-
2
-
-
1842829596
-
Virus interference. II. Some properties of interferon
-
Isaacs, A., Lindenmann, J. & Valentine, R. C. Virus interference. II. Some properties of interferon. Proc. R. Soc. Lond. B Biol. Sci. 147, 268-273 (1957).
-
(1957)
Proc. R. Soc. Lond. B Biol. Sci.
, vol.147
, pp. 268-273
-
-
Isaacs, A.1
Lindenmann, J.2
Valentine, R.C.3
-
3
-
-
33645366436
-
What makes a good anti-inflammatory drug target?
-
Simmons, D. L. What makes a good anti-inflammatory drug target? Drug Discov. Today 11, 210-219 (2006).
-
(2006)
Drug Discov. Today
, vol.11
, pp. 210-219
-
-
Simmons, D.L.1
-
4
-
-
0034735842
-
Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group
-
Lipsky, P. E. et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group. N. Engl. J. Med. 343, 1594-1602 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1594-1602
-
-
Lipsky, P.E.1
-
5
-
-
0027438710
-
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor?
-
Elliott, M. J. et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum. 36, 1681-1690 (1993).
-
(1993)
Arthritis Rheum.
, vol.36
, pp. 1681-1690
-
-
Elliott, M.J.1
-
6
-
-
0013511183
-
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
-
Moreland, L. W. et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N. Engl. J. Med. 337, 141-147 (1997).
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 141-147
-
-
Moreland, L.W.1
-
7
-
-
24944498854
-
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor-inhibition
-
Genovese, M. C. et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor-inhibition. N. Engl. J. Med. 353, 1114-1123 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 1114-1123
-
-
Genovese, M.C.1
-
8
-
-
0028519015
-
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
-
Powrie, F. et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1, 553-562 (1994).
-
(1994)
Immunity
, vol.1
, pp. 553-562
-
-
Powrie, F.1
-
9
-
-
0031015257
-
Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice
-
Kojouharoff, G. et al. Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice. Clin. Exp. Immunol. 107, 353-358 (1997).
-
(1997)
Clin. Exp. Immunol.
, vol.107
, pp. 353-358
-
-
Kojouharoff, G.1
-
10
-
-
0033103805
-
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
-
Kontoyiannis, D., Pasparakis, M., Pizarro, T. T., Cominelli, F. & Kollias, G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10, 387-398 (1999).
-
(1999)
Immunity
, vol.10
, pp. 387-398
-
-
Kontoyiannis, D.1
Pasparakis, M.2
Pizarro, T.T.3
Cominelli, F.4
Kollias, G.5
-
11
-
-
0035106502
-
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohns disease
-
Kosiewicz, M. M. et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohns disease. J. Clin. Invest. 107, 695-702 (2001).
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 695-702
-
-
Kosiewicz, M.M.1
-
12
-
-
0030818051
-
Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice
-
Neurath, M. F. et al. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur. J. Immunol. 27, 1743-1750 (1997).
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 1743-1750
-
-
Neurath, M.F.1
-
13
-
-
0030267786
-
Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice
-
Mori, L., Iselin, S., De Libero, G. & Lesslauer, W. Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice. J. Immunol. 157, 3178-3182 (1996).
-
(1996)
J. Immunol.
, vol.157
, pp. 3178-3182
-
-
Mori, L.1
Iselin, S.2
De Libero, G.3
Lesslauer, W.4
-
14
-
-
0031916192
-
TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
-
Liu, J. et al. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nature Med. 4, 78-83 (1998).
-
(1998)
Nature Med.
, vol.4
, pp. 78-83
-
-
Liu, J.1
-
15
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor? for Crohns disease
-
Targan, S. R. et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohns disease. N. Engl. J. Med. 337, 1029-1035 (1997).
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 1029-1035
-
-
Targan, S.R.1
-
16
-
-
0344926414
-
Etanercept as monotherapy in patients with psoriasis
-
Leonardi, C. L. et al. Etanercept as monotherapy in patients with psoriasis. N. Engl. J. Med. 349, 2014-2022 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 2014-2022
-
-
Leonardi, C.L.1
-
17
-
-
0033546665
-
TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
-
The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
-
The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 53, 457-465 (1999).
-
(1999)
Neurology
, vol.53
, pp. 457-465
-
-
-
18
-
-
0036151047
-
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohns disease
-
ten Hove, T., van Montfrans, C., Peppelenbosch, M. P. & van Deventer, S. J. Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohns disease. Gut 50, 206-211 (2002).
-
(2002)
Gut
, vol.50
, pp. 206-211
-
-
Ten Hove, T.1
Van Montfrans, C.2
Peppelenbosch, M.P.3
Van Deventer, S.J.4
-
19
-
-
0016723594
-
An endotoxin-induced serum factor that causes necrosis of tumors
-
Carswell, E. A. et al. An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Natl Acad. Sci. USA 72, 3666-3670 (1975).
-
(1975)
Proc. Natl Acad. Sci. USA
, vol.72
, pp. 3666-3670
-
-
Carswell, E.A.1
-
20
-
-
0000161413
-
The treatment of malignant tumors by repeated inoculations of erysipelas; With a report of ten original cases
-
Coley, W. B. The treatment of malignant tumors by repeated inoculations of erysipelas; with a report of ten original cases. Am. J. Med. Sci. 105, 487-511 (1893).
-
(1893)
Am. J. Med. Sci.
, vol.105
, pp. 487-511
-
-
Coley, W.B.1
-
21
-
-
33645782015
-
TNF-α in cancer treatment: Molecular insights, antitumor effects, and clinical utility
-
van Horssen, R., Ten Hagen, T. L. & Eggermont, A. M. TNF-α in cancer treatment: molecular insights, antitumor effects, and clinical utility. Oncologist 11, 397-408 (2006).
-
(2006)
Oncologist
, vol.11
, pp. 397-408
-
-
Van Horssen, R.1
Ten Hagen, T.L.2
Eggermont, A.M.3
-
22
-
-
0343183120
-
Crucial role of TNF-α in CD8 T cellmediated elimination of 3LL-A9 Lewis lung carcinoma cells in vivo
-
Prevost-Blondel, A., Roth, E., Rosenthal, F. M. & Pircher, H. Crucial role of TNF-α in CD8 T cellmediated elimination of 3LL-A9 Lewis lung carcinoma cells in vivo. J. Immunol. 164, 3645-3651 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 3645-3651
-
-
Prevost-Blondel, A.1
Roth, E.2
Rosenthal, F.M.3
Pircher, H.4
-
23
-
-
36448978124
-
TNF-α is critical for antitumor but not antiviral T cell immunity in mice
-
Calzascia, T. et al. TNF-α is critical for antitumor but not antiviral T cell immunity in mice. J. Clin. Invest. 117, 3833-3845 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3833-3845
-
-
Calzascia, T.1
-
24
-
-
33646696885
-
Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and metaanalysis of rare harmful effects in randomized controlled trials
-
Bongartz, T. et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and metaanalysis of rare harmful effects in randomized controlled trials. JAMA 295, 2275-2285 (2006).
-
(2006)
JAMA
, vol.295
, pp. 2275-2285
-
-
Bongartz, T.1
-
25
-
-
67549122368
-
Etanercept therapy in rheumatoid arthritis and the risk of malignancies: A systematic review and individual patient data meta-analysis of randomised controlled trials
-
Bongartz, T. et al. Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-analysis of randomised controlled trials. Ann. Rheum. Dis. 68, 1177-1183 (2009).
-
(2009)
Ann. Rheum. Dis.
