-
1
-
-
0037449737
-
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
-
Aggarwal, S., N. Ghilardi, M. H. Xie, F. J. de Sauvage, and A. L. Gurney. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278:1910-1914.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 1910-1914
-
-
Aggarwal, S.1
Ghilardi, N.2
Xie, M.H.3
De Sauvage, F.J.4
Gurney, A.L.5
-
2
-
-
33646433989
-
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
-
Chen, Y., C. L. Langrisb, B. McKenzie, B. Joyce-Shaikh, J. S. Stumhofer, T. McClanahan, W. Blumenschein, T. Churakovsa, J. Low, L. Presta, C. A. Hunter, R. A. Kastelein, and D. J. Cua. 2006. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J. Clin. Investig. 116:1317-1326.
-
(2006)
J. Clin. Investig.
, vol.116
, pp. 1317-1326
-
-
Chen, Y.1
Langrisb, C.L.2
McKenzie, B.3
Joyce-Shaikh, B.4
Stumhofer, J.S.5
McClanahan, T.6
Blumenschein, W.7
Churakovsa, T.8
Low, J.9
Presta, L.10
Hunter, C.A.11
Kastelein, R.A.12
Cua, D.J.13
-
3
-
-
0036467445
-
Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present
-
Cooper, A. M., A. Kipnis, J. Turner, J. Magram, J. Ferrante, and I. M. Orme. 2002. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J. Immunol. 168:1322-1327.
-
(2002)
J. Immunol.
, vol.168
, pp. 1322-1327
-
-
Cooper, A.M.1
Kipnis, A.2
Turner, J.3
Magram, J.4
Ferrante, J.5
Orme, I.M.6
-
4
-
-
33746215298
-
Cutting edge: IFN-γ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection
-
Cruz, A., S. A. Khader, E. Torrado, A. Fraga, J. E. Pearl, J. Pedrosa, A. M. Cooper, and A. G. Castro. 2006. Cutting edge: IFN-γ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J. Immunol. 177:1416-1420.
-
(2006)
J. Immunol.
, vol.177
, pp. 1416-1420
-
-
Cruz, A.1
Khader, S.A.2
Torrado, E.3
Fraga, A.4
Pearl, J.E.5
Pedrosa, J.6
Cooper, A.M.7
Castro, A.G.8
-
5
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua, D. J., J. Sherlock, Y. Chen, C. A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, S. Zurawski, M. Wiekowski, S. A. Lira, D. Gorman, R. A. Kastelein, and J. D. Sedgwick. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421:744-748.
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
Lucian, L.7
To, W.8
Kwan, S.9
Churakova, T.10
Zurawski, S.11
Wiekowski, M.12
Lira, S.A.13
Gorman, D.14
Kastelein, R.A.15
Sedgwick, J.D.16
-
6
-
-
0031707741
-
Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans
-
Decken, K., G. Kohler, K. Palmer-Lehmann, A. Wunderlin, F. Mattner, J. Magram, M. K. Gately, and G. Alber. 1998. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect. Immun. 66:4994-5000.
-
(1998)
Infect. Immun.
, vol.66
, pp. 4994-5000
-
-
Decken, K.1
Kohler, G.2
Palmer-Lehmann, K.3
Wunderlin, A.4
Mattner, F.5
Magram, J.6
Gately, M.K.7
Alber, G.8
-
7
-
-
22644443508
-
Interleukin-12p40 mediates transient protection against Mycobacterium avium infection in the absence of interleukin-12
-
Ehlers, S., J. Lehmann, H. Mossmann, G. Alber, and C. Holscher. 2005. Interleukin-12p40 mediates transient protection against Mycobacterium avium infection in the absence of interleukin-12. Immunobiology 210:217-227.
-
(2005)
Immunobiology
, vol.210
, pp. 217-227
-
-
Ehlers, S.1
Lehmann, J.2
Mossmann, H.3
Alber, G.4
Holscher, C.5
-
8
-
-
0036127059
-
In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukjn-12 (IL-12) but not on IL-12 p70
-
Elkins, K. L., A. Cooper, S. M. Colombini, S. C. Cowley, and T. L. Kieffer. 2002. In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukjn-12 (IL-12) but not on IL-12 p70. Infect. Immun. 70:1936-1948.
-
(2002)
Infect. Immun.
, vol.70
, pp. 1936-1948
-
-
Elkins, K.L.1
Cooper, A.2
Colombini, S.M.3
Cowley, S.C.4
Kieffer, T.L.5
-
9
-
-
0038759100
-
The role of interleukin-12 in human infectious diseases: Only a faint signature
-
Fieschi, C., and J. L. Casanova. 2003. The role of interleukin-12 in human infectious diseases: only a faint signature. Eur. J. Immunol. 33:1461-1464.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 1461-1464
-
-
Fieschi, C.1
Casanova, J.L.2
-
10
-
-
0031943618
-
The interleukjn-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
-
Gately, M. K., L. M. Renzetti, J. Magram, A. S. Stern, L. Adorini, U. Gubler, and D. H. Presky. 1998. The interleukjn-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:495-521.
