The role of genetic variants in human longevity

Ageing Research Reviews

Volumn 9, Issue SUPPL., 2010, Pages

  Chung, Wen Hung ^a   Dao, Ro Lan ^a   Chen, Liang Kung ^b,c   Hung, Shuen Iu ^c  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Aging; Genetics; Human; Longevity; Polymorphisms

Indexed keywords

APOLIPOPROTEIN E; ARYLDIALKYLPHOSPHATASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR RECEPTOR; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; SOMATOMEDIN C; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1;

AGING; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE PHENOTYPE CORRELATION; HUMAN; ISCHEMIC HEART DISEASE; LIPOPROTEIN METABOLISM; LONGEVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; RESPIRATORY CHAIN; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVIEW; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE;

AGING; ANIMALS; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; LONGEVITY; POLYMORPHISM, GENETIC;

EID: 77957949843     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2010.08.001     Document Type: Review

References (125)

1. Anisimov S.V., Volkova M.V., Lenskaya L.V., Khavinson V.K., Solovieva D.V., et al. Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population. J. Gerontol. A: Biol. Sci. Med. Sci. 2001, 56:B27-B32.
2. Anselmi C.V., Malovini A., Roncarati R., Novelli V., Villa F., et al. Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Res. 2009, 12:95-103.
3. Ara S., Lee P.S.Y., Hansen M.F., Saya H. Codon 72 polymorphism of the TP53 gene. Nucleic Acids Res. 1990, 18:4961.
4. Beckstead W.A., Ebbert M.T., Rowe M.J., McClellan D.A. Evolutionary pressure on mitochondrial cytochrome b is consistent with a role of CytbI7T affecting longevity during caloric restriction. PLoS One 2009, 4:5836.
5. Bishop N.A., Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat. Rev. Genet. 2007, 8:835-844.
6. Blanché H., Cabanne L., Sahbatou M., Thomas G. A study of French centenarians: are ACE and APOE associated with longevity?. C. R. Acad. Sci. III 2001, 324:129-135.
7. Boily-Larouche G., Zijenah L.S., Mbizvo M., Ward B.J., Roger M. DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility. Hum. Immunol. 2007, 68:523-530.
8. Bojesen S.E., Nordestgaard B.G. The common germline Arg72Pro polymorphism of p53 and increased longevity in humans. Cell Cycle 2008, 7:158-163.
9. Bonafè M., Olivieri F., Mari D., Baggio G., Mattace R., et al. P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. Am. J. Hum. Genet. 1999, 65:1782-1785.
10. Bonafè M., Olivieri F., Mari D., Baggio G., Mattace R., et al. p53 variants predisposing to cancer are present in healthy centenarians. Am. J. Hum. Genet. 1999, 64:292-295.
11. Bonafè M., Marchegiani F., Cardelli M., Olivieri F., Cavallone L., et al. Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. Eur. J. Hum. Genet. 2002, 10:292-296.
12. Bonafè M., Barbieri M., Marchegiani F., Olivieri F., Ragno E., et al. Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositides 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J. Clin. Endocrinol. Metab. 2003, 88:3299-3304.
13. Bougeard G., Baert-Desurmont S., Tournier I., Vasseur S., Martin C., et al. Impact of the MDM2 SNP309 and p53 arg72-to-pro polymorphism on age of tumour onset in Li-Fraumeni syndrome. J. Med. Genet. 2006, 43:531-533.
14. Bourdon J.C. p53 and its isoforms in cancer. Br. J. Cancer 2007, 97:277-282.
15. Brunet A., Datta S.R., Greenberg M.E. Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr. Opin. Neurobiol. 2001, 11:297-305.
16. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303:2011-2015.
17. Burgering B.M., Kops G.J. Cell cycle and death control: long live Forkheads. Trends Biochem. Sci. 2002, 27:352-360.
18. Bustamante C.D., Nielsen R., Hartl D.L. A maximum likelihood method for analyzing pseudogene evolution: implications for silent site evolution in humans and rodents. Mol. Biol. Evol. 2002, 19:110-127.