, vol.68
, pp. 1177-1183
-
-
Bongartz, T.1
-
26
-
-
70350548170
-
Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor-therapies: Does the risk change with the time since start of treatment?
-
Askling, J. et al. Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor-therapies: does the risk change with the time since start of treatment? Arthritis Rheum. 60, 3180-3189 (2009).
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 3180-3189
-
-
Askling, J.1
-
27
-
-
55949103220
-
Autoimmune and inflammatory disorders and risk of malignant lymphomas - An update
-
Smedby, K. E., Askling, J., Mariette, X. & Baecklund, E. Autoimmune and inflammatory disorders and risk of malignant lymphomas - an update. J. Intern. Med. 264, 514-527 (2008).
-
(2008)
J. Intern. Med.
, vol.264
, pp. 514-527
-
-
Smedby, K.E.1
Askling, J.2
Mariette, X.3
Baecklund, E.4
-
28
-
-
66149084485
-
Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: Relative risks and time trends in the Swedish Biologics Register
-
Askling, J. et al. Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register. Ann. Rheum. Dis. 68, 648-653 (2009).
-
(2009)
Ann. Rheum. Dis.
, vol.68
, pp. 648-653
-
-
Askling, J.1
-
29
-
-
33750497844
-
Inflammation and cancer: How hot is the link?
-
Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K. & Sethi, G. Inflammation and cancer: how hot is the link? Biochem. Pharmacol. 72, 1605-1621 (2006).
-
(2006)
Biochem. Pharmacol.
, vol.72
, pp. 1605-1621
-
-
Aggarwal, B.B.1
Shishodia, S.2
Sandur, S.K.3
Pandey, M.K.4
Sethi, G.5
-
30
-
-
0032983865
-
Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis
-
Moore, R. J. et al. Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis. Nature Med. 5, 828-831 (1999).
-
(1999)
Nature Med.
, vol.5
, pp. 828-831
-
-
Moore, R.J.1
-
31
-
-
0033568358
-
Essential role of tumor necrosis factor α (TNF- α) in tumor promotion as revealed by TNF-α-deficient mice
-
Suganuma, M. et al. Essential role of tumor necrosis factor α (TNF- α) in tumor promotion as revealed by TNF-α-deficient mice. Cancer Res. 59, 4516-4518 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 4516-4518
-
-
Suganuma, M.1
-
32
-
-
0034684651
-
Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice
-
Knight, B. et al. Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J. Exp. Med. 192, 1809-1818 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1809-1818
-
-
Knight, B.1
-
33
-
-
74549167737
-
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
-
Park, E. J. et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140, 197-208 (2010).
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, E.J.1
-
34
-
-
4644324186
-
NF-κB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky, E. et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 431, 461-466 (2004).
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
-
35
-
-
12844254964
-
Granulomatous infections due to tumor necrosis factor blockade: Correction
-
Wallis, R. S., Broder, M., Wong, J. & Beenhouwer, D. Granulomatous infections due to tumor necrosis factor blockade: correction. Clin. Infect. Dis. 39, 1254-1255 (2004).
-
(2004)
Clin. Infect. Dis.
, vol.39
, pp. 1254-1255
-
-
Wallis, R.S.1
Broder, M.2
Wong, J.3
Beenhouwer, D.4
-
36
-
-
2342468669
-
Granulomatous infectious diseases associated with tumor necrosis factor antagonists
-
Wallis, R. S., Broder, M. S., Wong, J. Y., Hanson, M. E. & Beenhouwer, D. O. Granulomatous infectious diseases associated with tumor necrosis factor antagonists. Clin. Infect. Dis. 38, 1261-1265 (2004).
-
(2004)
Clin. Infect. Dis.
, vol.38
, pp. 1261-1265
-
-
Wallis, R.S.1
Broder, M.S.2
Wong, J.Y.3
Hanson, M.E.4
Beenhouwer, D.O.5
-
37
-
-
43649107676
-
Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis
-
Spohn, G. et al. Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis. Eur. J. Immunol. 38, 877-887 (2008).
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 877-887
-
-
Spohn, G.1
-
38
-
-
22544436130
-
Reactivation of latent granulomatous infections by infliximab
-
Wallis, R. S., Broder, M., Wong, J., Lee, A. & Hoq, L. Reactivation of latent granulomatous infections by infliximab. Clin. Infect. Dis. 41 (Suppl. 3), 194-198 (2005).
-
(2005)
Clin. Infect. Dis.
, vol.41
, Issue.SUPPL. 3
, pp. 194-198
-
-
Wallis, R.S.1
Broder, M.2
Wong, J.3
Lee, A.4
Hoq, L.5
-
39
-
-
58149215702
-
Chitosan/siRNA nanoparticlemediated TNF-α knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
-
Howard, K. A. et al. Chitosan/siRNA nanoparticlemediated TNF-α knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol. Ther. 17, 162-168 (2009).
-
(2009)
Mol. Ther.
, vol.17
, pp. 162-168
-
-
Howard, K.A.1
-
40
-
-
17244378648
-
Effects of treatment with small interfering RNA on joint inflammation in mice with collageninduced arthritis
-
Schiffelers, R. M., Xu, J., Storm, G., Woodle, M. C. & Scaria, P. V. Effects of treatment with small interfering RNA on joint inflammation in mice with collageninduced arthritis. Arthritis Rheum. 52, 1314-1318 (2005).
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 1314-1318
-
-
Schiffelers, R.M.1
Xu, J.2
Storm, G.3
Woodle, M.C.4
Scaria, P.V.5
-
41
-
-
38449086094
-
Cutting edge: TNF-α-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock
-
Horiuchi, K. et al. Cutting edge: TNF-α-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J. Immunol. 179, 2686-2689 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 2686-2689
-
-
Horiuchi, K.1
-
42
-
-
44849120587
-
Drug insight: Tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis
-
Moss, M. L., Sklair-Tavron, L. & Nudelman, R. Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nature Clin. Pract Rheumatol. 4, 300-309 (2008).
-
(2008)
Nature Clin. Pract Rheumatol.
, vol.4
, pp. 300-309
-
-
Moss, M.L.1
Sklair-Tavron, L.2
Nudelman, R.3
-
43
-
-
33751042569
-
Drug evaluation: Apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis
-
Thabet, M. M. & Huizinga, T. W. Drug evaluation: apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis. Curr. Opin. Investig. Drugs 7, 1014-1019 (2006).
-
(2006)
Curr. Opin. Investig. Drugs
, vol.7
, pp. 1014-1019
-
-
Thabet, M.M.1
Huizinga, T.W.2
-
44
-
-
0032515018
-
An essential role for ectodomain shedding in mammalian development
-
Peschon, J. J. et al. An essential role for ectodomain shedding in mammalian development. Science 282, 1281-1284 (1998).
-
(1998)
Science
, vol.282
, pp. 1281-1284
-
-
Peschon, J.J.1
-
45
-
-
17644368573
-
Interleukin-6: From basic science to medicine - 40 years in immunology
-
Kishimoto, T. Interleukin-6: from basic science to medicine - 40 years in immunology. Annu. Rev. Immunol. 23, 1-21 (2005).
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 1-21
-
-
Kishimoto, T.1
-
46
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-deficient mice
-
Kopf, M. et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368, 339-342 (1994).
-
(1994)
Nature
, vol.368
, pp. 339-342
-
-
Kopf, M.1
-
47
-
-
0029007193
-
Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: Correlation with inefficient neutrophilia
-
Dalrymple, S. A. et al. Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect. Immun. 63, 2262-2268 (1995).
-
(1995)
Infect. Immun.
