The α4β2 agonist SIB 1765F, but not the α7 agonist AR-R 17779, cross-sensitises to the psychostimulant effects of nicotine

Psychopharmacology

Volumn 150, Issue 2, 2000, Pages 233-236

  Grottick, A J ^a   Wyler, R ^a   Higgins, G A ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

4 2 receptor; 7 receptor; Locomotor activity; Nicotine; Sensitisation

Indexed keywords

3 ETHYNYL 5 (1 METHYL 2 PYRROLIDINYL)PYRIDINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; NICOTINE; PSYCHOSTIMULANT AGENT; AR-R 17779; BRIDGED COMPOUND; NICOTINIC AGENT; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; SPIRO COMPOUND; SPIRO[1 AZABICYCLO[2.2.2]OCTANE 3,2' THIAZOLIDINE] 2' ONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; LOCOMOTION; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; STIMULATION; ANIMAL; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BRIDGED COMPOUNDS; MALE; MOTOR ACTIVITY; NICOTINE; NICOTINIC AGONISTS; PYRIDINES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SPIRO COMPOUNDS;

EID: 0033623950     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000444     Document Type: Article

References (20)

1. 3H] ABT-418: a novel cholinergic channel ligand. J Pharmacol Exp Ther 270:310-318
2. Benwell MEM, Balfour DJK (1992) The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity. Br J Pharmacol 105:849-856
3. Benwell MEM, Balfour DJK (1996) The effect of ABT-418 on mesolimbic dopamine systems and locomotion in the rat. Br J Pharmacol 119:297P
4. Clarke PBS, Kumar R (1983) The effects of nicotine on locomotor activity in non-tolerant and tolerant rats. Br J Pharmacol 78:329-337
5. Gordon J, Gurley DA, Tran O, Machulskis A, Zongrone J, Luhowskylj S, Ryan T, Mack, Loch J III, Balestra M, DeCory T, Sampognaro A, Wright N, Verhoest P, Macor J, Kover A, Wu E, Griffith R, Mullen G, Murray R, Blosser J (1998) AR-R 17779: the first high affinity, subtype-selective full agonist at the rodent α7 nicotinic acetylcholine receptor. Soc Neurosci Abstr 24:331.9
6. Grottick AJ, Wyler R, Higgins GA (1999) Studies investigating the role of nicotine α7 receptors in reward and attention. Soc Neurosci Abstr 25:786.2
7. Gurley DA, Lanthorn T, Ryan T, Luhowskyj S, Gordon J (1998) Comparison of nicotine and the alpha7-selective agonist AR-R 17779 on nAchR α7 expressed in Xenopus oocytes. Soc Neurosci Abstr 24:331.10
8. Kaiser F, Hudzik T, Borrelli A, Awere S, Cramer C, Widzowski D (1998) AR-R 17779, a selective α7 nicotinic agonist, has anxiolytic and sensory gating-enhancing properties and reduced nicotine-like side effects. Soc Neurosci Abstr 24:331.11
9. Kalivas PW, Stewart J (1991) Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Rev 16:223-244
10. Lena C, Changeux JP (1997) Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders. Curr Opin Neurobiol 7:674-682
11. Levin ED, Bettegowda C, Blosser J, Gordon J (1999) AR-R 17779, an α7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol 10:675-780
12. Lukas RJ, Changeux JP, Le Novere N, Albuquerque EX, Balfour DJ, Berg DK, Bertrand D, Chiappinelli VA, Clarke PBS, Collins AC, Dani JA, Grady SR, Kellar KJ, Lindstrom JM, Marks MJ, Quik M, Taylor PW, Wonnacott S (1999) International Union of Pharmacology XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 51:397-401
13. Menzaghi F, Whelan KT, Risbrough VB, Rao TS, Lloyd GK (1997) Effects of a novel cholinergic ion channel agonist SIB1765F on locomotor activity in rats. J Pharmacol Exp Ther 280:384-392
14. Picciotto MR, Zoll M, Rimondini R, Lena C, Mirubio LM, Pich EM, Fuxe K, Changeux J-P (1998) Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine. Nature 391:173-177
15. Pidoplichko VI, DeBiasi M, Williams JT, Dani JA (1997) Nicotine activates and desensitises midbrain dopamine neurons. Nature 390:401-404
16. Reavill C, Stolerman IP (1990) Locomotor activity in rats after administration of nicotinic agonists intracerebrally. Br J Pharmacol 99:273-278
17. Sacaan I, Reid RT, Santori EM, Addmas P, Correa LD, Mahaffy LS, Bleicher L, Cosford NDP, Stauderman KA, McDonald IA, Rao TS, Lloyd G (1997) Pharmacological characterisation of SIB-1765F: a novel cholinergic ion channel agonist. J Pharmacol Exp Ther 280:373-383
18. Shoaib M, Stolerman IP (1992) MK801 attenuates behavioural adaptation to chronic nicotine administration in rats. Br J Pharmacol 105:514-515
19. Shoaib M, Schindler CW, Goldberg SR, Pauly JR (1997) Behavioural and biochemical adaptations to nicotine in rats: influence of MK801, an NMDA receptor antagonist. Psychopharmacology 134:121-130
20. Stolerman IP, Chandler CJ, Garcha HS, Newton JM (1997) Selective antagonism of behavioural effects of nicotine by dihydro-beta-erythroidine in rats. Psychopharmacology 129:390-397