-
1
-
-
0037042299
-
Alzheimer disease
-
Cummings JL, Cole G. Alzheimer disease. JAMA 287, 2335-2338 (2002).
-
(2002)
JAMA
, vol.287
, pp. 2335-2338
-
-
Cummings, J.L.1
Cole, G.2
-
3
-
-
0036829434
-
Amyloid-b and tau serve antioxidant functions in the aging and Alzheimer brain
-
Smith MA, Casadesus G, Joseph JA et al. Amyloid-b and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radic. Biol. Med. 33, 1194-1199 (2002).
-
(2002)
Free Radic. Biol. Med.
, vol.33
, pp. 1194-1199
-
-
Smith, M.A.1
Casadesus, G.2
Joseph, J.A.3
-
4
-
-
17044435830
-
Tau phosphorylation in Alzheimer's disease: Pathogen or protector?
-
Lee HG, Perry G, Moreira PI et al. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends Mol. Med. 11, 164-169 (2005).
-
(2005)
Trends Mol Med.
, vol.11
, pp. 164-169
-
-
Lee, H.G.1
Perry, G.2
Moreira, P.I.3
-
6
-
-
0035081475
-
Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid b-protein
-
Selkoe DJ. Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid b-protein. J. Alzheimers Dis. 3, 75-80 (2001).
-
(2001)
J. Alzheimers Dis.
, vol.3
, pp. 75-80
-
-
Selkoe, D.J.1
-
7
-
-
4143139576
-
APOE genotype effects on Alzheimer's disease onset and epidemiology
-
Ashford J W. APOE genotype effects on Alzheimer's disease onset and epidemiology. J. Mol. Neurosci. 23, 157-165 (2004).
-
(2004)
J. Mol. Neurosci.
, vol.23
, pp. 157-165
-
-
Ashford, J.W.1
-
8
-
-
4143082424
-
ApoE-dependent plasticity in Alzheimer's disease
-
Teter B. ApoE-dependent plasticity in Alzheimer's disease. J. Mol. Neurosci. 23, 167-179 (2004).
-
(2004)
J. Mol. Neurosci.
, vol.23
, pp. 167-179
-
-
Teter, B.1
-
9
-
-
0031038918
-
Alzheimer's disease: Genotypes, phenotypes, and treatments
-
Selkoe DJ. Alzheimer's disease: genotypes, phenotypes, and treatments. Science 275, 630-631 (1997).
-
(1997)
Science
, vol.275
, pp. 630-631
-
-
Selkoe, D.J.1
-
10
-
-
33645105621
-
Presenilin clinical mutations can affect g-secretase activity by different mechanisms
-
Bentahir M, Nyabi O, Verhamme J et al. Presenilin clinical mutations can affect g-secretase activity by different mechanisms. J. Neurochem. 96, 732-742 (2006).
-
(2006)
J. Neurochem.
, vol.96
, pp. 732-742
-
-
Bentahir, M.1
Nyabi, O.2
Verhamme, J.3
-
11
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185 (1992).
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
12
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
13
-
-
18744374615
-
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
-
Perry G, Nunomura A, Hirai K et al. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radic. Biol. Med. 33, 1475-1479 (2002).
-
(2002)
Free Radic. Biol. Med.
, vol.33
, pp. 1475-1479
-
-
Perry, G.1
Nunomura, A.2
Hirai, K.3
-
14
-
-
0032229327
-
Reactive oxygen species mediate cellular damage in Alzheimer disease
-
Perry G, Castellani RJ, Hirai K et al. Reactive oxygen species mediate cellular damage in Alzheimer disease. J. Alzheimers Dis. 1, 45-55 (1998).
-
(1998)
J. Alzheimers Dis.
, vol.1
, pp. 45-55
-
-
Perry, G.1
Castellani, R.J.2
Hirai, K.3
-
15
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300 (1956).
-
(1956)
J. Gerontol.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
16
-
-
0017177978
-
Free radical theory of aging: Inhibition of amyloidosis in mice by antioxidants; Possible mechanism
-
Harman D, Eddy DE, Noffsinger J. Free radical theory of aging: inhibition of amyloidosis in mice by antioxidants; possible mechanism. J. Am. Geriatr. Soc. 24, 203-210 (1976).
-
(1976)
J. Am. Geriatr. Soc.
, vol.24
, pp. 203-210
-
-
Harman, D.1
Eddy, D.E.2
Noffsinger, J.3
-
18
-
-
0033899208
-
Glutathione, oxidative stress and neurodegeneration
-
Schulz JB, Lindenau J, Sey fried J et al. Glutathione, oxidative stress and neurodegeneration. Eur. J. Biochem. 267(16), 4904-4911 (2000).
