Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27KIP1

Molecular and Cellular Biology

Volumn 20, Issue 24, 2000, Pages 9138-9148

  Dijkers, P F ^a   Medema, R H ^a   Pals, C ^a   Banerji, L ^a   Thomas, N S B ^a   Lam, E W F ^a   Burgering, B M T ^a   Raaijmakers, J A M ^a   Lammers, J W J ^a   Koenderman, L ^a   Coffer, P J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYTOKINE; INTERLEUKIN 3; MESSENGER RNA; PROTEIN P27; TAMOXIFEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR L1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN COS1; CELL SURVIVAL; CONTROLLED STUDY; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL CYCLE PROTEINS; CELL LINE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYTOKINES; DNA-BINDING PROTEINS; ENZYME INHIBITORS; EOSINOPHILS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GENES, REPORTER; HEMATOPOIETIC STEM CELLS; HUMANS; HYDROXYTESTOSTERONES; INTERLEUKIN-3; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PROMOTER REGIONS (GENETICS); PTEN PHOSPHOHYDROLASE; RNA; SIGNAL TRANSDUCTION; SIROLIMUS; TAMOXIFEN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MURINAE;

EID: 0034459180     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.24.9138-9148.2000     Document Type: Article

References (62)

1. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
2. Cytokines: Coordinators of immune and inflammatory responses
3. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
4. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
5. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes
6. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
7. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
8. Activation of the STAT3/acute phase response factor transcription factor by interleukin-5
9. Regulation of ceil death protease caspase-9 by phosphorylation
10. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer
11. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
12. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
13. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
14. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
15. Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family
16. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
17. Role of cyclin A and p27 in anti-IgM induced G1 growth arrest of murine B-cell lymphomas
18. Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9
19. Alterations of the MMAC1/PTEN gene in lymphoid malignancies
20. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
21. Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors
22. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
23. Translational control of p27Kip1 accumulation during the cell cycle
24. Cytokine-induced protein kinase B activation and Bad phosphorylation do not correlate with cell survival of hematopoietic cells
25. Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry
26. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
27. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
28. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
29. An improved method for the isolation of eosinophilic granulocytes from peripheral blood of normal individuals
30. Direct control of the Forkhead transcription factor AFX by protein kinase B
31. Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1
32. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
33. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
34. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
35. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
36. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
37. Peripheral blood lymphocytes as target cells of retroviral vector-mediated gene transfer
38. Growth suppression by p16ink4 requires functional retinoblastoma protein
39. p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases
40. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
41. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
42. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
43. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
44. Impact of the expression of cyclin-dependent kinase inhibitor p27Kip1 and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma
45. Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies
46. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
47. Identification of cytokine-regutated genes in human leukocytes in vivo
48. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
49. Cyclin E-CDK2 is a regulator of p27Kip1
50. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
51. Interleukin 5 and B cell differentiation
52. Negative regulation of the forkhead transcription factor FKHR by Akt
53. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
54. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
55. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
56. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morphotinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
57. p27Kip1 overexpression causes apoptotic death of mammalian cells
58. Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
59. Life, death, and the pursuit of apoptosis
60. Differential modulation of G1 cyclins and the Cdk inhibitor p27kip1 by platelet-derived growth factor and plasma factors in density-arrested fibroblasts
61. Increased p27Kip1 cyclin-dependent kinase inhibitor gene expression following anti-IgM treatment promotes apoptosis of WEHI 231 B cells
62. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway