Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis

Circulation

Volumn 117, Issue 20, 2008, Pages 2662-2669

  Ikonomidis, Ignatios ^a   Lekakis, John P ^a   Nikolaou, Maria ^a   Paraskevaidis, Ioannis ^a   Andreadou, Ioanna ^b   Kaplanoglou, Theophania ^a   Katsimbri, Pelagia ^a   Skarantavos, Grigorios ^a   Soucacos, Panayiotis N ^a   Kremastinos, Dimitrios T ^a  

^a Department of Cardiology ^*

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Endothelium; Inflammation; Inhibitors; Interleukins; Microcirculation

Indexed keywords

3 NITROTYROSINE; C REACTIVE PROTEIN; CHOLESTEROL; ENDOTHELIN 1; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; PLACEBO; PREDNISOLONE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TRIACYLGLYCEROL; ENDOTHELIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; NITRIC OXIDE; RECOMBINANT PROTEIN;

ACUTE DRUG ADMINISTRATION; ADULT; ARTERY BLOOD FLOW; ARTERY COMPLIANCE; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL FUNCTION; BRACHIAL ARTERY; CHOLESTEROL BLOOD LEVEL; CHRONIC DRUG ADMINISTRATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY FLOW RESERVE; CROSSOVER PROCEDURE; DIASTOLE; DISEASE MARKER; DOPPLER ECHOCARDIOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFECT; FEMALE; HEART LEFT VENTRICLE FUNCTION; HUMAN; INJECTION SITE ERYTHEMA; LIPOPROTEIN BLOOD LEVEL; M MODE ECHOCARDIOGRAPHY; MALE; MITRAL VALVE; OXIDATIVE STRESS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE DRUG DOSE; SYSTOLE; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; AGED; BLOOD VESSEL; DRUG ANTAGONISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ARTHRITIS, RHEUMATOID; BLOOD VESSELS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELINS; FEMALE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; MALE; MIDDLE AGED; NITRIC OXIDE; OXIDATIVE STRESS; RECOMBINANT PROTEINS; VENTRICULAR FUNCTION, LEFT;

EID: 47649086507     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.107.731877     Document Type: Article

References (37)

