Proteins with weakly funneled energy landscapes challenge the classical structure-function paradigm

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 38, 2008, Pages 14237-14238

  Papoian, Garegin A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORISMATE MUTASE;

CATALYSIS; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; METHANOCOCCUS JANNASCHII; MOLECULAR BIOLOGY; NONHUMAN; NOTE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BIOPHYSICAL PHENOMENA; BIOPHYSICS; ENZYMES; PROTEIN CONFORMATION; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 55749083564     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807977105     Document Type: Note

References (14)

1. Fischer E (1890) Über die optischen Isomeren des Traubenzuckers, der Gluconsäure und der Zuckersäure [Concerning the optical isomers of the grape sugars, gluconic acid and saccharic acid]. Ber Dtsch Chem Ges 23: 2611-2620.
2. Fersht, A (1999) Structure and Mechanism in Protein Science (Freeman, New York).
3. Henzler-Wildman KA, et al. (2007) A hierarchy of time-scales in protein dynamics is linked to enzyme catalysis. Nature 450:913-916.
4. Min W, et al. (2005) Fluctuating enzymes: Lessons from single-molecule studies. Acc Chem Res 38:923-931.
5. Romero P, et al. (2001) Sequence complexity of disordered proteins. Proteins Struct Funct Genet 42:38-48.
6. Papoian GA, Wolynes PG (2003) The physics and bioinformatics of binding and folding: An energy landscape perspective. Biopolymers 68:333-349.
7. Dyson HJ, Wright PE. (2002) Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol 12:54-60.
8. Pervushin K, Vamvaca K, Vgeli B, Hilvert, D (2007) Structure and dynamics of a molten globular enzyme. Nat Struct Mol Biol 14:1202-1206.
9. Roca M, Messer B, Hilvert D, Warshel A (2008) On the relationship between folding and chemical landscapes in enzyme catalysis. Proc Natl Acad Sci USA 105:13877-13882.
10. Levy Y, Cho SS, Onuchic JN, Wolynes PG (2005) A survey of flexible protein binding mechanisms and their transition states using native topology-based energy landscapes. J Mol Biol 346:1121-1145.
11. Wolynes P, Onuchic J, Thirumalai D (1995) Navigating the folding routes. Science 267:1619-1620.
12. McNulty BC, Young GB, Pielak GJ (2006) Macromolecular crowding in the Escherichia coli periplasm maintains α-synuclein disorder. J Mol Biol 355:893-897.
13. Materese CK, Goldmon CC, Papoian GA (2008) Hierarchical organization of eglin c native state dynamics is shaped by competing direct and water-mediated interactions. Proc Natl Acad Sci USA 105:10659-10664.
14. Osvath S, Sabelko JJ, Gruebele M (2003) Tuning the heterogeneous early folding dynamics of phosphoglycerate kinase. J Mol Biol 333:187-199.