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Volumn 32, Issue 5, 2007, Pages 954-966

Molecular mechanisms of life- And health-span extension: Role of calorie restriction and exercise intervention

Author keywords

Aging; Apoptosis; Dysfunction; Frailty; Human; Inflammation; Intervention; Muscle; Oxidative stress

Indexed keywords

ANIMAL; CALORIC INTAKE; CALORIC RESTRICTION; EXERCISE; HUMAN; LONGEVITY; PHYSIOLOGY; REVIEW;

EID: 36148957445     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H07-085     Document Type: Review
Times cited : (62)

References (121)
  • 1
    • 0023391947 scopus 로고
    • Changes in fibre type, number and diameter in developing and ageing skeletal muscle
    • PMID:3429325
    • Alnaqeeb, M.A., and Goldspink, G. 1987. Changes in fibre type, number and diameter in developing and ageing skeletal muscle. J. Anat. 153: 31-45. PMID:3429325.
    • (1987) J. Anat , vol.153 , pp. 31-45
    • Alnaqeeb, M.A.1    Goldspink, G.2
  • 2
    • 0030738721 scopus 로고    scopus 로고
    • Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging
    • PMID:9225140
    • Anglade, P., Vyas, S., Hirsch, E.C., and Agid, Y. 1997. Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging. Histol. Histopathol. 12: 603-610. PMID:9225140.
    • (1997) Histol. Histopathol , vol.12 , pp. 603-610
    • Anglade, P.1    Vyas, S.2    Hirsch, E.C.3    Agid, Y.4
  • 3
    • 0038623652 scopus 로고    scopus 로고
    • Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
    • PMID:12724520, doi:10.1073/pnas.1035720100
    • Anson, R.M., Guo, Z., De, C.R., Iyun, T., Rios, M., Hagepanos, A., et al. 2003. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc. Natl. Acad. Sci. U.S.A. 100: 6216-6220. doi:10.1073/pnas.1035720100. PMID:12724520.
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 6216-6220
    • Anson, R.M.1    Guo, Z.2    De, C.R.3    Iyun, T.4    Rios, M.5    Hagepanos, A.6
  • 4
    • 0024462118 scopus 로고
    • Effects of ageing on enzyme-histochemical, morphometrical and contractile properties of the soleus muscle in the rat
    • PMID:2809627, doi:10.1016/0022-510X(89) 90165-2
    • Ansved, T., and Larsson, L. 1989. Effects of ageing on enzyme-histochemical, morphometrical and contractile properties of the soleus muscle in the rat. J. Neurol. Sci. 93: 105-124. doi:10.1016/0022-510X(89) 90165-2. PMID:2809627.
    • (1989) J. Neurol. Sci , vol.93 , pp. 105-124
    • Ansved, T.1    Larsson, L.2
  • 5
    • 0030982145 scopus 로고    scopus 로고
    • Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle
    • PMID:9212081
    • Aspnes, L.E., Lee, C.M., Weindruch, R., Chung, S.S., Roecker, E.B., and Aiken, J.M. 1997. Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J. 11: 573-581. PMID:9212081.
    • (1997) FASEB J , vol.11 , pp. 573-581
    • Aspnes, L.E.1    Lee, C.M.2    Weindruch, R.3    Chung, S.S.4    Roecker, E.B.5    Aiken, J.M.6
  • 6
    • 77956783904 scopus 로고    scopus 로고
    • The critical role of the ubiquitin-proteasome pathway in muscle wasting in comparison to lysosomal and Ca2+ dependent systems
    • Attaix, D., and Taillandier, D. 1998. The critical role of the ubiquitin-proteasome pathway in muscle wasting in comparison to lysosomal and Ca2+ dependent systems. Adv. Mol. Cell Biol. 27235-27266.
    • (1998) Adv. Mol. Cell Biol , pp. 27235-27266
    • Attaix, D.1    Taillandier, D.2
  • 7
    • 0035954510 scopus 로고    scopus 로고
    • Impaired glucose tolerance as a disease
    • 6A, 16H-19H. doi:10.1016/S0002-9149(01)01832-X. PMID:11576521
    • Baron, A.D. 2001. Impaired glucose tolerance as a disease. Am. J. Cardiol. 88 (6A): 16H-19H. doi:10.1016/S0002-9149(01)01832-X. PMID:11576521.
    • (2001) Am. J. Cardiol , vol.88
    • Baron, A.D.1
  • 8
    • 0034096242 scopus 로고    scopus 로고
    • Body composition in healthy aging
    • PMID:10865787
    • Baumgartner, R.N. 2000. Body composition in healthy aging. Ann. N. Y. Acad. Sci. 904: 437-448. PMID:10865787.
    • (2000) Ann. N. Y. Acad. Sci , vol.904 , pp. 437-448
    • Baumgartner, R.N.1
  • 9
    • 0035160315 scopus 로고    scopus 로고
    • Quantification and sequencing of somatic deleted mtDNA in single cells: Evidence for partially duplicated mtDNA in aged human tissues
    • PMID:11136709, doi:10.1093/hmg/10.1.17
    • Bodyak, N.D., Nekhaeva, E., Wei, J.Y., and Khrapko, K. 2001. Quantification and sequencing of somatic deleted mtDNA in single cells: evidence for partially duplicated mtDNA in aged human tissues. Hum. Mol. Genet. 10: 17-24. doi:10.1093/hmg/10.1.17. PMID:11136709.
    • (2001) Hum. Mol. Genet , vol.10 , pp. 17-24
    • Bodyak, N.D.1    Nekhaeva, E.2    Wei, J.Y.3    Khrapko, K.4
  • 10
    • 0035504933 scopus 로고    scopus 로고
    • Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection
    • PMID:11691938, doi:10.1093/nar/29.21.4502
    • Cao, Z., Wanagat, J., McKiernan, S.H., and Aiken, J.M. 2001. Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res. 29: 4502-4508. doi:10.1093/nar/29.21.4502. PMID:11691938.
    • (2001) Nucleic Acids Res , vol.29 , pp. 4502-4508
    • Cao, Z.1    Wanagat, J.2    McKiernan, S.H.3    Aiken, J.M.4
  • 12
    • 3242714939 scopus 로고    scopus 로고
    • Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet
    • PMID:15247027, doi:10.1196/annals.1297.045
    • Cassano, P., Lezza, A.M., Leeuwenburgh, C., Cantatore, P., and Gadaleta, M.N. 2004. Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet. Ann. N. Y. Acad. Sci. 1019: 269-273. doi:10.1196/annals.1297.045. PMID:15247027.
    • (2004) Ann. N. Y. Acad. Sci , vol.1019 , pp. 269-273
    • Cassano, P.1    Lezza, A.M.2    Leeuwenburgh, C.3    Cantatore, P.4    Gadaleta, M.N.5
  • 13
    • 1342286106 scopus 로고    scopus 로고
    • Antioxidants and physical performance in elderly persons: The Invecchiare in Chianti (In-CHIANTI) study
    • PMID:14749236
    • Cesari, M., Pahor, M., Bartali, B., Cherubini, A., Penninx, B.W., Williams, G.R., et al. 2004. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (In-CHIANTI) study. Am. J. Clin. Nutr. 79: 289-294. PMID:14749236.
    • (2004) Am. J. Clin. Nutr , vol.79 , pp. 289-294
    • Cesari, M.1    Pahor, M.2    Bartali, B.3    Cherubini, A.4    Penninx, B.W.5    Williams, G.R.6
  • 14
    • 0032212809 scopus 로고    scopus 로고
    • Role of cytokines in AIDS wasting
    • PMID:9834928, doi:10.1016/ 80899-9007(98)00108-7
    • Chang, H.R., Dulloo, A.G., and Bistrian, B.R. 1998. Role of cytokines in AIDS wasting. Nutrition, 14: 853-863. doi:10.1016/ 80899-9007(98)00108-7. PMID:9834928.
    • (1998) Nutrition , vol.14 , pp. 853-863
    • Chang, H.R.1    Dulloo, A.G.2    Bistrian, B.R.3
  • 15
    • 0037427414 scopus 로고    scopus 로고
    • MtDNA mutations in aging and apoptosis
    • PMID:12729587, doi: 10.1016/S0006-291X(03) 00625-9
    • Chomyn, A., and Attardi, G. 2003. MtDNA mutations in aging and apoptosis. Biochem. Biophys. Res. Commun. 304: 519-529. doi: 10.1016/S0006-291X(03) 00625-9. PMID:12729587.