19. Caliebe A., Kleindorp R., Blanché H., Christiansen L., Puca A.A., et al. No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis. Ageing Res. Rev. 2010, 9:238-244.
20. Campisi J. Cancer and ageing: rival demons?. Nat. Rev. Cancer 2003, 3:339-349.
21. Campo S., Sardo M.A., Trimarchi G., Bonaiuto M., Fontana L., et al. Association between serum paraoxonase (PON1) gene promoter T(-107)C polymorphism, PON1 activity and HDL levels in healthy Sicilian octogenarians. Exp. Gerontol. 2004, 39:1089-1094.
22. Carter C.S., Hofer T., Seo A.Y., Leeuwenburgh C. Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention. Appl. Physiol. Nutr. Metab. 2007, 32:954-966.
23. Cerinic M.M., Generini S., Partsch G., Pignone A., Dini G., et al. Synoviocytes from osteoarthritis and rheumatoid arthritis produce plasminogen activators and plasminogen activator inhibitor-1 and display u-PA receptors on their surface. Life Sci. 1998, 63:441-453.
24. Chang B.D., Watanabe K., Broude E.V., Fang J., Poole J.C., et al. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:4291-4296.
25. Cheng C.L., Gao T.Q., Wang Z., Li D.D. Role of insulin/insulin-like growth factor 1 signaling pathway in longevity. World J. Gastroenterol. 2005, 11:1891-1895.
26. Cherry N., Mackness M., Durrington P., Povey A., Dippnall M., et al. Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip. Lancet 2002, 359:763-764.
27. Choudhury A.R., Ju Z., Djojosubroto M.W., Schienke A., Lechel A., Schaetzlein S., et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat. Genet. 2007, 39:99-105.
28. Christensen K., Johnson T.E., Vaupel J.W. The quest for genetic determinants of human longevity: challenges and insights. Nat. Rev. Genet. 2006, 7:436-448.
29. Clancy D.J., Gems D., Harshman L.G., Oldham S., Stocker H., et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 2001, 292:104-106.
30. Cohen E., Dillin A. The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat. Rev. Neurosci. 2008, 9:759-767.
31. De Benedictis G., Falcone E., Rose G., Ruffolo R., Spadafora P., et al. DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus. Hum. Genet. 1997, 99:312-318.
32. De Benedictis G., Carotenuto L., Carrieri G., De Luca M., Falcone E., et al. Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur. J. Hum. Genet. 1998, 6:534-541.
33. De Benedictis G., Carotenuto L., Carrieri G., De Luca M., Falcone E., et al. Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur. J. Hum. Genet. 2009, 6:534-541.
34. De Lucs M., Rose G., Bonafè M., Garasto S., Greco V., et al. Sex-sepecific longevity associations defined by tyrosine hydroxylase-insulin-insulin growth factor 2 haplotypes on the 11p15.5 chromosomal region. Exp. Gerontol. 2001, 36:1663-1671.
35. Dijkers R.H., Medema C., Pals L., Banerji N.S., Thomas, et al. Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27 (KIP1). Mol. Cell Biol. 2000, 20:9138-9148.
36. Dillin A., Crawford D.K., Kenyon C. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 2002, 298:830-834.
37. Dozmrov I., Bartke A., Miller R.A. Array-based expression analysis of mouse liver genes: effect of age and of the longevity mutant Prop 1df. J. Gerontol. 2001, 56:B72-B80.
38. Draganov D.I., Teiber J.F., Speelman A., Osawa Y., Sunahara R., et al. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J. Lipid Res. 2005, 46:1239-1247.
39. Dudek S.M., Johnson G.V. Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide. Brain Res. 1994, 651:129-133.
40. Dumont P., Leu J.I., Della Pietra A.C.L., George D.L., Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet. 2003, 33:357-365.
41. Eggertsen G., Tegelman R., Ericsson S., Angelin B., Berglund L. Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations. Clin. Chem. 1993, 39:2125-2129.
42. el-Deiry W.S., Harper J.W., O'Connor P.M., Velculescu V.E., Canman C.E., et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 1994, 54:1169-1174.
43. Flachsbart F., Caliebe A., Kleindorp R., Blanché H., von Eller-Eberstein H., et al. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2700-2705.