-
(2000)
Eur. J. Biochem.
, vol.267
, Issue.16
, pp. 4904-4911
-
-
Schulz, J.B.1
Lindenau, J.2
Sey Fried, J.3
-
19
-
-
0030885482
-
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
-
Smith MA, Harris PL, Sayre LM et al. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl Acad. Sci. USA 94, 9866-9868 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 9866-9868
-
-
Smith, M.A.1
Harris, P.L.2
Sayre, L.M.3
-
20
-
-
27544484846
-
Are mitochondria critical in the pathogenesis of Alzheimer's disease?
-
Reddy PH, Beal MF. Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Res. Brain Res. Rev. 49, 618-632 (2005).
-
(2005)
Brain Res. Brain Res. Rev.
, vol.49
, pp. 618-632
-
-
Reddy, P.H.1
Beal, M.F.2
-
21
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 430, 631-639 (2004).
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
22
-
-
33646152108
-
Mitochondria are a direct site of A b accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression
-
Manczak M, Anekonda TS, Henson E et al Mitochondria are a direct site of A b accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum. Mol Genet. 15, 1437-1449 (2006).
-
(2006)
Hum. Mol Genet.
, vol.15
, pp. 1437-1449
-
-
Manczak, M.1
Anekonda, T.S.2
Henson, E.3
-
23
-
-
39149122810
-
Amyloid b, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
-
Reddy PH, Beal MF. Amyloid b, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol. Med. 14, 45-53 (2008).
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 45-53
-
-
Reddy, P.H.1
Beal, M.F.2
-
24
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai K, Aliev G, Nunomura A et al Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci. 21, 3017-3023 (2001).
-
(2001)
J. Neurosci.
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
-
25
-
-
0037010312
-
Role of mitochondrial dysfunction in Alzheimer's disease
-
Castellani R, Hirai K, Aliev G et al. Role of mitochondrial dysfunction in Alzheimer's disease. J. Neurosci. Res. 70, 357-360 (2002).
-
(2002)
J. Neurosci. Res.
, vol.70
, pp. 357-360
-
-
Castellani, R.1
Hirai, K.2
Aliev, G.3
-
26
-
-
48749085779
-
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fbroblasts from sporadic Alzheimer's disease patients
-
Wang X, Su B, Fujioka H et al. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fbroblasts from sporadic Alzheimer's disease patients. Am. J. Pathol. 173, 470-482 (2008).
-
(2008)
Am. J. Pathol.
, vol.173
, pp. 470-482
-
-
Wang, X.1
Su, B.2
Fujioka, H.3
-
27
-
-
58049218922
-
Amyloid-b overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fssion/fusion proteins
-
Wang X, Su B, Siedlak SL et al. Amyloid-b overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fssion/fusion proteins. Proc. Natl Acad. Sci. USA 105, 19318-19323 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 19318-19323
-
-
Wang, X.1
Su, B.2
Siedlak, S.L.3
-
28
-
-
53549129483
-
Cyclophilin D defciency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
-
Du H, Guo L, Fang F et al. Cyclophilin D defciency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat. Med. 14, 1097-1105 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 1097-1105
-
-
Du, H.1
Guo, L.2
Fang, F.3
-
29
-
-
0033569839
-
Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease
-
Russell RL, Siedlak SL, Raina AK et al Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease. Arch. Biochem. Biophys. 370, 236-239 (1999).
-
(1999)
Arch. Biochem. Biophys.
, vol.370
, pp. 236-239
-
-
Russell, R.L.1
Siedlak, S.L.2
Raina, A.K.3
-
30
-
-
0027332651
-
Brain a-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
-
Mastrogiacomo F, Bergeron C, Kish SJ. Brain a-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. J. Neurochem. 61, 2007-2014 (1993).
-
(1993)
J. Neurochem.
, vol.61
, pp. 2007-2014
-
-
Mastrogiacomo, F.1
Bergeron, C.2
Kish, S.J.3
-
31
-
-
34249881080
-
Auto phagocytosis of mitochondria is prominent in Alzheimer disease
-
Moreira PI, Siedlak SL, Wang X et al. Auto phagocytosis of mitochondria is prominent in Alzheimer disease. J. Neuropathol. Exp. Neurol. 66, 525-532 (2007).
-
(2007)
J. Neuropathol. Exp. Neurol.
, vol.66
, pp. 525-532
-
-
Moreira, P.I.1
Siedlak, S.L.2
Wang, X.3
-
32
-
-
0028023533
-
Functional alterations in Alzheimer's disease: Selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation
-
Simonian NA, Hyman BT. Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J. Neuropathol. Exp. Neurol. 53, 508-512 (1994).
