A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

Science

Volumn 286, Issue 5438, 1999, Pages 304-306

  Salvemini, Daniela ^a   Wang, Zhi Qiang ^b   Zweier, Jay L ^c   Samouilov, Alexandre ^c   Macarthur, Heather ^d   Misko, Thomas P ^b   Currie, Mark G ^b   Cuzzocrea, Salvatore ^e   Sikorski, James A ^b   Riley, Dennis P ^a  

^a MetaPhore Pharmaceuticals   (United States)

^b MONSANTO COMPANY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; M 40404; MACROCYCLIC COMPOUND; MANGANESE DERIVATIVE; MANGANESEDICHLORO(3,10,13,20,26 PENTAAZATETRACYCLO[20.3.1.0(4,9).0(14,19)] 1(26),22(23),24 HEXACOSATRIENE); SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; CELL ADHESION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; RAT; REPERFUSION INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOPROTECTION; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG STABILITY; INFLAMMATION; INTERLEUKIN-1; L-LACTATE DEHYDROGENASE; MALE; MOLECULAR MIMICRY; NEUTROPHILS; ORGANOMETALLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPLANCHNIC CIRCULATION; SUPEROXIDE DISMUTASE; SUPEROXIDES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0033536644     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5438.304     Document Type: Article

References (33)