, vol.63
, pp. 2262-2268
-
-
Dalrymple, S.A.1
-
48
-
-
0030734571
-
Lethal tuberculosis in interleukin-6- deficient mutant mice
-
Ladel, C. H. et al. Lethal tuberculosis in interleukin-6- deficient mutant mice. Infect. Immun. 65, 4843-4849 (1997).
-
(1997)
Infect. Immun.
, vol.65
, pp. 4843-4849
-
-
Ladel, C.H.1
-
49
-
-
0030914438
-
Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice
-
Suzuki, Y. et al. Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice. Infect. Immun. 65, 2339-2345 (1997).
-
(1997)
Infect. Immun.
, vol.65
, pp. 2339-2345
-
-
Suzuki, Y.1
-
50
-
-
0029913685
-
Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans
-
Romani, L. et al. Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J. Exp. Med. 183, 1345-1355 (1996).
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1345-1355
-
-
Romani, L.1
-
51
-
-
0031852288
-
IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
-
Eugster, H. P., Frei, K., Kopf, M., Lassmann, H. & Fontana, A. IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Eur. J. Immunol. 28, 2178-2187 (1998).
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 2178-2187
-
-
Eugster, H.P.1
Frei, K.2
Kopf, M.3
Lassmann, H.4
Fontana, A.5
-
52
-
-
0032534730
-
IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
-
Samoilova, E. B., Horton, J. L., Hilliard, B., Liu, T. S. & Chen, Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161, 6480-6486 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 6480-6486
-
-
Samoilova, E.B.1
Horton, J.L.2
Hilliard, B.3
Liu, T.S.4
Chen, Y.5
-
53
-
-
13144259627
-
Interleukin 6 plays a key role in the development of antigen-induced arthritis
-
Ohshima, S. et al. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl Acad. Sci. USA 95, 8222-8226 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 8222-8226
-
-
Ohshima, S.1
-
54
-
-
0032536542
-
Interleukin 6 is required for the development of collagen-induced arthritis
-
Alonzi, T. et al. Interleukin 6 is required for the development of collagen-induced arthritis. J. Exp. Med. 187, 461-468 (1998).
-
(1998)
J. Exp. Med.
, vol.187
, pp. 461-468
-
-
Alonzi, T.1
-
55
-
-
0037458105
-
Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3
-
Eriksson, U. et al. Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3. Circulation 107, 320-325 (2003).
-
(2003)
Circulation
, vol.107
, pp. 320-325
-
-
Eriksson, U.1
-
56
-
-
4344590199
-
Distinct contribution of IL-6, TNF-α, IL-1 and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice
-
Hata, H. et al. Distinct contribution of IL-6, TNF-α, IL-1 and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J. Clin. Invest. 114, 582-588 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 582-588
-
-
Hata, H.1
-
57
-
-
0034193039
-
IL-6 is required for the development of Th1 cellmediated murine colitis
-
Yamamoto, M., Yoshizaki, K., Kishimoto, T. & Ito, H. IL-6 is required for the development of Th1 cellmediated murine colitis. J. Immunol. 164, 4878-4882 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 4878-4882
-
-
Yamamoto, M.1
Yoshizaki, K.2
Kishimoto, T.3
Ito, H.4
-
58
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo
-
Atreya, R. et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nature Med. 6, 583-588 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 583-588
-
-
Atreya, R.1
-
59
-
-
0024269961
-
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
-
Hirano, T. et al. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18, 1797 - 1801 (1988).
-
(1988)
Eur. J. Immunol.
, vol.18
, pp. 1797-1801
-
-
Hirano, T.1
-
60
-
-
0343019918
-
Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes
-
Grossman, R. M. et al. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc. Natl Acad. Sci. USA 86, 6367-6371 (1989).
-
(1989)
Proc. Natl Acad. Sci. USA
, vol.86
, pp. 6367-6371
-
-
Grossman, R.M.1
-
61
-
-
0026607022
-
Evidence for continuous stimulation of interleukin-6 production in Crohns disease
-
Gross, V., Andus, T., Caesar, I., Roth, M. & Scholmerich, J. Evidence for continuous stimulation of interleukin-6 production in Crohns disease. Gastroenterology 102, 514-519 (1992).
-
(1992)
Gastroenterology
, vol.102
, pp. 514-519
-
-
Gross, V.1
Andus, T.2
Caesar, I.3
Roth, M.4
Scholmerich, J.5
-
62
-
-
0028796711
-
Soluble interleukin-6 receptors in inflammatory bowel disease: Relation to circulating interleukin-6
-
Mitsuyama, K. et al. Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6. Gut 36, 45-49 (1995).
-
(1995)
Gut
, vol.36
, pp. 45-49
-
-
Mitsuyama, K.1
-
63
-
-
0142250392
-
Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence
-
Trikha, M., Corringham, R., Klein, B. & Rossi, J. F. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin. Cancer Res. 9, 4653-4665 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 4653-4665
-
-
Trikha, M.1
Corringham, R.2
Klein, B.3
Rossi, J.F.4
-
64
-
-
0029780037
-
Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop
-
van Zaanen, H. C. et al. Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop. J. Clin. Invest. 98, 1441-1448 (1996).
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1441-1448
-
-
Van Zaanen, H.C.1
-
65
-
-
0031811798
-
Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: A phase i dose-escalating study
-
van Zaanen, H. C. et al. Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: a phase I dose-escalating study. Br. J. Haematol. 102, 783-790 (1998).
-
(1998)
Br. J. Haematol.
, vol.102
, pp. 783-790
-
-
Van Zaanen, H.C.1
-
66
-
-
0033959608
-
Improvement in Castlemans disease by humanized anti-interleukin-6 receptor antibody therapy
-
Nishimoto, N. et al. Improvement in Castlemans disease by humanized anti-interleukin-6 receptor antibody therapy. Blood 95, 56-61 (2000).
-
(2000)
Blood
, vol.95
, pp. 56-61
-
-
Nishimoto, N.1
-
67
-
-
40749114497
-
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebocontrolled, randomised trial
-
Smolen, J. S. et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebocontrolled, randomised trial. Lancet 371, 987-997 (2008).
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
-
68
-
-
52149099504
-
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
-
Emery, P. et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann. Rheum. Dis. 67, 1516-1523 (2008).
-
(2008)
Ann. Rheum. Dis.
, vol.67
, pp. 1516-1523
-
-
Emery, P.1
-
69
-
-
73449118587
-
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
-
Jones, G. et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann. Rheum. Dis. 69, 88-96 (2010).
-
(2010)
Ann. Rheum. Dis.
, vol.69
, pp. 88-96
-
-
Jones, G.1
-
70
-
-
40749152243
-
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: A randomised, double-blind, placebocontrolled, withdrawal phase III trial
-
Yokota, S. et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebocontrolled, withdrawal phase III trial. Lancet 371, 998-1006 (2008).
-
(2008)
Lancet
, vol.371
, pp. 998-1006
-
-
Yokota, S.1
-
71
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
-
Jostock, T. et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur. J. Biochem. 268, 160-167 (2001).
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 160-167
-
-
Jostock, T.1
-
72
-
-
59849091830
-
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis
-
Nowell, M. A. et al. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J. Immunol. 182, 613-622 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 613-622
-
-
Nowell, M.A.1
-
73
-
-
33646596542
-
Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6
-
Ohtaki, H. et al. Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc. Natl Acad. Sci. USA 103, 7488-7493 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 7488-7493
-
-
Ohtaki, H.1
-
74
-
-
22244468321
-
Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: Possible involvement of Stat3 activation in the protection of neurons
-
Yamashita, T. et al. Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons. J. Neurochem. 94, 459-468 (2005).
