Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis

Arthritis and Rheumatism

Volumn 52, Issue 4, 2005, Pages 1314-1318

  Schiffelers, Raymond M ^a,b   Xu, Jun ^a   Storm, Gert ^b   Woodle, Martin C ^a   Scaria, Puthupparampil V ^a  

^a Intradigm Corporation   (United States)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; DOUBLE STRANDED RNA; LUCIFERASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; ELECTROPORATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; RNA INTERFERENCE; SILENCER GENE; TREATMENT OUTCOME;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CELL LINE; COLLAGEN; DISEASE MODELS, ANIMAL; ELECTROPORATION; FEMALE; GENE SILENCING; GENE TARGETING; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; JOINTS; LUCIFERASES; MICE; MICE, NUDE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 17244378648     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.20975     Document Type: Article

References (20)

1. Zamore PD. Ancient pathways programmed by small RNAs. Science 2002;296:1265-9.
2. Tuschl T, Borkhardt A. Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy. Mol Interv 2002;2:158-67.
3. Schiffelers RM, Woodle MC, Scaria P. Pharmaceutical prospects for RNA interference. Pharm Res 2004;21:1-7.
4. Arend WP. Physiology of cytokine pathways in rheumatoid arthritis [review]. Arthritis Rheum 2001;45:101-6.
5. Lubberts E. The role of IL-17 and family members in the pathogenesis of arthritis. Curr Opin Investig Drugs 2003;4:572-7.
6. D'Ambrosio D, Panina-Bordignon P, Sinigaglia F. Chemokine receptors in inflammation: an overview. J Immunol Methods 2003;273:3-13.
7. Muramatsu T, Mizutani Y, Ohmori Y, Okumura J. Comparison of three nonviral transfection methods for foreign gene expression in early chicken embryos in ovo. Biochem Biophys Res Commun 1997;230:376-80.
8. Funahashi J, Okafuji T, Ohuchi H, Noji S, Tanaka H, Nakamura H. Role of Pax-5 in the regulation of a mid-hindbrain organizer's activity. Dev Growth Differ 1999;41:59-72.
9. Aihara H, Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998;16:867-70.
10. Katahira T, Nakamura H. Gene silencing in chick embryos with a vector-based small interfering RNA system. Dev Growth Differ 2003;45:361-7.
11. Celiker MY, Ramamurthy N, Xu JW, Wang M, Jiang Y, Greenwald R, et al. Inhibition of adjuvant-induced arthritis by systemic tissue inhibitor of metalloproteinases 4 gene delivery. Arthritis Rheum 2002;46:3361-8.
12. Ohashi S, Kubo T, Kishida T, Ikeda T, Takahashi K, Arai Y, et al. Successful genetic transduction in vivo into synovium by means of electroporation. Biochem Biophys Res Commun 2002;293:1530-5.
13. Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells, using small interfering RNAs. Methods 2002;26:199-213.
14. Zald PB, Cotter MA II, Robertson ES. Improved transfection efficiency of 293 cells by radio frequency electroporation. Biotechniques 2000;28:418.
15. Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum 2004;50:1686-9.
16. Filleur S, Courtin A, Ait-Si-Ali S, Guglielmi J, Merle C, Harel-Bellan A, et al. siRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. Cancer Res 2003;63:3919-22.
17. Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci U S A 1992;89:9784-8.
18. Gould DJ, Bright C, Chernajovsky Y. Inhibition of established collagen-induced arthritis with a tumour necrosis factor-α inhibitor expressed from a self-contained doxycycline regulated plasmid. Arthritis Res Ther 2004;6:R103-13.
19. Mukherjee P, Wu B, Mayton L, Kim SH, Robbins PD, Wooley PH. TNF receptor gene therapy results in suppression of IgG2a anticollagen antibody in collagen induced arthritis. Ann Rheum Dis 2003;62:707-14.
20. Kishida T, Asada H, Gojo S, Ohashi S, Shin-Ya M, Yasutomi K, et al. Sequence-specific gene silencing in murine muscle induced by electroporation-mediated transfer of short interfering RNA. J Gene Med 2004;6:105-10.