    • (2003) Biochem. Biophys. Res. Commun , vol.304 , pp. 519-529
    • Chomyn, A.1    Attardi, G.2
  • 16
    • 0037112204 scopus 로고    scopus 로고
    • Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction
    • PMID:12424787, doi:10.1002/jemt.10203
    • Chung, H.Y., Kim, H.J., Kim, K.W., Choi, J.S., and Yu, B.P. 2002. Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc. Res. Tech. 59: 264-272. doi:10.1002/jemt.10203. PMID:12424787.
    • (2002) Microsc. Res. Tech , vol.59 , pp. 264-272
    • Chung, H.Y.1    Kim, H.J.2    Kim, K.W.3    Choi, J.S.4    Yu, B.P.5
  • 17
    • 0032992534 scopus 로고    scopus 로고
    • Mitochondria in organismal aging and degeneration
    • PMID:10076026
    • Cortopassi, G.A., and Wong, A. 1999. Mitochondria in organismal aging and degeneration. Biochim. Biophys. Acta, 1410: 183-193. PMID:10076026.
    • (1999) Biochim. Biophys. Acta , vol.1410 , pp. 183-193
    • Cortopassi, G.A.1    Wong, A.2
  • 18
    • 0026732706 scopus 로고
    • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
    • PMID: 1502147, doi:10.1073/pnas.89.16.7370
    • Cortopassi, G.A., Shibata, D., Soong, N.W., and Arnheim, N. 1992. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. U.S.A. 89: 7370-7374. doi:10.1073/pnas.89.16.7370. PMID: 1502147.
    • (1992) Proc. Natl. Acad. Sci. U.S.A , vol.89 , pp. 7370-7374
    • Cortopassi, G.A.1    Shibata, D.2    Soong, N.W.3    Arnheim, N.4
  • 19
    • 0037418174 scopus 로고    scopus 로고
    • Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum
    • PMID:12606714, doi:10.1073/pnas.0630589100
    • Coskun, P.E., Ruiz-Pesini, E., and Wallace, D.C. 2003. Control region mtDNA variants: longevity, climatic adaptation, and a forensic conundrum. Proc. Natl. Acad. Sci. U.S.A. 100: 2174-2176. doi:10.1073/pnas.0630589100. PMID:12606714.
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 2174-2176
    • Coskun, P.E.1    Ruiz-Pesini, E.2    Wallace, D.C.3
  • 20
    • 0037164094 scopus 로고    scopus 로고
    • Platelet activation in obese women: Role of inflammation and oxidant stress
    • PMID:12387653, doi:10.1001/jama.288.16.2008
    • Davi, G., Guagnano, M.T., Ciabattoni, G., Basili, S., Falco, A., Marinopiccoli, M., et al. 2002. Platelet activation in obese women: role of inflammation and oxidant stress. JAMA, 288: 2008-2014. doi:10.1001/jama.288.16.2008. PMID:12387653.
    • (2002) JAMA , vol.288 , pp. 2008-2014
    • Davi, G.1    Guagnano, M.T.2    Ciabattoni, G.3    Basili, S.4    Falco, A.5    Marinopiccoli, M.6
  • 21
    • 0842346331 scopus 로고    scopus 로고
    • Determinants of F2-isoprostane biosynthesis and inhibition in man
    • PMID:15037160
    • Davi, G., Falco, A., and Patrono, C. 2004. Determinants of F2-isoprostane biosynthesis and inhibition in man. Chem. Phys. Lipids, 128: 149-163. PMID:15037160.
    • (2004) Chem. Phys. Lipids , vol.128 , pp. 149-163
    • Davi, G.1    Falco, A.2    Patrono, C.3
  • 22
    • 0036049037 scopus 로고    scopus 로고
    • Effects of antioxidants on immune system ageing
    • PMID:12142953, doi:10.1038/sj.ejcn.1601476
    • De la Fuente, M. 2002. Effects of antioxidants on immune system ageing. Eur. J. Clin. Nutr. 56 (Suppl. 3): S5-S8. doi:10.1038/sj.ejcn.1601476. PMID:12142953.
    • (2002) Eur. J. Clin. Nutr , vol.56 , Issue.SUPPL. 3
    • De la Fuente, M.1
  • 23
    • 0037110426 scopus 로고    scopus 로고
    • Evidence and age-related distribution of mtDNA D-loop point mutations in skeletal muscle from healthy subjects and mitochondrial patients
    • PMID: 12220698, doi:10.1016/S0022- 510X(02)00247-2
    • Del Bo, R., Bordoni, A., Martinelli Boneschi, F., Crimi, M., Sciacco, M., Bresolin, N., et al. 2002. Evidence and age-related distribution of mtDNA D-loop point mutations in skeletal muscle from healthy subjects and mitochondrial patients. J. Neurol. Sci. 202: 85-91. doi:10.1016/S0022- 510X(02)00247-2. PMID: 12220698.
    • (2002) J. Neurol. Sci , vol.202 , pp. 85-91
    • Del Bo, R.1    Bordoni, A.2    Martinelli Boneschi, F.3    Crimi, M.4    Sciacco, M.5    Bresolin, N.6
  • 25
    • 0347318125 scopus 로고    scopus 로고
    • Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis represser, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12
    • PMID:14732288, doi:10.1016/j. freeradbiomed.2003.10.003
    • Dirks, A.J., and Leeuwenburgh, C. 2004. Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis represser, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12. Free Radic. Biol. Med. 36: 27-39. doi:10.1016/j. freeradbiomed.2003.10.003. PMID:14732288.
    • (2004) Free Radic. Biol. Med , vol.36 , pp. 27-39
    • Dirks, A.J.1    Leeuwenburgh, C.2
  • 26
    • 22344444732 scopus 로고    scopus 로고
    • The role of apoptosis in age-related skeletal muscle atrophy
    • PMID:15974633
    • Dirks, A.J., and Leeuwenburgh, C. 2005. The role of apoptosis in age-related skeletal muscle atrophy. Sports Med. 35: 473-483. PMID:15974633.
    • (2005) Sports Med , vol.35 , pp. 473-483
    • Dirks, A.J.1    Leeuwenburgh, C.2
  • 27
    • 28244466940 scopus 로고    scopus 로고
    • Caloric restriction in humans: Potential pitfalls and health concerns
    • PMID:16226298, doi:10.1016/j.mad.2005.09.001
    • Dirks, A.J., and Leeuwenburgh, C. 2006. Caloric restriction in humans: potential pitfalls and health concerns. Mech. Ageing Dev. 127: 1-7. doi:10.1016/j.mad.2005.09.001. PMID:16226298.
    • (2006) Mech. Ageing Dev , vol.127 , pp. 1-7
    • Dirks, A.J.1    Leeuwenburgh, C.2
  • 28
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • PMID:11773609
    • Droge, W. 2002. Free radicals in the physiological control of cell function. Physiol. Rev. 82: 47-95. PMID:11773609.
    • (2002) Physiol. Rev , vol.82 , pp. 47-95
    • Droge, W.1
  • 29
    • 0030347163 scopus 로고    scopus 로고
    • Cell suicide in health and disease
    • PMID:8923763
    • Duke, R.C., Ojcius, D.M., and Young, J.D. 1996. Cell suicide in health and disease. Sci. Am. 275: 80-87. PMID:8923763.
    • (1996) Sci. Am , vol.275 , pp. 80-87
    • Duke, R.C.1    Ojcius, D.M.2    Young, J.D.3
  • 30
    • 0028789750 scopus 로고
    • Interleukin-6 induces proteolysis by activating intracellular proteases (cathepsins B and L, proteasome) in C2C12 myotubes
    • PMID:7493444
    • Ebisui, C., Tsujinaka, T., Morimoto, T., Kan, K., Iijima, S., Yano, M., et al. 1995. Interleukin-6 induces proteolysis by activating intracellular proteases (cathepsins B and L, proteasome) in C2C12 myotubes. Clin. Sci. 89: 431-439. PMID:7493444.