-
(2005)
J. Neurochem.
, vol.94
, pp. 459-468
-
-
Yamashita, T.1
-
75
-
-
0029846756
-
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
-
Cressman, D. E. et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274, 1379-1383 (1996).
-
(1996)
Science
, vol.274
, pp. 1379-1383
-
-
Cressman, D.E.1
-
76
-
-
0037011992
-
Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: Involvement of induction of Bcl-2 and Bcl-xL proteins
-
Hong, F. et al. Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-xL proteins. Oncogene 21, 32-43 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 32-43
-
-
Hong, F.1
-
77
-
-
16844387413
-
The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury
-
Klein, C. et al. The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury. J. Clin. Invest. 115, 860-869 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 860-869
-
-
Klein, C.1
-
78
-
-
0033970969
-
Increased toxin-induced liver injury and fibrosis in interleukin-6- deficient mice
-
Kovalovich, K. et al. Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology 31, 149-159 (2000).
-
(2000)
Hepatology
, vol.31
, pp. 149-159
-
-
Kovalovich, K.1
-
79
-
-
0025774888
-
Anti-interleukin-6 antibodies in normal human serum
-
Hansen, M. B., Svenson, M., Diamant, M. & Bendtzen, K. Anti-interleukin-6 antibodies in normal human serum. Scand. J. Immunol. 33, 777-781 (1991).
-
(1991)
Scand. J. Immunol.
, vol.33
, pp. 777-781
-
-
Hansen, M.B.1
Svenson, M.2
Diamant, M.3
Bendtzen, K.4
-
80
-
-
0029800642
-
Anti-interleukin-6 autoantibodies in plasma are associated with an increased frequency of infections and increased mortality of patients with alcoholic cirrhosis
-
Homann, C. et al. Anti-interleukin-6 autoantibodies in plasma are associated with an increased frequency of infections and increased mortality of patients with alcoholic cirrhosis. Scand. J. Immunol. 44, 623-629 (1996).
-
(1996)
Scand. J. Immunol.
, vol.44
, pp. 623-629
-
-
Homann, C.1
-
81
-
-
0031831906
-
Interleukin-1 interleukin-1 receptors and interleukin-1 receptor antagonist
-
Dinarello, C. A. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int. Rev. Immunol. 16, 457-499 (1998).
-
(1998)
Int. Rev. Immunol.
, vol.16
, pp. 457-499
-
-
Dinarello, C.A.1
-
82
-
-
1642285783
-
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
-
Agostini, L. et al. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20, 319-325 (2004).
-
(2004)
Immunity
, vol.20
, pp. 319-325
-
-
Agostini, L.1
-
83
-
-
12144288979
-
Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID
-
Neven, B. et al. Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS and FCU. Blood 103, 2809-2815 (2004).
-
(2004)
MWS and FCU. Blood
, vol.103
, pp. 2809-2815
-
-
Neven, B.1
-
84
-
-
4043104941
-
Response to anakinra in a de novo case of neonatal-onset multisystem inflammatory disease
-
Hawkins, P. N., Bybee, A., Aganna, E. & McDermott, M. F. Response to anakinra in a de novo case of neonatal-onset multisystem inflammatory disease. Arthritis Rheum. 50, 2708-2709 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 2708-2709
-
-
Hawkins, P.N.1
Bybee, A.2
Aganna, E.3
McDermott, M.F.4
-
85
-
-
1042290321
-
Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra
-
Hawkins, P. N., Lachmann, H. J., Aganna, E. & McDermott, M. F. Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum. 50, 607-612 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 607-612
-
-
Hawkins, P.N.1
Lachmann, H.J.2
Aganna, E.3
McDermott, M.F.4
-
86
-
-
17244381937
-
Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease
-
Lovell, D. J., Bowyer, S. L. & Solinger, A. M. Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease. Arthritis Rheum. 52, 1283-1286 (2005).
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 1283-1286
-
-
Lovell, D.J.1
Bowyer, S.L.2
Solinger, A.M.3
-
87
-
-
66649102432
-
Use of canakinumab in the cryopyrin-associated periodic syndrome
-
Lachmann, H. J. et al. Use of canakinumab in the cryopyrin-associated periodic syndrome. N. Engl. J. Med. 360, 2416-2425 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 2416-2425
-
-
Lachmann, H.J.1
-
88
-
-
49449094892
-
A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome
-
Goldbach-Mansky, R. et al. A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome. Arthritis Rheum. 58, 2432-2442 (2008).
-
(2008)
Arthritis Rheum.
, vol.58
, pp. 2432-2442
-
-
Goldbach-Mansky, R.1
-
89
-
-
49449094179
-
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrinassociated periodic syndromes: Results from two sequential placebo-controlled studies
-
Hoffman, H. M. et al. Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrinassociated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum. 58, 2443-2452 (2008).
-
(2008)
Arthritis Rheum.
, vol.58
, pp. 2443-2452
-
-
Hoffman, H.M.1
-
90
-
-
34047174085
-
A pilot study of IL-1 inhibition by anakinra in acute gout
-
So, A., De Smedt, T., Revaz, S. & Tschopp, J. A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res. Ther. 9, R28 (2007).
-
(2007)
Arthritis Res. Ther.
, vol.9
-
-
So, A.1
De Smedt, T.2
Revaz, S.3
Tschopp, J.4
-
91
-
-
70349402166
-
The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: Results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study
-
Jul doi:10.1136/ard.2009.108936
-
Terkeltaub, R. et al. The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study. Ann. Rheum. Dis. 26 Jul 2009 (doi:10.1136/ard.2009.108936).
-
(2009)
Ann. Rheum. Dis.
, vol.26
-
-
Terkeltaub, R.1
-
92
-
-
0141998606
-
Molecular identification of a danger signal that alerts the immune system to dying cells
-
Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516-521 (2003).
-
(2003)
Nature
, vol.425
, pp. 516-521
-
-
Shi, Y.1
Evans, J.E.2
Rock, K.L.3
-
93
-
-
33746747096
-
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
-
Chen, C. J. et al. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J. Clin. Invest. 116, 2262-2271 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2262-2271
-
-
Chen, C.J.1
-
94
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006).
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
95
-
-
31544441415
-
Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
-
Matsuki, T., Nakae, S., Sudo, K., Horai, R. & Iwakura, Y. Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis. Int. Immunol. 18, 399-407 (2006).
-
(2006)
Int. Immunol.
, vol.18
, pp. 399-407
-
-
Matsuki, T.1
Nakae, S.2
Sudo, K.3
Horai, R.4
Iwakura, Y.5
-
96
-
-
0037415555
-
Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis
-
Eriksson, U. et al. Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J. Exp. Med. 197, 323-331 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 323-331
-
-
Eriksson, U.1
-
97
-
-
0029875804
-
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF α, anti-IL-1 α/β, and IL-1Ra
-
Joosten, L. A., Helsen, M. M., van de Loo, F. A. & van den Berg, W. B. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF α, anti-IL-1 α/β, and IL-1Ra. Arthritis Rheum. 39, 797-809 (1996).
-
(1996)
Arthritis Rheum.
, vol.39
, pp. 797-809
-
-
Joosten, L.A.1
Helsen, M.M.2
Van De Loo, F.A.3
Van Den Berg, W.B.4
-
98
-
-
0037332006
-
Mice transgenic for intracellular interleukin-1 receptor antagonist type 1 are protected from collagen-induced arthritis
-
Palmer, G. et al. Mice transgenic for intracellular interleukin-1 receptor antagonist type 1 are protected from collagen-induced arthritis. Eur. J. Immunol. 33, 434-440 (2003).