1. Pasceri V, Yeh ET. A tale of two diseases: atherosclerosis and rheumatoid arthritis. Circulation. 1999;100:2124-2126.
2. Baskol G, Demir H, Baskol M, Kilic E, Ates F, Karakukcu C, Ustdal M. Investigation of protein oxidation and lipid peroxidation in patients with rheumatoid arthritis. Cell Biochem Funct. 2006;24:307-311.
3. Kaur H, Halliwell B. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation: nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett. 1994;350:9-12.
4. Kaplan MJ. Cardiovascular disease in rheumatoid arthritis. Curr Opin Rheumatol. 2006;18:289-297.
5. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood. 1991; 77:1627-1652.
6. Sironi M, Brevario F, Prosperio A, Biondi A, Vecchi A, Van Damme L, Dejana E, Mantovani A. IL-1 stimulates IL-6 production in endothelial cells. J Immunol. 1989;142:549-553.
7. Pache M, Schwarz HA, Kaiser HJ, Wöest P, Kloti M, Dubler B, Flammer J. Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis. Med Sci Monit. 2002;8: CR616-CR619.
8. Corder R, Carrier M, Khan N, Klemm P, Vane JR. Cytokine regulation of endothelin-1 release from bovine aortic endothelial cells. J Cardiovasc Pharmacol. 1995;26:S56-S58.
9. Takahashi T, Nishizawa Y, Hato F, Shintaku H, Maeda N, Fujiwara N, Inaba M, Kobayashi K, Kitagawa S. Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. Microvasc Res. 2007;73: 29-34.
10. Espey MG, Miranda KM, Pluta RM, Wink DA. Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals. J Biol Chem. 2000;275:11341-11347.
11. Peluffo G, Radi R. Biochemistry of protein tyrosine nitration in cardiovascular pathology. Cardiovasc Res. 2007;75:291-302.
12. Haruna Y, Morita Y, Komai N, Yada Sakuta T, Tomita N, Fox DA, Kashihara N. Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase. Arthritis Rheum. 2006;54:1847-1855.
13. Zou M, Jendral M, Ullrich V. Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. Br J Pharmacol. 1999;126:1283-1292.
14. Klemm P, Warner TD, Corder R, Vane JR. Endothelin-1 mediates coronary vasoconstriction caused by exogenous and endogenous cytokines. J Cardiovasc Pharmacol. 1995;26(suppl 3):S419-S421.
15. Weinstein DM, Mihm MJ, Bauer JA. Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice. J Pharmacol Exp Ther. 2000;294:396-401.
16. Finkel MS, Hoffman RA, Shen L, Oddis CV, Simmons RL, Hattler BG. Interleukin 6 as a mediator of stunned myocardium. Am J Cardiol. 1993;71:1231-1232.
17. Ikonomidis I, Athanassopoulos G, Lekakis J, Venetsanou K, Marinou M, 18. Leff JA, Bodman ME, Cho OJ, Rohrbach S, Reiss OK, Vannice JL, Repine JE. Post-insult treatment with interleukin-1 receptor antagonist decreases oxidative lung injury in rats given intratracheal interleukin-1. Am J Respir Crit Care Med. 1994;150:109-112.
18. Fleischmann RM, Schechtman J, Bennett R, Handel ML, Burmester GR, Tesser J, Modafferi D, Poulakos J, Sun G. Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: a large, international, multicenter, placebocontrolled trial. Arthritis Rheum. 2003;48:927-934.
19. Furst DE. Anakinra: review of recombinant human interleukin-I receptor antagonist in the treatment of rheumatoid arthritis. Clin Ther. 2004;26: 1960-1975.
20. Hozumi T, Eisenberg M, Sugioka K, Kokkirala AR, Watanabe H, Teragaki M, Yoshikawa J, Homma S. Change in coronary flow reserve on transthoracic Doppler echocardiography after a single high-fat meal inyoung healthy men. Ann Intern Med. 2002;136:523-528.
21. Coppola A, Astarita C, Liguori E, Fontana D, Oliviero M, Esposito K, Coppola L, Giugliano D. Impairment of coronary circulation by acute hyperhomocysteinaemia and reversal by antioxidant vitamins. J Intern Med. 2004;256:398-405.
22. Takagi A, Tsurumi Y, Ishizuka N, Omori H, Arai K, Hagiwara N, Kasanuki H. Single administration of cerivastatin, an HMG-CoA reductase inhibitor, improves the coronary flow velocity reserve: a transthoracic Doppler echocardiography study. Heart Vessels. 2006;21: 298-301.
23. Wilkinson IB, Qasem A, McEniery CM, Webb DJ, Avolio AP, Cockcroft JR. Nitric oxide regulates local arterial distensibility in vivo. Circulation. 2002;105:213-217.
24. Widlansky ME, Price DT, Gokce N, Eberhardt RT, Duffy SJ, Holbrook M, Maxwell C, Palmisano J, Keaney JF Jr, Morrow JD, Vita JA. Shortand long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. Hypertension. 2003;42:310-315.
25. Lekakis JP, Papamichael CM, Barbaki P, Papaioannou TG, Stamatelopoulos KS, Dagre AG, Stamatelopoulos SF. Comparison of low-density lipoprotein cholesterol lowering by pravastatin to 100 mg/dl versus-100 mg/dl on brachial artery vasoreactivity in patients with severe hypercholesterolemia and previous atherosclerotic events or diabetes mellitus. Am J Cardiol. 2002;89:857- 860.
26. Hildick-Smith DJ, Shapiro LM. Coronary flow reserve improves after aortic valve replacement for aortic stenosis: an adenosine transthoracic echocardiography study. J Am Coll Cardiol. 2000;36:1889-1896.
27. Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quinones M. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol. 1997;30:1527-1533.
28. Ikonomidis I, Lekakis J, Stamatelopoulos K, Markomihelakis N, Kaklamanis PG, Mavrikakis M. Aortic elastic properties and left ventricular diastolic function in patients with Adamantiades-Behcet's disease. J Am Coll Cardiol. 2004;43:1075-1081.
29. Maki-Petaja KM, Hall FC, Booth AD, Wallace SM, Yasmin, Bearcroft PW, Harish S, Furlong A, McEniery CM, Brown J, Wilkinson IB. Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy. Circulation. 2006;114:1185-1192.
30. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315-324.
31. Sokka T, Kankainen A, Hannonen P. Scores for functional disability in patients with rheumatoid arthritis are correlated at higher levels with pain scores than with radiographic scores. Arthritis Rheum. 2000;43:386-389.
32. Egi K, Conrad NE, Kwan J, Schulze C, Schulz R, Wildhirt SM. Inhibition 34. Coopamah MD, Freedman J, Semple JW. Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist. Blood. 2003; 102:2862-2867.
33. Okada H, Woodcock-Mitchell J, Mitchell J, Sakamoto T, Marutsuka K, Sobel BE, Fuji S. Induction of plasminogen activator inhibitor type-1 and type-1 collagen expression in rat cardiac microvascular endothelial cells by interleukin-1 and its dependence on oxygen-centered free radicals. Circulation. 1998;97:2175-2182.
34. Gui Y, Zheng XL, Hollenberg MD. Interleukin-1b, Src- and non-Src tyrosine kinases, and nitric oxide synthase induction in rat aorta in vitro. Am J Physiol Heart Circ Physiol. 2000;279:H566-H576.
35. Garat C, Arend WP. Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38-mitogen activated protein kinase and NF-kB pathways. Cytokine. 2003;23:31- 40.
36. Nichols WW, O'Rourke MF. Properties of the arterial wall. In: McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles 3rd ed. London, United Kingdom: Edward Arnold; 1990:77-114.
37. Hurlimann D, Forster A, Noll G, Enseleit F, Chenevard R, Distler O, Bechir M, Spieker LE, Neidhart M, Michel BA, Gay RE, Luscher TF, Gay S, Ruschitzka F. Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis. Circulation. 2002;106: 2184-2187.