α-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: Insight from environmentally coupled tunneling models

Journal of the American Chemical Society

Volumn 128, Issue 43, 2006, Pages 14053-14058

  Pudney, Christopher R ^a   Hay, Sam ^a   Sutcliffe, Michael J ^a,b   Scrutton, Nigel S ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN; MATHEMATICAL MODELS; RATE CONSTANTS; TUNNELING (EXCAVATION);

FLAVOENZYMES; HYDROGEN TUNNELING; MORPHINONE REDUCTASE (MR); TUNNELING MODELS;

ENZYME KINETICS;

FLAVOPROTEIN; HYDROGEN; ISOTOPE; MORPHINONE REDUCTASE; OXIDOREDUCTASE; PENTAERYTHRITOL TETRANITRATE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME MECHANISM; GEOMETRY; HYDROGEN TUNNELING; KINETIC ISOTOPE EFFECT; MOLECULAR DYNAMICS; MOLECULAR MODEL; TEMPERATURE DEPENDENCE;

ENZYMES; KINETICS; MODELS, CHEMICAL; NAD; NADP;

EID: 33750434286     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0614619     Document Type: Article

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