    • (1995) Clin. Sci , vol.89 , pp. 431-439
    • Ebisui, C.1    Tsujinaka, T.2    Morimoto, T.3    Kan, K.4    Iijima, S.5    Yano, M.6
  • 31
    • 22144434468 scopus 로고    scopus 로고
    • Sarcopenia is not due to lack of regenerative drive in senescent skeletal muscle
    • PMID:15771610, doi:10.1111/j.1474-9728.2005.00145.x
    • Edstrom, E., and Ulfhake, B. 2005. Sarcopenia is not due to lack of regenerative drive in senescent skeletal muscle. Aging Cell, 4: 65-77. doi:10.1111/j.1474-9728.2005.00145.x. PMID:15771610.
    • (2005) Aging Cell , vol.4 , pp. 65-77
    • Edstrom, E.1    Ulfhake, B.2
  • 32
    • 18244386768 scopus 로고    scopus 로고
    • Age and sex influence on oxidative damage and functional status in human skeletal muscle
    • doi:10.1023/A:1013122805060. PMID:11808774
    • Fano, G., Mecocci, P., Vecchiet, J., Belia, S., Fulle, S., Polidori, M.C., et al. 2001. Age and sex influence on oxidative damage and functional status in human skeletal muscle. J. Muscle Res. Cell Motil. 22: 345-351. doi:10.1023/A:1013122805060. PMID:11808774.
    • (2001) J. Muscle Res. Cell Motil , vol.22 , pp. 345-351
    • Fano, G.1    Mecocci, P.2    Vecchiet, J.3    Belia, S.4    Fulle, S.5    Polidori, M.C.6
  • 34
    • 0036903170 scopus 로고    scopus 로고
    • Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels
    • PMID: 12473005, doi:10.1046/j.1532-5415.2002. 50605.x
    • Ferrucci, L., Penninx, B.W., Volpato, S., Harris, T.B., Bandeen-Roche, K., Balfour, J., et al. 2002. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J. Am. Geriatr. Soc. 50: 1947-1954. doi:10.1046/j.1532-5415.2002. 50605.x. PMID: 12473005.
    • (2002) J. Am. Geriatr. Soc , vol.50 , pp. 1947-1954
    • Ferrucci, L.1    Penninx, B.W.2    Volpato, S.3    Harris, T.B.4    Bandeen-Roche, K.5    Balfour, J.6
  • 35
    • 0026639187 scopus 로고
    • Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activity
    • PMID:1321035
    • Foury, F., and Vanderstraeten, S. 1992. Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activity. EMBO J. 11: 2717-2726. PMID:1321035.
    • (1992) EMBO J , vol.11 , pp. 2717-2726
    • Foury, F.1    Vanderstraeten, S.2
  • 36
    • 10544222015 scopus 로고    scopus 로고
    • Fujita, J., Tsujinaka, T., Yano, M., Ebisui, C., Saito, H., Katsume, A., et al. 1996. Anti-interleukin-6 receptor antibody prevents muscle atrophy in colon-26 adenocarcinoma-bearing mice with modulation of lysosomal and ATP-ubiquitin-dependent proteolytic pathways. Int. J. Cancer, 68: 637-643. doi:10.1002/(SICI) 1097-0215(19961127)68:5<637::AID-IJC14>3.0. CO;2-Z. PMID:8938147.
    • Fujita, J., Tsujinaka, T., Yano, M., Ebisui, C., Saito, H., Katsume, A., et al. 1996. Anti-interleukin-6 receptor antibody prevents muscle atrophy in colon-26 adenocarcinoma-bearing mice with modulation of lysosomal and ATP-ubiquitin-dependent proteolytic pathways. Int. J. Cancer, 68: 637-643. doi:10.1002/(SICI) 1097-0215(19961127)68:5<637::AID-IJC14>3.0. CO;2-Z. PMID:8938147.
  • 37
    • 0032181128 scopus 로고    scopus 로고
    • Aging and mitochondria
    • PMID:9893945, doi:10.1016/S0300-9084(00)88881-1
    • Gadaleta, M.N., Cormio, A., Pesce, V., Lezza, A.M., and Cantatore, P. 1998. Aging and mitochondria. Biochimie, 80: 863-870. doi:10.1016/S0300-9084(00)88881-1. PMID:9893945.
    • (1998) Biochimie , vol.80 , pp. 863-870
    • Gadaleta, M.N.1    Cormio, A.2    Pesce, V.3    Lezza, A.M.4    Cantatore, P.5
  • 38
    • 0027372066 scopus 로고
    • Acute treatment with tumour necrosis factor-alpha induces changes in protein metabolism in rat skeletal muscle
    • PMID:8264567, doi:10.1007/BF00926829
    • Garcia-Martinez, C., Lopez-Soriano, F.J., and Argiles, J.M. 1993. Acute treatment with tumour necrosis factor-alpha induces changes in protein metabolism in rat skeletal muscle. Mol. Cell. Biochem. 125: 11-18. doi:10.1007/BF00926829. PMID:8264567.
    • (1993) Mol. Cell. Biochem , vol.125 , pp. 11-18
    • Garcia-Martinez, C.1    Lopez-Soriano, F.J.2    Argiles, J.M.3
  • 39
    • 0343196715 scopus 로고    scopus 로고
    • Decrease of rotenone inhibition is a sensitive parameter of complex I damage in brain non-synaptic mitochondria of aged rats
    • PMID:9237684, doi: 10.1016/ 80014-5793(97)00638-8
    • Genova, M.L., Bovina, C., Marchetti, M., Pallotti, F., Tietz, C., Biagini, G., et al. 1997. Decrease of rotenone inhibition is a sensitive parameter of complex I damage in brain non-synaptic mitochondria of aged rats. FEBS Lett. 410: 467-469. doi: 10.1016/ 80014-5793(97)00638-8. PMID:9237684.
    • (1997) FEBS Lett , vol.410 , pp. 467-469
    • Genova, M.L.1    Bovina, C.2    Marchetti, M.3    Pallotti, F.4    Tietz, C.5    Biagini, G.6
  • 40
    • 13844282117 scopus 로고    scopus 로고
    • Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys
    • PMID:15379855, doi:10.1111/j.1474-9728.2004.00122.x
    • Gokey, N.G., Cao, Z., Pak, J.W., Lee, D., McKiernan, S.H., McKenzie, D., et al. 2004. Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys. Aging Cell, 3: 319-326. doi:10.1111/j.1474-9728.2004.00122.x. PMID:15379855.
    • (2004) Aging Cell , vol.3 , pp. 319-326
    • Gokey, N.G.1    Cao, Z.2    Pak, J.W.3    Lee, D.4    McKiernan, S.H.5    McKenzie, D.6
  • 41
    • 0019985958 scopus 로고
    • Effects of intermittent feeding upon growth and life span in rats
    • PMID:7117847
    • Goodrick, C.L., Ingram, D.K., Reynolds, M.A., Freeman, J.R., and Cider, N.L. 1982. Effects of intermittent feeding upon growth and life span in rats. Gerontology, 28: 233-241. PMID:7117847.
    • (1982) Gerontology , vol.28 , pp. 233-241
    • Goodrick, C.L.1    Ingram, D.K.2    Reynolds, M.A.3    Freeman, J.R.4    Cider, N.L.5
  • 42
    • 0021091047 scopus 로고
    • Effects of intermittent feeding upon growth, activity, and lifespan in rats allowed voluntary exercise
    • PMID:6641783
    • Goodrick, C.L., Ingram, D.K., Reynolds, M.A., Freeman, J.R., and Cider, N.L. 1983. Effects of intermittent feeding upon growth, activity, and lifespan in rats allowed voluntary exercise. Exp. Aging Res. 9: 203-209. PMID:6641783.
    • (1983) Exp. Aging Res , vol.9 , pp. 203-209
    • Goodrick, C.L.1    Ingram, D.K.2    Reynolds, M.A.3    Freeman, J.R.4    Cider, N.L.5
  • 43
    • 0028292936 scopus 로고
    • A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission
    • PMID:8126356
    • Guralnik, J.M., Simonsick, E.M., Ferrucci, L., Glynn, R.J., Berkman, L.F., Blazer, D.G., et al. 1994. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J. Gerontol. 49: M85-M94. PMID:8126356.
