajotte, R.V.3
Korbutt, G.S.4
-
62
-
-
38749108893
-
β cells can be generated from endogenous progenitors in injured adult mouse pancreas
-
Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H 2008 β cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132:197-207
-
(2008)
Cell
, vol.132
, pp. 197-207
-
-
Xu, X.1
D'Hoker, J.2
Stangé, G.3
Bonné, S.4
De Leu, N.5
Xiao, X.6
Van De Casteele, M.7
Mellitzer, G.8
Ling, Z.9
Pipeleers, D.10
Bouwens, L.11
Scharfmann, R.12
Gradwohl, G.13
Heimberg, H.14
-
63
-
-
2342510386
-
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor Y, Brown J, Martinez OI, Melton DA 2004 Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
64
-
-
34247644369
-
Growth and regeneration of adult β cells does not involve specialized progenitors
-
Teta M, Rankin MM, Long SY, Stein GM, Kushner JA 2007 Growth and regeneration of adult β cells does not involve specialized progenitors. Dev Cell 12:817-826
-
(2007)
Dev Cell
, vol.12
, pp. 817-826
-
-
Teta, M.1
Rankin, M.M.2
Long, S.Y.3
Stein, G.M.4
Kushner, J.A.5
-
65
-
-
0042822112
-
Increased β-cell apoptosis prevents adaptive increase in β-cell mass in mouse model of type 2 diabetes: Evidence for role of islet amyloid formation rather than direct action of amyloid
-
Butler AE, Janson J, Soeller WC, Butler PC 2003 Increased β-cell apoptosis prevents adaptive increase in β-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52:2304-2314
-
(2003)
Diabetes
, vol.52
, pp. 2304-2314
-
-
Butler, A.E.1
Janson, J.2
Soeller, W.C.3
Butler, P.C.4
-
66
-
-
34250901731
-
Transforming growth factor-β is a critical regulator of adult human islet plasticity
-
Hanley S, Rosenberg L 2007 Transforming growth factor-β is a critical regulator of adult human islet plasticity. Mol Endocrinol 21:1467-1477
-
(2007)
Mol Endocrinol
, vol.21
, pp. 1467-1477
-
-
Hanley, S.1
Rosenberg, L.2
|