The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

Neuropharmacology

Volumn 56, Issue 1, 2009, Pages 254-263

  Feuerbach, Dominik ^a   Lingenhoehl, Kurt ^a   Olpe, Hans Rudolf ^a   Vassout, Annick ^a   Gentsch, Conrad ^a   Chaperon, Frederique ^a   Nozulak, Joachim ^a   Enz, Albert ^a   Bilbe, Graeme ^a   McAllister, Kevin ^a   Hoyer, Daniel ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

7 Nicotinic acetylcholine receptor; Cognitive deficit; JN403; Memory; Sensory gating

Indexed keywords

(1 AZABICYCLO[2.2.2]OCT 3 YL)CARBAMIC ACID 1 (2 FLUOROPHENYL)ETHYL ESTER; BUNGAROTOXIN RECEPTOR; CHLORDIAZEPOXIDE; JN 403; NICOTINE; NICOTINIC AGENT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANXIETY; ARTICLE; AUDIOGENIC SEIZURE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; FEMALE; GATE CONTROL THEORY; HYPERALGESIA; LEARNING; MALE; MEMORY; MOUSE; NEUROMODULATION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SOCIAL BEHAVIOR; TAIL FLICK TEST; TRANQUILIZING ACTIVITY;

ACOUSTIC STIMULATION; ANALYSIS OF VARIANCE; ANIMALS; CARBAMATES; COGNITION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; EPILEPSY; EVOKED POTENTIALS, AUDITORY; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; MALE; MICE; MICE, INBRED DBA; NICOTINE; NICOTINIC AGONISTS; PAIN; PAIN THRESHOLD; QUINUCLIDINES; RATS; RECEPTORS, NICOTINIC; SENSORY GATING; SOCIAL BEHAVIOR; TIME FACTORS;

EID: 58049109125     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.08.025     Document Type: Article

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