Heterodimerization of the GABA B receptor-implications for GPCR signaling and drug discovery

Advances in Pharmacology

Volumn 58, Issue C, 2010, Pages 63-91

  Marshall, Fiona H ^a   Foord, Steven M ^a  

^a Heptares Therapeutics Ltd   (United Kingdom)

Author keywords

Allosteric modulator; Drug discovery; G protein coupled receptor; Heterodimerization

Indexed keywords

2,6 DI TERT BUTYL 4 (3 HYDROXY 2,2 DIMETHYLPROPYL)PHENOL; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B1 RECEPTOR; 4 AMINOBUTYRIC ACID B2 RECEPTOR; BACLOFEN; G PROTEIN COUPLED RECEPTOR; HETERODIMER; N,N' DICYCLOPENTYL 2 METHYLTHIO 5 NITRO 4,6 PYRIMIDINEDIAMINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; COGNITIVE DEFECT; DIMERIZATION; DRUG DEVELOPMENT; DRUG MECHANISM; HUMAN; HYPOTHERMIA; LIGAND BINDING; MOLECULAR CLONING; MUSCLE RELAXATION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEDATION; SIDE EFFECT; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION; REVIEW;

ANIMALS; DRUG DISCOVERY; HUMANS; MODELS, BIOLOGICAL; PHYLOGENY; PROTEIN MULTIMERIZATION; RECEPTORS, GABA-B; SIGNAL TRANSDUCTION;

EID: 77955066146     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(10)58003-7     Document Type: Chapter

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