Differential physiologic responses of α7 nicotinic acetylcholine receptors to β-amyloid1-40 and β-amyloid1-42

Journal of Neurobiology

Volumn 55, Issue 1, 2003, Pages 25-30

  Lee, Daniel H S ^a   Wang, Hoau Yan ^b  

^a BIOGEN   (United States)

^b CITY UNIVERSITY OF NEW YORK MEDICAL SCHOOL   (United States)

Author keywords

Amyloid peptides; Alzheimer's disease; Neurodegeneration; Neurons; Nicotinic acetylcholine receptors

Indexed keywords

ACETYLCHOLINE; AMYLOID BETA PROTEIN; ATROPINE; BETA AMYLOID[1-40]; BETA AMYLOID[1-42]; BUFFER; CALCIUM; CATION CHANNEL; CONOTOXIN; CYTISINE; EPIBATIDINE; MONOMER; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; OLIGOMER; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; NERVE CELL; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT;

ACETYLCHOLINE; ALKALOIDS; AMYLOID BETA-PROTEIN; ANIMALS; ATROPINE; AZOCINES; BICYCLO COMPOUNDS, HETEROCYCLIC; CALCIUM; CALCIUM CHANNEL BLOCKERS; CONOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FRONTAL LOBE; MUSCARINIC ANTAGONISTS; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PEPTIDE FRAGMENTS; POTASSIUM; PYRIDINES; QUINOLIZINES; RATS; RECEPTORS, NICOTINIC; SUBCELLULAR FRACTIONS; SYNAPTOSOMES;

EID: 0037381479     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/neu.10203     Document Type: Article

References (26)

1. Alkondon M., Pereira EF, Almeida LE, Randall WR, Albuquerque EX. 2000. Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus. Neuropharmacology 39:2726-2739.
2. Auld DS, Kar S, Quirion R. 1998. Beta-amyloid peptides as direct cholinergic neuromodulators: a missing link. Trends Neurosci 21:43-49.
3. Behl C, Davis JB, Lesley R, Schubert D. 1994. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77:817-827.
4. 125I]-alpha-bungarotoxin binding in human postmortem brain. J Comp Neurol 387:385-398.
5. Burdick D, Soreghans B, Kwon M, Kosmoski J, Knauer M, Henschen A, Yates J, Cotman C, Glabe C. 1991. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem 267:546-554.
6. D'Andrea MR, Nagele RG, Wang H-Y, Peterson PA, Lee DHS. 2001. Evidence that neurons accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. Histopathology 38:120-134.
7. Delbono O, Gopalakrishnan M, Renganathan M, Monteggia LM, Messi ML, Sullivan JP. 1997. Activation of the recombinant human α7 nicotinic acetylcholine receptor significantly raises intracellular free calcium. J Pharmacol Exp Ther 280:428-438.
8. Dineley KT, Bell KA, Bui D, Sweatt JD. 2002. beta-Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Biol Chem 277:25056-25061.
9. Fabian-Fine R, Skehel P, Errington ML, Davies HA, Sher E, Stewart MG, Fine A. 2001. Ultrastructural distribution of the α7 nicotinic acetylcholine receptor subunit in rat hippocampus. J Neurosci 21:7993-8003.
10. Flood JF, Roberts E, Sherman MA, Kaplan BE, Morley JE. 1994. Topography of a binding site for small amnesic peptides deduced from structure-activity studies: relation to amnesic effect of amyloid β proteins. Proc Natl Acad Sci USA 91:380-384.
11. Gray R, Rajan AS, Radcliffe KA, Yakehiro M, Dani JA. 1996. Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383:713-716.
12. Hardy J, Allsop D. 1991. Amyloid deposition as the central event in the etiology of Alzheimer's disease. Trends Pharmacol Sci 12:383-388.
13. Itoh A, Akaike T, Sokabe M, Nitta A, Iida R, Olariu A, Yamada K, Nabeshima T. 1999. Impairments of long-term potentiation in hippocampal slices of β-amyloid-infused rats. Eur J Pharmacol 382:167-175.
14. Kar S, Issa AM, Seta D, Auld DS, Collier B, Quirion R. 1998. Amyloid β-peptide inhibits high-affinity choline uptake and acetylcholine release in rat hippocampal slices. J Neurochem 70:2179-2187.
15. Koh J, Yang LL, Cotman C. 1990. β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res 533:315-320.
16. Liu Q, Kawai H, Berg DK. 2001. beta-Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. Proc Natl Acad Sci USA 98:4734-4739.
17. McGehee DS, Heath MJ, Gelber S, Devay P, Role LW. 1995. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269:1692-1696.
18. McGehee DS, Role LW. 1996. Presynaptic ionotropic receptors. Curr Opin Neurobiol 6:342-349.
19. Nag S, Yee BK, Tang F. 1999. Reduction in somatostatin and substance P levels and choline acetyltransferase activity in the cortex and hippocampus of the rat after chronic intracerebroventricular infusion of β-amyloid(1-40). Brain Res Bull 50:251-262.
20. Nagele RG, D'Andrea MR, Anderson WJ, Wang H.-Y. 2002. Accumulation of beta-amyloid1-42 in neurons is facilitated by the alpha7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 110:199-211.
21. 1-42 peptide directly modulates nicotinic receptors in the rat hippocampal slice. J Neurosci 21:RC120.
22. Quik M, Philie J, Choremis J. 1997. Modulation of α7 nicotinic receptor-mediated calcium influx by nicotinic agonists. Mol Pharmacol 51:499-506.
23. 1-42 binds to α7 nicotinic acetylcholine receptor with high affinity: implications for Alzheimer's disease. J Biol Chem 275:5626-5632.
24. 1-42 binds selectively and with picomolar affinity to α7 nicotinic acetylcholine receptors. J Neurochem 75:1155-1161.
25. i protein. Neuropeptides 33:197-205.
26. Zhang Y, McLaughlin R, Goodyer C, LeBlanc A. 2002. Selective cytotoxicity of intracellular amyloid β peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156:519-529.