44. Frisoni G.B., Louhija J., Geroldi C., Trabucchi M. Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. J. Gerontol. A: Biol. Sci. Med. Sci. 2001, 56:M75-M78.
45. Garigan D., Hsu A.L., Fraser A.G., Kamath R.S., Ahringer J., et al. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heatshock factor and bacterial proliferation. Genetics 2002, 161:1101-1112.
46. Gaspari L., Pedotti P., Bonafè M., Franceschi C., Marinelli D., et al. Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls. Biomarkers 2003, 8:522-528.
47. GenAge Database, 2010. http://genomics.senescence.info/genes/longevity.html.
48. Gravina S., Lescai F., Hurteau G., Brock G.J., Saramaki A., et al. Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging 2009, 1:470-480.
49. Greer E.L., Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005, 24:7410-7425.
50. Herndon L.A., Schmeissner P.J., Dudaronek J.M., Brown P.A., Listner K.M., et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 2002, 419:808-814.
51. Herskind A.M., McGue M., Holm N.V., Sørensen T.I., Harvald B., et al. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum. Genet. 1996, 97:319-323.
52. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003, 421:182-187.
53. Hsin H., Kenyon C. Signals from the reproductive system regulate the lifespan of C. elegans. Nature 1999, 399:362-366.
54. Hu M.C., Lee D.F., Xia W., Golfman L.S., Ou-Yang F., et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004, 117:225-237.
55. Hwangbo D.S., Gersham B., Tu M.P., Palmer M., Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2001, 429:562-566.
56. Ikeda T., Obayashi H., Hasegawa G., Nakamura N., Yoshikawa T., et al. Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration. Am. J. Ophthal. 2001, 132:191-195.
57. Ito T., Yasue H., Yoshimura M., Nakamura S., Nakayama M., et al. Paraoxonase gene gln192-to-arg (Q192R) polymorphism is associated with coronary artery spasm. Hum. Genet. 2002, 110:89-94.
58. Jensen L.E., Whitehead A.S. Regulation of serum amyloid A protein expression during the acute-phase response. Biochem. J. 1998, 334(Pt 3):489-503.
59. Jones J.S., Chi X., Gu X., Lynch P.M., Amos C.I., et al. p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. Clin. Cancer Res. 2004, 10:5845-5849.
60. Junger M.A., Rintelen F., Stocker H., Wasserman J.D., Vegh M., et al. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2003, 2:20.
61. Kappeler L., De Magalhaes F.C., Dupont J., Leneuve P., Cervera P., et al. Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol. 2008, 6:e254.
62. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 2005, 120:449-460.
63. Kenyon C., Murphy C.T. Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nat. Genet. 2006, 38:397-398.
64. Khabour O.F., Abdelhalim E.S., Abu-Wardeh A. Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population. BMC Geriatr. 2009, 15:57.
65. Kojima T., Kamei H., Aizu T., Arai Y., Takayama M., et al. Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Exp. Gerontol. 2004, 39:1595-1598.
66. Kolovou G.D., Anagnostopoulou K.K. Apolipoprotein E polymorphism, age and coronary heart disease. Ageing Res. Rev. 2007, 6:94-108.
67. Kolovou G.D., Yiannakouris N., Hatzivassiliou M., Malakos J., Daskalova D., et al. Association of apolipoprotein E polymorphism with myocardial infarction in Greek patients with coronary artery disease. Curr. Med. Res. Opin. 2002, 18:118-124.
68. Kolovou G.D., Anagnostopoulou K.K., Cokkinos D.V. Apolipoprotein epsilon4 homozygosity and essential hypertension. South Med. J. 2004, 97:1022.
69. Kops R.H., Medema J., Glassford M.A., Essers P.F., Dijkers, et al. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell Biol. 2002, 22:2025-2236.
70. Kops G.J., Dansen T.B., Polderman P.E., Saarloos I., Wirtz K.W., et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 2002, 419:316-321.
