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Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 43, 2006, Pages 15753-15758

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase

(4) Wang, Lin a Goodey, Nina M b Benkovic, Stephen J b Kohen, Amnon a

a University of Iowa ^* (United States)

b PENNSYLVANIA STATE UNIVERSITY (United States)

Author keywords

Enzyme dynamics; Hydrogen transfer; Hydrogen tunneling; Kinetic isotope effect; Structure function

Indexed keywords

DIHYDROFOLATE REDUCTASE; ISOTOPE; MONOMER;

ARTICLE; BIOTRANSFORMATION; DYNAMICS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; MUTANT; MUTATION; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM MECHANICS; TEMPERATURE DEPENDENCE;

ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; MUTATION; NADP; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 33750441144 PISSN: 00278424 EISSN: None Source Type: Journal
DOI: 10.1073/pnas.0606976103 Document Type: Article

Times cited : (153)

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