Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis

Journal of Experimental Medicine

Volumn 186, Issue 1, 1997, Pages 39-45

  Cooper, Andrea M ^a   Magram, Jeanne ^b   Ferrante, Jessica ^b   Orme, Ian M ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; MACROPHAGE ACTIVATION; MALE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUBERCULOSIS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; IMMUNITY, CELLULAR; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 0030790652     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.1.39     Document Type: Article

References (33)

1. Orme, I.M. 1987. The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis. J. Immunol. 138:293-298.
2. Orme, I.M., A.D. Roberts, J.P. Griffin, and J.S. Abrams. 1993. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J. Immunol. 151:518-525.
3. Orme, I.M., E.S. Miller, A.D. Roberts, S.K. Furney, J.P. Griffin, K.M. Dobos, D. Chi, B. Rivoire, and P.J. Brennan. 1992. T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens. J. Immunol. 148:189-196.
4. Orme, I.M. 1988. Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection. J. Immunol. 140:3589-3593.
5. Cooper, A.M., D.K. Dalton, T.A. Stewart, J.P. Griffin, D.G. Russell, and I.M. Orme. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J. Exp. Med. 178: 2243-2247.
6. Flynn, J.L., J. Chan, K.J. Triebold, D.K. Dalton, T.A. Stewart, and B.R. Bloom. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2254.
7. D'Andrea, A., M. Rengaraju, N.M. Valiante, J. Chehimi, M. Kubin, M. Aste, S.H. Chan, M. Kobayashi, D. Young, E. Nickbarg et al. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387-1398.
8. Manetti, R., P. Parronchi, M.G. Giudizi, M.P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin-12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199-1204.
9. Hsieh, C.S., S.E. Macatonia, C.S. Tripp, S.F. Wolf, A. O'Garra, and K.M. Murphy. 1993. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science (Wash. DC). 260:547-549.
10. Murphy, E.E., G. Terres, S.E. Macatonia, C.S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223-231.
11. Flynn, J.L., M.M. Goldstein, K.J. Triebold, J. Sypek, S. Wolf, and B.R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155:2515-2524.
12. Cooper, A.M., A.D. Roberts, E.R. Rhoades, J.E. Callahan, D.M. Getzy, and I.M. Orme. 1995. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology. 84:423-432.
13. Magram, J., S.E. Connaughton, R.R. Warner, D.M. Carvajal, C.-Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D.A. Faherty, and M.K. Gately. 1996. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity. 4:471-481.
14. Cooper, A.M., J.E. Callahan, J.P. Griffin, A.D. Roberts, and I.M. Orme. 1995. Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis. Infect. Immun. 63:3259-3265.
15. Cooper, A.M., and J.L. Flynn. 1995. The protective immune response to Mycobacterium tuberculosis. Curr. Opin. Immunol. 7:512-516.
16. Orme, I.M. 1988. A mouse model of the recrudescence of latent tuberculosis in the elderly. Am. Rev. Respir. Dis. 137: 716-718.
17. Roach, T.I.A., A.F. Kiderlen, and J.M. Blackwell. 1991. Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains. Inject. Immun. 59:3935-3944.
18. Zurawski, G., and J.E. de Vries. 1994. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today. 15:19-26.
19. Okamura, H., K. Nagata, T. Komatsu, T. Tanimoto, Y. Nukata, F. Tanabe, K. Akita, K. Tongoe, T. Okura, S. Fukuda, and M. Kurimoto. 1995. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect. Immun. 63:3966-3972.
20. Okamura, H., H. Tsutsui, T. Komatsu, M. Yatsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature (Lond.). 378:88-91.
21. Gu, Y., K. Kuida, H. Tsutsui, G. Ku, K. Hsiao, M.A. Fleming, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi et al. 1997. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme. Science (Wash. DC). 275:206-209.
22. Wu, C.Y., R.R. Warrier, D.M. Carvajal, A.O. Chua, L.J. Minetti, R. Chizzonite, P.K. Mongini, A.S. Stern, U. Gubler, D.H. Presky, and M.K. Gately. 1996. Biological function and distribution of human interleukin-12 receptor beta chain. Eur. J. Immunol. 26:345-350.
23. Presky, D.H., H. Yang, L.J. Minetti, A.O. Chua, N. Nabavi, C.Y. Wu, M.K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two b-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA. 93: 14002-14007.
24. Guler, M.L., J.D. Gorham, C.S. Hsieh, A.J. Mackay, R.G. Steen, W.F. Dietrich, and K.M. Murphy. 1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 cell development. Science (Wash. DC). 271:984-987.
25. Wenner, C.A., M.L. Guler, S.E. Macatonia, A. O'Garra, and K.M. Murphy. 1996. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J. Immunol. 156:1442-1447.
26. Szabo, S.J., N.G. Jacobson, A.S. Dighe, U. Gubler, and K.M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2:665-675.
27. Szabo, S.J., U. Gubler, and K.M. Murphy. 1997. Selective expression of IL-12 receptor beta 2 subunit mRNA in Th1 cells: regulation by IFN-gamma. J. Exp. Med. 185:817-825.
28. Austrup, F., D. Vestweber, E. Borges, M. Lohning, R. Brauer, U. Herz, H. Renz, R. Hallman, A. Scheffold, A. Radbruch, and A. Hamann. 1997. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissue. Nature (Lond.). 385:81-83.
29. Borges, E., W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber. 1997. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J. Exp. Med. 185:573-578.
30. Schall, T.J., K. Bacon, K.J. Toy, and D.V. Goeddel. 1990. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature (Lond.). 347:669-671.
31. Car, B.D., V.M. Eng, B. Schnyder, M. LeHir, A.N. Shakhov, G. Woerly, S. Huang, M. Aguet, T.D. Anderson, and B. Ryffel. 1995. Role of interferon-gamma in interleukin 12-induced pathology in mice. Am. J. Pathol. 147:1693-1707.
32. Leung, D.Y., M. Gately, A. Trumble, B. Ferguson-Darnell, P.M. Schlievert, and L.J. Picker. 1995. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J. Exp. Med. 181: 747-753.
33. Nagami, P.H., and T.T. Yoshikawa. 1983. Tuberculosis in the geriatric patient. J. Amer. Ger. Soc. 31:356-363.