71. Kuzuya M., Ando F., Iguchi A., Shimokata H. Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort. Am. J. Clin. Nutr. 2008, 87:1939-1944.
72. Lambert A.J., Brand M.D. Reactive oxygen species production by mitochondria. Methods Mol. Biol. 2009, 554:165-181.
73. Lee S.S., Kennedy S., Tolonen A.C., Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science 2003, 300:644-647.
74. Lescai F., Marchegiani F., Franceschi C. PON1 is a longevity gene: results of a meta-analysis. Aging Res. Rev. 2009, 8:277-284.
75. Li P., Lee H., Guo S., Unterman T.G., Jenster G., et al. AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. Mol. Cell Biol. 2003, 23:104-118.
76. Li Y., Wang W.J., Cao H., Lu J., Wu C., et al. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum. Mol. Genet. 2009, 18:4897-4904.
77. Li H., Wang C.Y., Wang J.X., Tang N.L., Xie L., et al. The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population. BMC Med. Genet. 2009, 10:134.
78. Lin K., Dorman J.B., Rodan A., Kenyon C. DAF-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 1997, 278:1319-1322.
79. Lin S.S., Manchester J.K., Gordon J.I. Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae. J. Biol. Chem. 2001, 276:36000-36007.
80. Louhija J., Miettinen H.E., Kontula K., Tikkanen M.J., Miettinen T.A., et al. Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscler. Thromb. 1994, 14:1084-1089.
81. Lunetta K.L., D'Agostino R.B., Karasik D., Benjamin E.J., Guo C.Y., et al. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med. Genet. 2007, 8(Suppl. 1):S13.
82. Marin M.C., Jost C.A., Brooks L.A., Irwin M.S., O'Nions J., et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat. Genet. 2000, 25:47-54.
83. Mitchell D.A., Fadden A.J., Drickamer K. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. J. Biol. Chem. 2001, 276:28939-28945.
84. Miyauchi H., Minamino T., Tateno K., Kunieda T., Toko H., et al. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J. 2004, 23:212-220.
85. Nachtigal M., Al-Assaad Z., Mayer E.P., Kim K., Monsigny M. Galectin-3 expression in human atherosclerotic lesions. Am. J. Pathol. 1998, 152:1199-1208.
86. O'Dell S.D., Miller G.J., Cooper J.A., Hindmarsh P.C., Pringle P.J., et al. ApaI polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males. Int. J. Obes. Relat. Metab. Disord. 1997, 21:822-825.
87. Pawelec G., Larbi A. Immunity and ageing in man: annual review 2006/2007. Exp. Gerontol. 2008, 43:34-38.
88. Pawlikowska L., Hu D., Huntsman S., Sung A., Chu C., et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 2009, 8:460-472.
89. Pepe G., Di Perna V., Resta F., Lovecchio M., Chimienti G., et al. In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians. Atherosclerosis 1998, 137:407-417.
90. Pim D., Banks L. p53 polymorphic variants at codon 72 exert different effects on cell cycle progression. Int. J. Cancer 2004, 108:196-199.
91. Puigserver P., Rhee J., Donovan J., Walkey C.J., Yoon J.C., et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003, 423:550-555.
92. Ramaswamy S., Nakamura N., Sansal I., Bergeron L., Sellers W.R. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2002, 2:81-91.
93. Rea I.M., McKeown P.P., McMaster D., Young I.S., Patterson C., et al. Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. Exp. Gerontol. 2004, 39:629-635.
94. Risch N., Zhang H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 1995, 268:1584-1589.
95. Rubinsztein D.C., Easton D.F. Apolipoprotein E genetic variation and Alzheimer's disease. A meta-analysis. Dement. Geriatr. Cogn. Disord. 1999, 10:199-209.
96. Russell S.J., Kahn C.R. Endocrine regulation of ageing. Nat. Rev. Mol. Cell Biol. 2007, 8:681-691.
97. Schächter F., Faure-Delanef L., Guénot F., Rouger H., Froguel P., et al. Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 1994, 6:29-32.
98. Seki T., Selby J., Häupl T., Winchester R. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Arthritis Rheum. 1998, 41:1356-1364.