-
(1994)
J. Neuropathol. Exp. Neurol.
, vol.53
, pp. 508-512
-
-
Simonian, N.A.1
Hyman, B.T.2
-
33
-
-
0025011401
-
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias
-
Yates CM, Butterworth J, Tennant MC et al. Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias. J. Neurochem. 55, 1624-1630 (1990).
-
(1990)
J. Neurochem.
, vol.55
, pp. 1624-1630
-
-
Yates, C.M.1
Butterworth, J.2
Tennant, M.C.3
-
34
-
-
0033964859
-
In situoxidative catalysis by neurofbrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals
-
Sayre LM, Perry G, Harris PL et al. In situoxidative catalysis by neurofbrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. J. Neurochem. 74, 270-279 (2000).
-
(2000)
J. Neurochem.
, vol.74
, pp. 270-279
-
-
Sayre, L.M.1
Perry, G.2
Harris, P.L.3
-
35
-
-
0032514165
-
Promotion of transition metal-induced reactive oxygen species formation by b-amyloid
-
Bondy SC, Guo-Ross SX, Truong AT. Promotion of transition metal-induced reactive oxygen species formation by b-amyloid. Brain Res. 799, 91-96 (1998).
-
(1998)
Brain Res.
, vol.799
, pp. 91-96
-
-
Bondy, S.C.1
Guo-Ross, S.X.2
Truong, A.T.3
-
36
-
-
18344414746
-
The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
-
DOI 10.1021/bi990438f
-
Huang X, Atwood CS, Hartshorn MA et al. The Ab peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 38, 7609-7616 (1999). (Pubitemid 29289332)
-
(1999)
Biochemistry
, vol.38
, Issue.24
, pp. 7609-7616
-
-
Huang, X.1
Atwood, C.S.2
Hartshorn, M.A.3
Multhaup, G.4
Goldstein, L.E.5
Scarpa, R.C.6
Cuajungco, M.P.7
Gray, D.N.8
Lim, J.9
Moir, R.D.10
Tanzi, R.E.11
Bush, A.I.12
-
37
-
-
0033559462
-
RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease
-
Nunomura A, Perry G, Pappolla MA et al. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J. Neurosci. 19, 1959-1964 (1999). (Pubitemid 29133374)
-
(1999)
Journal of Neuroscience
, vol.19
, Issue.6
, pp. 1959-1964
-
-
Nunomura, A.1
Perry, G.2
Pappolla, M.A.3
Wade, R.4
Hirai, K.5
Chiba, S.6
Smith, M.A.7
-
38
-
-
0141617737
-
Apolipoprotein E, oxidative stress and EGb 761 in Alzheimer's disease brain
-
Packer L, Christen Y (Eds). Elsevier, Paris, France
-
Ramassamy C, Krzywokowski P, Bastianetto S et al. Apolipoprotein E, oxidative stress and EGb 761 in Alzheimer's disease brain. In: Ginkgo Biloba Extract (EGb 761) Study: Lesson From Cell Biology. Packer L, Christen Y (Eds). Elsevier, Paris, France, 69-83 (1998).
-
(1998)
Ginkgo Biloba Extract (EGb 761) Study: Lesson from Cell Biology
, pp. 69-83
-
-
Ramassamy, C.1
Krzywokowski, P.2
Bastianetto, S.3
-
39
-
-
33947178563
-
Alzheimer disease, the two-hit hypothesis: An update
-
Zhu X, Lee HG, Perry G et al. Alzheimer disease, the two-hit hypothesis: an update. Biochim. Biophys. Acta 1772, 494-502 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1772
, pp. 494-502
-
-
Zhu, X.1
Lee, H.G.2
Perry, G.3
-
40
-
-
1642358352
-
Alzheimer's disease: The two-hit hypothesis
-
Zhu X, Raina AK, Perry G et al. Alzheimer's disease: the two-hit hypothesis. Lancet Neurol. 3, 219-226 (2004).
-
(2004)
Lancet Neurol.
, vol.3
, pp. 219-226
-
-
Zhu, X.1
Raina, A.K.2
Perry, G.3
-
41
-
-
0034797352
-
JNK/SAPK and p38 in Alzheimer disease: The 'two hit' hypothesis
-
Differential activation of neuronal ERK
-
Zhu X, Castellani RJ, Takeda A et al. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mech. Ageing Dev. 123, 39-46 (2001).