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 434-440
-
-
Palmer, G.1
-
99
-
-
67149130597
-
Anakinra for rheumatoid arthritis: A systematic review
-
Mertens, M. & Singh, J. A. Anakinra for rheumatoid arthritis: a systematic review. J. Rheumatol, 36, 1118-1125 (2009).
-
(2009)
J. Rheumatol
, vol.36
, pp. 1118-1125
-
-
Mertens, M.1
Singh, J.A.2
-
100
-
-
47649086507
-
Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis
-
Ikonomidis, I. et al. Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis. Circulation 117, 2662-2669 (2008).
-
(2008)
Circulation
, vol.117
, pp. 2662-2669
-
-
Ikonomidis, I.1
-
101
-
-
24644519812
-
Involvement of tumor necrosis factor-α in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice
-
Matsuki, T. et al. Involvement of tumor necrosis factor-α in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice. Circulation 112, 1323-1331 (2005).
-
(2005)
Circulation
, vol.112
, pp. 1323-1331
-
-
Matsuki, T.1
-
102
-
-
33745873727
-
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
-
Sutton, C., Brereton, C., Keogh, B., Mills, K. H. & Lavelle, E. C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203, 1685-1691 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1685-1691
-
-
Sutton, C.1
Brereton, C.2
Keogh, B.3
Mills, K.H.4
Lavelle, E.C.5
-
103
-
-
18644385243
-
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
-
Pascual, V., Allantaz, F., Arce, E., Punaro, M. & Banchereau, J. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J. Exp. Med. 201, 1479-1486 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1479-1486
-
-
Pascual, V.1
Allantaz, F.2
Arce, E.3
Punaro, M.4
Banchereau, J.5
-
104
-
-
0141784866
-
IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
-
Matsuki, T., Horai, R., Sudo, K. & Iwakura, Y. IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J. Exp. Med. 198, 877-888 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 877-888
-
-
Matsuki, T.1
Horai, R.2
Sudo, K.3
Iwakura, Y.4
-
105
-
-
34247170807
-
Interleukin1-receptor antagonist in type 2 diabetes mellitus
-
Larsen, C. M. et al. Interleukin1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356, 1517-1526 (2007).
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
-
106
-
-
61449122079
-
Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1βinduced interleukin 6 production and the myeloma proliferative component
-
Lust, J. A. et al. Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1βinduced interleukin 6 production and the myeloma proliferative component. Mayo Clin. Proc. 84, 114-122 (2009).
-
(2009)
Mayo Clin. Proc.
, vol.84
, pp. 114-122
-
-
Lust, J.A.1
-
107
-
-
46249090513
-
Colony-stimulating factors in inflammation and autoimmunity
-
Hamilton, J. A. Colony-stimulating factors in inflammation and autoimmunity. Nature Rev. Immunol. 8, 533-544 (2008).
-
(2008)
Nature Rev. Immunol.
, vol.8
, pp. 533-544
-
-
Hamilton, J.A.1
-
108
-
-
0027249086
-
Rheumatoid arthritis: Opposing actions of haemopoietic growth factors and slowacting anti-rheumatic drugs
-
Hamilton, J. A. Rheumatoid arthritis: opposing actions of haemopoietic growth factors and slowacting anti-rheumatic drugs. Lancet 342, 536-539 (1993).
-
(1993)
Lancet
, vol.342
, pp. 536-539
-
-
Hamilton, J.A.1
-
109
-
-
53349143503
-
GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival
-
Sonderegger, I. et al. GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival. J. Exp. Med. 205, 2281-2294 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2281-2294
-
-
Sonderegger, I.1
-
110
-
-
0032193230
-
Protection from collagen-induced arthritis in granulocyte-macrophage colonystimulating factor-deficient mice
-
Campbell, I. K. et al. Protection from collagen-induced arthritis in granulocyte-macrophage colonystimulating factor-deficient mice. J. Immunol. 161, 3639-3644 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 3639-3644
-
-
Campbell, I.K.1
-
111
-
-
0035476518
-
Granulocyte macrophage colony-stimulating factor: A new putative therapeutic target in multiple sclerosis
-
McQualter, J. L. et al. Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis. J. Exp. Med. 194, 873-882 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 873-882
-
-
McQualter, J.L.1
-
112
-
-
38849170507
-
Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis
-
Sainathan, S. K. et al. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm. Bowel Dis. 14, 88-99 (2008).
-
(2008)
Inflamm. Bowel Dis.
, vol.14
, pp. 88-99
-
-
Sainathan, S.K.1
-
113
-
-
0037048904
-
Treatment of active Crohns disease with recombinant human granulocyte-macrophage colony-stimulating factor
-
Dieckgraefe, B. K. & Korzenik, J. R. Treatment of active Crohns disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 360, 1478-1480 (2002).
-
(2002)
Lancet
, vol.360
, pp. 1478-1480
-
-
Dieckgraefe, B.K.1
Korzenik, J.R.2
-
114
-
-
19444363154
-
Sargramostim for active Crohns disease
-
Korzenik, J. R., Dieckgraefe, B. K., Valentine, J. F., Hausman, D. F. & Gilbert, M. J. Sargramostim for active Crohns disease. N. Engl. J. Med. 352, 2193-2201 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 2193-2201
-
-
Korzenik, J.R.1
Dieckgraefe, B.K.2
Valentine, J.F.3
Hausman, D.F.4
Gilbert, M.J.5
-
115
-
-
0023682969
-
Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression
-
Antman, K. S. et al. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N. Engl. J. Med. 319, 593-598 (1988).
-
(1988)
N. Engl. J. Med.
, vol.319
, pp. 593-598
-
-
Antman, K.S.1
-
116
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua, D. J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003).
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
-
117
-
-
0346962972
-
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
-
Murphy, C. A. et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198, 1951-1957 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1951-1957
-
-
Murphy, C.A.1
-
118
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen, D. et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116, 1310-1316 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
-
119
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish, C. L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
-
120
-
-
0036677420
-
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
-
Becher, B., Durell, B. G. & Noelle, R. J. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110, 493-497 (2002).
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 493-497
-
-
Becher, B.1
Durell, B.G.2
Noelle, R.J.3
-
121
-
-
0035500288
-
Dual role of the IL-12/IFN-α axis in the development of autoimmune myocarditis: Induction by IL-12 and protection by IFN-α
-
Eriksson, U., Kurrer, M. O., Sebald, W., Brombacher, F. & Kopf, M. Dual role of the IL-12/IFN-α axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-α. J. Immunol. 167, 5464-5469 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 5464-5469
-
-
Eriksson, U.1
Kurrer, M.O.2
Sebald, W.3
Brombacher, F.4
Kopf, M.5
-
122
-
-
0030587910
-
IFN-α plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
-
Willenborg, D. O., Fordham, S., Bernard, C. C., Cowden, W. B. & Ramshaw, I. A. IFN-α plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157, 3223-3227 (1996).
-
(1996)
J. Immunol.
, vol.157
, pp. 3223-3227
-
-
Willenborg, D.O.1
Fordham, S.2
Bernard, C.C.3
Cowden, W.B.4
Ramshaw, I.A.5
-
123
-
-
34248572345
-
TH-17 cells in the circle of immunity and autoimmunity
-
Bettelli, E., Oukka, M. & Kuchroo, V. K. TH-17 cells in the circle of immunity and autoimmunity. Nature Immunol. 8, 345-350 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 345-350
-
-
Bettelli, E.1
Oukka, M.2
Kuchroo, V.K.3
-
124
-
-
41549134361
-
Th17 cell differentiation: The long and winding road
-
McGeachy, M. J. & Cua, D. J. Th17 cell differentiation: the long and winding road. Immunity 28, 445-453 (2008).
