Nausea associated with nicotinic agonist therapy in schizophrenia

Clinical Psychopharmacology and Neuroscience

Volumn 7, Issue 1, 2009, Pages 26-27

  Hashimoto, Kenji ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUNGAROTOXIN RECEPTOR; DMXB A; NICOTINIC AGENT; PLACEBO; SEROTONIN 3 RECEPTOR; TROPISETRON; UNCLASSIFIED DRUG;

ALERTNESS; ALOGIA; ANHEDONIA; ARTICLE; ATTENTION DISTURBANCE; CLINICAL TRIAL; COGNITIVE DEFECT; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFICACY; HEARING IMPAIRMENT; HUMAN; NAUSEA; NEGATIVE SYNDROME; NONHUMAN; RECEPTOR BLOCKING; RESTLESSNESS; SCHIZOPHRENIA; SPEECH DISORDER; UNSPECIFIED SIDE EFFECT;

EID: 62649085127     PISSN: 17381088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Martin LF, Kem WR, Freedman R. Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology (Berl) 2004;174:54-64.
2. Hashimoto K, Koike K, Shimizu E, Iyo M. a7 Nicotinic receptor agonists as potential therapeutic drugs for schizophrenia. Curr Med Chem-CNS Agents 2005;5:171-184.
3. Hashimoto K, Hattori E. Part II: Candidate genes and models. 4: Neurotransmission. In: Neurogenetics of Psychiatric Disorders (Medical Psychiatry Series 37), editors. Sawa A, McInnis MG, Informa Healthcare; 2007. p.81-100.
4. Freedman F, Olincy A, Buchanan RW, Harris JG, Gold JM, Johnson L, et al. Initial phase 2 trial of a nicotinic agonist in schizophrenia. Am J Psychiatry 2008;165:1040-1047.
5. Simpson K, Spencer CM, McClellan KJ. Tropisetron: an update of its use in the prevention of chemotherapy-induced nausea and vomiting. Drugs 2000;59:1297-1315.
6. Koike K, Hashimoto K, Takai N, Shimizu E, Komatsu N, Watanabe H, et al. Tropisetron improves deficits in auditory P50 suppression in schizophrenia. Schizophr Res 2005;76:67-72.
7. Hashimoto K, Iyo M, Freedman R, Stevens KE. Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: role of alpha7 nicotinic acetylcholine receptors. Psychopharmacology (Berl) 2005;183:13-19.
8. Hashimoto K, Fujita Y, Ishima T, Hagiwara H, Iyo M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron: role of alpha7 nicotinic receptors. Eur J Pharmacol 2006;553:191-195.