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 495-521
-
-
Gately, M.K.1
Renzetti, L.M.2
Magram, J.3
Stern, A.S.4
Adorini, L.5
Gubler, U.6
Presky, D.H.7
-
11
-
-
25144515561
-
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
-
Happel, K. I., P. J. Dubin, M. Zheng, N. Ghilardi, C. Lockhart, L. J. Quinton, A. R. Odden, J. E. Shellito, G. J. Bagby, S. Nelson, and J. K. Kolls. 2005. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J. Exp. Med. 202:761-769.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 761-769
-
-
Happel, K.I.1
Dubin, P.J.2
Zheng, M.3
Ghilardi, N.4
Lockhart, C.5
Quinton, L.J.6
Odden, A.R.7
Shellito, J.E.8
Bagby, G.J.9
Nelson, S.10
Kolls, J.K.11
-
12
-
-
23944460617
-
Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs
-
Happel, K. I., E. A. Lockhart, C. M. Mason, E. Porretta, E. Keoshkerian, A. R. Odden, S. Nelson, and A. J. Ramsay. 2005. Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs. Infect. Immun. 73:5782-5788.
-
(2005)
Infect. Immun.
, vol.73
, pp. 5782-5788
-
-
Happel, K.I.1
Lockhart, E.A.2
Mason, C.M.3
Porretta, E.4
Keoshkerian, E.5
Odden, A.R.6
Nelson, S.7
Ramsay, A.J.8
-
13
-
-
0035892749
-
A protective and agonistic function of IL-12p40 in mycobacterial infection
-
Holscher, C., R. A. Atkinson, B. Arendse, N. Brown, E. Myburgh, G. Alber, and F. Brombacher. 2001. A protective and agonistic function of IL-12p40 in mycobacterial infection. J. Immunol. 167:6957-6966.
-
(2001)
J. Immunol.
, vol.167
, pp. 6957-6966
-
-
Holscher, C.1
Atkinson, R.A.2
Arendse, B.3
Brown, N.4
Myburgh, E.5
Alber, G.6
Brombacher, F.7
-
14
-
-
23244458100
-
IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available
-
Khader, S. A., J. E. Pearl, K. Sakamoto, L. Gilmartin, G. K. Bell, D. M. Jelley-Gibbs, N. Ghilardi, F. deSauvage, and A. M. Cooper. 2005. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J. Immunol. 175:788-795.
-
(2005)
J. Immunol.
, vol.175
, pp. 788-795
-
-
Khader, S.A.1
Pearl, J.E.2
Sakamoto, K.3
Gilmartin, L.4
Bell, G.K.5
Jelley-Gibbs, D.M.6
Ghilardi, N.7
DeSauvage, F.8
Cooper, A.M.9
-
15
-
-
0024566140
-
The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
-
Kindler, V., A. P. Sappino, G. E. Grau, P. F. Piguet, and P. Vassalli. 1989. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 56:731-740.
-
(1989)
Cell
, vol.56
, pp. 731-740
-
-
Kindler, V.1
Sappino, A.P.2
Grau, G.E.3
Piguet, P.F.4
Vassalli, P.5
-
16
-
-
30744434833
-
IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12
-
Kleinschek, M. A., U. Muller, S. J. Brodie, W. Stenzel, G. Kohler, W. M. Blumenschein, R. K. Straubinger, T. McClanahan, R. A. Kastelein, and G. Alber. 2006. IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J. Immunol. 176:1098-1106.
-
(2006)
J. Immunol.
, vol.176
, pp. 1098-1106
-
-
Kleinschek, M.A.1
Muller, U.2
Brodie, S.J.3
Stenzel, W.4
Kohler, G.5
Blumenschein, W.M.6
Straubinger, R.K.7
McClanahan, T.8
Kastelein, R.A.9
Alber, G.10
-
17
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish, C. L., Y. Chen, W. M. Blumenschein, J. Mattson, B. Basham, J. D. Sedgwick, T. McClanahan, R. A. Kastelein, and D. J. Cua. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201:233-240.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
Mattson, J.4
Basham, B.5
Sedgwick, J.D.6
McClanahan, T.7
Kastelein, R.A.8
Cua, D.J.9
-
18
-
-
0035500298
-
IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis
-
Lehmann, J., S. Bellmann, C. Werner, R. Schroder, N. Schutze, and G. Alber. 2001. IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J. Immunol. 167:5304-5315.
-
(2001)
J. Immunol.
, vol.167
, pp. 5304-5315
-
-
Lehmann, J.1
Bellmann, S.2
Werner, C.3
Schroder, R.4
Schutze, N.5
Alber, G.6
-
19
-
-
3242805827
-
IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12
-
Lieberman, L. A., F. Cardillo, A. M. Owyang, D. M. Rennick, D. J. Cua, R. A. Kastelein, and C. A. Hunter. 2004. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J. Immunol. 173:1887-1893.