-
(2001)
Mech. Ageing Dev.
, vol.123
, pp. 39-46
-
-
Zhu, X.1
Castellani, R.J.2
Takeda, A.3
-
42
-
-
0030767243
-
The cholinergic system in Alzheimer's disease
-
Kasa P, Rakonczay Z, Gulya K. The cholinergic system in Alzheimer's disease. Prog. Neurobiol. 52, 511-535 (1997).
-
(1997)
Prog. Neurobiol.
, vol.52
, pp. 511-535
-
-
Kasa, P.1
Rakonczay, Z.2
Gulya, K.3
-
43
-
-
0020657372
-
Presynaptic cholinergic dysfunction in patients with dementia
-
Sims NR, Bowen DM, Allen SJ et al. Presynaptic cholinergic dysfunction in patients with dementia. J. Neurochem. 40, 503-509 (1983).
-
(1983)
J. Neurochem.
, vol.40
, pp. 503-509
-
-
Sims, N.R.1
Bowen, D.M.2
Allen, S.J.3
-
44
-
-
0026440987
-
Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations
-
Intraventricular Bethanecol Study Group
-
DeKosky ST, Harbaugh RE, Schmitt FA et al. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group. Ann. Neurol. 32, 625-632 (1992).
-
(1992)
Ann. Neurol.
, vol.32
, pp. 625-632
-
-
Dekosky, S.T.1
Harbaugh, R.E.2
Schmitt, F.A.3
-
46
-
-
0034535351
-
Cholinesterase inhibitors stabilize Alzheimer's disease
-
Giacobini E. Cholinesterase inhibitors stabilize Alzheimer's disease. Ann. NY Acad. Sci. 920, 321-327 (2000).
-
(2000)
Ann. NY Acad. Sci.
, vol.920
, pp. 321-327
-
-
Giacobini, E.1
-
47
-
-
0035123732
-
Do cholinesterase inhibitors have disease-modifying effects in Alzheimer's disease?
-
Giacobini E. Do cholinesterase inhibitors have disease-modifying effects in Alzheimer's disease? CNS Drugs 15, 85-91 (2001).
-
(2001)
CNS Drugs
, vol.15
, pp. 85-91
-
-
Giacobini, E.1
-
48
-
-
0036050824
-
Long-term stabilizing effect of cholinesterase inhibitors in the therapy of Alzheimer' disease
-
Giacobini E. Long-term stabilizing effect of cholinesterase inhibitors in the therapy of Alzheimer' disease. J. Neural. Transm. Suppl. 62, 181-187 (2002).
-
(2002)
J. Neural. Transm. Suppl.
, vol.62
, pp. 181-187
-
-
Giacobini, E.1
-
49
-
-
0027731677
-
Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5- dimethyladamantan)
-
Parsons CG, Gruner R, Rozental J et al. Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology 32, 1337-1350 (1993).
-
(1993)
Neuropharmacology
, vol.32
, pp. 1337-1350
-
-
Parsons, C.G.1
Gruner, R.2
Rozental, J.3
-
50
-
-
0030052030
-
Learning defcits induced by chronic intraventricular infusion of quinolinic acid-protection by MK-801 and memantine
-
Misztal M, Frankiewicz T, Parsons CG et al. Learning defcits induced by chronic intraventricular infusion of quinolinic acid-protection by MK-801 and memantine. Eur. J. Pharmacol. 296, 1-8 (1996).
-
(1996)
Eur. J. Pharmacol.
, vol.296
, pp. 1-8
-
-
Misztal, M.1
Frankiewicz, T.2
Parsons, C.G.3
-
51
-
-
0029743772
-
Theeffects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis
-
Wenk GL, Danysz W, Roice DD. Theeffects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis. Neuroreport 7, 1453-1456 (1996).
-
(1996)
Neuroreport
, vol.7
, pp. 1453-1456
-
-
Wenk, G.L.1
Danysz, W.2
Roice, D.D.3
-
52
-
-
0030042201
-
Danysz W Infusion of (+)-MK-801 and memantine-contrasting effects on radial maze learning in rats with entorhinal cortex lesion
-
Zajaczkowski W, Quack G, Danysz W Infusion of (+)-MK-801 and memantine-contrasting effects on radial maze learning in rats with entorhinal cortex lesion. Eur. J. Pharmacol. 296, 239-246 (1996).
-
(1996)
Eur. J. Pharmacol.
, vol.296
, pp. 239-246
-
-
Zajaczkowski, W.1
Quack, G.2
-
53
-
-
0029899586
-
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
-
Bruce AJ, Boling W, Kindy MS et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat. Med. 2, 788-794 (1996).