-
(2008)
Immunity
, vol.28
, pp. 445-453
-
-
McGeachy, M.J.1
Cua, D.J.2
-
125
-
-
41549135632
-
The biological functions of T helper 17 cell effector cytokines in inflammation
-
Ouyang, W., Kolls, J. K. & Zheng, Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28, 454-467 (2008).
-
(2008)
Immunity
, vol.28
, pp. 454-467
-
-
Ouyang, W.1
Kolls, J.K.2
Zheng, Y.3
-
126
-
-
61749093508
-
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
-
Haak, S. et al. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 119, 61-69 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 61-69
-
-
Haak, S.1
-
127
-
-
40049103352
-
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
-
Kreymborg, K. et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 179, 8098-8104 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 8098-8104
-
-
Kreymborg, K.1
-
128
-
-
46749133961
-
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
-
Sonderegger, I., Kisielow, J., Meier, R., King, C. & Kopf, M. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur. J. Immunol. 38, 1833-1838 (2008).
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 1833-1838
-
-
Sonderegger, I.1
Kisielow, J.2
Meier, R.3
King, C.4
Kopf, M.5
-
129
-
-
46749156754
-
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
-
Coquet, J. M., Chakravarti, S., Smyth, M. J. & Godfrey, D. I. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180, 7097-7101 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 7097-7101
-
-
Coquet, J.M.1
Chakravarti, S.2
Smyth, M.J.3
Godfrey, D.I.4
-
130
-
-
33846608131
-
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
-
Cargill, M. et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am. J. Hum. Genet. 80, 273-290 (2007).
-
(2007)
Am. J. Hum. Genet.
, vol.80
, pp. 273-290
-
-
Cargill, M.1
-
131
-
-
35748981184
-
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
-
Burton, P. R. et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genet. 39, 1329-1337 (2007).
-
(2007)
Nature Genet.
, vol.39
, pp. 1329-1337
-
-
Burton, P.R.1
-
132
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr, R. H. et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-1463 (2006).
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
-
133
-
-
59149087627
-
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
-
Silverberg, M. S. et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nature Genet. 41, 216-220 (2009).
-
(2009)
Nature Genet.
, vol.41
, pp. 216-220
-
-
Silverberg, M.S.1
-
134
-
-
43449111187
-
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
-
Leonardi, C. L. et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371, 1665-1674 (2008).
-
(2008)
Lancet
, vol.371
, pp. 1665-1674
-
-
Leonardi, C.L.1
-
135
-
-
43449139402
-
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
-
Papp, K. A. et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 371, 1675-1684 (2008).
-
(2008)
Lancet
, vol.371
, pp. 1675-1684
-
-
Papp, K.A.1
-
136
-
-
60249084148
-
Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: Randomised, double-blind, placebo-controlled, crossover trial
-
Gottlieb, A. et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet 373, 633-640 (2009).
-
(2009)
Lancet
, vol.373
, pp. 633-640
-
-
Gottlieb, A.1
-
137
-
-
53049091561
-
A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohns disease
-
Sandborn, W. J. et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohns disease. Gastroenterology 135, 1130-1141 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
-
138
-
-
48849087125
-
Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: A phase II, double-blind, placebo-controlled, randomised, dose-ranging study
-
Segal, B. M. et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol. 7, 796-804 (2008).
-
(2008)
Lancet Neurol.
, vol.7
, pp. 796-804
-
-
Segal, B.M.1
-
139
-
-
0033057576
-
IL-12 and IFN-α in host defense against mycobacteria and salmonella in mice and men
-
Jouanguy, E. et al. IL-12 and IFN-α in host defense against mycobacteria and salmonella in mice and men. Curr. Opin. Immunol. 11, 346-351 (1999).
-
(1999)
Curr. Opin. Immunol.
, vol.11
, pp. 346-351
-
-
Jouanguy, E.1
-
140
-
-
33750450544
-
Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection
-
Chackerian, A. A. et al. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Infect. Immun. 74, 6092-6099 (2006).
-
(2006)
Infect. Immun.
, vol.74
, pp. 6092-6099
-
-
Chackerian, A.A.1
-
141
-
-
0030790652
-
Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis
-
Cooper, A. M., Magram, J., Ferrante, J. & Orme, I. M. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J. Exp. Med. 186, 39-45 (1997).
-
(1997)
J. Exp. Med.
, vol.186
, pp. 39-45
-
-
Cooper, A.M.1
Magram, J.2
Ferrante, J.3
Orme, I.M.4
-
142
-
-
35348915412
-
IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
-
Zelante, T. et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol. 37, 2695-2706 (2007).
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 2695-2706
-
-
Zelante, T.1
-
143
-
-
0029847368
-
Functional diversity of helper T lymphocytes
-
Abbas, A. K., Murphy, K. M. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787-793 (1996).
-
(1996)
Nature
, vol.383
, pp. 787-793
-
-
Abbas, A.K.1
Murphy, K.M.2
Sher, A.3
-
144
-
-
0034881151
-
Randomized double-blind trial of anti-interferon-γ antibodies in rheumatoid arthritis
-
Sigidin, Y. A., Loukina, G. V., Skurkovich, B. & Skurkovich, S. Randomized, double-blind trial of anti-interferon-γ antibodies in rheumatoid arthritis. Scand. J. Rheumatol. 30, 203-207 (2001).
-
(2001)
Scand. J. Rheumatol.
, vol.30
, pp. 203-207
-
-
Sigidin, Y.A.1
Loukina, G.V.2
Skurkovich, B.3
Skurkovich, S.4
-
145
-
-
33746176176
-
Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohns disease
-
Hommes, D. W. et al. Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohns disease. Gut 55, 1131-1137 (2006).
-
(2006)
Gut
, vol.55
, pp. 1131-1137
-
-
Hommes, D.W.1
-
146
-
-
0034762869
-
Genetic ablation of interferon-γ up-regulates interleukin-1β expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain
-
Guedez, Y. B. et al. Genetic ablation of interferon-γ up-regulates interleukin-1β expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. Arthritis Rheum. 44, 2413-2424 (2001).
-
(2001)
Arthritis Rheum.
, vol.44
, pp. 2413-2424
-
-
Guedez, Y.B.1
-
147
-
-
0034033440
-
Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-α receptor-deficient mice
-
Camoglio, L. et al. Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-α receptor-deficient mice. Eur. J. Immunol. 30, 1486-1495 (2000).
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 1486-1495
-
-
Camoglio, L.1
-
148
-
-
46949086111
-
A rush to judgment on Th17
-
Steinman, L. A rush to judgment on Th17. J. Exp. Med. 205, 1517-1522 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1517-1522
-
-
Steinman, L.1
-
149
-
-
0036219062
-
Genetic dissection of immunity to mycobacteria: The human model
-
Casanova, J. L. & Abel, L. Genetic dissection of immunity to mycobacteria: the human model. Annu. Rev. Immunol. 20, 581-620 (2002).
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 581-620
-
-
Casanova, J.L.1
Abel, L.2
-
150
-
-
33847206969
-
IL-17 family cytokines and the expanding diversity of effector T cell lineages
-
Weaver, C. T., Hatton, R. D., Mangan, P. R. & Harrington, L. E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25, 821-852 (2007).
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 821-852
-
-
Weaver, C.T.1
Hatton, R.D.2
Mangan, P.R.3
Harrington, L.E.4
-
151
-
-
34248574863
-
A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
-
Chang, S. H. & Dong, C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res. 17, 435-440 (2007).
-
(2007)
Cell Res.
