Heterodimerization with β2-adrenergic receptors promotes surface expression and functional activity of α1D-adrenergic receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 1, 2005, Pages 16-23

  Uberti, Michelle A ^a,b   Hague, Chris ^a   Oller, Heide ^a   Minneman, Kenneth P ^a   Hall, Randy A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (4 HYDROXYPHENYL)ETHYLAMINOMETHYL]TETRALONE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1D ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; IODINE 125; ISOPRENALINE; NORADRENALIN; PHENTOLAMINE; PINDOLOL; PRAZOSIN; ADRENERGIC RECEPTOR ALPHA(1D); ALPHA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM; CELL SURFACE RECEPTOR; SALBUTAMOL;

ADRENERGIC ACTIVITY; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; CELL MEMBRANE; CELL STRAIN HEK293; CELL SURFACE; CELL TYPE; CONTROLLED STUDY; DIMERIZATION; EMBRYO; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTRACELLULAR TRANSPORT; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RECEPTOR BINDING; BIOSYNTHESIS; CELL LINE; CONFOCAL MICROSCOPY; GENETICS; METABOLISM; PHYSIOLOGY; PLASMID; RADIOASSAY; WESTERN BLOTTING;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; BLOTTING, WESTERN; CALCIUM; CELL LINE; HUMANS; IMMUNOPRECIPITATION; MICROSCOPY, CONFOCAL; PLASMIDS; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED;

EID: 15744405558     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.079541     Document Type: Article

References (40)