-
(1996)
Nat. Med.
, vol.2
, pp. 788-794
-
-
Bruce, A.J.1
Boling, W.2
Kindy, M.S.3
-
54
-
-
0034284973
-
Extension of life-span with superoxide dismutase/catalase mimetics
-
Melov S, Ravenscroft J, Malik S et al. Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-1569 (2000).
-
(2000)
Science
, vol.289
, pp. 1567-1569
-
-
Melov, S.1
Ravenscroft, J.2
Malik, S.3
-
55
-
-
0026343873
-
Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfde, and vitamin e
-
Adams JD, Jr., Klaidman LK, Odunze IN et al. Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfde, and vitamin E. Mol. Chem. Neuropathol. 14, 213-226 (1991).
-
(1991)
Mol. Chem. Neuropathol.
, vol.14
, pp. 213-226
-
-
Adams Jr., J.D.1
Klaidman, L.K.2
Odunze, I.N.3
-
56
-
-
0028059308
-
Oxidative damage in neurodegenerative disease
-
Jenner P. Oxidative damage in neurodegenerative disease. Lancet 344, 796-798 (1994).
-
(1994)
Lancet
, vol.344
, pp. 796-798
-
-
Jenner, P.1
-
57
-
-
0029125266
-
Free radical involvement in neuropsychiatric illnesses
-
Lohr JB, Browning JA. Free radical involvement in neuropsychiatric illnesses. Psychopharmacol. Bull. 31, 159-165 (1995).
-
(1995)
Psychopharmacol. Bull.
, vol.31
, pp. 159-165
-
-
Lohr, J.B.1
Browning, J.A.2
-
58
-
-
1442314722
-
Early vitamin e supplementation in young but not aged mice reduces Ab levels and amyloid deposition in a transgenic model of Alzheimer's disease
-
Sung S, Yao Y, Uryu K et al. Early vitamin E supplementation in young but not aged mice reduces Ab levels and amyloid deposition in a transgenic model of Alzheimer's disease. FASEB J. 18, 323-325 (2004).
-
(2004)
FASEB J.
, vol.18
, pp. 323-325
-
-
Sung, S.1
Yao, Y.2
Uryu, K.3
-
59
-
-
0030967165
-
A controlled trial of selegiline, a-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's disease cooperative study
-
Sano M, Ernesto C, Thomas RG et al. A controlled trial of selegiline, a-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N. Engl. J. Med. 336, 1216-1222 (1997).
-
(1997)
N. Engl. J. Med.
, vol.336
, pp. 1216-1222
-
-
Sano, M.1
Ernesto, C.2
Thomas, R.G.3
-
60
-
-
0037178579
-
Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study
-
Morris MC, Evans DA, Bienias JL et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 287, 3230-3237 (2002).
-
(2002)
JAMA
, vol.287
, pp. 3230-3237
-
-
Morris, M.C.1
Evans, D.A.2
Bienias, J.L.3
-
61
-
-
0037178573
-
Dietary intake of antioxidants and risk of Alzheimer disease
-
Engelhart MJ, Geerlings MI, Ruitenberg A et al. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 287, 3223-3229 (2002).
-
(2002)
JAMA
, vol.287
, pp. 3223-3229
-
-
Engelhart, M.J.1
Geerlings, M.I.2
Ruitenberg, A.3
-
62
-
-
38549169416
-
Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults
-
Gray SL, Anderson ML, Crane PK et al. Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults. J. Am. Geriatr. Soc. 56(2), 291-295 (2008).
-
(2008)
J. Am. Geriatr. Soc.
, vol.56
, Issue.2
, pp. 291-295
-
-
Gray, S.L.1
Anderson, M.L.2
Crane, P.K.3
-
63
-
-
55049112715
-
Vitamin for Alzheimer's disease and mild cognitive impairment
-
Isaac MG, Quinn R, Tabet N. Vitamin for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst. Rev. 16(3), CD002854 (2008).
-
(2008)
Cochrane Database Syst. Rev.
, vol.16
, Issue.3
-
-
Isaac, M.G.1
Quinn, R.2
Tabet, N.3
-
64
-
-
20344381835
-
Vitamin e and donepezil for the treatment of mild cognitive impairment
-
Petersen RC, Thomas RG, Grundman M et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N. Engl. J. Med. 352(23), 2379-2388 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, Issue.23
, pp. 2379-2388
-
-
Petersen, R.C.1
Thomas, R.G.2
Grundman, M.3
-
65
-
-
56649112752
-
Ginkgo biloba for prevention of dementia: A randomized controlled trial
-
DeKosky ST, Williamson JD, Fitzpatrick AL et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 300(19), 2253-2262 (2008).