, vol.17
, pp. 435-440
-
-
Chang, S.H.1
Dong, C.2
-
152
-
-
61949463911
-
IL-17 and Th17 cells
-
Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V. K. IL-17 and Th17 Cells. Annu. Rev. Immunol. 27, 485-517 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 485-517
-
-
Korn, T.1
Bettelli, E.2
Oukka, M.3
Kuchroo, V.K.4
-
153
-
-
69249145293
-
Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa
-
Khader, S. A., Gaffen, S. L. & Kolls, J. K. Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol. 2, 403-411 (2009).
-
(2009)
Mucosal Immunol.
, vol.2
, pp. 403-411
-
-
Khader, S.A.1
Gaffen, S.L.2
Kolls, J.K.3
-
154
-
-
58149231532
-
Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
-
Ishigame, H. et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30, 108-119 (2009).
-
(2009)
Immunity
, vol.30
, pp. 108-119
-
-
Ishigame, H.1
-
155
-
-
77950535421
-
LY2439821, a humanized anti-IL-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis
-
Genovese, M. et al. LY2439821, a humanized anti-IL-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis. Arthritis Rheum. 62, 929-939 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 929-939
-
-
Genovese, M.1
-
156
-
-
77953253840
-
AIN457 shows a good safety profile and clinical benefit in patients with active rheumatoid arthritis (RA) despite methotrexate therapy: 16-weeks results from a randomized proof-of-concept trial
-
Tak, P. et al. AIN457 shows a good safety profile and clinical benefit in patients with active rheumatoid arthritis (RA) despite methotrexate therapy: 16-weeks results from a randomized proof-of-concept trial. Arthritis Rheum. 60 (Suppl. 10), 1922 (2009).
-
(2009)
Arthritis Rheum.
, vol.60
, Issue.SUPPL. 10
, pp. 1922
-
-
Tak, P.1
-
157
-
-
33846906224
-
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
-
Zheng, Y. et al. Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648-651 (2007).
-
(2007)
Nature
, vol.445
, pp. 648-651
-
-
Zheng, Y.1
-
158
-
-
54949142477
-
Cytokine-mediated regulation of antimicrobial proteins
-
Kolls, J. K., McCray, P. B. Jr & Chan, Y. R. Cytokine-mediated regulation of antimicrobial proteins. Nature Rev. Immunol. 8, 829-835 (2008).
-
(2008)
Nature Rev. Immunol.
, vol.8
, pp. 829-835
-
-
Kolls, J.K.1
McCray Jr., P.B.2
Chan, Y.R.3
-
159
-
-
57849117363
-
ROR-t and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
-
Sanos, S. L. et al. ROR-t and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nature Immunol. 10, 83-91 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 83-91
-
-
Sanos, S.L.1
-
160
-
-
57449118239
-
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
-
Satoh-Takayama, N. et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 29, 958-970 (2008).
-
(2008)
Immunity
, vol.29
, pp. 958-970
-
-
Satoh-Takayama, N.1
-
161
-
-
59649099774
-
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
-
Cella, M. et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 457, 722-725 (2009).
-
(2009)
Nature
, vol.457
, pp. 722-725
-
-
Cella, M.1
-
162
-
-
57449090428
-
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
-
Zenewicz, L. A. et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29, 947-957 (2008).
-
(2008)
Immunity
, vol.29
, pp. 947-957
-
-
Zenewicz, L.A.1
-
163
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto, K. et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
-
164
-
-
70949087383
-
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
-
Glocker, E. O. et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N. Engl. J. Med. 361, 2033-2045 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2033-2045
-
-
Glocker, E.O.1
-
165
-
-
35348983341
-
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
-
Zenewicz, L. A. et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647-659 (2007).
-
(2007)
Immunity
, vol.27
, pp. 647-659
-
-
Zenewicz, L.A.1
-
166
-
-
40049098958
-
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
-
Aujla, S. J. et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nature Med. 14, 275-281 (2008).
-
(2008)
Nature Med.
, vol.14
, pp. 275-281
-
-
Aujla, S.J.1
-
167
-
-
40049083827
-
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
-
Zheng, Y. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nature Med. 14, 282-289 (2008).
-
(2008)
Nature Med.
, vol.14
, pp. 282-289
-
-
Zheng, Y.1
-
168
-
-
25444434157
-
Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
-
Leonard, W. J. & Spolski, R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nature Rev. Immunol. 5, 688-698 (2005).
-
(2005)
Nature Rev. Immunol.
, vol.5
, pp. 688-698
-
-
Leonard, W.J.1
Spolski, R.2
-
169
-
-
42649134105
-
Interleukin-21: Basic biology and implications for cancer and autoimmunity
-
Spolski, R. & Leonard, W. J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26, 57-79 (2008).
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 57-79
-
-
Spolski, R.1
Leonard, W.J.2
-
170
-
-
0034597789
-
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
-
Parrish-Novak, J. et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408, 57-63 (2000).
-
(2000)
Nature
, vol.408
, pp. 57-63
-
-
Parrish-Novak, J.1
-
171
-
-
47549112840
-
IL-21 and TGF-α are required for differentiation of human TH17 cells
-
Yang, L. et al. IL-21 and TGF-α are required for differentiation of human TH17 cells. Nature 454, 350-352 (2008).
-
(2008)
Nature
, vol.454
, pp. 350-352
-
-
Yang, L.1
-
172
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
-
Korn, T. et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature 448, 484-487 (2007).
-
(2007)
Nature
, vol.448
, pp. 484-487
-
-
Korn, T.1
-
173
-
-
34547204946
-
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
-
Nurieva, R. et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448, 480-483 (2007).
-
(2007)
Nature
, vol.448
, pp. 480-483
-
-
Nurieva, R.1
-
174
-
-
33847412873
-
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
-
Frohlich, A. et al. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood 109, 2023-2031 (2007).
-
(2007)
Blood
, vol.109
, pp. 2023-2031
-
-
Frohlich, A.1
-
175
-
-
46749151286
-
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
-
Nurieva, R. I. et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29, 138-149 (2008).
-
(2008)
Immunity
, vol.29
, pp. 138-149
-
-
Nurieva, R.I.1
-
176
-
-
46749115446
-
A fundamental role for interleukin-21 in the generation of T follicular helper cells
-
Vogelzang, A. et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29, 127-137 (2008).
-
(2008)
Immunity
, vol.29
, pp. 127-137
-
-
Vogelzang, A.1
-
177
-
-
77149122105
-
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
-
Linterman, M. A. et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J. Exp. Med. 207, 353-363 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 353-363
-
-
Linterman, M.A.1
-
178
-
-
77954500603
-
Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner
-
Bessa, J., Kopf, M. & Bachmann, M. F. Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner. J. Immunol. 184, 4615-4619 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 4615-4619
-
-
Bessa, J.1
Kopf, M.2
Bachmann, M.F.3
-
179
-
-
41549160141
-
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
-
Sawalha, A. H. et al. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann. Rheum. Dis. 67, 458-461 (2008).
-
(2008)
Ann. Rheum. Dis.
, vol.67
, pp. 458-461
-
-
Sawalha, A.H.1
-
180
-
-
33947215987
-
IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
-
Herber, D. et al. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J. Immunol. 178, 3822-3830 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 3822-3830
-
-
Herber, D.1
-
181
-
-
41549131849
-
T follicular helper (TFH) cells in normal and dysregulated immune responses
-
King, C., Tangye, S. G. & Mackay, C. R. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 26, 741-766 (2008).
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 741-766
-
-
King, C.1
Tangye, S.G.2
MacKay, C.R.3
-
182
-
-
18244405108
-
IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
-
Fort, M. M. et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15, 985-995 (2001).
