Apolipoprotein E genetic variation and Alzheimer's disease. A meta-analysis

Dementia and Geriatric Cognitive Disorders

Volumn 10, Issue 3, 1999, Pages 199-209

  Rubinsztein, David C ^a   Easton, Douglas F ^b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Alzheimer's disease; Apolipoprotein E; Meta analysis

Indexed keywords

APOLIPOPROTEIN E;

ALLELE; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; FAMILY HISTORY; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; ONSET AGE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CROSS-SECTIONAL STUDIES; GENOTYPE; HUMANS; VARIATION (GENETICS);

EID: 0032926539     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017120     Document Type: Article

References (44)

1. Heston LL: Alzheimer's disease; in King RA, Rotter JI, Motulsky AG (eds): The Genetic Basis of Common Diseases. Oxford, Oxford University Press, 1992, pp 792-800.
2. Roses AD, Devlin B, Conneally PM, Small GW, Saunders AM, Pritchard M, Locke PA, Haines JL, Pericak-Vance MA, Risch N: Measuring the genetic contribution of APOE in late-onset Alzheimer disease. Am J Hum Genet 1995;57(suppl):A202.
3. Cruts M, Hendricks L, van Broekhoven C: The presenilin genes: A new gene family involved in Alzheimer disease pathology. Hum Mol Genet 1996;5:1449-1455.
4. Hanlon CS, Rubinsztein DC: Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans. Atherosclerosis 1995;112:85-90.
5. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
6. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC Jr, Rimmler JB, Locke PA, Conneally PM, Schmader KE, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994;7:180-184.
7. Sandbrink R, Hartmann T, Masters CL, Beyreuther K: Genes contributing to Alzheimer's disease. Mol Psychiatry 1996;1:27-40.
8. Van Dujin CM, de Knijff P, Wehnert A, De Voecht J, Bronzova JB, Havekas LM, Hofman A, Van Broekhoven C: The apolipoprotein E ε2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol 1995;37:605-610.
9. Breslow NE, Day NE: Statistical Methods in Core Research. IARC Sci Publ No 32. Lyon, IARC, 1980, vol 1: The Design and Analysis of Case-Control Studies.
10. Risch N: Linkage analysis for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990;46:222-228.
11. Lehtimaki T, Pirttila T, Mehta PD, Wisniewski HM, Frey H, Nikkari T: Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease. Hum Genet 1995;95:39-42.
12. Mak YT, Chiu H, Woo J, Kay R, Chan YS, Hui E, Sze KH, Lum C, Kwok T, Pang CP: Apolipoprotein E genotype and Alzheimer's disease in Hong Kong elderly Chinese. Neurology 1996;46:146-149.
13. Sakoda S, Kuriyama M, Osame M, Osame M, Takahashi K, Yamano T: Apolipoprotein E ε4. Neurology 1994;44:2420-2421.
14. Frisoni GB, Calbresi L, Geroldi C, Bianchetti A, D'Acquarica AL, Govoni S, Sirtori CR, Trabucchi M, Franceschini G: Apolipoprotein E ε4 allele in Alzheimer's disease and vascular dementia. Dementia 1994;5:240-242.
15. Tsai M-S, Tangalos EG, Petersen RC, Smith GE, Schaid DJ, Kokmen E, Ivnik RJ, Thibodeau SN: Apolipoprotein E: Risk factor for Alzheimer disease. Am J Hum Genet 1994;54: 643-649.
16. Lucotte G, David F, Visvikis S, Leininger-Muller B, Siest G, Babron MC, Couderc R: Apolipoprotein E ε4 allele and Alzheimer's disease. Lancet 1993;342:1309.
17. Tsuda T, Lopez R, Rogaeva EA, Freedman M, Rogaev E, Drachman D, Pollen D, Haines J, Liang Y, McLachlan DR, Duara R, St-George-Hyslop P: Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and apolipoprotein CIl genes due to linkage disequilibrium? Ann Neurol 1994;36:97-100.
18. Dai XY, Nanko S, Hattori M, Fukuda R, Nagata K, Isse K, Ueki A, Kazamatsuri H: Association of apolipoprotein E4 with sporadic Alzheimer's disease is more pronounced in early onset type. Neurosci Lett 1994;175:74-76.
19. Talbot C, Lendon C, Craddock N, Shears S, Morris JC, Goate A: Protection against Alzheimer's disease with apoE ε2. Lancet 1994; 343:1432-1433.
20. Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S: Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993;342:697-699.
21. Tang M-X, Maestre G, Tsai W-Y, Liu X-H, Feng L, Chung W-Y, Chun M, Schofield P, Stern Y, Tycko B, Mayeux R: Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians and Hispanics in New York City. Am J Hum Genet 1996;58: 574-584.
22. Henderson AS, Easteal S, Jorm AF, Mackinnon AJ, Korten AE, Christensen H, Croft L, Jacomb PA: Apolipoprotein E-allele epsilon-4, dementia and cognitive decline in a population sample. Lancet 1995;346:1387-1390.