-
(2008)
JAMA
, vol.300
, Issue.19
, pp. 2253-2262
-
-
Dekosky, S.T.1
Williamson, J.D.2
Fitzpatrick, A.L.3
-
66
-
-
33646349444
-
Mitochondrial oxidative damage in aging and Alzheimer's disease: Implications for mitochondrially targeted antioxidant therapeutics
-
Reddy PH. Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. J. Biomed. Biotechnol. 2006(3), 31372 (2006).
-
(2006)
J. Biomed. Biotechnol.
, vol.2006
, Issue.3
, pp. 31372
-
-
Reddy, P.H.1
-
67
-
-
29344446328
-
Targeting antioxidants to mitochondria: A new therapeutic direction
-
Sheu SS, Nauduri D, Anders MW. Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim. Biophys. Acta. 1762, 256-265 (2006).
-
(2006)
Biochim. Biophys. Acta.
, vol.1762
, pp. 256-265
-
-
Sheu, S.S.1
Nauduri, D.2
Anders, M.W.3
-
68
-
-
33847071146
-
Targeting antioxidants to mitochondria by conjugation to lipophilic cations
-
Murphy MP, Smith RA. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu. Rev. Pharmacol. Toxicol. 47, 629-656 (2007).
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 629-656
-
-
Murphy, M.P.1
Smith, R.A.2
-
69
-
-
34248159898
-
Mitochondrial targeting of quinines: Therapeutic implications
-
Cochemé HM, Kelso GF, James AM et al. Mitochondrial targeting of quinines: therapeutic implications. Mitochondrion S94-S102 (2007).
-
(2007)
Mitochondrion
-
-
Cochemé, H.M.1
Kelso, G.F.2
James, A.M.3
-
70
-
-
20444392739
-
Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools
-
James AM, Cochemé HM, Smith RA et al. Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. J. Biol. Chem. 280, 21295-21312 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 21295-21312
-
-
James, A.M.1
Cochemé, H.M.2
Smith, R.A.3
-
71
-
-
0033536644
-
A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats
-
Salvemini D, Wang ZQ, Zweier JL et al. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science 286, 304-306 (1999).
-
(1999)
Science
, vol.286
, pp. 304-306
-
-
Salvemini, D.1
Wang, Z.Q.2
Zweier, J.L.3
-
72
-
-
21244448078
-
Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic: Insights into the interaction of ebselen with mitochondria
-
Filipovska A, Kelso GF, Brown SE et al. Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic: insights into the interaction of ebselen with mitochondria. J. Biol. Chem. 280, 23113-23126 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23113-23126
-
-
Filipovska, A.1
Kelso, G.F.2
Brown, S.E.3
-
73
-
-
0346814090
-
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: Studies using a mitochondria- targeted spin trap derived from a-phenyl-N-tert-butylnitrone
-
Murphy MP, Echtay KS, Blaikie FH et al. Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from a-phenyl-N-tert-butylnitrone. J. Biol. Chem. 278(49), 48534-48545 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.49
, pp. 48534-48545
-
-
Murphy, M.P.1
Echtay, K.S.2
Blaikie, F.H.3
-
74
-
-
4544370680
-
Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury
-
Zhao K, Zhao GM, Wu D et al. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J. Biol. Chem. 279(33), 34682-34690 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.33
, pp. 34682-34690
-
-
Zhao, K.1
Zhao, G.M.2
Wu, D.3
-
75
-
-
69449096141
-
Over expression of SOD-2 reduces hippocampal superoxide and prevents memory defcits in a mouse model of Alzheimer's disease
-
Massaad CA, Washington TM, Pautler RG et al. Over expression of SOD-2 reduces hippocampal superoxide and prevents memory defcits in a mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 106, 13576-13581 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 13576-13581
-
-
Massaad, C.A.1
Washington, T.M.2
Pautler, R.G.3
-
76
-
-
35348981740
-
Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-p peptide
-
Hayashi T, Shishido N, Nakayama K et al. Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-p peptide. Free Radic. Biol. Med. 43, 1552-1559 (2007).
-
(2007)
Free Radic. Biol. Med.
, vol.43
, pp. 1552-1559
-
-
Hayashi, T.1
Shishido, N.2
Nakayama, K.3
-
77
-
-
35948936850
-
Three histidine residues of amyloid-p peptide control the redox activity of copper and iron
-
Nakamura M, Shishido N, Nunomura A et al. Three histidine residues of amyloid-p peptide control the redox activity of copper and iron. Biochemistry 46, 12737-12743 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 12737-12743
-
-
Nakamura, M.1
Shishido, N.2
Nunomura, A.3
-
78
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits p-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny RA, Atwood CS, Xilinas ME et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits p-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30, 665-676 (2001).
