Discovery of the α7 nicotinic acetylcholine receptor agonists. (R)-3′-(5-chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3, 5′-[1′,3′]-oxazolidin-2′-one as a novel, potent, selective, and orally bioavailable ligand

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2678-2686

  Tatsumi, Ryo ^a   Fujio, Masakazu ^a   Satoh, Hiroyuki ^a   Katayama, Jiro ^a   Takanashi, Shin Ichi ^a   Hashimoto, Kenji ^a,b   Tanaka, Hiroshi ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3' (5 CHLOROTHIOPHEN 2 YL)SPIRO 1 AZABICYCLO[2.2.2]OCTANE 3,5' [1',3']OXAZOLIDIN 2' ONE; BUNGAROTOXIN RECEPTOR; DIZOCILPINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; OXAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG; 3' (5 CHLOROTHIOPHEN 2 YL)SPIRO 1 AZABICYCLO(2.2.2)OCTANE 3,5' (1',3') OXAZOLIDIN 2' ONE; 3'-(5-CHLOROTHIOPHEN-2-YL)SPIRO-1-AZABICYCLO(2.2.2)OCTANE-3,5'-(1',3')-OXAZOLIDIN-2'-ONE; ALPHA-BUNGAROTOXIN RECEPTOR; LIGAND; NEUROLEPTIC AGENT; OXAZOLE DERIVATIVE; QUINUCLIDINE DERIVATIVE;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; COGNITION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; LIGAND BINDING; MOLECULAR BIOLOGY; NONHUMAN; RAT; SCHIZOPHRENIA; SENSORY NERVE; ANIMAL; BIOAVAILABILITY; BLOOD BRAIN BARRIER; BRAIN; CELL CULTURE; CHEMISTRY; DRUG EFFECT; EVOKED AUDITORY RESPONSE; IN VITRO STUDY; METABOLISM; NERVE CELL; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; RADIOASSAY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIPSYCHOTIC AGENTS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; EVOKED POTENTIALS, AUDITORY; LIGANDS; NEURONS; NICOTINIC AGONISTS; OXAZOLES; QUINUCLIDINES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17144370948     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049188d     Document Type: Article

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