1. Akhter SA, Milano CA, Shotwell KF, Cho MC, Rockman HA, Lefkowitz RJ, and Koch WJ (1997) Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors: in vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. J Biol Chem 272:21253-21259.
2. Alonso-Llamazares A, Zamanillo D, Casanova E, Ovalle S, Calvo P, and Chinchetru MA (1995) Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse. J Neurochem 65: 2387-2392.
3. Angers S, Salahpour A, and Bouvier M (2002) Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu Rev Pharmacol Toxicol 42:409-435.
4. Balasubramanian S, Teissere JA, Raju DV, and Hall RA (2004) Heterooligomeration between GABAA and GABAB receptors regulates GABAB receptor trafficking. J Biol Chem 279:18840-18850.
5. Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL, et al. (2001) Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the eatecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 60:1181-1188.
6. Cavalli A, Lattion AL, Hummler E, Nenniger M, Pedrazzini T, Aubert JF, Michel MC, Yang M, Lembo G, Vecchione C, et al. (1997) Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor. Proc Natl Acad Sci USA 94:11589-11594.
7. Chalothorn D, McCune DF, Edelmann SE, Garcia-Cazarin ML, Tsujimoto G, and Piascik MT (2002) Differences in the cellular localization and agonist-mediated internalization properties of the alpha(1)-adrenoceptor subtypes. Mol Pharmacol 61:1008-1016.
8. Claing A, Laporte SA, Caron MG, and Lefkowua RJ (2002) Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol 66:61-79.
9. Daaka Y, Luttrell LM, and Lefkowitz RJ (1997) Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature (Lond) 390:88-91.
10. Daly CJ, Milligan CM, Milligan G, Mackenzie JF, and McGrath JC (1998) Cellular localization and pharmacological characterization of functioning alpha-1 adrenoceptors by fluorescent ligand binding and image analysis reveals identical binding properties of clustered and diffuse populations of receptors. J Pharmacol Exp Ther 286:984-990.
11. Daunt DA, Hurt C, Hein L, Kallio J, Feng F, and Kobilka BK (1997) Subtype-specific intracellular trafficking of alpha2-adrenergic receptors. Mol Pharmacol 51:711-720.
12. Dzimiri N (2002) Receptor crosstalk: implications for cardiovascular function, disease and therapy. Eur J Biochem 269:4713-4730.
13. Garcia-Sainz JA and Torres-Padilla ME (1999) Modulation of basal intracellular calcium by inverse agonists and phorbol myristate acetate in rat-1 fibroblasts stably expressing alpha1d-adrenoceptors. FEBS Lett 443:277-281.
14. Garcia-Sainz JA, Vazquez-Cuevas FG, and Romero-Avila MT (2001) Phosphorylation and desensitization of alpha1d-adrenergic receptors. Biochem J 353:603-610.
15. Guimaraes S and Moura D (2001) Vascular adrenoceptors: an update. Pharmacol Rev 53:319-356.
16. Hague C, Uberti MA, Chen Z, Bush CF, Jones SV, Ressler KJ, Hall RA, and Minneman KP (2004a) Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor. Proc Natl Acad Sci USA 101:13672-13676.
17. Hague C, Uberti MA, Chen Z, Hall RA, and Minneman KP (2004b) Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. J Biol Chem 279:15541-15549.
18. Hieble JP, Bylund DB, Clarke DE, Eikenburg DC, Langer SZ, Lefkowitz RJ, Minneman KP, and Ruffolo RR Jr (1995) International Union of Pharmacology: X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol Rev 47:267-270.
19. Hurt CM, Feng FY, and Kobilka B (2000) Cell-type specific targeting of the alpha 2c-adrenoceptor: evidence for the organization of receptor microdomains during neuronal differentiation of PC12 cells. J Biol Chem 275:35424-35431.
20. Kavelaars A (2002) Regulated expression of alpha-1 adrenergic receptors in the immune system. Brain Behav Immun 16:799-807.
21. Lu M, Echeverri F, and Moyer BD (2003) Endoplasmic reticulum retention, degradation and aggregation of olfactory G-protein coupled receptors. Traffic 4:416-433.
22. Marshall FH, Jones KA, Kaupmann K, and Bettler B (1999) GABAB receptors: the first 7TM heterodimers. Trends Pharmacol Sci 20:396-399.
23. McClintock TS, Landers TM, Gimelbrant AA, Fuller LZ, Jackson BA, Jayawickreme CK, and Lerner MR (1997) Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors. Brain Res Mol Brain Res 48:270-278.
24. McCune DF, Edelmann SE, Olges JR, Post GR, Waldrop BA, Waugh DJ, Perez DM, and Piascik MT (2000) Regulation of the cellular localization and signaling properties of the alpha(1B)- and alpha(1D)-adrenoceptors by agonists and inverse agonists. Mol Pharmacol 57:659-666.
25. Michelotti GA, Price DT, and Schwinn DA (2000) Alpha 1-adrenergic receptor regulation: basic science and clinical implications. Pharmacol Ther 88:281-309.
26. Nicholas AP, Hokfelt T, and Pieribone VA (1996) The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends Pharmacol Sci 17:245-255.
27. Olli-Lahdesmaki T, Kallio J, and Scheinin M (1999) Receptor subtype-induced targeting and subtype-specific internalization of human alpha(2)-adrenoceptors in PC12 cells. J Neurosci 19:9281-9288.
28. Sadalge A, Coughlin L, Fu H, Wang B, Valladares O, Valentino R, and Blendy JA (2003) alpha 1d Adrenoceptor signaling is required for stimulus induced locomotor activity. Mol Psychiatry 8:664-672.
29. Tan CM, Brady AE, Nickols HH, Wang Q, and Limbird LE (2004) Membrane trafficking of G protein-coupled receptors. Annu Rev Pharmacol Toxicol 44:559-609.
30. Tanoue A, Koshimizu TA, and Tsujimoto G (2002) Transgenic studies of alpha(1)-adrenergic receptor subtype function. Life Sci 71:2207-2215.
31. Theroux TL, Esbenshade TA, Peavy RD, and Minneman KP (1996) Coupling efficiencies of human alpha 1-adrenergic receptor subtypes: titration of receptor density and responsiveness with inducible and repressible expression vectors. Mol Pharmacol 50:1376-1387.
32. Turnbull L, McCloskey DT, O'Connell TD, Simpson PC, and Baker AJ (2003) Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. Am J Physiol Heart Circ Physiol 284:H1104-H1109.
33. Uberti MA, Hall RA, and Minneman KP (2003) Subtype-specific dimerization of alpha 1-adrenoceptors: effects on receptor expression and pharmacological properties. Mol Pharmacol 64:1379-1390.
34. Vicentic A, Robeva A, Rogge G, Uberti M, and Minneman KP (2002) Biochemistry and pharmacology of epitope-tagged alpha(1)-adrenergic receptor subtypes. J Pharmacol Exp Ther 302:58-65.
35. Waldo GL, Northup JK, Perkins JP, and Harden TK (1983) Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. J Biol Chem 258:13900-13908.
36. Waldrop BA, Mastalerz D, Piascik MT, and Post GR (2002) alpha(1B)- and alpha(1D)-Adrenergic receptors exhibit different requirements for agonist and mitogen-activated protein kinase activation to regulate growth responses in rat 1 fibroblasts. J Pharmacol Exp Ther 300:83-90.
37. Wanamaker CP, Christianson JC, and Green WN (2003) Regulation of nicotinic acetylcholine receptor assembly. Ann N Y Acad Sci 998:66-80.
38. Young MA, Vatner DE, and Vatner SF (1990) Alpha- and beta-adrenergic control of large coronary arteries in conscious calves. Basic Res Cardiol 85(Suppl 1):97-109.
39. Yue Y, Qu Y, and Boutjdir M (2004) Beta- and alpha-adrenergic cross-signaling for L-type Ca current is impaired in transgenic mice with constitutive activation of epsilonPKC. Biochem Biophys Res Commun, 314:749-754.
40. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, and Zuker CS (2003) The receptors for mammalian sweet and umami taste. Cell 115:255-266.