23. Jarvik GP, Larson EB, Goddard K, Kukull WA, Schellenberg GD, Wijsman EM: Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. Am J Hum Genet 1996;58: 191-200.
24. Poduslo SE, Riggs D, Schwankhaus J, Osborne A, Crawford F, Mullan M: Association of apolipoprotein E but not B with Alzheimer's disease. Hum Genet 1995;96:597-600.
25. Liddell M, Williams J, Bayer A, Kaiser F, Owen M: Confirmation of association between the ε4 allele of apolipoprotein E and Alzheimer's disease. J Med Genet 1994;31:197-200.
26. Gearing M, Schneider JA, Rebeck GW, Hyman BT, Mirra SS: Alzheimer's disease with and without coexisting Parkinson's disease changes: Apolipoprotein E genotype and neuropathologic correlates. Neurology 1995;45: 1985-1990.
27. St Clair D, Rennie M, Slorach E, Norrman J, Yates C, Carothers A: Apolipoprotein E ε4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers. J Med Genet 1995;32:642-644.
28. Harrington CR, Louwagie J, Rossau R, Vanmechelen E, Perry RH, Perry EK, Xuereb JH, Roth M, Wischik CM: Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types: Significance for etiological theories of Alzheimer's disease. Am J Pathol 1994;145:1472-1484.
29. Peacock ML, Fink JK: ApoE ε4 allelic association with Alzheimer's disease: Independent confirmation using denaturing gradient gel electrophoresis. Neurology 1994;44:339-241.
30. Galasko D, Saitoh T, Xia Y, Thal LJ, Katzman R, Hill LR, Hansen L: The apolipoprotein E allele ε4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease. Neurology 1994;44:1950-1951.
31. Gomez-Isla T, West HL, Rebeck GW, Harr SD, Growdon JH, Losascio JL, Peris TT, Lipsitz LA, Hyman BT: Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease. Ann Neurol 1996;39:62-70.
32. Lehtovirta M, Helisami S, Mannermaa A, Soininen H, Koivisto K, Ryynanen M, Riekkinen P Sr: Apolipoprotein E polymorphism and Alzheimer's disease in Eastern Finland. Neurosci Lett 1995;185:13-15.
33. Benjamin R, Leake A, McArthur FK, Ince PG, Candy JM, Edwardson JA, Morris CM, Bjertness E: Protective effect of apoE ε2 in Alzheimer's disease. Lancet 1994;344:473.
34. Nalbantoglu J, Gilfix BM, Bertrand P, Robitaille Y, Gauthier S, Rosenblatt DS, Poirier J: Predictive value of apolipoprotein E genotypingin Alzheimer's disease: Results of an autopsy series and an analysis of several combined studies. Ann Neurol 1994;36:889-895.
35. Kamboh MI, Sanghera DK, Ferrell RE, De Kosky ST: APOE*4-associated Alzheimer's disease risk is modified by αl-antichymotrypsin polymorphism. Nat Genet 1995;10:486-488.
36. Lannfelt L, Lilius L, Nastase M, Viitanen M, Fratiglioni L, Eggertsen G, Berglund L, Angelin B, Under J, Winblad B, Basun H: Lack of association between apolipoprotein E allele α4 and sporadic Alzheimer's disease. Neurosci Lett 1994;169:175-178.
37. Yu C-E, Payami H, Olson JM, Boehnke M, Wijsman EM, Orr HT, Kukull WA, Goddard KAB, Nemens E, White JA, Alonso ME, Taylor TD, Ball MJ, Kaye J, Morris J, Chui H, Sadovnick AD, Martin GM, Larson EB, Heston LL, Bird TD, Schellenberg GD: The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. Am J Hum Genet 1994;54:631-642.
38. Kawamata J, Tanaka S, Shimohama S, Ueda K, Kimura J: Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. J Neurol Neurosurg Psychiatry 1994;57:1414-1416.
39. Sorbi S, Nacmias B, Forleo P, Latorraca S, Gobbini I, Bracco L, Piacentini S, Amaducci L: Apo E allele frequencies in Italian sporadic and familial Alzheimer's disease. Neurosci Lett 1994;177:100-102.
40. van Gool WA, Evenhuis HM, van Duijn CM, Dutch Study Group on Down's Syndrome and Ageing: A case-control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome. Ann Neurol 1995;38: 225-230.
41. Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D: Genetic associations with human longevity and the APOE and ACE loci. Nat Genet 1994; 6:29-32.
42. Davignon J, Gregg RE, Sing CF: Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988;8:1-21.
43. Galinsky D, Tysoe C, Brayne C, Easton DF, Huppert FA, Dening TR, Paykel ES, Rubinsztein DC: Analysis of the apoE/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. Atherosclerosis 1997; 129:177-183.
44. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Myers RH, Pericak-Vance MA, Risch N, van Dujin CM: Effects of age, sex and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis. JAMA 1997;278:1349-1356.