(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2-one], a Conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor

Journal of Medicinal Chemistry

Volumn 43, Issue 22, 2000, Pages 4045-4050

  Mullen, G ^a   Napier, J ^a,b   Balestra, M ^a   Decory, T ^a   Hale, G ^a   Macor, J ^a,c   Mack, R ^a   Loch III, J ^a   Wu, E ^a,d   Kover, A ^a,c   Verhoest, P ^a,e   Sampognaro, A ^a   Phillips, E ^a   Zhu, Y ^a   Murray, R ^a   Griffith, R ^a,f   Blosser, J ^a   Gurley, D ^a   Machulskis, A ^a   Zongrone, J ^a   Rosen, A ^a   Gordon, J ^a   more..

^a ASTRAZENECA   (United Kingdom)

^b ABBOTT LABORATORIES   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d ScinoPharm   (Taiwan)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f Tanabe Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE DERIVATIVE; BUNGAROTOXIN RECEPTOR; NICOTINIC AGENT; NICOTINIC RECEPTOR; SPIRO(1 AZABICYCLO[2.2.2]OCTANE 3,5' OXAZOLIDIN 2' ONE); SPIRO[1 AZABICYCLO[2.2.2]OCTANE 3,2' THIAZOLIDINE] 2' ONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; NONHUMAN; RAT; RECEPTOR AFFINITY;

ACETYLCHOLINE; ANIMALS; BRIDGED COMPOUNDS; HIPPOCAMPUS; NICOTINIC AGONISTS; OOCYTES; PROSENCEPHALON; RADIOLIGAND ASSAY; RATS; RECEPTORS, NICOTINIC; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0034597576     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000249r     Document Type: Article

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