    • (1994) J. Gerontol , vol.49
    • Guralnik, J.M.1    Simonsick, E.M.2    Ferrucci, L.3    Glynn, R.J.4    Berkman, L.F.5    Blazer, D.G.6
  • 44
    • 33645526333 scopus 로고    scopus 로고
    • Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: A randomized controlled trial
    • PMID:16595757, doi:10.1001/jama.295.13.1539
    • Heilbronn, L.K., De, J.L., Frisard, M.I., DeLany, J.P., Larson-Meyer, D.E., Rood, J., et al. 2006. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA, 295: 1539-1548. doi:10.1001/jama.295.13.1539. PMID:16595757.
    • (2006) JAMA , vol.295 , pp. 1539-1548
    • Heilbronn, L.K.1    De, J.L.2    Frisard, M.I.3    DeLany, J.P.4    Larson-Meyer, D.E.5    Rood, J.6
  • 45
    • 1442355816 scopus 로고    scopus 로고
    • Fiber atrophy and hypertrophy in skeletal muscles of late middle-aged Fischer 344 x Brown Norway Fl-hybrid rats
    • PMID:14999023
    • Hepple, R.T., Ross, K.D., and Rempfer, A.B. 2004. Fiber atrophy and hypertrophy in skeletal muscles of late middle-aged Fischer 344 x Brown Norway Fl-hybrid rats. J. Gerontol. A Biol. Sci. Med. Sci. 59: 108-117. PMID:14999023.
    • (2004) J. Gerontol. A Biol. Sci. Med. Sci , vol.59 , pp. 108-117
    • Hepple, R.T.1    Ross, K.D.2    Rempfer, A.B.3
  • 46
    • 0033929763 scopus 로고    scopus 로고
    • Apoptosis in the aging process
    • PMID:10928285, doi:10.1007/s004419900156
    • Higami, Y., and Shimokawa, I. 2000. Apoptosis in the aging process. Cell Tissue Res. 301: 125-132. doi:10.1007/s004419900156. PMID:10928285.
    • (2000) Cell Tissue Res , vol.301 , pp. 125-132
    • Higami, Y.1    Shimokawa, I.2
  • 47
    • 0030944390 scopus 로고    scopus 로고
    • Effect of aging and dietary restriction on hepatocyte proliferation and death in male F344 rats
    • PMID:9042773, doi:10.1007/s004410050793
    • Higami, Y., Shimokawa, I., Okimoto, T., Tomita, M., Yuo, T., and Ikeda, T. 1997. Effect of aging and dietary restriction on hepatocyte proliferation and death in male F344 rats. Cell Tissue Res. 288: 69-77. doi:10.1007/s004410050793. PMID:9042773.
    • (1997) Cell Tissue Res , vol.288 , pp. 69-77
    • Higami, Y.1    Shimokawa, I.2    Okimoto, T.3    Tomita, M.4    Yuo, T.5    Ikeda, T.6
  • 49
    • 0024226812 scopus 로고
    • Exercise and longevity: Studies on rats
    • PMID:3053868
    • Holloszy, J.O. 1988. Exercise and longevity: studies on rats. J. Gerontol. 43: B149-B151. PMID:3053868.
    • (1988) J. Gerontol , vol.43
    • Holloszy, J.O.1
  • 50
    • 0026550694 scopus 로고
    • Exercise and food restriction in rats
    • PMID:1542046
    • Holloszy, J.O. 1992. Exercise and food restriction in rats. J. Nutr. 122 (3 Suppl): 774-777. PMID:1542046.
    • (1992) J. Nutr , vol.122 , Issue.3 SUPPL. , pp. 774-777
    • Holloszy, J.O.1
  • 51
    • 0027252538 scopus 로고
    • Exercise increases average longevity of female rats despite increased food intake and no growth retardation
    • PMID:8482812
    • Holloszy, J.O. 1993. Exercise increases average longevity of female rats despite increased food intake and no growth retardation. J. Gerontol. 48: B97-B100. PMID:8482812.
    • (1993) J. Gerontol , vol.48
    • Holloszy, J.O.1
  • 52
    • 0031058447 scopus 로고    scopus 로고
    • Mortality rate and longevity of food-restricted exercising male rats: A reevaluation
    • PMID:9049716
    • Holloszy, J.O. 1997. Mortality rate and longevity of food-restricted exercising male rats: a reevaluation. J. Appl. Physiol. 82: 399-403. PMID:9049716.
    • (1997) J. Appl. Physiol , vol.82 , pp. 399-403
    • Holloszy, J.O.1
  • 53
    • 0023259349 scopus 로고
    • Effects of exercise on longevity of rats
    • PMID:3556607
    • Holloszy, J.O., and Smith, E.K. 1987. Effects of exercise on longevity of rats. Fed. Proc. 46: 1850-1853. PMID:3556607.
    • (1987) Fed. Proc , vol.46 , pp. 1850-1853
    • Holloszy, J.O.1    Smith, E.K.2
  • 54
    • 0022410244 scopus 로고
    • Effect of voluntary exercise on longevity of rats
    • PMID:4055572
    • Holloszy, J.O., Smith, E.K., Vining, M., and Adams, S. 1985. Effect of voluntary exercise on longevity of rats. J. Appl. Physiol. 59: 826-831. PMID:4055572.
    • (1985) J. Appl. Physiol , vol.59 , pp. 826-831
    • Holloszy, J.O.1    Smith, E.K.2    Vining, M.3    Adams, S.4
  • 55
    • 0026051958 scopus 로고
    • Skeletal muscle atrophy in old rats: Differential changes in the three fiber types
    • PMID:1745075, doi: 10.1016/0047-6374(91)90131-I
    • Holloszy, J.O., Chen, M., Cartee, G.D., and Young, J.C. 1991. Skeletal muscle atrophy in old rats: differential changes in the three fiber types. Mech. Ageing Dev. 60: 199-213. doi: 10.1016/0047-6374(91)90131-I. PMID:1745075.
    • (1991) Mech. Ageing Dev , vol.60 , pp. 199-213
    • Holloszy, J.O.1    Chen, M.2    Cartee, G.D.3    Young, J.C.4
  • 56
    • 33744494572 scopus 로고    scopus 로고
    • The free radical fantasy: A panoply of paradoxes
    • PMID:16803966, doi:10.1196/annals.1354.004
    • Howes, R.M. 2006. The free radical fantasy: a panoply of paradoxes. Ann. N. Y. Acad. Sci. 1067: 22-26. doi:10.1196/annals.1354.004. PMID:16803966.
    • (2006) Ann. N. Y. Acad. Sci , vol.1067 , pp. 22-26
    • Howes, R.M.1
  • 58
    • 0036246979 scopus 로고    scopus 로고
    • Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    • PMID:12028177, doi:10.1046/j.1532-5415.2002.50216.x
    • Janssen, I., Heymsfield, S.B., and Ross, R. 2002. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J. Am. Geriatr. Soc. 50: 889-896. doi:10.1046/j.1532-5415.2002.50216.x. PMID:12028177.
    • (2002) J. Am. Geriatr. Soc , vol.50 , pp. 889-896
    • Janssen, I.1    Heymsfield, S.B.2    Ross, R.3
  • 59
    • 33646012604 scopus 로고    scopus 로고
    • Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6
    • PMID:16567369
    • Kalani, R., Judge, S., Carter, C., Pahor, M., and Leeuwenburgh, C. 2006. Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6. J. Gerontol. A Biol. Sci. Med. Sci. 61: 211-217. PMID:16567369.
    • (2006) J. Gerontol. A Biol. Sci. Med. Sci , vol.61 , pp. 211-217
    • Kalani, R.1    Judge, S.2    Carter, C.3    Pahor, M.4    Leeuwenburgh, C.5
  • 60
    • 0033151863 scopus 로고    scopus 로고
    • Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions
    • PMID:10325435
    • Khrapko, K., Bodyak, N., Thilly, W.G., Van Orsouw, N.J., Zhang, X., Coller, H.A., et al. 1999. Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res. 27: 2434-2441. PMID:10325435.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2434-2441
    • Khrapko, K.1    Bodyak, N.2    Thilly, W.G.3    Van Orsouw, N.J.4    Zhang, X.5    Coller, H.A.6
  • 61
    • 27744524523 scopus 로고    scopus 로고
    • On the relevance of mitochondrial fusions for the accumulation of mitochondrial deletion mutants: A modelling study
    • PMID:16164426, doi:10.1111/j.1474-9726. 2005.00169.x
    • Kowald, A., Jendrach, M., Pohl, S., Bereiter-Hahn, J., and Hammerstein, P. 2005. On the relevance of mitochondrial fusions for the accumulation of mitochondrial deletion mutants: a modelling study. Aging Cell, 4: 273-283. doi:10.1111/j.1474-9726. 2005.00169.x. PMID:16164426.
