Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: Possible involvement of Stat3 activation in the protection of neurons

Journal of Neurochemistry

Volumn 94, Issue 2, 2005, Pages 459-468

  Yamashita, Toru ^a,b,d   Sawamoto, Kazunobu ^a,d   Suzuki, Shigeaki ^a   Suzuki, Norihiro ^a   Adachi, Kazuhide ^a,d   Kawase, Takeshi ^a   Mihara, Masahiko ^c   Ohsugi, Yoshiyuki ^c   Abet, Koji ^b   Okano, Hideyuki ^a,d  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Focal cerebral ischemia; Interleukin 6; Interleukin6 receptor antibody; Neuroprotection; Signal transducer and activation of transcription 3

Indexed keywords

COMPLEMENTARY DNA; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MESSENGER RNA; RECEPTOR ANTIBODY; STAT3 PROTEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN ISCHEMIA; CASPASE 3; CASPASES; CELL COUNT; CEREBRAL CORTEX; CHI-SQUARE DISTRIBUTION; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HISTOCYTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; NEURONS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERLEUKIN-6; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 22244468321     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03227.x     Document Type: Article

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