Functional diversity of signaling pathways through g protein-coupled receptor heterodimerization with a species-specific orphan receptor subtype

Molecular Biology and Evolution

Volumn 27, Issue 5, 2010, Pages 1097-1106

  Sakai, Tsubasa ^a   Aoyama, Masato ^a   Kusakabe, Takehiro ^b   Tsuda, Motoyuki ^c   Satake, Honoo ^a  

^a SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^b KONAN UNIVERSITY   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Ciona intestinalis; Evolution; GnRH; GPCR heterodimerization; Orphan GPCR

Indexed keywords

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GONADORELIN; HETERODIMER; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPEPTIDE; RECEPTOR SUBTYPE;

ARTICLE; ASCIDIACEA; BINDING ASSAY; CALCIUM MOBILIZATION; CELL STRAIN HEK293; CIONA INTESTINALIS; CONTROLLED STUDY; DIMERIZATION; ENZYME PHOSPHORYLATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOPRECIPITATION; LIGAND BINDING; NONHUMAN; PARALOGY; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; CELL MEMBRANE; CIONA INTESTINALIS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GONADOTROPIN-RELEASING HORMONE; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SPACE; LIGANDS; MODELS, BIOLOGICAL; ORPHAN NUCLEAR RECEPTORS; OVARY; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; RECEPTORS, LHRH; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY;

ANIMALIA; ASCIDIA; CIONA; CIONA INTESTINALIS; INVERTEBRATA; VERTEBRATA;

EID: 77951582541     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msp319     Document Type: Article

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