    • (2005) Aging Cell , vol.4 , pp. 273-283
    • Kowald, A.1    Jendrach, M.2    Pohl, S.3    Bereiter-Hahn, J.4    Hammerstein, P.5
  • 62
    • 0037287897 scopus 로고    scopus 로고
    • Mutation and intracellular clonal expansion of mitochondrial genomes: Two synergistic components of the aging process?
    • PMID:12618006, doi:10.1016/S0047-6374(02)00169-0
    • Kraytsberg, Y., Nekhaeva, E., Bodyak, N.B., and Khrapko, K. 2003. Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process? Mech. Ageing Dev. 124: 49-53. doi:10.1016/S0047-6374(02)00169-0. PMID:12618006.
    • (2003) Mech. Ageing Dev , vol.124 , pp. 49-53
    • Kraytsberg, Y.1    Nekhaeva, E.2    Bodyak, N.B.3    Khrapko, K.4
  • 63
    • 22344456832 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
    • PMID:16020738, doi:10.1126/science.1112125
    • Kujoth, G.C., Hiona, A., Pugh, T.D., Someya, S., Panzer, K., Wohlgemuth, S.E., et al. 2005. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (Washington, D.C.), 309: 481-484. doi:10.1126/science.1112125. PMID:16020738.
    • (2005) Science (Washington, D.C.) , vol.309 , pp. 481-484
    • Kujoth, G.C.1    Hiona, A.2    Pugh, T.D.3    Someya, S.4    Panzer, K.5    Wohlgemuth, S.E.6
  • 64
    • 0018151316 scopus 로고
    • Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22-65 years
    • PMID:208350
    • Larsson, L., Sjodin, B., and Karlsson, J. 1978. Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22-65 years. Acta Physiol. Scand. 103: 31-39. PMID:208350.
    • (1978) Acta Physiol. Scand , vol.103 , pp. 31-39
    • Larsson, L.1    Sjodin, B.2    Karlsson, J.3
  • 65
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • PMID:10464095, doi:10.1126/science.285.5432.1390
    • Lee, C.K., Klopp, R.G., Weindruch, R., and Prolla, T.A. 1999. Gene expression profile of aging and its retardation by caloric restriction. Science (Washington, D.C.), 285: 1390-1393. doi:10.1126/science.285.5432.1390. PMID:10464095.
    • (1999) Science (Washington, D.C.) , vol.285 , pp. 1390-1393
    • Lee, C.K.1    Klopp, R.G.2    Weindruch, R.3    Prolla, T.A.4
  • 67
    • 0028863055 scopus 로고    scopus 로고
    • Lexell, J. 1995. Human aging, muscle mass, and fiber type composition. J. Gerontol. A Biol. Sci. Med. Sci. 50 (Spec No): 11-16.
    • Lexell, J. 1995. Human aging, muscle mass, and fiber type composition. J. Gerontol. A Biol. Sci. Med. Sci. 50 (Spec No): 11-16.
  • 68
    • 0031802331 scopus 로고    scopus 로고
    • Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha
    • PMID:9657527
    • Li, Y.P., Schwartz, R.J., Waddell, I.D., Holloway, B.R., and Reid, M.B. 1998. Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. FASEB J. 12: 871-880. PMID:9657527.
    • (1998) FASEB J , vol.12 , pp. 871-880
    • Li, Y.P.1    Schwartz, R.J.2    Waddell, I.D.3    Holloway, B.R.4    Reid, M.B.5
  • 69
    • 0036957705 scopus 로고    scopus 로고
    • 8-iso-prostaglandin F2alpha as a useful clinical biomarker of oxidative stress in ESRD patients
    • PMID:12566669, doi:10.1159/000066962
    • Lim, P.S., Chang, Y.M., Thien, L.M., Wang, N.P., Yang, C.C., Chen, T.T., and Hsu, W.M. 2002. 8-iso-prostaglandin F2alpha as a useful clinical biomarker of oxidative stress in ESRD patients. Blood Purif. 20: 537-542. doi:10.1159/000066962. PMID:12566669.
    • (2002) Blood Purif , vol.20 , pp. 537-542
    • Lim, P.S.1    Chang, Y.M.2    Thien, L.M.3    Wang, N.P.4    Yang, C.C.5    Chen, T.T.6    Hsu, W.M.7
  • 70
    • 0029030425 scopus 로고
    • Is late-life caloric restriction beneficial?
    • PMID:7548264
    • Lipman, R.D., Smith, D.E., Bronson, R.T., and Blumberg, J. 1995. Is late-life caloric restriction beneficial? Aging (Milano), 7: 136-139. PMID:7548264.
    • (1995) Aging (Milano) , vol.7 , pp. 136-139
    • Lipman, R.D.1    Smith, D.E.2    Bronson, R.T.3    Blumberg, J.4
  • 71
    • 0027305562 scopus 로고
    • Effects of tumor necrosis factor-alpha on muscle-protein turnover in female Wistar rats
    • PMID:8340946, doi:10. 1093/jnci/85.16.1334
    • Llovera, M., Lopez-Soriano, F.J., and Argiles, J.M. 1993. Effects of tumor necrosis factor-alpha on muscle-protein turnover in female Wistar rats. J. Natl. Cancer Inst. 85: 1334-1339. doi:10. 1093/jnci/85.16.1334. PMID:8340946.
    • (1993) J. Natl. Cancer Inst , vol.85 , pp. 1334-1339
    • Llovera, M.1    Lopez-Soriano, F.J.2    Argiles, J.M.3
  • 72
    • 0029885829 scopus 로고    scopus 로고
    • Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats
    • PMID:8630016, doi:10.1006/bbrc.1996.0651
    • Llovera, M., Carbo, N., Garcia-Martinez, C., Costelli, P., Tessitore, L., Baccino, P.M., et al. 1996. Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats. Biochem. Biophys. Res. Commun. 221: 653-655. doi:10.1006/bbrc.1996.0651. PMID:8630016.
    • (1996) Biochem. Biophys. Res. Commun , vol.221 , pp. 653-655
    • Llovera, M.1    Carbo, N.2    Garcia-Martinez, C.3    Costelli, P.4    Tessitore, L.5    Baccino, P.M.6
  • 73
    • 0031566181 scopus 로고    scopus 로고
    • TNF can directly induce the expression of ubiquitin-dependent proteolytic system in rat soleus muscles
    • PMID:9016756, doi:10.1006/bbrc.1996.5827
    • Llovera, M., Garcia-Martinez, C., Agell, N., Lopez-Soriano, F.J., and Argiles, J.M. 1997. TNF can directly induce the expression of ubiquitin-dependent proteolytic system in rat soleus muscles. Biochem. Biophys. Res. Commun. 230: 238-241. doi:10.1006/bbrc.1996.5827. PMID:9016756.
    • (1997) Biochem. Biophys. Res. Commun , vol.230 , pp. 238-241
    • Llovera, M.1    Garcia-Martinez, C.2    Agell, N.3    Lopez-Soriano, F.J.4    Argiles, J.M.5
  • 74
    • 0032416035 scopus 로고    scopus 로고
    • Different cytokines modulate ubiquitin gene expression in rat skeletal muscle
    • PMID: 9929164, doi:10.1016/S0304-3835(98)00216-X
    • Llovera, M., Carbo, N., Lopez-Soriano, J., Garcia-Martinez, C., Busquets, S., Alvarez, B., et al. 1998. Different cytokines modulate ubiquitin gene expression in rat skeletal muscle. Cancer Lett. 133: 83-87. doi:10.1016/S0304-3835(98)00216-X. PMID: 9929164.
