Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase: Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes

Journal of Biological Chemistry

Volumn 276, Issue 27, 2001, Pages 24581-24587

  Basran, Jaswir ^a   Sutcliffe, Michael J ^a   Scrutton, Nigel S ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEUTERIUM; ENZYMES; HYDROGEN BONDS; IONIZATION; PH EFFECTS; RATE CONSTANTS; REDUCTION;

THERMAL EXCITATION;

BIOCHEMISTRY;

ASPARTIC ACID; GLUTAMINE; HISTIDINE; MUTANT PROTEIN; QUERCETIN; TRIMETHYLAMINE; TRIMETHYLAMINE DEHYDROGENASE; TYROSINE; UNCLASSIFIED DRUG; CARBON; DEUTERIUM; METHYLAMINE; N DEMETHYLASE; RIBOFLAVIN DERIVATIVE;

ARTICLE; CARBON HYDROGEN BOND; DEUTERIUM ISOTOPE EFFECT; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; GENE MUTATION; HYDROGEN BOND; HYDROGEN TUNNELING; IONIZATION; ISOTOPE LABELING; KINETICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTON TRANSPORT; QUANTUM MECHANICS; QUANTUM TUNNELING; REDUCTION; STOP FLOW KINETIC; TEMPERATURE DEPENDENCE; VIBRATION; CHEMICAL MODEL; HEAT; METABOLISM; PH;

ASPARTIC ACID; CARBON; DEUTERIUM; FLAVINS; HEAT; HISTIDINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; METHYLAMINES; MODELS, CHEMICAL; OXIDOREDUCTASES, N-DEMETHYLATING; TYROSINE;

EID: 0035816680     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101178200     Document Type: Article

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