The Neuroprotective Effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a Novel α7 Ligand, Is Prevented through Angiotensin II Activation of a Tyrosine Phosphatase

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 1, 2004, Pages 16-27

  Marrero, Mario B ^a   Papke, Roger L ^b   Bhatti, Balwinder S ^c   Shaw, Seán ^a   Bencherif, Merouane ^c  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c TARGACEPT INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 PYRIDYL) 1 AZABICYCLO[3.2.2]NONANE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; ACETYLCHOLINESTERASE; ADENOSINE RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN RECEPTOR; BRADYKININ RECEPTOR; GALANIN RECEPTOR; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; JANUS KINASE 2; MUSCARINIC RECEPTOR; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXYTOCIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; TC 1698; THROMBOXANE A2 RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASOPRESSIN V1 RECEPTOR;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYME INDUCTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANGIOTENSIN II; ANIMALS; APOPTOSIS; BICYCLO COMPOUNDS; ENZYME ACTIVATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 2; NEUROPROTECTIVE AGENTS; PC12 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RATS; RECEPTORS, NICOTINIC; SERINE; SHP1 PROTEIN TYROSINE PHOSPHATASE; TYROSINE; TYRPHOSTINS;

EID: 1642343387     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.061655     Document Type: Article

References (31)

1. Ahmed ST and Ivashkiv LB (2000) Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways. J Immunol 165:5227-5237.
2. Bencherif M, Lovette ME, Fowler KW, Arrington S, Reeves L, Caldwell WS, and Lippiello PM (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther 279:1413-1421.
3. Bencherif M and Schmitt JD (2002) Targeting neuronal nicotinic receptors: a path to new therapies. CNS Neurol Disord 1:319-327.
4. Breese CR, Adams C, Logel J, Drebing C, Rollins Y, Barnhart M, Sullivan B, Demasters BK, Freedman R, and Leonard S (1997) Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain. J Comp Neurol 387:385-398.
5. Court J, Martin-Ruiz C, Piggott M, Spurden D, Griffiths M, and Perry E (2001) Nicotinic receptor abnormalities in Alzheimer's disease. Biol Psychiatry 49:175-184.
6. Davies AR, Hardick DJ, Blagbrough IS, Potter BV, Wolstenholme AJ, and Wonnacott S (1999) Characterization of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptors. Neuropharmacology 38:679-690.
7. Dicou E, Attoub S, and Gressens P (2001) Neuroprotective effects of leptin in vivo and in vitro. Neuroreport 12:3947-3951.
8. Dineley KT, Westerman M, Bui D, Bell K, Ashe KH, and Sweatt JD (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci 21:4125-4133.
9. Donnelly-Roberts DL, Xue IC, Arneric SP, and Sullivan JP (1996) In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418. Brain Res 719:36-44.
10. Ge J and Barnes NM (1996) Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders. Eur J Pharmacol 297:299-306.
11. Horiuchi M, Akishita M, and Dzau VJ (1998) Molecular and cellular mechanism of angiotensin II-mediated apoptosis. Endocr Res 24:307-314.
12. Kem WR (2000) The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). Behav Brain Res 113:169-181.
13. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, and Akaike A (2001) alpha 7 Nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 276:13541-13546.
14. Kitagawa H, Takenouchi T, Azuma R, Wesnes KA, Kramer WG, Clody DE, and Burnett AL (2003) Safety, pharmacokinetics and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology 28:542-551.
15. Kunioku H, Inoue K, and Tomida M (2001) Interleukin-6 protects rat PC12 cells from serum deprivation or chemotherapeutic agents through the phosphatidylinositol 3-kinase and STAT3 pathways. Neurosci Lett 309:13-16.
16. Lehtonen JY, Daviet L, Nahmias C, Horiuchi M, and Dzau VJ (1999) Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis. Mol Endocrinol 13:1051-1060.
17. Liu Q, Kawai H, and Berg DK (2001) beta-Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. Proc Natl Acad Sci USA 98:4734-4739.
18. Lukas RJ and Cullen MJ (1988) An isotopic rubidium ion efflux assay for the functional characterization of nicotinic acetylcholine receptors in clonal cell lines. Anal Biochem 175:212-218.
19. Marrero MB, Schieffer B, Bernstein KE, and Ling BN (1996) Angiotensin II-induced tyrosine phosphorylation in mesangial and vascular smooth muscle cells. Clin Exp Pharmacol Physiol 23:83-88.
20. Marrero MB, Venema VJ, Ju H, Eaton DC, and Venema RC (1998) Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: roles of SHP-1 and SHP-2. Am J Physiol 275:C1216-C1223.
21. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, et al. (1996) Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature (Lond) 379:645-648.
22. Narain Y, Yip A, Murphy T, Brayne C, Easton D, Evans JG, Xuereb J, Cairns N, Esiri MM, Furlong RA, et al. (2000) The ACE gene and Alzheimer's disease susceptibility. J Med Genet 37:695-697.
23. Newhouse PA, Potter A, Kelton M, and Corwin J (2001) Nicotinic treatment of Alzheimer's disease. Biol Psychiatry 49:268-278.
24. Nordberg A, Hellstrom-Lindahl E, Lee M, Johnson M, Mousavi M, Hall R, Perry E, Bednar I, and Court J (2002) Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw). J Neurochem 81:655-658.
25. Papke RL and Papke JKP (2002) Comparative pharmacology of rat and human a7 nAChR conducted with net charge analysis. Br J Pharmacol 137:49-61.
26. Romano C and Goldstein A (1980) Stereospecific nicotine receptors on rat brain membranes. Science (Wash DC), 210:647-650.
27. Savaskan E, Hock C, Olivieri G, Bruttel S, Rosenberg C, Hulette C, and Muller-Spahn F (2001) Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia. Neurobiol Aging 22:541-546.
28. Sharlow ER, Pacifici R, Crouse J, Batac J, Todokoro K, and Wojchowski DM (1997) Hematopoietic cell phosphatase negatively regulates erythropoietin-induced hemoglobinization in erythroleukemic SKT6 cells. Blood 90:2175-2187.
29. Shaw S, Bencherif M, and Marrero MB (2002) Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid. J Biol Chem 277:44920-44924.
30. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, et al. (2003) Nicotinic acetylcholine receptor a7 subunits is an essential regulator of inflammation. Nature (Lond) 421:384-388.
31. Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, and Reitz AB (2000) beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem 275:5626-5632.