    • (1998) Cancer Lett , vol.133 , pp. 83-87
    • Llovera, M.1    Carbo, N.2    Lopez-Soriano, J.3    Garcia-Martinez, C.4    Busquets, S.5    Alvarez, B.6
  • 75
    • 0035282929 scopus 로고    scopus 로고
    • What do mitochondrial diseases teach us about normal mitochondrial functions...that we already knew: Threshold expression of mitochondrial defects
    • PMID:11239482
    • Mazat, J.P., Rossignol, R., Malgat, M., Rocher, C., Faustin, B., and Letellier, T. 2001. What do mitochondrial diseases teach us about normal mitochondrial functions...that we already knew: threshold expression of mitochondrial defects. Biochim. Biophys. Acta, 1504: 20-30. PMID:11239482.
    • (2001) Biochim. Biophys. Acta , vol.1504 , pp. 20-30
    • Mazat, J.P.1    Rossignol, R.2    Malgat, M.3    Rocher, C.4    Faustin, B.5    Letellier, T.6
  • 76
    • 0030915211 scopus 로고    scopus 로고
    • Physical activity as a factor in the action of dietary restriction on aging: Effects in Fischer 344 rats
    • PMID:9177588
    • McCarter, R.J., Shimokawa, I., Ikeno, Y., Higami, Y., Hubbard, G.B., Yu, B.P., and McMahan, C.A. 1997. Physical activity as a factor in the action of dietary restriction on aging: effects in Fischer 344 rats. Aging (Milano), 9: 73-79. PMID:9177588.
    • (1997) Aging (Milano) , vol.9 , pp. 73-79
    • McCarter, R.J.1    Shimokawa, I.2    Ikeno, Y.3    Higami, Y.4    Hubbard, G.B.5    Yu, B.P.6    McMahan, C.A.7
  • 77
    • 0002458132 scopus 로고
    • The effect of retarded growth upon the length of life span and upon the ultimate body size
    • McCay, C.M., Crowell, M.F., and Maynard, L.A. 1935. The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr. 10: 63-79.
    • (1935) J. Nutr , vol.10 , pp. 63-79
    • McCay, C.M.1    Crowell, M.F.2    Maynard, L.A.3
  • 78
    • 0036239678 scopus 로고    scopus 로고
    • Mitochondrial DNA deletion mutations: A causal role in sarcopenia
    • PMID:11985577, doi:10.1046/j.1432-1033.2002.02867.x
    • McKenzie, D., Bua, E., McKiernan, S., Cao, Z., and Aiken, J.M. 2002. Mitochondrial DNA deletion mutations: a causal role in sarcopenia. Eur. J. Biochem. 269: 2010-2015. doi:10.1046/j.1432-1033.2002.02867.x. PMID:11985577.
    • (2002) Eur. J. Biochem , vol.269 , pp. 2010-2015
    • McKenzie, D.1    Bua, E.2    McKiernan, S.3    Cao, Z.4    Aiken, J.M.5
  • 79
    • 0032955553 scopus 로고    scopus 로고
    • Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle
    • PMID:9895220, doi:10.1016/S0891-5849(98)00208-1
    • Mecocci, P., Fano, G., Fulle, S., MacGarvey, U., Shinobu, L., Polidori, M.C., et al. 1999. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic. Biol. Med. 26: 303-308. doi:10.1016/S0891-5849(98)00208-1. PMID:9895220.
    • (1999) Free Radic. Biol. Med , vol.26 , pp. 303-308
    • Mecocci, P.1    Fano, G.2    Fulle, S.3    MacGarvey, U.4    Shinobu, L.5    Polidori, M.C.6
  • 80
    • 0038303852 scopus 로고    scopus 로고
    • The Arthritis, Diet and Activity Promotion Trial (ADAPT): Design, rationale, and baseline results
    • PMID:12865040
    • Miller, G.D., Rejeski, W.J., Williamson, J.D., Morgan, T., Sevick, M.A., Loeser, R.F., et al. 2003. The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results. Control. Clin. Trials, 24: 462-480. PMID:12865040.
    • (2003) Control. Clin. Trials , vol.24 , pp. 462-480
    • Miller, G.D.1    Rejeski, W.J.2    Williamson, J.D.3    Morgan, T.4    Sevick, M.A.5    Loeser, R.F.6
  • 83
    • 0037117576 scopus 로고    scopus 로고
    • Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues
    • PMID:11943860, doi:10.1073/pnas.072670199
    • Nekhaeva, E., Bodyak, N.D., Kraytsberg, Y., McGrath, S.B., Van Orsouw, N.J., Pluzhnikov, A., et al. 2002a. Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc. Natl. Acad. Sci. U.S.A. 99: 5521-5526. doi:10.1073/pnas.072670199. PMID:11943860.
    • (2002) Proc. Natl. Acad. Sci. U.S.A , vol.99 , pp. 5521-5526
    • Nekhaeva, E.1    Bodyak, N.D.2    Kraytsberg, Y.3    McGrath, S.B.4    Van Orsouw, N.J.5    Pluzhnikov, A.6
  • 84
    • 0037198055 scopus 로고    scopus 로고
    • 20026. mtLOH (mitochondrial loss of heteroplasmy), aging, and 'surrogate self
    • PMID:12044937, doi:10.1016/S0047-6374(02)00026-X
    • Nekhaeva, E., Kraytsberg, Y., and Khrapko, K. 20026. mtLOH (mitochondrial loss of heteroplasmy), aging, and 'surrogate self. Mech. Ageing Dev. 123: 891-898. doi:10.1016/S0047-6374(02)00026-X. PMID:12044937.
    • Mech. Ageing Dev , vol.123 , pp. 891-898
    • Nekhaeva, E.1    Kraytsberg, Y.2    Khrapko, K.3
  • 85
    • 0034749950 scopus 로고    scopus 로고
    • Weight change in old age and its association with mortality
    • x. PMID:11890489, doi:10. 1046/j.1532-5415.2001.49258
    • Newman, A.B., Yanez, D., Harris, T., Duxbury, A., Enright, P.L., and Fried, L.P. 2001. Weight change in old age and its association with mortality. J. Am. Geriatr. Soc. 49: 1309-1318. doi:10. 1046/j.1532-5415.2001.49258. x. PMID:11890489.
    • (2001) J. Am. Geriatr. Soc , vol.49 , pp. 1309-1318
    • Newman, A.B.1    Yanez, D.2    Harris, T.3    Duxbury, A.4    Enright, P.L.5    Fried, L.P.6
  • 86
    • 5444222767 scopus 로고    scopus 로고
    • Association of visceral adipose tissue with incident myocardial infarction in older men and women: The Health, Aging and Body Composition Study
    • PMID:15466496, doi:10.1093/aje/kwh281
    • Nicklas, B.J., Penninx, B.W., Cesari, M., Kritchevsky, S.B., Newman, A.B., Kanaya, A.M., et al. 2004. Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study. Am. J. Epidemiol. 160: 741-749. doi:10.1093/aje/kwh281. PMID:15466496.
    • (2004) Am. J. Epidemiol , vol.160 , pp. 741-749
    • Nicklas, B.J.1    Penninx, B.W.2    Cesari, M.3    Kritchevsky, S.B.4    Newman, A.B.5    Kanaya, A.M.6
  • 87
    • 0033824462 scopus 로고    scopus 로고
    • Age and sex differences in human skeletal muscle: Role of reactive oxygen species
    • PMID:10993482, doi:10.1080/10715760000301451
    • Pansarasa, O., Castagna, L., Colombi, B., Vecchiet, J., Felzani, G., and Marzatico, F. 2000. Age and sex differences in human skeletal muscle: role of reactive oxygen species. Free Radic. Res. 33: 287-293. doi:10.1080/10715760000301451. PMID:10993482.
    • (2000) Free Radic. Res , vol.33 , pp. 287-293
    • Pansarasa, O.1    Castagna, L.2    Colombi, B.3    Vecchiet, J.4    Felzani, G.5    Marzatico, F.6
  • 89
    • 11244328276 scopus 로고    scopus 로고
    • Lifelong aspirin supplementation as a means to extending life span
    • PMID:15671726, doi:10.1089/rej.2004.7.243
    • Phillips, T., and Leeuwenburgh, C. 2004. Lifelong aspirin supplementation as a means to extending life span. Rejuvenation Res. 7: 243-251. doi:10.1089/rej.2004.7.243. PMID:15671726.