99. Seripa D., Franceschi M., Matera M.G., Panza F., Kehoe P.G., et al. Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. J. Gerontol. A: Biol. Sci. Med. Sci. 2006, 61:918-923.
100. Serrato M., Marian A.J. A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease. J. Clin. Invest. 1995, 96:3005-3008.
101. Smith J.D. Apolipoproteins and aging: emerging mechanisms. Ageing Res. Rev. 2002, 1:345-365.
102. Steger R.W., Bartke A., Cecim M. Premature ageing in transgenic mice expressing different growth hormone genes. J. Reprod. Fertil. 1993, 46(Suppl.):61-75.
103. Stessman J., Maaravi Y., Hammerman-Rozenberg R., Cohen A., Nemanov L., et al. Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. Mech. Ageing Dev. 2005, 126:333-339.
104. Storey A., Thomas M., Kalita A., Harwood C., Gardiol D., et al. Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer. Nature 1998, 393:229-234.
105. Tan Q., Bellizzi D., Rose G., Garasto S., Franceschi C., et al. The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach. Mech. Ageing Dev. 2002, 123:1403-1410.
106. Tarry-Adkins J.L., Ozanne S.E., Norden A., Cherif H., Hales C.N. Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity. Am. J. Physiol. Renal. Physiol. 2006, 290:F509-F516.
107. Tatar M., Kopelman A., Epstein D., Tu M.P., Yin C.M., et al. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001, 292:107-110.
108. Thomas M., Kalita A., Labrecque S., Pim D., Banks L., et al. Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol. Cell Biol. 1999, 19:1092-1100.
109. Toledo F., Wahl G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 2006, 6:909-923.
110. Tran H., Brunet A., Grenier J.M., Datta S.R., Fornace A.J., et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 2002, 296:530-534.
111. Tullet J.M., Hertweck M., An J.H., Baker J., Hwang J.Y., et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 2008, 132:1025-1038.
112. van Der Horst A., Burgering B.M. Stressing the role of FoxO proteins in lifespan and disease. Nat. Rev. Mol. Cell Biol. 2007, 8:440-450.
113. van Heemst D., Mooijaart S.P., Beekman M., Schreuder J., de Craen A.J., et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol. 2005, 40:11-15.
114. van Hemmst D., Beekman M., Mooijaart S.P., Heijmans B.T., Brandt B.W., et al. Reduced insulin/IGF-1 signalling and human longevity. Aging Cell 2005, 4:79-85.
115. Vasto S., Candore G., Balistreri C.R., Caruso M., Colonna-Romano G., et al. Inflammatory networks in ageing, age-related diseases and longevity. Mech. Ageing Dev. 2007, 128:83-91.
116. Vivanco I., Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2002, 7:489-501.
117. Vousden K.H., Lane D.P. p53 in health and disease. Nat. Rev. Mol. Cell Biol. 2007, 8:275-283.
118. Willcox B.J., He Q., Chen R., Yano K., Masaki K.H., et al. Midlife risk factors and healthy survival in men. JAMA 2006, 296:2343-2350.
119. Willcox B.J., Donlon T.A., He Q., Chen R., Grove J.S., et al. FOXO3A genotype is strongly associated with human longevity. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:13987-13992.
120. Wilson P.W.F., Schaefer E.J., Larson M.G., Ordovas J.M. Apolipoprotein E alleles and risk of coronary disease, a meta-analysis. Arterioscler. Thromb. Vasc. Biol. 1996, 16:1250-1255.
121. Wolkow C.A., Kimura K.D., Lee M.S., Ruvkun G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 2000, 290:147-150.
122. Xia Y., Gueguen R., Vincent-Viry M., Siest G., Visvikis S. Effect of six candidate genes on early aging in a French population. Aging Clin. Exp. Res. 2003, 15:111-116.
123. Yashin A.I., Iachine I.A., Harris J.R. Half of the variation in susceptibility to mortality is genetic: findings from Swedish twin survival data. Behav. Genet. 1999, 29:11-19.
124. Yu C.E., Oshima J., Fu Y.H., Wijsman E.M., Hisama F., et al. Positional cloning of the Werner's syndrome gene. Science 1996, 272:258-262.
125. Zanella F., Link W., Carnero A. Understanding FOXO, new views on old transcription factors. Curr. Cancer Drug Targets 2010, 10:135-146.