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
-
79
-
-
0025726462
-
Intramuscular desferoxamine in patients with Alzheimer's disease
-
Crapper McLachlan DR, Dalton AJ, Kruck TP et al. Intramuscular desferoxamine in patients with Alzheimer's disease. Lancet 337, 1304-1308 (1991).
-
(1991)
Lancet
, vol.337
, pp. 1304-1308
-
-
Crapper McLachlan, D.R.1
Dalton, A.J.2
Kruck, T.P.3
-
80
-
-
0027515763
-
Desferoxamine and Alzheimer's disease: Video home behavior assessment of clinical course and measures of brain aluminum
-
McLachlan DR, Smith WL, Kruck TPA. Desferoxamine and Alzheimer's disease: video home behavior assessment of clinical course and measures of brain aluminum. Ther. Drug Monit. 15, 602-607 (1993).
-
(1993)
Ther. Drug Monit.
, vol.15
, pp. 602-607
-
-
McLachlan, D.R.1
Smith, W.L.2
Tpa, K.3
-
81
-
-
33748202940
-
Nanoparticle iron chelators: A new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance
-
Liu G, Men P, Harris PL et al. Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance. Neurosci. Lett. 406, 189-193 (2006).
-
(2006)
Neurosci. Lett.
, vol.406
, pp. 189-193
-
-
Liu, G.1
Men, P.2
Harris, P.L.3
-
82
-
-
77449089898
-
Nanoparticle and iron chelators as a potential novel Alzheimer therapy
-
Liu G, Men P, Perry G, Smith MA. Nanoparticle and iron chelators as a potential novel Alzheimer therapy. Methods Mol. Biol. 610, 123-144 (2010).
-
(2010)
Methods Mol. Biol.
, vol.610
, pp. 123-144
-
-
Liu, G.1
Men, P.2
Perry, G.3
Smith, M.A.4
-
83
-
-
47149108940
-
Effect of Dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
-
Doody RS, Gavrilova SI, Sano M et al. Effect of Dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet 372, 207-215 (2008).
-
(2008)
Lancet
, vol.372
, pp. 207-215
-
-
Doody, R.S.1
Gavrilova, S.I.2
Sano, M.3
-
84
-
-
3242887701
-
Comparative study of action mechanisms of dimebon and memantin on AMPA-and NMDA-subtypes glutamate receptors in rat cerebral neurons
-
Grigorev VV, Dranyi OA, Bachurin SO. Comparative study of action mechanisms of dimebon and memantin on AMPA-and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull. Exp. Biol. Med. 136(5), 474-477 (2003).
-
(2003)
Bull. Exp. Biol. Med.
, vol.136
, Issue.5
, pp. 474-477
-
-
Grigorev, V.V.1
Dranyi, O.A.2
Bachurin, S.O.3
-
86
-
-
0037713338
-
Mitochondria as a target for neurotoxins and neuroprotective agents
-
Bachurin SO, Shevtsova EP, Kireeva EG et al. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann. NY Acad. Sci. 993, 334-344 (2003).
-
(2003)
Ann. NY Acad. Sci.
, vol.993
, pp. 334-344
-
-
Bachurin, S.O.1
Shevtsova, E.P.2
Kireeva, E.G.3
-
87
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
Nunomura A, Perry G, Aliev G et al. Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60, 759-767 (2001).
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
-
88
-
-
58149191631
-
Effcacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: A 1-year, open-label pilot study with an 16 month caregiver extension
-
Chan A, Paskavitz J, Remington R et al. Effcacy of a vitamin/ nutriceutical formulation for early-stage Alzheimer's disease: a 1-year, open-label pilot study with an 16 month caregiver extension. Am. J. Alzheimers Dis. Other Demen. 23(6), 571-585 (2009).
-
(2009)
Am. J. Alzheimers Dis. Other Demen.
, vol.23
, Issue.6
, pp. 571-585
-
-
Chan, A.1
Paskavitz, J.2
Remington, R.3
-
89
-
-
33745266146
-
Effcacy of rosiglitazone in a genetically defned population with mi ld-to-moderate Alzheimer's disease
-
Risner ME, Saunders AM, Altman JF et al. Effcacy of rosiglitazone in a genetically defned population with mi ld-to-moderate Alzheimer's disease. Pharmacogenomics J. 6, 246-254 (2006).
