Choline is a selective agonist of α7 nicotinic acetylcholine receptors in the rat brain neurons

European Journal of Neuroscience

Volumn 9, Issue 12, 1997, Pages 2734-2742

  Alkondon, Manickavasagom ^a   Pereira, Edna F R ^a   Cortes, Wellington S ^a,b   Maelicke, Alfred ^c   Albuquerque, Edson X ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Choline; Hippocampus; Olfactory bulb; Rat; Thalamus; Trimethylamine; Two step neurotransmitter; 7 nAChR

Indexed keywords

CHOLINE; NEUROTRANSMITTER; NICOTINIC RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL STRAIN; HIPPOCAMPUS; NEUROTRANSMITTER RELEASE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT; THALAMUS;

EID: 0031410384     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1997.tb01702.x     Document Type: Article

References (29)

1. Albuquerque, E. X., Alkondon, M., Pereira, E. F. R., Castro, N. G., Schrattenholz, A., Barbosa, C. T. F., Bonfante-Cabarcas, R., Aracava, Y., Eisenberg, H. M. and Maelicke, A. (1997) Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function. J. Pharmacol. Exp. Ther., 280, 1117-1136.
2. Alkondon, M. and Albuquerque, E. X. (1991) Initial characterization of the nicotinic acetylcholine receptors in rat hippocampal neurons. J. Receptor Res., 11, 1001-1022.
3. Alkondon, M. and Albuquerque, E. X. (1993) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons: I. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther., 265, 1455-1473
4. Alkondon, M. and Albuquerque, E. X. (1994) Presence of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat olfactory bulb neurons. Neurosci. Lett., 176, 152-156.
5. Alkondon, M. and Albuquerque, E. X. (1995) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. III. Agonist actions of the novel alkaloid epibatidine and analysis of type II current. J. Pharmacol. Exp. Ther., 274, 771-782.
6. Alkondon, M., Reinhardt, S., Lobron, C., Hermsen, B., Maelicke, A. and Albuquerque, E. X. (1994) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. The rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization. J. Pharmacol. Exp. Ther., 271, 494-506.
7. Alkondon, M., Rocha, E. S., Maelicke, A. and Albuquerque, E. X. (1996) Diversity of nicotinic acetylcholine receptors in rat brain. V. α-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons, and presynaptic modulation of glutamate release. J. Pharmacol. Exp. Ther., 278, 1460-1471.
8. Alkondon, M., Pereira, E. F. R. and Albuquerque, E. X. (1997) Choline: an efficacious endogenous agonist at α7-bearing neuronal nicotinic receptors. Biophys. J., 72, A151.
9. Aubert, I., Cécyre, D., Gauthier, S. and Quirion, R. (1996) Comparative ontogenic profile of cholinergic markers, including nicotinic and muscarinic receptors, in rat brain. J. Comp. Neurol., 369, 31-55.
10. Castro, N. G. and Albuquerque, E. X. (1995) α-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability. Biophys. J., 68, 516-524.
11. Chiappinelli, V. A. and Giacobini, E. (1978) Time course of appearance of alpha-bungarotoxin binding sites during development of chick ciliary ganglion and iris. Neurochem. Res., 3, 465-478.
12. Costa, L. G. and Murphy, S. D. (1984) Interaction of choline with nicotinic and muscarinic cholinergic receptors in the rat brain in vitro. Clin. Exp. Pharmacol. Physiol., 11, 649-654.
13. Coutcher, J. B., Cawley, G. and Wecker, L. (1992) Dietary choline supplementation increases the density of nicotine binding sites in rat brain. J. Pharmacol. Exp. Ther., 262, 1128-1132.
14. Del Castillo, J. and Katz, B. (1957) Interaction at end plate receptors between different choline derivatives. Proc. R. Soc. Lond. Ser. B, 146, 369-381.
15. Gray, R., Rajan, A. S., Radcliffe, K. A., Yakehiro, M. and Dani, J. A. (1996) Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature, 383, 713-716.
16. LeNovere, N. and Changeux, J.-P. (1995) Molecular evolution of the nicotinic acetylcholine receptor family: an example of multigene family in excitable cells. J. Mol. Evol., 40, 155-172.
17. Lindstrom, J. (1996) Neuronal nicotinic acetylcholine receptors. In Narahashi, T. (ed.), Ion Channels. Plenum Press, New York, Vol. 4, pp. 377-450.
18. Mandelzys, A., De Koninck, P. and Cooper, E. (1995) Agonist and toxin sensitivities of ACh-evoked currents on neurons expressing multiple nicotinic ACh receptor subunits. J. Neurophysiol., 74, 1212-1221.
19. McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P. and Role, L. R. (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science, 269, 1692-1696.
20. Mizumozi, S. J., Patterson, T. A., Sternberg, H., Rosenzweig, M. R., Bennett, E. L. and Timiras, P. S. (1985) Effects of dietary choline on memory and brain chemistry in aged mice. Neurobiol. Aging, 6, 51-56.
21. Morley, B. J., Robinson, G. R., Brown, G. B., Kemp, G. E. and Bradley, R. J. (1977) Effects of dietary choline on nicotinic acetylcholine receptors in brain. Nature, 266, 848-850.
22. Mulle, C., Vidal, C., Benoit, P. and Changeux, J.-P. (1991) Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system. J. Neurosci., 11, 2588-2597.
23. Papke, R. L., Bencherif, M. and Lippiello, P. (1996) An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype. Neurosci. Lett., 213, 201-204.
24. Prinz, H. and Maelicke, A. (1992) Ligand binding to the membrane-bound acetylcholine receptor from Torpedo marmorata: a complete mathematical analysis. Biochemistry, 31, 6728-6738.
25. Rocha, E. S., Alkondon, M., Burt, D. and Albuquerque, E. X. (1995) A presynaptic modulatory role for the α-bungarotoxin-sensitive nicotinic acetylcholine receptors (nAChRs) in rat olfactory bulb neurons. Soc. Neurosci. Abstr., 21, 1331.
26. Sterz, R., Peper, K., Simon, J., Ebert, J. P., Edge, M., Pagala, M. and Bradley, R. J. (1986) Agonist and blocking effects of choline at the neuromuscular junction. Brain Res., 385, 99-114.
27. Wecker, L. (1990) Choline utilization by central cholinergic neurons. In Wurtman, R. J. and Wurtman, J. J. (eds), Nutrition and the Brain. Raven Press, New York, Vol. 8, pp. 147-162.
28. Zeisel, S. H., Gelenberg, A. J., Growdon, J: H. and Wurtman, R. J. (1980) Use of choline in the treatment of tardive dyskinesia. Adv. Biochem. Psychopharmacol., 24, 463-470.
29. Zorumski, C. F., Thio, L. L., Isenberg, K. E. and Clifford, D. B. (1992) Nicotinic acetylcholine currents in cultured postnatal rat hippocampal neurons. Mol. Pharmacol., 41, 931-936.