-
(2004)
J. Immunol.
, vol.173
, pp. 1887-1893
-
-
Lieberman, L.A.1
Cardillo, F.2
Owyang, A.M.3
Rennick, D.M.4
Cua, D.J.5
Kastelein, R.A.6
Hunter, C.A.7
-
20
-
-
16044363695
-
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses
-
Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4:471-481.
-
(1996)
Immunity
, vol.4
, pp. 471-481
-
-
Magram, J.1
Connaughton, S.E.2
Warrier, R.R.3
Carvajal, D.M.4
Wu, C.Y.5
Ferrante, J.6
Stewart, C.7
Sarmiento, U.8
Faherty, D.A.9
Gately, M.K.10
-
21
-
-
0346962972
-
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
-
Murphy, C. A., C. L. Langrish, Y. Chen, W. Blumenschein, T. McClanahan, R. A. Kastelein, J. D. Sedgwick, and D. J. Cua. 2003. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198:1951-1957.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1951-1957
-
-
Murphy, C.A.1
Langrish, C.L.2
Chen, Y.3
Blumenschein, W.4
McClanahan, T.5
Kastelein, R.A.6
Sedgwick, J.D.7
Cua, D.J.8
-
22
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, F. Zonin, E. Vaisberg, T. Churakova, M. Liu, D. Gorman, J. Wagner, S. Zurawski, Y. Liu, J. S. Abrams, K. W. Moore, D. Rennick, R. de Waal-Malefyt, C. Hannum, J. F. Bazan, and R. A. Kastelein. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715-725.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
Vega, F.7
Yu, N.8
Wang, J.9
Singh, K.10
Zonin, F.11
Vaisberg, E.12
Churakova, T.13
Liu, M.14
Gorman, D.15
Wagner, J.16
Zurawski, S.17
Liu, Y.18
Abrams, J.S.19
Moore, K.W.20
Rennick, D.21
De Waal-Malefyt, R.22
Hannum, C.23
Bazan, J.F.24
Kastelein, R.A.25
more..
-
23
-
-
24744431846
-
Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17
-
Rutitzky, L. I., J. R. Lopes da Rosa, and M. J. Stadecker. 2005. Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17. J. Immunol. 175:3920-3926.
-
(2005)
J. Immunol.
, vol.175
, pp. 3920-3926
-
-
Rutitzky, L.I.1
Lopes Da Rosa, J.R.2
Stadecker, M.J.3
-
24
-
-
0032432066
-
Acquired resistance but not innate resistance to Mycobacterium bovis bacillus Calmette-Guerin is compromised by interleukin-12 ablation
-
Thompson-Snipes, L., E. Skamene, and D. Radzioch. 1998. Acquired resistance but not innate resistance to Mycobacterium bovis bacillus Calmette-Guerin is compromised by interleukin-12 ablation. Infect. Immun. 66:5268-5274.
-
(1998)
Infect. Immun.
, vol.66
, pp. 5268-5274
-
-
Thompson-Snipes, L.1
Skamene, E.2
Radzioch, D.3
-
25
-
-
2342468669
-
Granulomatous infectious diseases associated with tumor necrosis factor antagonists
-
Wallis, R. S., M. S. Broder, J. Y. Wong, M. E. Hanson, and D. O. Been homier. 2004. Granulomatous infectious diseases associated with tumor necrosis factor antagonists. Clin. Infect. Dis. 38:1261-1265.
-
(2004)
Clin. Infect. Dis.
, vol.38
, pp. 1261-1265
-
-
Wallis, R.S.1
Broder, M.S.2
Wong, J.Y.3
Hanson, M.E.4
Been Homier, D.O.5
-
26
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
-
Wiekowski, M. T., M. W. Leach, E. W. Evans, L. Sullivan, S. C. Chen, G. Vassileva, J. F. Bazan, D. M. Gorman, R. A. Kastelein, S. Narula, and S. A. Lira. 2001. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 166:7563-7570.
-
(2001)
J. Immunol.
, vol.166
, pp. 7563-7570
-
-
Wiekowski, M.T.1
Leach, M.W.2
Evans, E.W.3
Sullivan, L.4
Chen, S.C.5
Vassileva, G.6
Bazan, J.F.7
Gorman, D.M.8
Kastelein, R.A.9
Narula, S.10
Lira, S.A.11
-
27
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen, D., J. Cheung, H. Scheerens, F. Poulet, T. McClanahan, B. McKenzie, M. A. Kleinschek, A. Owyang, J. Mattson, W. Blumenschein, E. Murphy, M. Sathe, D. J. Cua, R. A. Kastelein, and D. Rennick. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Investig. 116:1310-1316.
-
(2006)
J. Clin. Investig.
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
Poulet, F.4
McClanahan, T.5
McKenzie, B.6
Kleinschek, M.A.7
Owyang, A.8
Mattson, J.9
Blumenschein, W.10
Murphy, E.11
Sathe, M.12
Cua, D.J.13
Kastelein, R.A.14
Rennick, D.15
|