-
(2006)
Pharmacogenomics J.
, vol.6
, pp. 246-254
-
-
Risner, M.E.1
Saunders, A.M.2
Altman, J.F.3
-
90
-
-
33745141581
-
Recommendations of the National Heart Lung, and Blood Institute working group on cerebrovascular biology and disease
-
Iadecola C, Goldman SS, Harder DR et al. Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and disease. Stroke 37, 1578-1581 (2006).
-
(2006)
Stroke
, vol.37
, pp. 1578-1581
-
-
Iadecola, C.1
Goldman, S.S.2
Harder, D.R.3
-
91
-
-
8644277006
-
Reactive oxygen species in vascular biology: Implications in hypertension
-
Touyz RM, Schiffrin EL. Reactive oxygen species in vascular biology: implications in hypertension. Histochem. Cell Biol., 122, 339-352 (2004).
-
(2004)
Histochem. Cell Biol.
, vol.122
, pp. 339-352
-
-
Touyz, R.M.1
Schiffrin, E.L.2
-
92
-
-
34548684314
-
Role of advanced glycation end products in hypertension and atherosclerosis: Therapeutic implications
-
Vasdev S, Gill V, Singal P. Role of advanced glycation end products in hypertension and atherosclerosis: therapeutic implications. Cell Biochem. Biophys. 49, 48-63 (2007).
-
(2007)
Cell Biochem. Biophys.
, vol.49
, pp. 48-63
-
-
Vasdev, S.1
Gill, V.2
Singal, P.3
-
93
-
-
0033854560
-
Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats
-
Vaziri ND, Wang XQ, Oveisi F et al. Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats. Hypertension 36, 142-146 (2000).
-
(2000)
Hypertension
, vol.36
, pp. 142-146
-
-
Vaziri, N.D.1
Wang, X.Q.2
Oveisi, F.3
-
94
-
-
33749045289
-
Mechanisms of disease: Oxidative stress and infammation in the pathogenesis of hypertension
-
Vaziri ND, Rodriguez-Iturbe B. Mechanisms of disease: oxidative stress and infammation in the pathogenesis of hypertension. Nat. Clin. Pract. Nephrol. 2, 582-593 (2006).
-
(2006)
Nat. Clin. Pract. Nephrol.
, vol.2
, pp. 582-593
-
-
Vaziri, N.D.1
Rodriguez-Iturbe, B.2
-
95
-
-
4444329422
-
Reactive oxygen species vascular oxidative stress, and redox signaling in hypertension: What is the clinical signifcance?
-
Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical signifcance? Hypertension 44, 248-252 (2004).
-
(2004)
Hypertension
, vol.44
, pp. 248-252
-
-
Touyz, R.M.1
-
96
-
-
1842528400
-
Convergence of atherosclerosis and Alzheimer's disease: Infammation, cholesterol, and misfolded proteins
-
Casserly I, Topol E. Convergence of atherosclerosis and Alzheimer's disease: infammation, cholesterol, and misfolded proteins. Lancet 363, 1139-1146 (2004).
-
(2004)
Lancet
, vol.363
, pp. 1139-1146
-
-
Casserly, I.1
Topol, E.2
-
97
-
-
4444333965
-
Recent trials of antioxidant therapy: What should we be telling our patients?
-
Hasnain BI, Mooradian AD. Recent trials of antioxidant therapy: what should we be telling our patients? Cleve. Clin. J. Med. 71, 327-334 (2004).
-
(2004)
Cleve. Clin. J. Med.
, vol.71
, pp. 327-334
-
-
Hasnain, B.I.1
Mooradian, A.D.2
-
98
-
-
0033514107
-
Antioxidant consumption and risk of coronary heart disease: Emphasison vitamin C, vitamin E, and b-carotene: A statement for healthcare professionals from the American Heart Association
-
AHA Science Advisory.
-
Tribble DL. AHA Science Advisory. Antioxidant consumption and risk of coronary heart disease: emphasison vitamin C, vitamin E, and b-carotene: a statement for healthcare professionals from the American Heart Association. Circulation 99, 591-595 (1999).
-
(1999)
Circulation
, vol.99
, pp. 591-595
-
-
Tribble, D.L.1
-
99
-
-
33646855957
-
Neuropathology of Alzheimer disease: Pathognomonic but not pathogenic
-
Castellani RJ, Lee HG, Zhu X et al. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathol. 111, 503-509 (2006).
-
(2006)
Acta Neuropathol.
, vol.111
, pp. 503-509
-
-
Castellani, R.J.1
Lee, H.G.2
Zhu, X.3
|