1. J. M. McCord and I. Fridovich, J. Biol. Chem. 244, 6049 (1969); I. Fridovich, ibid. 264, 7761 (1989).
2. J. M. McCord and I. Fridovich, J. Biol. Chem. 244, 6049 (1969); I. Fridovich, ibid. 264, 7761 (1989).
3. D. E. Cabelli, D. P. Riley, J. A. Rodriguez, J. S. Valentine, H. Zhu, in Biomimetic Oxidations Catalyzed by Transition Metal Complexes, B. Meunier, Ed. (World Scientific, Singapore, in press).
4. A. Petkau, Cancer Treat. Rev. 13, 17 (1986); G. Jadot, A. Vaille, J. Maldonado, P. Vanelle, Clin. Pharmacokinet. 28, 17 (1995).
5. A. Petkau, Cancer Treat. Rev. 13, 17 (1986); G. Jadot, A. Vaille, J. Maldonado, P. Vanelle, Clin. Pharmacokinet. 28, 17 (1995).
6. D. P. Riley, Chem. Rev., in press; D. P. Riley and R. H. Weiss, CA Tech. 1, 41 (1997).
7. D. P. Riley, Chem. Rev., in press; D. P. Riley and R. H. Weiss, CA Tech. 1, 41 (1997).
8. D. P. Riley and R. H. Weiss, J. Am. Chem. Soc. 116, 387 (1994); D. P. Riley et al., Inorg. Chem. 35, 5213 (1996); D. P. Riley, S. L. Henke, P. J. Lennon, R. H. Weiss, W. L. Neumann J. Am. Chem. Soc. 119, 6522 (1997).
9. D. P. Riley and R. H. Weiss, J. Am. Chem. Soc. 116, 387 (1994); D. P. Riley et al., Inorg. Chem. 35, 5213 (1996); D. P. Riley, S. L. Henke, P. J. Lennon, R. H. Weiss, W. L. Neumann J. Am. Chem. Soc. 119, 6522 (1997).
10. D. P. Riley and R. H. Weiss, J. Am. Chem. Soc. 116, 387 (1994); D. P. Riley et al., Inorg. Chem. 35, 5213 (1996); D. P. Riley, S. L. Henke, P. J. Lennon, R. H. Weiss, W. L. Neumann J. Am. Chem. Soc. 119, 6522 (1997).
11. R. H. Weiss et al., J. Biol. Chem. 268, 23049 (1993); R. H. Weiss, D. J. Fretland, D. A. Baron, U. S. Ryan, D. P. Riley, ibid. 271, 26149 (1996); M. M. Hardy, A. G. Flickinger, D. P. Riley, R. H. Weiss, U. S. Ryan, ibid. 269, 18535 (1994).
12. R. H. Weiss et al., J. Biol. Chem. 268, 23049 (1993); R. H. Weiss, D. J. Fretland, D. A. Baron, U. S. Ryan, D. P. Riley, ibid. 271, 26149 (1996); M. M. Hardy, A. G. Flickinger, D. P. Riley, R. H. Weiss, U. S. Ryan, ibid. 269, 18535 (1994).
13. R. H. Weiss et al., J. Biol. Chem. 268, 23049 (1993); R. H. Weiss, D. J. Fretland, D. A. Baron, U. S. Ryan, D. P. Riley, ibid. 271, 26149 (1996); M. M. Hardy, A. G. Flickinger, D. P. Riley, R. H. Weiss, U. S. Ryan, ibid. 269, 18535 (1994).
14. D. P. Riley, S. L. Henke, P. J. Lennon, K. Aston, Inorg. Chem. 38, 1908 (1999).
15. Supplementary information is available at www. sciencemag.org/feature/data/1042101.shl
16. 3)] was administered as an iv bolus at 30 min before or 3 hours after the injection of carrageenan with each point representing the change in edema compared with control measurements taken before carrageenan injection. Rats were housed and cared for in accordance with the guidelines of the Institutional Animal Care and Use Committee and in accordance with National Institutes of Health guidelines on laboratory animal welfare.
17. D. Salvemini et al., Br. J. Pharmacol. 118, 829 (1996).
18. M. Di Rosa and D. A. Willoughby, J. Pharm. Pharmacol. 23, 297 (1971); K. Seibert et al., Proc. Natl. Acad. Sci. U.S.A. 91, 12013 (1994).
19. M. Di Rosa and D. A. Willoughby, J. Pharm. Pharmacol. 23, 297 (1971); K. Seibert et al., Proc. Natl. Acad. Sci. U.S.A. 91, 12013 (1994).
20. A. Ianaro, C. A. O'Donnell, M. Di Rosa, F. Y. Liew, Immunology 82, 370 (1994).
21. D. Salvemini, Z.-Q. Wang, M. Stern, M. G. Currie, T. P. Misko, Proc. Natl. Acad. Sci. U.S.A. 95, 2659 (1998).
22. R. Hirschelmann and H. Beckmeier, Experientia 37, 1313 (1981).
23. I. U. Schraufstatter, P. A. Hyslop, J. Jackson, C. C. Cochrane, Int. J. Tissue React. 9, 317 (1987); J. S. Warren, K. R. Yabroff, D. M. Mandel, K. J. Johnson, P. A. Ward, Free Radical Biol. Med. 8, 163 (1990).
24. I. U. Schraufstatter, P. A. Hyslop, J. Jackson, C. C. Cochrane, Int. J. Tissue React. 9, 317 (1987); J. S. Warren, K. R. Yabroff, D. M. Mandel, K. J. Johnson, P. A. Ward, Free Radical Biol. Med. 8, 163 (1990).
25. D. Salvemini et al., J. Clin. Invest. 96, 301 (1995).
26. J. P. Portanova et al., J. Exp. Med. 184, 883 (1996).
27. F. Squadrito et al., Br. J. Pharmacol. 115, 395 (1995).
28. D. R. Deshmukh et al., Am. J. Physiol. 273, C1130 (1997); Y. Horie et al., Circ. Res. 83, 691 (1998).
29. D. R. Deshmukh et al., Am. J. Physiol. 273, C1130 (1997); Y. Horie et al., Circ. Res. 83, 691 (1998).
30. H. Bitterman, N. Aoki, A. M. Lefer, Proc. Soc. Exp. Biol. Med. 188, 265 (1988).
31. J. S. Beckman, T. W. Beckman, J. Chen, P. A. Marshall, B. A. Freeman, Proc. Natl. Acad. Sci. U.S.A. 87, 1620 (1990); R. Radi, J. S. Beckman, K. M. Bush, B. A. Freeman, Arch. Biochem. Biophys. 288, 481 (1991); H. Rubbo et al., J. Biol. Chem. 269, 26066 (1994).
32. J. S. Beckman, T. W. Beckman, J. Chen, P. A. Marshall, B. A. Freeman, Proc. Natl. Acad. Sci. U.S.A. 87, 1620 (1990); R. Radi, J. S. Beckman, K. M. Bush, B. A. Freeman, Arch. Biochem. Biophys. 288, 481 (1991); H. Rubbo et al., J. Biol. Chem. 269, 26066 (1994).
33. J. S. Beckman, T. W. Beckman, J. Chen, P. A. Marshall, B. A. Freeman, Proc. Natl. Acad. Sci. U.S.A. 87, 1620 (1990); R. Radi, J. S. Beckman, K. M. Bush, B. A. Freeman, Arch. Biochem. Biophys. 288, 481 (1991); H. Rubbo et al., J. Biol. Chem. 269, 26066 (1994).