Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions

Journal of the American Chemical Society

Volumn 132, Issue 32, 2010, Pages 11329-11335

  Pudney, Christopher R ^a   Johannissen, Linus O ^a,b   Sutcliffe, Michael J ^a,b   Hay, Sam ^a   Scrutton, Nigel S ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; COMPRESSIVE MODE; CONFORMATIONAL STATE; DIRECT ANALYSIS; DONOR-ACCEPTOR DISTANCE; DONOR-ACCEPTORS; DYNAMICAL EFFECTS; ENZYME CATALYSIS; ENZYME CATALYZED REACTION; FORCE CONSTANTS; ISOTOPE EFFECT; KINETIC ISOTOPE EFFECTS; MORPHINONE REDUCTASE; REACTION BARRIERS; REACTIVE COMPLEXES; TUNNELING REACTION;

ENZYMES; ISOTOPES;

CARRIER MOBILITY;

ISOTOPE; MORPHINONE REDUCTASE; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; COMPRESSION; CONFORMATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; EQUILIBRIUM CONSTANT; FORCE; MOLECULAR DYNAMICS; MUTATION; POTENTIOMETRY; SPECTROSCOPY; TEMPERATURE DEPENDENCE;

ANIMALS; BACTERIAL PROTEINS; HYDROGEN; ISOTOPES; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS; MUTATION; OXIDOREDUCTASES; TEMPERATURE;

EID: 77955581308     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1048048     Document Type: Article

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