-
(2001)
Immunity
, vol.15
, pp. 985-995
-
-
Fort, M.M.1
-
183
-
-
33645896155
-
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
-
Owyang, A. M. et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J. Exp. Med. 203, 843-849 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 843-849
-
-
Owyang, A.M.1
-
184
-
-
33645888708
-
Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
-
Fallon, P. G. et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med. 203, 1105-1116 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1105-1116
-
-
Fallon, P.G.1
-
185
-
-
0035846998
-
IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1
-
Lee, J. et al. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J. Biol. Chem. 276, 1660-1664 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 1660-1664
-
-
Lee, J.1
-
186
-
-
56149091567
-
Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities
-
Rickel, E. A. et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J. Immunol. 181, 4299-4310 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 4299-4310
-
-
Rickel, E.A.1
-
187
-
-
33748064320
-
IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice
-
Tamachi, T. et al. IL-25 enhances allergic airway inflammation by
-
(2006)
J. Allergy Clin. Immunol.
, vol.118
, pp. 606-614
-
-
Tamachi, T.1
-
188
-
-
36749051929
-
Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma
-
Ballantyne, S. J. et al. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J. Allergy Clin. Immunol. 120, 1324-1331 (2007).
-
(2007)
J. Allergy Clin. Immunol.
, vol.120
, pp. 1324-1331
-
-
Ballantyne, S.J.1
-
189
-
-
33846458998
-
IL-25 regulates Th17 function in autoimmune inflammation
-
Kleinschek, M. A. et al. IL-25 regulates Th17 function in autoimmune inflammation. J. Exp. Med. 204, 161-170 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 161-170
-
-
Kleinschek, M.A.1
-
190
-
-
34247891512
-
TSLP: An epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
-
Liu, Y. J. et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu. Rev. Immunol. 25, 193-219 (2007).
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 193-219
-
-
Liu, Y.J.1
-
191
-
-
25844515028
-
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
-
Zhou, B. et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nature Immunol. 6, 1047-1053 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 1047-1053
-
-
Zhou, B.1
-
192
-
-
27744510433
-
TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
-
Ito, T. et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 202, 1213-1223 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1213-1223
-
-
Ito, T.1
-
193
-
-
23944459169
-
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
-
Yoo, J. et al. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J. Exp. Med. 202, 541-549 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 541-549
-
-
Yoo, J.1
-
194
-
-
0036301998
-
Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
-
Soumelis, V. et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature Immunol. 3, 673-680 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 673-680
-
-
Soumelis, V.1
-
195
-
-
25144525707
-
A role for TSLP in the development of inflammation in an asthma model
-
Al-Shami, A., Spolski, R., Kelly, J., Keane-Myers, A. & Leonard, W. J. A role for TSLP in the development of inflammation in an asthma model. J. Exp. Med. 202, 829-839 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 829-839
-
-
Al-Shami, A.1
Spolski, R.2
Kelly, J.3
Keane-Myers, A.4
Leonard, W.J.5
-
196
-
-
33847134006
-
Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
-
Allakhverdi, Z. et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J. Exp. Med. 204, 253-258 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 253-258
-
-
Allakhverdi, Z.1
-
197
-
-
63449112387
-
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis
-
Taylor, B. C. et al. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J. Exp. Med. 206, 655-667 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 655-667
-
-
Taylor, B.C.1
-
198
-
-
2542486456
-
Asthma: Mechanisms of disease persistence and progression
-
Cohn, L., Elias, J. A. & Chupp, G. L. Asthma: mechanisms of disease persistence and progression. Annu. Rev. Immunol. 22, 789-815 (2004).
-
(2004)
Annu. Rev. Immunol.
, vol.22
, pp. 789-815
-
-
Cohn, L.1
Elias, J.A.2
Chupp, G.L.3
-
199
-
-
0030689729
-
Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
-
Cohn, L., Homer, R. J., Marinov, A., Rankin, J. & Bottomly, K. Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186, 1737-1747 (1997).
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1737-1747
-
-
Cohn, L.1
Homer, R.J.2
Marinov, A.3
Rankin, J.4
Bottomly, K.5
-
200
-
-
0034995872
-
Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
-
Borish, L. C. et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J. Allergy Clin. Immunol. 107, 963-970 (2001).
-
(2001)
J. Allergy Clin. Immunol.
, vol.107
, pp. 963-970
-
-
Borish, L.C.1
-
201
-
-
0033454115
-
Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebocontrolled trial
-
Borish, L. C. et al. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebocontrolled trial. Am. J. Respir. Crit. Care Med. 160, 1816-1823 (1999).
-
(1999)
Am. J. Respir. Crit. Care Med.
, vol.160
, pp. 1816-1823
-
-
Borish, L.C.1
-
202
-
-
0035719975
-
Th2 cytokines and asthma. Interleukin-4: Its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
-
Steinke, J. W. & Borish, L. Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir. Res. 2, 66-70 (2001).
-
(2001)
Respir. Res.
, vol.2
, pp. 66-70
-
-
Steinke, J.W.1
Borish, L.2
-
203
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response
-
Leckie, M. J. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet 356, 2144-2148 (2000).
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
-
204
-
-
0038643527
-
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
-
Kips, J. C. et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am. J. Respir. Crit. Care Med. 167, 1655-1659 (2003).
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 1655-1659
-
-
Kips, J.C.1
-
205
-
-
0346816643
-
Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis
-
Plotz, S. G. et al. Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis. N. Engl. J. Med. 349, 2334-2339 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 2334-2339
-
-
Plotz, S.G.1
-
206
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
Nair, P. et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N. Engl. J. Med. 360, 985-993 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 985-993
-
-
Nair, P.1
-
207
-
-
65249098980
-
Immunodrugs: Therapeutic VLP-based vaccines for chronic diseases
-
Jennings, G. T. & Bachmann, M. F. Immunodrugs: therapeutic VLP-based vaccines for chronic diseases. Annu. Rev. Pharmacol. Toxicol. 49, 303-326 (2009).
-
(2009)
Annu. Rev. Pharmacol. Toxicol.
, vol.49
, pp. 303-326
-
-
Jennings, G.T.1
Bachmann, M.F.2
-
208
-
-
33751254750
-
Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis
-
Rohn, T. A. et al. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur. J. Immunol. 36, 2857-2867 (2006).
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 2857-2867
-
-
Rohn, T.A.1
-
209
-
-
33751242743
-
Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis
-
Sonderegger, I. et al. Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur. J. Immunol. 36, 2849-2856 (2006).
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 2849-2856
-
-
Sonderegger, I.1
-
210
-
-
34249809700
-
A virus-like particle-based vaccine selectively targeting soluble TNF-α protects from arthritis without inducing reactivation of latent tuberculosis
-
Spohn, G. et al. A virus-like particle-based vaccine selectively targeting soluble TNF-α protects from arthritis without inducing reactivation of latent tuberculosis. J. Immunol. 178, 7450-7457 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 7450-7457
-
-
Spohn, G.1
-
211
-
-
77953240156
-
Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity
-
Yu, D. & Vinuesa, C. G. Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity. Cell. Mol. Immunol. 7, 198-203 (2010).
-
(2010)
Cell. Mol. Immunol.
, vol.7
, pp. 198-203
-
-
Yu, D.1
Vinuesa, C.G.2
-
212
-
-
33846515975
-
Induction of IL-4 expression in CD4+ T cells by thymic stromal lymphopoietin
-
Omori, M. & Ziegler, S. Induction of IL-4 expression in CD4+ T cells by thymic stromal lymphopoietin. J. Immunol. 178, 1396-1404 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 1396-1404
-
-
Omori, M.1
Ziegler, S.2
|