The α7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia

Journal of Chemical Neuroanatomy

Volumn 20, Issue 3-4, 2000, Pages 299-306

  Freedman, Robert ^a   Adams, Catherine E ^a   Leonard, Sherry ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Cerebral cortex; Cholecystokinin; GABA; Hippocampus; Human chromosome 15; Nicotinic receptor; Nitric oxide; Post mortem; Somatostatin; Thalamus

Indexed keywords

4 AMINOBUTYRIC ACID; ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR; CHOLECYSTOKININ; GLUTAMATE DECARBOXYLASE; NICOTINIC RECEPTOR; NITRIC OXIDE SYNTHASE; RECEPTOR SUBUNIT; SOMATOSTATIN; SYNAPSIN I; UNCLASSIFIED DRUG; ALPHA-BUNGAROTOXIN RECEPTOR; BUNGAROTOXIN RECEPTOR;

ADULT; AGED; ARTICLE; CHROMOSOME 15Q; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; IMMUNOREACTIVITY; INTERNEURON; MALE; MANIC DEPRESSIVE PSYCHOSIS; NEUROTRANSMISSION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; SCHIZOPHRENIA; TISSUE DISTRIBUTION; METABOLISM; PATHOLOGY; REVIEW;

HIPPOCAMPUS; HUMANS; INTERNEURONS; RECEPTORS, NICOTINIC; SCHIZOPHRENIA;

EID: 0034351614     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-0618(00)00109-5     Document Type: Article

References (80)

1. Nicotinic antagonist alpha-bungarotoxin binding to rat hippocampal neurons containing nitric oxide synthase
2. Sensory physiology and catecholamines in schizophrenia and mania
3. Normalization of auditory physiology by cigarette smoking in schizophrenic patients
4. Localization of mRNA for CHRNA7 in human fetal brain
5. Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development
6. Nicotinic receptor activation in human cerebral cortical interneurons: A mechanism for inhibition and disinhibition of neuronal networks
7. Differences in the subregional and cellular distribution of GABAA receptor binding in the hippocampal formation of schizophrenic brain
8. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
9. Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells
10. 125I]-alpha-bungarotoxin binding in human postmortem brain
11. 3H]nicotine binding in human postmortem brain
12. Abnormal regulation of the high affinity nicotinic receptors in subjects with schizophrenia
13. Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics
14. Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients
15. Neurotransmitter interactions in schizophrenia-therapeutic implications
16. Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: Alpha-bungarotoxin and nicotine binding in the thalamus
17. Cholinesterase inhibitors: A new class of psychotropic compounds
18. No evidence of linkage between schizophrenia and markers at chromosome 15q13-14
19. Synaptic connections of neuropeptide Y (NPY) immunoreactive neurons in the hilar area of the rat hippocampus
20. Reduced cholecystokinin-like and somatostatin-like immunoreactivity in limbic lobe is associated with negative symptoms in schizophrenia
21. Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells
22. Alpha-bungarotoxin binding to hippocampal interneurons: Immunocytochemical characterization and effects on growth factor expression
23. Schizophrenia and nicotinic receptors
24. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
25. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia
26. 125I]alpha-bungarotoxin binding marks primary sensory area developing rat neocortex
27. Neuropeptide deficits in schizophrenia vs. Alzheimer's disease cerebral cortex
28. Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)
29. Hippocampal synaptic transmission enhanced by low concentrations of nicotine
30. NMDA-dependent modulation of CA1 local circuit inhibition
31. Decreased protein level of nicotinic receptor alpha7 subunit in the frontal cortex from schizophrenic brain
32. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease
33. Cortical cholinergic markers in schizophrenia
34. Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord
35. Regional distribution of nicotinic receptor subunit mRNAs in human brain: Comparison between Alzheimer and normal brain
36. The relationship of alpha-bungarotoxin binding activity and cholinergic termination within the rat hippocampus
37. Seizures and schizophrenia
38. 'Dormant inhibitory neurons': Do they exist and what is their functional impact?
39. Effects of dopamine on spontaneous and evoked activity of caudate neurons
40. Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: A possible neurochemical basis for 'hypofrontality'
41. NIMH Genetics Initiative Millenium Consortium - Linkage analysis of African-American pedigrees
42. Somatostatin-like immunoreactive neurons in the hippocampus: An immunocytochemical study in the rat
43. 2+ fluctuations modulate the rate of neuronal migration
44. Nerve growth factor mRNA is expressed by GABAergic neurons in rat hippocampus
45. Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH Genetics Initiative
46. Hippocampal pathologic findings in schizophrenia. A morphometric study
47. Cholinergic gating of response to auditory stimuli in rat hippocampus
48. Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease
49. No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families
50. Nicotine withdrawal in the rat: Role of alpha7 nicotinic receptors in the ventral tegmental area
51. Increased levels of the nicotine metabolite cotinine in schizophrenic smokers compared to other smokers
52. NMDA receptor hypofunction model of schizophrenia
53. Mice homozygous for the L250T mutation in the α7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within one day of birth
54. Prospects for research on schizophrenia. 3. Neurophysiology. Neuropathological findings
55. Hippocampal α7 nicotinic cholinergic receptor, neuronal nitric oxide synthase, and glutamic acid decarboxylase mRNA co-localization in schizophrenia
56. Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia
57. Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families
58. Peptides, the limbic lobe and schizophrenia
59. The thalamus and neuropsychiatric illness
60. Afferent fibers from the septum terminate on gamma aminobutyric acid (GABA-)interneurons and granule cells in the area dentata of the rat
61. Various types of non-pyramidal hippocampal neurons project to the septum and contralateral hippocampus
62. Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17
63. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three-dimensional, stereologic counting method
64. UB-165: A novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes
65. Immunocytochemical localization of GABA-, cholecystokinin-, vasoactive intestinal polypeptide-, and somatostatin-like immunoreactivity in the area dentata and hippocampus of the rat
66. Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat
67. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia
68. Impairment of inhibitory synaptic transmission in mice lacking synapsin I
69. Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain
70. A genome scan using a pharmacogenetic approach indicates a susceptibility locus for bipolar disorder on 15q14
71. Imaging of calcium variations in living dendritic spines of cultured rat hippocampal neurons
72. Neurons in rat hippocampus that synthesize nitric oxide
73. Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia
74. VASE-containing N-CAM isoforms are increased in the hippocampus in bipolar disorder but not schizophrenia
75. 2+
76. Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings
77. Beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
78. Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: Histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein
79. Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons
80. A subclass of prefrontal gamma-aminobutyric acid axon terminals are selectively altered in schizophrenia