A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 25, 2005, Pages 9050-9055

  Waldhoer, Maria ^a   Fong, Jamie ^a   Jones, Robert M ^c   Lunzer, Mary M ^b   Sharma, Shiv K ^b   Kostenis, Evi ^d   Portoghese, Philip S ^b,e   Whistler, Jennifer L ^a  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c ARENA PHARMACEUTICALS   (United States)

^d 7TM Pharma ^*  (Denmark)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Opioid

Indexed keywords

6' GUANIDINONALTRINDOLE; ANALGESIC AGENT; DIMER; G PROTEIN COUPLED RECEPTOR; OPIATE AGONIST; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG TARGETING; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; TISSUE SPECIFICITY;

ANALGESICS; CELL LINE; DIMERIZATION; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; GUANIDINES; HUMANS; KIDNEY; KINETICS; NALTREXONE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, OPIOID; TRANSFECTION;

EID: 21144446486     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501112102     Document Type: Article

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