Dual role of the IL-12/IFN-γ axis in the development of autoimmune myocarditis: Induction by IL-12 and protection by IFN-γ

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5464-5469

  Eriksson, U ^a   Kurrer, M O ^a   Sebald, W ^a   Brombacher, F ^a   Kopf, M ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12;

ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; MOUSE; MYOCARDITIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 0035500288     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5464     Document Type: Article

References (40)

1. Review of microbial infections and the immune response to cardiac antigens
2. Viral infection and the pathogenesis of dilated cardiomyopathy
3. Cardiac myosin induces myocarditis in genetically predisposed mice
4. Evidence for autoimmunity to myosin and other heart-specific autoantigens in patients with dilated cardiomyopathy and their relatives
5. Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice
6. Myosin-induced acute myocarditis is a T cell-mediated disease
7. Susceptibility to myocarditis is dependent on the response of αβ T lymphocytes to coxsackieviral infection
8. Cellular and molecular mechanisms of murine autoimmune myocarditis
9. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
10. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
11. IL-12: Initiation cytokine for cell-mediated immunity
12. IL-12-deficient mice are defective in IFNγ production and type cytokine responses
13. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
14. + effector cells default to the Th2 pathway in interferon γ- deficient mice infected with Leishmania major
15. Antibodies to interleukin 12 abrogate established experimental colitis in mice
16. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
17. Interleukin 12 protects from a T helper type I-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon γ, nitric oxide, and apoptosis
18. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice
19. Recombinant murine interleukin-12 facilitates induction of cardiac myosin-specific type 1 helper T cells in rats
20. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferonγ expression by T cells
21. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-γ and nitric oxide synthetase 2
22. Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor
23. Differences between IL-4- and IL-4 receptor a-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling
24. A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction
25. Immune responses of IL-4, IL-5, IL-6 deficient mice
26. Lethal autoimmune myocarditis in interferon-γ receptor-deficient mice: Enhanced disease severity by impaired inducible nitric oxide synthase induction
27. Differences between IL-4Rα-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses
28. The role of IL-12 in the induction of organ-specific autoimmune diseases
29. Organ-specific autoimmunity
30. Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-γ receptor-deficient mice
31. Interferon-γ confers resistance to experimental allergic encephalomyelitis
32. Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
33. Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity
34. Autoimmune myocarditis does not require B cells for antigen presentation
35. Tumor necrosis factor α and lymphotoxin α are not required for induction of acute experimental autoimmune encephalomyelitis
36. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
37. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
38. CCR5 is characteristic of Th1 lymphocytes
39. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
40. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on α1,3-fucosyltransferase VII gene expression