H-tunneling in the Multiple H-transfers of the Catalytic Cycle of Morphinone Reductase and in the Reductive Half-reaction of the Homologous Pentaerythritol Tetranitrate Reductase

Journal of Biological Chemistry

Volumn 278, Issue 45, 2003, Pages 43973-43982

  Basran, Jaswir ^a   Harris, Richard J ^a   Sutcliffe, Michael J ^a   Scrutton, Nigel S ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COENZYMES; GROUND STATE; ISOTOPES; OXIDATION; REACTION KINETICS; SUBSTRATES;

QUANTUM TUNNELING;

BIOCHEMISTRY;

2 CYCLOHEXENONE; FLAVOPROTEIN; HYDRIDE; HYDROGEN; ISOTOPE; MORPHINONE; MORPHINONE REDUCTASE; NICOTINAMIDE; OXIDOREDUCTASE; PENTAERYTHRITOL TETRANITRATE REDUCTASE; PENTAERYTHRITYL TETRANITRATE; PROTON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CALCULATION; CATALYSIS; CHANNEL GATING; CHEMICAL BOND; COENZYME; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; HEAT; MOLECULAR DYNAMICS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS; REDUCTION; STEADY STATE; TEMPERATURE; TEMPERATURE DEPENDENCE; TUNNELING MECHANISM; VIBRATION;

BACTERIAL PROTEINS; CATALYSIS; CHEMISTRY, PHYSICAL; CYCLOHEXANONES; DEUTERIUM; ESCHERICHIA COLI; FLAVIN MONONUCLEOTIDE; FLAVINS; HYDROGEN; HYDROGEN-ION CONCENTRATION; KINETICS; NAD; OXIDATION-REDUCTION; OXIDOREDUCTASES; SPECTROPHOTOMETRY; TEMPERATURE; THERMODYNAMICS;

EID: 0242582914     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305983200     Document Type: Article

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