    • (2004) Rejuvenation Res , vol.7 , pp. 243-251
    • Phillips, T.1    Leeuwenburgh, C.2
  • 90
    • 16344385647 scopus 로고    scopus 로고
    • Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction
    • PMID:15665035
    • Phillips, T., and Leeuwenburgh, C. 2005. Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB J. 19: 668-670. PMID:15665035.
    • (2005) FASEB J , vol.19 , pp. 668-670
    • Phillips, T.1    Leeuwenburgh, C.2
  • 91
    • 0036238915 scopus 로고    scopus 로고
    • The role of apoptosis in the normal aging brain, skeletal muscle, and heart
    • PMID:11976189
    • Pollack, M., Phaneuf, S., Dirks, A., and Leeuwenburgh, C. 2002. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Ann. N. Y. Acad. Sci. 959: 93-107. PMID:11976189.
    • (2002) Ann. N. Y. Acad. Sci , vol.959 , pp. 93-107
    • Pollack, M.1    Phaneuf, S.2    Dirks, A.3    Leeuwenburgh, C.4
  • 92
    • 33748805784 scopus 로고    scopus 로고
    • One year of caloric restriction in humans: Feasibility and effects on body composition and abdominal adipose tissue
    • PMID:16960025
    • Racette, S.B., Weiss, E.P., Villareal, D.T., Arif, H., Steger-May, K., Schechtman, K.B., et al. 2006. One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. J. Gerontol. A Biol. Sci. Med. Sci. 61: 943-950. PMID:16960025.
    • (2006) J. Gerontol. A Biol. Sci. Med. Sci , vol.61 , pp. 943-950
    • Racette, S.B.1    Weiss, E.P.2    Villareal, D.T.3    Arif, H.4    Steger-May, K.5    Schechtman, K.B.6
  • 93
    • 0038814116 scopus 로고    scopus 로고
    • Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon
    • PMID:12559411, doi:10.1016/S0531-5565(02)00116-X
    • Radak, Z., Takahashi, R., Kumiyama, A., Nakamoto, H., Ohno, H., Ookawara, T., and Goto, S. 2002. Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon. Exp. Gerontol. 37: 1423-1430. doi:10.1016/S0531-5565(02)00116-X. PMID:12559411.
    • (2002) Exp. Gerontol , vol.37 , pp. 1423-1430
    • Radak, Z.1    Takahashi, R.2    Kumiyama, A.3    Nakamoto, H.4    Ohno, H.5    Ookawara, T.6    Goto, S.7
  • 94
    • 0035017810 scopus 로고    scopus 로고
    • Flux-balance analysis of mitochondrial energy metabolism: Consequences of systemic stoichiometric constraints
    • PMID:11171647
    • Ramakrishna, R., Edwards, J.S., McCulloch, A., and Palsson, B.O. 2001. Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280: R695-R704. PMID:11171647.
    • (2001) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.280
    • Ramakrishna, R.1    Edwards, J.S.2    McCulloch, A.3    Palsson, B.O.4
  • 95
    • 32044443218 scopus 로고    scopus 로고
    • The Fischer 344/NNiaHSd X Brown Norway/BiNia is a better model of sarcopenia than the Fischer 344/NNiaHSd: A comparative analysis of muscle mass and contractile properties in aging male rat models
    • PMID:16463110, doi:10.1007/s10522-005-4808-0
    • Rice, K.M., Linderman, J.K., Kinnard, R.S., and Blough, E.R. 2005. The Fischer 344/NNiaHSd X Brown Norway/BiNia is a better model of sarcopenia than the Fischer 344/NNiaHSd: a comparative analysis of muscle mass and contractile properties in aging male rat models. Biogerontology, 6: 335-343. doi:10.1007/s10522-005-4808-0. PMID:16463110.
    • (2005) Biogerontology , vol.6 , pp. 335-343
    • Rice, K.M.1    Linderman, J.K.2    Kinnard, R.S.3    Blough, E.R.4
  • 96
    • 0028237131 scopus 로고
    • Rheumatoid cachexia: Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation
    • PMID:8200971
    • Roubenoff, R., Roubenoff, R.A., Cannon, J.G., Kehayias, J.J., Zhuang, H., Wson-Hughes, B., et al. 1994. Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J. Clin. Invest. 93: 2379-2386. PMID:8200971.
    • (1994) J. Clin. Invest , vol.93 , pp. 2379-2386
    • Roubenoff, R.1    Roubenoff, R.A.2    Cannon, J.G.3    Kehayias, J.J.4    Zhuang, H.5    Wson-Hughes, B.6
  • 97
    • 0347356516 scopus 로고    scopus 로고
    • Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke
    • PMID:14671251
    • Sanchez-Moreno, C., Dashe, J.F., Scott, T., Thaler, D., Folstein, M.F., and Martin, A. 2004. Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke. Stroke, 35: 163-168. PMID:14671251.
    • (2004) Stroke , vol.35 , pp. 163-168
    • Sanchez-Moreno, C.1    Dashe, J.F.2    Scott, T.3    Thaler, D.4    Folstein, M.F.5    Martin, A.6
  • 98
    • 33646697132 scopus 로고    scopus 로고
    • Hepatic oxidative stress during aging: Effects of 8% long-term calorie restriction and lifelong exercise
    • PMID:16677097, doi:10.1089/ars.2006.8.529
    • Seo, A.Y., Hofer, T., Sung, B., Judge, S., Chung, H.Y., and Leeuwenburgh, C. 2006. Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise. Antioxid. Redox Signal. 8: 529-538. doi:10.1089/ars.2006.8.529. PMID:16677097.
    • (2006) Antioxid. Redox Signal , vol.8 , pp. 529-538
    • Seo, A.Y.1    Hofer, T.2    Sung, B.3    Judge, S.4    Chung, H.Y.5    Leeuwenburgh, C.6
  • 99
    • 25144474924 scopus 로고    scopus 로고
    • Adult and developmental myosin heavy chain isoforms in soleus muscle of aging Fischer Brown Norway rat
    • PMID:16086433
    • Snow, L.M., McLoon, L.K., and Thompson, L.V. 2005. Adult and developmental myosin heavy chain isoforms in soleus muscle of aging Fischer Brown Norway rat. Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 286: 866-873. PMID:16086433.
    • (2005) Anat. Rec. A Discov. Mol. Cell. Evol. Biol , vol.286 , pp. 866-873
    • Snow, L.M.1    McLoon, L.K.2    Thompson, L.V.3
  • 101
    • 0030941484 scopus 로고    scopus 로고
    • Diet and calorie restriction
    • PMID:9088917, doi:10.1016/S0531-5565(96)00065-4
    • Sprott, R.L. 1997. Diet and calorie restriction. Exp. Gerontol. 32: 205-214. doi:10.1016/S0531-5565(96)00065-4. PMID:9088917.
    • (1997) Exp. Gerontol , vol.32 , pp. 205-214
    • Sprott, R.L.1
  • 102
    • 0028929328 scopus 로고
    • Mechanisms and genes of cellular suicide
    • PMID:7878463, doi:10.1126/science.7878463
    • Steller, H. 1995. Mechanisms and genes of cellular suicide. Science (Washington, D.C.), 267: 1445-1449. doi:10.1126/science.7878463. PMID:7878463.
    • (1995) Science (Washington, D.C.) , vol.267 , pp. 1445-1449
    • Steller, H.1
  • 103
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • PMID:15164064, doi:10.1038/nature02517
    • Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J.N., Rovio, A.T., Bruder, C.E., et al. 2004. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (London), 429: 417-423. doi:10.1038/nature02517. PMID:15164064.
    • (2004) Nature (London) , vol.429 , pp. 417-423
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3    Spelbrink, J.N.4    Rovio, A.T.5    Bruder, C.E.6
  • 104
    • 13344261948 scopus 로고    scopus 로고
    • Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice
    • PMID:8550842
    • Tsujinaka, T., Fujita, J., Ebisui, C., Yano, M., Kominami, E., Suzuki, K., et al. 1996. Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. J. Clin. Invest. 97: 244-249. PMID:8550842.
    • (1996) J. Clin. Invest , vol.97 , pp. 244-249
    • Tsujinaka, T.1    Fujita, J.2    Ebisui, C.3    Yano, M.4    Kominami, E.5    Suzuki, K.6
  • 105
    • 0036223922 scopus 로고    scopus 로고
    • Skeletal muscle response to exercise and treatment: Another sibyl in the heart failure syndrome?
