Increased β-cell apoptosis and impaired insulin signaling pathway contributes to the onset of diabetes in OLETF rats

Cellular Physiology and Biochemistry

Volumn 21, Issue 5-6, 2008, Pages 445-454

  Zhao, Jiawei ^a   Zhang, Nina ^b,c   He, Min ^a   Yang, Zhihong ^a   Tong, Wei ^a   Wang, Qinghua ^a,b,c,d   Hu, Renming ^a  

^a FUDAN UNIVERSITY   (China)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d NONE   (Canada)

Author keywords

Diabetes onset; Glucose; Glucose tolerance; Insulin; Insulin resistance; Islet; cell mass

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PROTEIN KINASE B;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE HOMEOSTASIS; HYPERINSULINEMIA; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INNER CELL MASS; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

RATTUS;

EID: 42949144937     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000129637     Document Type: Article

References (46)