Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N′-dicyclopentyl-2-methylsulfanyl-5-nitro- pyrimidine-4,6-diamine): Anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 3, 2004, Pages 952-963

  Cryan, John F ^a   Kelly, Peter H ^a   Chaperon, Frederique ^a   Gentsch, Conrad ^a   Mombereau, Cedric ^a,b   Lingenhoehl, Kurt ^a   Froestl, Wolfgang ^a   Bettler, Bernhard ^a,c   Kaupmann, Klemens ^a   Spooren, Will P J M ^a,d  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c Pharmazentrum   (Switzerland)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; ANXIOLYTIC AGENT; BACLOFEN; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE; GS 39783; N,N' DICYCLOPENTYL 2 METHYLSULFANYL 5 NITROPYRIMIDINE 4,6 DIAMINE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CIRCLING BEHAVIOR; COGNITION; CONTROLLED STUDY; DRUG SAFETY; GABAERGIC SYSTEM; HYPOTHERMIA; LEARNING; LOCOMOTION; MALE; MAZE TEST; NEUROMODULATION; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-ANXIETY AGENTS; AVOIDANCE LEARNING; BACLOFEN; BENZODIAZEPINES; BODY TEMPERATURE; CYCLOPENTANES; DRUG COMBINATIONS; FEVER; GABA AGONISTS; MALE; MAZE LEARNING; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; ROTAROD PERFORMANCE TEST; STRESS; TIME FACTORS; TRACTION;

EID: 4243086935     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.066753     Document Type: Article

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