    • PMID:11959381
    • Vescovo, G. 2002. Skeletal muscle response to exercise and treatment: another sibyl in the heart failure syndrome? Int. J. Cardiol. 83: 33-34. PMID:11959381.
    • (2002) Int. J. Cardiol , vol.83 , pp. 33-34
    • Vescovo, G.1
  • 106
    • 0033981680 scopus 로고    scopus 로고
    • Mitochondrial defects in cardiomyopathy and neuromuscular disease
    • PMID:10650320, doi:10. 1067/mhj.2000.103934
    • Wallace, D.C. 2000. Mitochondrial defects in cardiomyopathy and neuromuscular disease. Am. Heart J. 139: S70-S85. doi:10. 1067/mhj.2000.103934. PMID:10650320.
    • (2000) Am. Heart J , vol.139
    • Wallace, D.C.1
  • 107
    • 0035127889 scopus 로고    scopus 로고
    • Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia
    • PMID:11156948, doi:10.1096/fj.00-0320com
    • Wanagat, J., Cao, Z., Pathare, P., and Aiken, J.M. 2001. Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J. 15: 322-332. doi:10.1096/fj.00-0320com. PMID:11156948.
    • (2001) FASEB J , vol.15 , pp. 322-332
    • Wanagat, J.1    Cao, Z.2    Pathare, P.3    Aiken, J.M.4
  • 108
    • 0030747292 scopus 로고    scopus 로고
    • The rate of mitochondrial mutagenesis is faster in mice than humans
    • PMID:9247611
    • Wang, E., Wong, A., and Cortopassi, G. 1997. The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat. Res. 377: 157-166. PMID:9247611.
    • (1997) Mutat. Res , vol.377 , pp. 157-166
    • Wang, E.1    Wong, A.2    Cortopassi, G.3
  • 109
    • 0035957323 scopus 로고    scopus 로고
    • Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
    • PMID:11274426, doi:10.1073/pnas.061013598
    • Wang, Y., Michikawa, Y., Mallidis, C., Bai, Y., Woodhouse, L., Yarasheski, K.E., et al. 2001. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc. Natl. Acad. Sci. U.S.A. 98: 4022-4027. doi:10.1073/pnas.061013598. PMID:11274426.
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , pp. 4022-4027
    • Wang, Y.1    Michikawa, Y.2    Mallidis, C.3    Bai, Y.4    Woodhouse, L.5    Yarasheski, K.E.6
  • 110
    • 18344372832 scopus 로고    scopus 로고
    • Reasons for intentional weight loss, unintentional weight loss, and mortality in older men
    • PMID:15883243, doi:10.1001/archinte.165.9.1035
    • Wannamethee, S.G., Shaper, A.G., and Lennon, L. 2005. Reasons for intentional weight loss, unintentional weight loss, and mortality in older men. Arch. Intern. Med. 165: 1035-1040. doi:10.1001/archinte.165.9.1035. PMID:15883243.
    • (2005) Arch. Intern. Med , vol.165 , pp. 1035-1040
    • Wannamethee, S.G.1    Shaper, A.G.2    Lennon, L.3
  • 111
    • 0030624330 scopus 로고    scopus 로고
    • Aging and regulation of apoptosis
    • PMID:9192177
    • Warner, H.R. 1997. Aging and regulation of apoptosis. Curr. Top. Cell. Regul. 35: 107-121. PMID:9192177.
    • (1997) Curr. Top. Cell. Regul , vol.35 , pp. 107-121
    • Warner, H.R.1
  • 112
    • 0033452557 scopus 로고    scopus 로고
    • Apoptosis: A two-edged sword in aging
    • 4B, 2837-2842. PMID:10652562
    • Warner, H.R. 1999. Apoptosis: a two-edged sword in aging. Anticancer Res. 19 (4B): 2837-2842. PMID:10652562.
    • (1999) Anticancer Res , vol.19
    • Warner, H.R.1
  • 113
    • 0022517746 scopus 로고
    • The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake
    • PMID:3958810
    • Weindruch, R., Walford, R.L., Fligiel, S., and Guthrie, D. 1986. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. Nutr. 116: 641-654. PMID:3958810.
    • (1986) J. Nutr , vol.116 , pp. 641-654
    • Weindruch, R.1    Walford, R.L.2    Fligiel, S.3    Guthrie, D.4
  • 114
    • 33750908045 scopus 로고    scopus 로고
    • Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: A randomized controlled trial
    • PMID:17093155
    • Weiss, E.P., Racette, S.B., Villareal, D.T., Fontana, L., Steger-May, K., Schechtman, K.B., et al. 2006. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am. J. Clin. Nutr. 84: 1033-1042. PMID:17093155.
    • (2006) Am. J. Clin. Nutr , vol.84 , pp. 1033-1042
    • Weiss, E.P.1    Racette, S.B.2    Villareal, D.T.3    Fontana, L.4    Steger-May, K.5    Schechtman, K.B.6
  • 115
    • 0025741445 scopus 로고
    • Ageing-associated 5 kb deletion in human liver mitochondrial DNA
    • PMID:2069552, doi:10.1016/0006-291X(91)91788-E
    • Yen, T.C., Su, J.H., King, K.L., and Wei, Y.H. 1991. Ageing-associated 5 kb deletion in human liver mitochondrial DNA. Biochem. Biophys. Res. Commun. 178: 124-131. doi:10.1016/0006-291X(91)91788-E. PMID:2069552.
    • (1991) Biochem. Biophys. Res. Commun , vol.178 , pp. 124-131
    • Yen, T.C.1    Su, J.H.2    King, K.L.3    Wei, Y.H.4
  • 117
    • 0029759443 scopus 로고    scopus 로고
    • Aging and oxidative stress: Modulation by dietary restriction
    • PMID:8891668, doi:10.1016/ 0891-5849(96)00162-1
    • Yu, B.P. 1996. Aging and oxidative stress: modulation by dietary restriction. Free Radic. Biol. Med. 21: 651-668. doi:10.1016/ 0891-5849(96)00162-1. PMID:8891668.
    • (1996) Free Radic. Biol. Med , vol.21 , pp. 651-668
    • Yu, B.P.1
  • 118
    • 0029785583 scopus 로고    scopus 로고
    • Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis
    • PMID:8687010, doi:10.1111/j.1749-6632. 1996.tb39047.x
    • Yu, B.P., and Yang, R. 1996. Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis. Ann. N. Y. Acad. Sci. 786: 1-11. doi:10.1111/j.1749-6632. 1996.tb39047.x. PMID:8687010.
    • (1996) Ann. N. Y. Acad. Sci , vol.786 , pp. 1-11
    • Yu, B.P.1    Yang, R.2
  • 119
    • 0022381249 scopus 로고
    • Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics
    • PMID:4056321
    • Yu, B.P., Masoro, E.J., and McMahan, C.A. 1985. Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J. Gerontol. 40: 657-670. PMID:4056321.
    • (1985) J. Gerontol , vol.40 , pp. 657-670
    • Yu, B.P.1    Masoro, E.J.2    McMahan, C.A.3
  • 120
    • 0035035753 scopus 로고    scopus 로고
    • Capacity for recovery and possible mechanisms in immobilization atrophy of young and old animals
    • PMID:11795512
    • Zarzhevsky, N., Menashe, O., Carmeli, E., Stein, H., and Reznick, A.Z. 2001. Capacity for recovery and possible mechanisms in immobilization atrophy of young and old animals. Ann. N. Y. Acad. Sci. 928: 212-225. PMID:11795512.
    • (2001) Ann. N. Y. Acad. Sci , vol.928 , pp. 212-225
    • Zarzhevsky, N.1    Menashe, O.2    Carmeli, E.3    Stein, H.4    Reznick, A.Z.5
  • 121
    • 0033859453 scopus 로고    scopus 로고
    • Cytokines and endotoxin induce cytokine receptors in skeletal muscle
    • PMID:10893340
    • Zhang, Y., Pilon, G., Marette, A., and Baracos, V.E. 2000. Cytokines and endotoxin induce cytokine receptors in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 279: E196-E205. PMID:10893340.
    • (2000) Am. J. Physiol. Endocrinol. Metab , vol.279
    • Zhang, Y.1    Pilon, G.2    Marette, A.3    Baracos, V.E.4


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